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公开(公告)号：US06905511B2
公开(公告)日：2005-06-14
申请号：US10379642
申请日：2003-03-05
申请人： Aiguo Wang , Aaron Essner
发明人： Aiguo Wang , Aaron Essner
摘要： A prosthetic medical device exhibiting improved wear resistance is fabricated by irradiating at least one polyolefinic material in the presence of an inert atmosphere to yield a cross-linked irradiated polyolefinic material; blending at least one non-irradiated polyolefinic material with the at least one irradiated polyolefinic material, and forming the prosthetic medical device from the blended material. Selectively cross-linked polymeric compositions may be created by blending a specific amount of cross-linked resins with a specific amount of uncross-linked resins then cured into a polymeric matrix whereby the desired degree or percentage of overall cross-linking is obtained. The polymeric material may then be formed directly into a finished article by injection molding the polymeric material.
摘要翻译： 通过在惰性气氛的存在下照射至少一种聚烯烃材料来制造显示出改善的耐磨性的假体医疗装置，得到交联的辐照聚烯烃材料; 将至少一种未经辐射的聚烯烃材料与所述至少一种辐射的聚烯烃材料混合，以及从所述混合材料形成所述假体医疗装置。 选择性交联的聚合物组合物可以通过将特定量的交联树脂与特定量的未交联树脂混合，然后固化成聚合物基体，从而获得所需的整体交联度或百分比来产生。 然后可以通过注射模制聚合物材料将聚合物材料直接形成成品。
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公开(公告)号：US06566451B2
公开(公告)日：2003-05-20
申请号：US10137050
申请日：2002-05-01
申请人： Aiguo Wang , Aaron Essner
发明人： Aiguo Wang , Aaron Essner
IPC分类号： B29B1308
摘要： Methods for fabricating prosthetic medical devices exhibiting improved wear resistance include selectively cross-linking polymeric resins then curing and shaping the polymer into a finished article. Selectively cross-linked polymeric compositions may be created by blending a specific amount of cross-linked resins with a specific amount of uncross-linked resins then cured into a polymeric matrix whereby the desired degree or percentage of overall cross-linking is obtained. The polymeric material may then be formed directly into a finished article by injection molding the polymeric material.
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3.发明授权公开(公告)号：US06436137B2
公开(公告)日：2002-08-20
申请号：US09909156
申请日：2001-07-19
申请人： Aiguo Wang , Aaron Essner
发明人： Aiguo Wang , Aaron Essner
IPC分类号： A61F202
摘要： Methods and compositions for fabricating prosthetic medical devices exhibiting improved wear resistance include selectively cross-linking polymeric resins then curing and shaping the polymer into a finished article. The selectively cross-linked polymeric compositions may be created by blending a specific amount of cross-linked resins with a specific amount of uncross-linked resins then cured into a polymeric matrix whereby the desired degree or percentage of overall cross-linking is obtained. The polymeric material may then be formed directly into a finished article by injection molding the polymeric material.
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公开(公告)号：US20050167893A1
公开(公告)日：2005-08-04
申请号：US11067139
申请日：2005-02-25
申请人： Aiguo Wang , Aaron Essner
发明人： Aiguo Wang , Aaron Essner
摘要： A prosthetic medical device exhibiting improved wear resistance is fabricated by sealing at least one polyolefinic material in an airtight container and providing an inert atmosphere within the airtight container. The polyolefinic material is exposed to an irradiation source to yield a cross-linked irradiated polyolefinic material. At least one non-irradiated polyolefinic material is blended with the irradiated polyolefinic material, and the prosthetic medical device is formed from the blended material. Selectively cross-linked polymeric compositions may be created by blending a specific amount of cross-linked resins with a specific amount of uncross-linked resins then cured into a polymeric matrix whereby the desired degree or percentage of overall cross-linking is obtained. The polymeric material may then be formed directly into a finished article by injection molding the polymeric material.
