公开(公告)号：US09575766B2

公开(公告)日：2017-02-21

申请号：US13991878

申请日：2011-12-29

申请人： Ahmad Yasin ,  Peggy J. Irelan ,  Ofer Levy ,  Emile Ziedan ,  Grant Zhou

发明人： Ahmad Yasin ,  Peggy J. Irelan ,  Ofer Levy ,  Emile Ziedan ,  Grant Zhou

IPC分类号： G06F9/38 ,  G06F11/34

CPC分类号： G06F9/3861 ,  G06F11/3466 ,  G06F11/3476 ,  G06F2201/86 ,  G06F2201/88

摘要： Some implementations provide techniques and arrangements for causing an interrupt in a processor in response to an occurrence of a number of events. A first event counter counts the occurrences of a type of event within the processor and outputs a signal to activate a second event counter in response to reaching a first predefined count. The second event counter counts the occurrences of the type of event within the processor and causes an interrupt of the processor in response to reaching a second predefined count.

摘要翻译： 一些实现提供了响应于多个事件的发生而在处理器中引起中断的技术和布置。 第一事件计数器对处理器内事件类型的发生进行计数，并响应于达到第一预定义计数而输出信号以激活第二事件计数器。 第二事件计数器对处理器内的事件类型的发生进行计数，并响应于达到第二预定义计数而导致处理器的中断。

公开(公告)号：US20140013091A1

公开(公告)日：2014-01-09

申请号：US13991878

申请日：2011-12-29

申请人： Ahmad Yasin ,  Peggy J. Irelan ,  Ofer Levy ,  Emile Ziedan ,  Grant Zhou

发明人： Ahmad Yasin ,  Peggy J. Irelan ,  Ofer Levy ,  Emile Ziedan ,  Grant Zhou

IPC分类号： G06F9/38

CPC分类号： G06F9/3861 ,  G06F11/3466 ,  G06F11/3476 ,  G06F2201/86 ,  G06F2201/88

摘要： Some implementations provide techniques and arrangements for causing an interrupt in a processor in response to an occurrence of a number of events. A first event counter counts the occurrences of a type of event within the processor and outputs a signal to activate a second event counter in response to reaching a first predefined count. The second event counter counts the occurrences of the type of event within the processor and causes an interrupt of the processor in response to reaching a second predefined count.

摘要翻译： 一些实现提供了响应于多个事件的发生而在处理器中引起中断的技术和布置。 第一事件计数器对处理器内事件类型的发生进行计数，并响应于达到第一预定义计数而输出信号以激活第二事件计数器。 第二事件计数器对处理器内的事件类型的发生进行计数，并响应于达到第二预定义计数而导致处理器的中断。

公开(公告)号：US09626274B2

公开(公告)日：2017-04-18

申请号：US14580676

申请日：2014-12-23

申请人： Ahmad Yasin ,  Rajshree A. Chabukswar ,  Ofer Levy ,  Michael W. Chynoweth ,  Charlie J. Hewett

发明人： Ahmad Yasin ,  Rajshree A. Chabukswar ,  Ofer Levy ,  Michael W. Chynoweth ,  Charlie J. Hewett

IPC分类号： G06F11/00 ,  G06F11/34 ,  G06F11/30 ,  G06F9/38

CPC分类号： G06F11/3471 ,  G06F9/30076 ,  G06F9/38 ,  G06F11/3024 ,  G06F11/3037 ,  G06F11/3466 ,  G06F11/348 ,  G06F2201/81 ,  G06F2201/88

摘要： A processor includes a front end, a decoder, a retirement unit, and a performance monitoring unit. The front end includes a decoder with logic to receive a tracking instruction to enable tracking of execution of a region of memory. The instruction is to define an address range of the region. The retirement includes logic to retire the tracking instruction and candidate instructions. The performance monitoring unit includes logic to determine that the candidate instructions are associated with an entrance and an exit to the address range, and to generate an alert based on the candidate instructions association with the entrance and the exit.

