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1.发明授权6-amino-pyrimidine-4-carboxamide derivatives and related compounds which bind to the sphingosine 1-phosphate (S1P) receptor for the treatment of multiple sclerosis 有权6-氨基 - 嘧啶-4-甲酰胺衍生物和与鞘氨醇1-磷酸（S1P）受体结合以治疗多发性硬化症的相关化合物公开(公告)号：US08399448B2
公开(公告)日：2013-03-19
申请号：US12671996
申请日：2008-07-29
IPC分类号： A61K31/33 , A61K31/497 , A61K31/535 , C07D239/24 , C07D401/12 , C07D403/12 , C07D413/12
CPC分类号： C07D239/42 , C07D401/12 , C07D403/12 , C07D413/12
摘要： The invention relates to compounds of formula (I): wherein X, W, Q, R, R1 and R2 have the meanings given in claim 1. The compounds are useful, for example, in the treatment of autoimmune disorders, such as multiple sclerosis.
摘要翻译： 本发明涉及式（I）的化合物：其中X，W，Q，R，R 1和R 2具有权利要求1中给出的含义。该化合物可用于例如治疗自身免疫性疾病如多发性硬化 。
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2.发明申请6-Amino-Pyrimidine-4-Carboxamide Derivatives and Related Compounds Which Bind to the Sphingosine 1-Phosphate (S1P) Receptor for the Treatment of Multiple Sclerosis 有权6-氨基 - 嘧啶-4-羧酰胺衍生物及其与1-磷酸鞘氨醇受体（S1P）接合治疗多发性硬化症的相关化合物公开(公告)号：US20100210619A1
公开(公告)日：2010-08-19
申请号：US12671996
申请日：2008-07-29
IPC分类号： A61K31/397 , C07D239/42 , A61K31/505 , C07D403/12 , A61K31/496 , C07D413/12 , A61K31/5377 , A61P3/10 , A61P19/02 , A61P17/06 , A61P11/06 , A61P1/00
CPC分类号： C07D239/42 , C07D401/12 , C07D403/12 , C07D413/12
摘要： The invention relates to compounds of formula (I): wherein X, W, Q, R, R1 and R2 have the meanings given in claim 15. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis.
摘要翻译： 本发明涉及式（I）的化合物：其中X，W，Q，R，R 1和R 2具有权利要求15中给出的含义。 治疗自身免疫性疾病，如多发性硬化症。
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公开(公告)号：US08202856B2
公开(公告)日：2012-06-19
申请号：US12809816
申请日：2008-12-17
申请人： Anna Quattropani , Christophe Cleva , Eric Sebille , Matthias Schwarz , Delphine Marin , Agnes Bombrun , Wesley Blackaby , Charles Baker-Glenn , Chris Knight , Craig Rouse
发明人： Anna Quattropani , Christophe Cleva , Eric Sebille , Matthias Schwarz , Delphine Marin , Agnes Bombrun , Wesley Blackaby , Charles Baker-Glenn , Chris Knight , Craig Rouse
IPC分类号： A61K31/397 , A61K31/4545 , A61K31/444 , A61K31/5377 , A61K31/4245 , A61K31/4439 , A61K31/4725 , A61K31/497 , C07D413/04 , C07D413/14 , C07D401/14 , A61P19/02 , A61P3/10 , A61P9/10 , A61P29/00 , A61P1/04 , A61P17/06 , A61P11/06
CPC分类号： C07D413/04 , C07D413/14
摘要： The invention relates to compounds of formula I: wherein R1, R2,Ra, Rb, X have the meanings given in claim 16. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis.
摘要翻译： 本发明涉及式I化合物：其中R1，R2，Ra，Rb，X具有权利要求1中给出的含义。 治疗自身免疫性疾病，如多发性硬化症。
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公开(公告)号：US06770656B2
公开(公告)日：2004-08-03
申请号：US10182745
申请日：2002-12-26
申请人： Serge Halazy , Matthias Schwarz , Bruno Antonsson , Agnes Bombrun , Jean-Claude Martinou , Dennis Church
发明人： Serge Halazy , Matthias Schwarz , Bruno Antonsson , Agnes Bombrun , Jean-Claude Martinou , Dennis Church
IPC分类号： C07D21304
CPC分类号： C07D217/26 , C07B2200/07 , C07C237/22 , C07C2601/14 , C07D207/16 , C07D211/60 , C07D277/06
摘要： The present invention is related to substituted amine derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such amine derivatives of formula (I). Said substituted amine derivatives are efficient modulators, in particular inhibitors, of the Bax function and/or activation. The present invention is furthermore related to novel substituted amine derivatives as well as methods of their preparation.