摘要翻译： 通过在气密容器中密封至少一种聚烯烃材料并在气密容器内提供惰性气氛来制造显示出改进的耐磨性的假体医疗装置。 将聚烯烃材料暴露于照射源以产生交联的辐照聚烯烃材料。 将至少一种未经照射的聚烯烃材料与被照射的聚烯烃材料混合，并且所述假体医疗装置由所述混合材料形成。 选择性交联的聚合物组合物可以通过将特定量的交联树脂与特定量的未交联树脂混合，然后固化成聚合物基体，从而获得所需的整体交联度或百分比来产生。 然后可以通过注射模制聚合物材料将聚合物材料直接形成成品。
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公开(公告)号：US20050043431A1
公开(公告)日：2005-02-24
申请号：US10957782
申请日：2004-10-04
申请人： Aiguo Wang , John Dumbleton , Aaron Essner , Shi-Shen Yau
发明人： Aiguo Wang , John Dumbleton , Aaron Essner , Shi-Shen Yau
CPC分类号： C08J3/28 , A61L27/16 , C08J3/247 , C08L23/06 , C08L2312/06
摘要： A method of producing an improved polyethylene, especially an ultra-high molecular weight polyethylene utilizes a sequential irradiation and annealing process to form a highly cross-linked polyethylene material. The use of sequential irradiation followed by sequential annealing after each irradiation allows each dose of irradiation in the series of doses to be relatively low while achieving a total dose which is sufficiently high to cross-link the material. The process may either be applied to a preformed material such as a rod or bar or sheet made from polyethylene resin or may be applied to a finished polyethylene part. If applied to a finished polyethylene part, the irradiation and annealing must be accomplished with the polyethylene material not in contact with oxygen at a concentration greater than 1% oxygen volume by volume. When applied to a preform, such as a rod, the annealing of the bulk polymer part of the rod from which the finished part is made must take place on the rod before the implant is machined therefrom and exposed to oxygen.
摘要翻译： 一种生产改进的聚乙烯，特别是超高分子量聚乙烯的方法，该聚乙烯利用顺序的照射和退火工艺来形成高度交联的聚乙烯材料。 在每次照射之后使用顺序照射，然后进行顺序退火，允许在一系列剂量中的每个剂量的照射相对较低，同时实现足够高的交联材料的总剂量。 该方法可以应用于预成型材料，例如由聚乙烯树脂制成的棒或棒或片，或者可以施加到成品聚乙烯部分上。 如果应用于成品聚乙烯部件，照射和退火必须用不超过1体积氧浓度的氧气接触的聚乙烯材料完成。 当应用于诸如棒的预成型件时，制造成品部件的棒的主体聚合物部分的退火必须在植入物从其加工并暴露于氧之前在棒上进行。
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公开(公告)号：US07714036B2
公开(公告)日：2010-05-11
申请号：US12315994
申请日：2008-12-09
申请人： Aiguo Wang , John H. Dumbleton , Aaron Essner , Shi-Shen Yau
发明人： Aiguo Wang , John H. Dumbleton , Aaron Essner , Shi-Shen Yau
IPC分类号： C08F10/00 , C08F110/00 , A61F2/02
CPC分类号： C08J3/28 , A61L27/16 , C08J3/247 , C08L23/06 , C08L2312/06
摘要： A method of producing an improved polyethylene, especially an ultra-high molecular weight polyethylene utilizes a sequential irradiation and annealing process to form a highly cross-linked polyethylene material. The use of sequential irradiation followed by sequential annealing after each irradiation allows each dose of irradiation in the series of doses to be relatively low while achieving a total dose which is sufficiently high to cross-link the material. The process may either be applied to a preformed material such as a rod or bar or sheet made from polyethylene resin or may be applied to a finished polyethylene part. If applied to a finished polyethylene part, the irradiation and annealing must be accomplished with the polyethylene material not in contact with oxygen at a concentration greater than 1% oxygen volume by volume. When applied to a preform, such as a rod, the annealing of the bulk polymer part of the rod from which the finished part is made must take place on the rod before the implant is machined therefrom and exposed to oxygen.