公开(公告)号：US20140380027A1

公开(公告)日：2014-12-25

申请号：US13922421

申请日：2013-06-20

申请人： Ahmad Yasin ,  Michael W. Chynoweth ,  Ofer Levy ,  Jason W. Brandt ,  Angela Schmid

发明人： Ahmad Yasin ,  Michael W. Chynoweth ,  Ofer Levy ,  Jason W. Brandt ,  Angela Schmid

IPC分类号： G06F9/30

CPC分类号： G06F9/3806 ,  G06F9/30058 ,  G06F9/30098 ,  G06F11/3419 ,  G06F11/348 ,  G06F2201/865 ,  G06F2201/88

摘要： A processing device implementing an elapsed cycle timer in last branch records (LBRs) is disclosed. A processing device of the disclosure includes a last branch record (LBR) counter to iterate with each cycle of the processing device and an LBR structure communicably coupled to the LBR counter. The LBR structure comprises a plurality of LBR entries. Furthermore, an LBR entry of the plurality of LBR entries comprises an address instruction pointer (IP) of a branch instruction executed by the processing device, an address IP of a target of the branch instruction, and an elapsed time field that stores a value of the LBR counter when the LBR entry is created.

摘要翻译： 公开了一种在最后的分支记录（LBR）中实现经过周期定时器的处理装置。 本公开的处理装置包括与处理装置的每个周期重复的最后一个分支记录（LBR）计数器和可通信地耦合到LBR计数器的LBR结构。 LBR结构包括多个LBR条目。 此外，多个LBR条目的LBR条目包括由处理装置执行的分支指令的地址指令指针（IP），分支指令的目标的地址IP以及存储分支指令的值的经过时间字段 当创建LBR条目时，LBR计数器。

公开(公告)号：US20160179650A1

公开(公告)日：2016-06-23

申请号：US14580676

申请日：2014-12-23

申请人： Ahmad Yasin ,  Rajshree A. Chabukswar ,  Ofer Levy ,  Michael W. Chynoweth ,  Charlie J. Hewett

发明人： Ahmad Yasin ,  Rajshree A. Chabukswar ,  Ofer Levy ,  Michael W. Chynoweth ,  Charlie J. Hewett

IPC分类号： G06F11/34 ,  G06F11/32 ,  G06F11/30

CPC分类号： G06F11/3471 ,  G06F9/30076 ,  G06F9/38 ,  G06F11/3024 ,  G06F11/3037 ,  G06F11/3466 ,  G06F11/348 ,  G06F2201/81 ,  G06F2201/88

摘要： A processor includes a front end, a decoder, a retirement unit, and a performance monitoring unit. The front end includes a decoder with logic to receive a tracking instruction to enable tracking of execution of a region of memory. The instruction is to define an address range of the region. The retirement includes logic to retire the tracking instruction and candidate instructions. The performance monitoring unit includes logic to determine that the candidate instructions are associated with an entrance and an exit to the address range, and to generate an alert based on the candidate instructions association with the entrance and the exit.

摘要翻译： 处理器包括前端，解码器，退休单元和性能监视单元。 前端包括具有逻辑的解码器，其具有接收跟踪指令以使得能够跟踪存储器区域的执行。 该指令是定义该区域的地址范围。 退休包括退出跟踪指令和候选指令的逻辑。 性能监视单元包括确定候选指令与地址范围的入口和出口相关联的逻辑，并且基于与入口和出口的候选指令关联来生成警报。

公开(公告)号：US20140056811A1

公开(公告)日：2014-02-27

申请号：US13976502

申请日：2011-12-26

申请人： Etai Jacob ,  Amir Toporik ,  Ronen Shemesh ,  Ofer Levy

发明人： Etai Jacob ,  Amir Toporik ,  Ronen Shemesh ,  Ofer Levy

IPC分类号： A61K47/48

CPC分类号： C07K14/78 ,  A61K47/62 ,  C07K14/47 ,  C07K2319/01

摘要： The present invention is related to peptides, which are suitable for use as cell-penetrating peptides (CPPs), variants thereof and/or complexes, fusion molecules and/or conjugates comprising same, use thereof for manufacture of compositions for diagnosing, treating and/or preventing of medical conditions.