摘要翻译： 本发明涉及特别用作药物活性化合物的取代胺衍生物，以及含有式（I）胺衍生物的药物制剂。 所述取代的胺衍生物是Bax功能和/或活化的有效调节剂，特别是抑制剂。 本发明还涉及新型取代的胺衍生物及其制备方法。
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公开(公告)号：US20090318486A1
公开(公告)日：2009-12-24
申请号：US11919471
申请日：2006-05-23
申请人： Matthias Schwarz , Eric Sebille , Christophe Cleva , Cedric Merlot , Dennis Church , Patrick Page , Jacqueline A. Macritchie , John Frederick Atherall , Stefano Crosignani , Doris Pupowicz
发明人： Matthias Schwarz , Eric Sebille , Christophe Cleva , Cedric Merlot , Dennis Church , Patrick Page , Jacqueline A. Macritchie , John Frederick Atherall , Stefano Crosignani , Doris Pupowicz
IPC分类号： A61K31/437 , C07D487/10 , A61K31/427 , C07D471/04 , A61P25/00
CPC分类号： C07D487/10
摘要： The present invention is related to the use of spiro derivatives of Formula (I) for the treatment and/or prevention of allergic diseases, inflammatory dermatoses and other diseases with an inflammatory component. Specifically, the present invention is related to the use of spiro derivatives for the modulation of CRTH2 activity.
摘要翻译： 本发明涉及式（I）的螺衍生物用于治疗和/或预防具有炎性成分的过敏性疾病，炎性皮肤病和其它疾病的用途。 具体地说，本发明涉及螺衍生物用于调节CRTH2活性的用途。
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公开(公告)号：US08236963B2
公开(公告)日：2012-08-07
申请号：US11919471
申请日：2006-05-23
申请人： Matthias Schwarz , Eric Sebille , Christophe Cleva , Cedric Merlot , Dennis Church , Patrick Page , Jacqueline A. Macritchie , John Frederick Atherall , Stefano Crosignani , Doris Pupowicz
发明人： Matthias Schwarz , Eric Sebille , Christophe Cleva , Cedric Merlot , Dennis Church , Patrick Page , Jacqueline A. Macritchie , John Frederick Atherall , Stefano Crosignani , Doris Pupowicz
IPC分类号： C07D277/20 , C07D271/06 , C07D417/14 , C07D487/10 , C07D261/06 , A61K31/44 , A61K31/431 , A61K31/4184 , A61K31/4196 , A61K31/41
CPC分类号： C07D487/10
摘要： The present invention is related to the use of spiro derivatives of Formula (I) for the treatment and/or prevention of allergic diseases, inflammatory dermatoses and other diseases with an inflammatory component. Specifically, the present invention is related to the use of spiro derivatives for the modulation of CRTH2 activity.
摘要翻译： 本发明涉及式（I）的螺衍生物用于治疗和/或预防具有炎性成分的过敏性疾病，炎性皮肤病和其它疾病的用途。 具体地说，本发明涉及螺衍生物用于调节CRTH2活性的用途。
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公开(公告)号：US20100305092A1
公开(公告)日：2010-12-02
申请号：US12809816
申请日：2008-12-17
IPC分类号： A61K31/397 , C07D413/04 , A61K31/4245 , C07D413/14 , A61K31/4439 , A61K31/5377 , C07D401/14 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/497 , A61P19/02 , A61P3/10 , A61P9/10 , A61P1/04 , A61P17/06 , A61P11/06 , A61P29/00
CPC分类号： C07D413/04 , C07D413/14
摘要： The invention relates to compounds of formula I: wherein R1, R2, Ra, Rb, X have the meanings given in claim 16. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis.