摘要翻译： 改进的聚乙烯，特别是超高分子量聚乙烯的生产方法利用顺序的照射和退火方法形成高度交联的聚乙烯材料。 在每次照射之后使用顺序照射，然后进行顺序退火，允许在一系列剂量中的每个剂量的照射相对较低，同时实现足够高的交联材料的总剂量。 该方法可以应用于预成型材料，例如由聚乙烯树脂制成的棒或棒或片，或者可以施加到成品聚乙烯部分上。 如果应用于成品聚乙烯部件，照射和退火必须用不超过1体积氧浓度的氧气接触的聚乙烯材料完成。 当应用于诸如棒的预成型件时，制造成品部件的棒的主体聚合物部分的退火必须在植入物从其加工并暴露于氧之前在棒上进行。
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公开(公告)号：US20090105439A1
公开(公告)日：2009-04-23
申请号：US12315994
申请日：2008-12-09
申请人： Aiguo Wang , John H. Dumbleton , Aaron Essner , Shi-Shen Yau
发明人： Aiguo Wang , John H. Dumbleton , Aaron Essner , Shi-Shen Yau
IPC分类号： C08F110/02
CPC分类号： C08J3/28 , A61L27/16 , C08J3/247 , C08L23/06 , C08L2312/06
摘要： A method of producing an improved polyethylene, especially an ultra-high molecular weight polyethylene utilizes a sequential irradiation and annealing process to form a highly cross-linked polyethylene material. The use of sequential irradiation followed by sequential annealing after each irradiation allows each dose of irradiation in the series of doses to be relatively low while achieving a total dose which is sufficiently high to cross-link the material. The process may either be applied to a preformed material such as a rod or bar or sheet made from polyethylene resin or may be applied to a finished polyethylene part. If applied to a finished polyethylene part, the irradiation and annealing must be accomplished with the polyethylene material not in contact with oxygen at a concentration greater than 1% oxygen volume by volume. When applied to a preform, such as a rod, the annealing of the bulk polymer part of the rod from which the finished part is made must take place on the rod before the implant is machined therefrom and exposed to oxygen.
摘要翻译： 改进的聚乙烯，特别是超高分子量聚乙烯的生产方法利用顺序的照射和退火方法形成高度交联的聚乙烯材料。 在每次照射之后使用顺序照射，然后进行顺序退火，允许在一系列剂量中的每个剂量的照射相对较低，同时实现足够高的交联材料的总剂量。 该方法可以应用于预成型材料，例如由聚乙烯树脂制成的棒或棒或片，或者可以施加到成品聚乙烯部分上。 如果应用于成品聚乙烯部件，照射和退火必须用不超过1体积氧浓度的氧气接触的聚乙烯材料完成。 当应用于诸如棒的预成型件时，制造成品部件的棒的主体聚合物部分的退火必须在植入物从其加工并暴露于氧之前在棒上进行。
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公开(公告)号：US20050113935A1
公开(公告)日：2005-05-26
申请号：US10931235
申请日：2004-08-30
申请人： Aiguo Wang , Aaron Essner , Alfred Zarnowski
发明人： Aiguo Wang , Aaron Essner , Alfred Zarnowski
IPC分类号： A61L27/00 , A61F2/00 , A61F2/30 , A61L27/16 , B29C35/02 , B29C35/08 , B29C67/00 , B29K23/00 , B29L31/48 , C08J7/00 , C08L23/06
CPC分类号： B29C35/08 , A61F2/30 , A61F2/3094 , A61F2002/30004 , A61F2250/0014 , A61L27/16 , B29C35/0266 , B29C2035/0844 , B29C2035/085 , B29C2035/0877 , B29K2023/065 , B29K2023/0675 , B29K2023/0683 , B29K2105/0088 , B29K2995/0087 , B29L2031/7532 , C08L23/06
摘要： An improved prosthetic medical device having improved wear resistance and toughness is provided in the present application. A method is provided to selectively cross-link the polymeric matrix comprising the medical device by employing an interrupting means such as a mask, wire mesh or chopper wheel placed in between the medical device and irradiation source. In addition, the medical device may be translated while being irradiated to further effect the selective cross-linking. The present invention also provides for an injection molding process wherein a prosthetic medical device is formed in a single step, then selectively cross-linked.