摘要翻译： 本发明涉及适合用作细胞穿透肽（CPP），其变体和/或复合物，包含其的融合分子和/或缀合物的肽，其用于制备用于诊断，治疗和/ 或预防医疗状况。

公开(公告)号：US08529943B2

公开(公告)日：2013-09-10

申请号：US13054914

申请日：2009-07-20

申请人： Yossef Kliger ,  Itamar Borukhov ,  Ofer Levy ,  Zohar Tiran ,  Assaf Wool ,  Ehud Schreiber ,  Anat Amir ,  Zurit Levine ,  Amir Toporik

发明人： Yossef Kliger ,  Itamar Borukhov ,  Ofer Levy ,  Zohar Tiran ,  Assaf Wool ,  Ehud Schreiber ,  Anat Amir ,  Zurit Levine ,  Amir Toporik

IPC分类号： C07K14/515 ,  C07K14/00 ,  C07K7/06 ,  C07K7/08 ,  C07K16/46 ,  A61K38/16 ,  A61K38/08 ,  A61K38/10

CPC分类号： C07K14/515 ,  A61K38/14 ,  A61K38/1891 ,  A61K45/06 ,  C07K9/00 ,  C07K9/001

摘要： Provided are angiopoietin-derived peptides or homologs or derivatives thereof, pharmaceutical composition including them, a use thereof for therapy and for the manufacture of a medicament, a method of treating a wide range of conditions, disorders and diseases therewith, nucleotide sequences encoding them, antibodies directed to epitopes thereof and fusion proteins including them.

摘要翻译： 提供来自血管生成素的肽或其同系物或衍生物，包含它们的药物组合物，其用于治疗和制备药物的用途，治疗各种病症，疾病和疾病的方法，编码它们的核苷酸序列， 针对其表位的抗体和包括它们的融合蛋白。

公开(公告)号：US20120238460A1

公开(公告)日：2012-09-20

申请号：US12739976

申请日：2008-11-10

申请人： Ofer Levy ,  Eva Guinan ,  Eugenie Suter

发明人： Ofer Levy ,  Eva Guinan ,  Eugenie Suter

IPC分类号： C40B30/04

CPC分类号： G01N33/6863 ,  G01N2333/523 ,  G01N2800/245 ,  G01N2800/50

摘要： Disclosed herein are methods for determining the likelihood of a subject to develop Acute graft versus host disease (aGVHD) upon receiving myeloablative allogeneic hematopoietic stem cell transplantation (HSCT). One such method comprises assaying for baseline plasma concentration of RANTES in a sample obtained from the subject, and comparing the baseline plasma concentration of RANTES to a predetermined level. The method may further comprise assaying for day 7 plasma concentration of RANTES in sample obtained from the subject, and comparing the day 7 plasma concentration of RANTES to a predetermined level. Another such method comprises assaying for day 7 plasma concentration of RANTES in a sample obtained from the subject, and comparing the day 7 plasma concentration of RANTES to a predetermined level. Another such method comprises assaying for donor plasma concentration of RANTES in a sample obtained from a donor of the hemtopoietic stem cells, and comparing the donor plasma concentration of RANTES to a predetermined level, wherein a donor plasma concentration of RANTES less than the predetermined level indicates a likelihood of the subject to develop aGVHD upon receiving myeloablative allogeneic HSCT from that donor. Other methods include assaying for day 0, or for day 7, plasma concentration of MCP-1 in a sample obtained from the subject, and comparing the day 0 or day 7, plasma concentration of MCP-1 to a predetermined level.