摘要翻译： 本发明涉及式I化合物：其中R1，R2，Ra，Rb，X具有权利要求1中给出的含义。 治疗自身免疫性疾病，如多发性硬化症。
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公开(公告)号：US20120028959A1
公开(公告)日：2012-02-02
申请号：US13262640
申请日：2010-03-26
申请人： Siva Sanjeeva Rao Thunuguntla , Hosahalli Subramanya , Satish Reddy Kunnam , Sekhar Reddy Sanivaru Vijay , Chakrapani Bingi , Raviraj Kusanur , Matthias Schwarz , Michael Arlt
发明人： Siva Sanjeeva Rao Thunuguntla , Hosahalli Subramanya , Satish Reddy Kunnam , Sekhar Reddy Sanivaru Vijay , Chakrapani Bingi , Raviraj Kusanur , Matthias Schwarz , Michael Arlt
IPC分类号： A61K31/55 , A61K31/4184 , C07D263/57 , A61K31/423 , C07D409/10 , C07D403/10 , C07D417/10 , A61K31/428 , C07D401/04 , A61K31/4439 , C07D413/10 , A61K31/5377 , A61P25/00 , A61P29/00 , A61P35/00 , A61P1/00 , C07D235/18
CPC分类号： C07D209/08 , C07D235/18 , C07D401/04 , C07D401/10 , C07D403/04 , C07D409/10 , C07D413/10 , C07D417/10 , C07D471/04
摘要： The invention relates to compounds of formula (I) wherein R1, R2, X1, X2, Y, Ra, Rb, Q have the meanings given in claim 1. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis and also in the treatment of cancer disorders.
摘要翻译： 本发明涉及式（I）化合物，其中R 1，R 2，X 1，X 2，Y，R a，R b，Q具有权利要求1中给出的含义。 在治疗自身免疫性疾病如多发性硬化以及治疗癌症中。
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公开(公告)号：US20100305137A1
公开(公告)日：2010-12-02
申请号：US12792665
申请日：2010-06-02
IPC分类号： A61K31/496 , A61P15/00 , A61P15/08
CPC分类号： C07D409/14 , A61K31/496 , C07D401/14 , C07D403/12 , C07D403/14 , C07D471/04 , C07D487/04
摘要： The invention provides 2-carboxamide piperazine compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are useful for the treatment of mammalian infertility.
摘要翻译： 本发明提供2-甲酰胺哌嗪化合物，以及使用或包含一种或多种这些化合物的治疗方法和药物组合物。 本发明的化合物可用于治疗哺乳动物不育症。
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10.发明申请THIAZOLIDINE CARBOXAMIDE DERIVATIVES AS MODULATORS OF THE PROSTAGLANDIN F RECEPTOR 有权作为PROSTAGLANDIN F受体的调节剂的噻唑烷羧酰胺衍生物公开(公告)号：US20090215749A9
公开(公告)日：2009-08-27
申请号：US12140682
申请日：2008-06-17
申请人： Patrick Naxos PAGE , Catherine Jorand-Lebrun , Anna Quattropani , Vincent Pomel , Matthias Schwarz , Estelle Hamelin , Russell J. Thomas
发明人： Patrick Naxos PAGE , Catherine Jorand-Lebrun , Anna Quattropani , Vincent Pomel , Matthias Schwarz , Estelle Hamelin , Russell J. Thomas
IPC分类号： A61K31/55 , C07D277/06 , A61K31/426 , A61P15/06 , A61P15/04 , C07D417/12
CPC分类号： C07D417/12 , A61K31/426 , A61K31/427 , C07D277/06 , C07D417/14 , Y02P20/582
摘要： The present invention is related to thiazolidine carboxamide derivatives of formula (II) for the treatment and/or prophylaxis of preterm labor, premature birth, dysmenorrhea and for stopping labor prior to cesarean delivery.
摘要翻译： 本发明涉及式（II）的噻唑烷羧酰胺衍生物，其用于治疗和/或预防早产，早产，痛经和用于在剖宫产分娩前停止劳动。
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