摘要翻译： 在本申请中提供了具有改善的耐磨性和韧性的改进的假体医疗装置。 提供了一种方法，通过采用放置在医疗装置和照射源之间的掩模，丝网或切碎轮等中断装置来选择性地交联包含医疗装置的聚合物基质。 此外，可以在照射医疗装置的同时进行平移，以进一步影响选择性交联。 本发明还提供了一种注射成型方法，其中在单一步骤中形成假体医疗装置，然后选择性地交联。
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公开(公告)号：US08030370B2
公开(公告)日：2011-10-04
申请号：US12757394
申请日：2010-04-09
申请人： Aiguo Wang , John H. Dumbleton , Aaron Essner , Shi-Shen Yau
发明人： Aiguo Wang , John H. Dumbleton , Aaron Essner , Shi-Shen Yau
CPC分类号： C08J3/28 , A61L27/16 , C08J3/247 , C08L23/06 , C08L2312/06
摘要： A method of producing an improved polyethylene, especially an ultra-high molecular weight polyethylene utilizes a sequential irradiation and annealing process to form a highly cross-linked polyethylene material. The use of sequential irradiation followed by sequential annealing after each irradiation allows each dose of irradiation in the series of doses to be relatively low while achieving a total dose which is sufficiently high to cross-link the material. The process may either be applied to a preformed material such as a rod or bar or sheet made from polyethylene resin or may be applied to a finished polyethylene part. If applied to a finished polyethylene part, the irradiation and annealing must be accomplished with the polyethylene material not in contact with oxygen at a concentration greater than 1% oxygen volume by volume. When applied to a preform, such as a rod, the annealing of the bulk polymer part of the rod from which the finished part is made must take place on the rod before the implant is machined therefrom and exposed to oxygen.
摘要翻译： 改进的聚乙烯，特别是超高分子量聚乙烯的生产方法利用顺序的照射和退火方法形成高度交联的聚乙烯材料。 在每次照射之后使用顺序照射，然后进行顺序退火，允许在一系列剂量中的每个剂量的照射相对较低，同时实现足够高的交联材料的总剂量。 该方法可以应用于预成型材料，例如由聚乙烯树脂制成的棒或棒或片，或者可以施加到成品聚乙烯部分上。 如果应用于成品聚乙烯部件，照射和退火必须用不超过1体积氧浓度的氧气接触的聚乙烯材料完成。 当应用于诸如棒的预成型件时，制造成品部件的棒的主体聚合物部分的退火必须在植入物从其加工并暴露于氧之前在棒上进行。
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公开(公告)号：US07186362B2
公开(公告)日：2007-03-06
申请号：US11067139
申请日：2005-02-25
申请人： Aiguo Wang , Aaron Essner
发明人： Aiguo Wang , Aaron Essner
摘要： A prosthetic medical device exhibiting improved wear resistance is fabricated by sealing at least one polyolefinic material in an airtight container and providing an inert atmosphere within the airtight container. The polyolefinic material is exposed to an irradiation source to yield a cross-linked irradiated polyolefinic material. At least one non-irradiated polyolefinic material is blended with the irradiated polyolefinic material, and the prosthetic medical device is formed from the blended material. Selectively cross-linked polymeric compositions may be created by blending a specific amount of cross-linked resins with a specific amount of uncross-linked resins then cured into a polymeric matrix whereby the desired degree or percentage of overall cross-linking is obtained. The polymeric material may then be formed directly into a finished article by injection molding the polymeric material.
摘要翻译： 通过在气密容器中密封至少一种聚烯烃材料并在气密容器内提供惰性气氛来制造显示出改进的耐磨性的假体医疗装置。 将聚烯烃材料暴露于照射源以产生交联的辐照聚烯烃材料。 将至少一种未经照射的聚烯烃材料与被照射的聚烯烃材料混合，并且所述假体医疗装置由所述混合材料形成。 选择性交联的聚合物组合物可以通过将特定量的交联树脂与特定量的未交联树脂混合，然后固化成聚合物基体，从而获得所需的整体交联度或百分比来产生。 然后可以通过注射模制聚合物材料将聚合物材料直接形成成品。
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