摘要翻译： 本文公开了用于确定受试者在接受清髓性同种异体造血干细胞移植（HSCT）时发展为急性移植物抗宿主病（aGVHD）的可能性的方法。 一种这样的方法包括测定从受试者获得的样品中RANTES的基线血浆浓度，并将RANTES的基线血浆浓度与预定水平进行比较。 该方法还可以包括测定从受试者获得的样品中RANTES的第7天血浆浓度，并将RANTES的第7天血浆浓度与预定水平进行比较。 另一种这样的方法包括测定从受试者获得的样品中RANTES的第7天血浆浓度，并将RANTES的第7天血浆浓度与预定水平进行比较。 另一种这样的方法包括测定从造血干细胞的供体获得的样品中RANTES的供体血浆浓度，并将RANTES的供体血浆浓度与预定水平进行比较，其中RANTES的供体血浆浓度小于预定水平表明 接受来自该供体的清髓性同种异体HSCT的受试者可能发生GV​​HD。 其他方法包括测定从受试者获得的样品中的第0天或第7天MCP-1的血浆浓度，并将MCP-1的血浆浓度与第0天或第7天的血浆浓度进行比较。

公开(公告)号：US20110311450A1

公开(公告)日：2011-12-22

申请号：US13131879

申请日：2009-12-08

申请人： Zurit Levine ,  Avi Rosenberg ,  Galit Rotman ,  Amit Novik ,  Amir Toporik ,  Yaron Kinar ,  Sergey Nemzer ,  Shira Walach ,  Eve Montia ,  Shirley Sameach-Greenwald ,  Liat Dassa ,  Merav Beiman ,  Anat Cohen-Dayag ,  Ofer Levy

发明人： Zurit Levine ,  Avi Rosenberg ,  Galit Rotman ,  Amit Novik ,  Amir Toporik ,  Yaron Kinar ,  Sergey Nemzer ,  Shira Walach ,  Eve Montia ,  Shirley Sameach-Greenwald ,  Liat Dassa ,  Merav Beiman ,  Anat Cohen-Dayag ,  Ofer Levy

IPC分类号： A61K49/00 ,  C12N9/96 ,  A61P35/00 ,  A61K39/395 ,  C40B30/04 ,  G01N33/574 ,  C07K16/30 ,  C12N5/078

CPC分类号： C07K16/28 ,  A61K38/00 ,  A61K39/39558 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3038 ,  C07K16/3053 ,  C07K16/3061 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/57484 ,  G01N33/577 ,  G01N2333/47

摘要： This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against KRTCAP3, FAM26F, MGC52498, FAM70A or TMEM154 antigens, which are differentially expressed in cancer, and diagnostic and therapeutic usages. This invention further relates to extracellular domains of KRTCAP3, FAM26F, MGC52498, FAM70A and TMEM154 proteins and variants, and therapeutic usages thereof.

摘要翻译： 本发明涉及用于产生免疫和非免疫的治疗剂和疾病诊断的新靶标。 更具体地，本发明提供针对在癌症中差异表达的KRTCAP3，FAM26F，MGC52498，FAM70A或TMEM154抗原以及诊断和治疗用途的治疗性抗体。 本发明还涉及KRTCAP3，FAM26F，MGC52498，FAM70A和TMEM154蛋白质和变体的细胞外结构域及其治疗用途。

公开(公告)号：US20090327663A1

公开(公告)日：2009-12-31

申请号：US12215526

申请日：2008-06-27

申请人： Zeev Sperber ,  Rafi Marom ,  Ofer Levy

发明人： Zeev Sperber ,  Rafi Marom ,  Ofer Levy

IPC分类号： G06F9/30

CPC分类号： G06F1/3203 ,  G06F1/3287 ,  G06F9/3855 ,  G06F9/3857 ,  G06F9/3865 ,  Y02D10/124 ,  Y02D10/171 ,  Y02D50/20

摘要： In one embodiment, the present invention includes a retirement unit to receive and retire executed instructions. The retirement unit may include a first array to receive information at allocation and a second array to receive information after execution. The retirement unit may further include logic to calculate an event associated with an executed instruction if information associated with the executed instruction is stored in an on-demand portion of at least one of arrays. Other embodiments are described and claimed.

摘要翻译： 在一个实施例中，本发明包括用于接收和退出执行的指令的退休单元。 退休单元可以包括用于在分配时接收信息的第一阵列和用于在执行之后接收信息的第二阵列。 如果与所执行的指令相关联的信息被存储在阵列中的至少一个的按需部分中，退休单元还可以包括用于计算与执行的指令相关联的事件的逻辑。 描述和要求保护其他实施例。