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    New heterocyclic compounds
    6.
    发明申请
    New heterocyclic compounds 审中-公开
    新杂环化合物

    公开(公告)号：US20080221103A1

    公开(公告)日：2008-09-11

    申请号：US12073635

    申请日：2008-03-07

    申请人： Ganapavarapu V.R. Sharma ,  Gaddam O. Reddy ,  Sriram Rajagopal ,  Uma Ramachandran ,  Sukunath Narayanan ,  Nagalakshmi Pichika ,  Venkatesh Nemmara Viswanathan ,  Lavanya Andiappan ,  Saravanan Thirunavukkarasu

    发明人： Ganapavarapu V.R. Sharma ,  Gaddam O. Reddy ,  Sriram Rajagopal ,  Uma Ramachandran ,  Sukunath Narayanan ,  Nagalakshmi Pichika ,  Venkatesh Nemmara Viswanathan ,  Lavanya Andiappan ,  Saravanan Thirunavukkarasu

    IPC分类号： A61K31/5377 ,  C07D239/24 ,  C07D413/14 ,  A61K31/435 ,  A61P37/06

    CPC分类号： C07D239/24 ,  C07D413/14

    摘要： Provided herein are heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof, wherein R1, R2, R3, R4 and R5 are as described herein. Further described herein in particular are heterocyclic compounds of the formula (I) for treating various diseases. and disorders by administering in a patient one or more TNF-α, Thromboxane synthase, 5-LOX, and PDE4 inhibitors. In particular described herein are methods for treating immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; ischemic heart disease; atherosclerosis; cancer; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS); psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; cachexia; asthma; bone resorption diseases; ischemia reperfusion injury; brain trauma; multiple sclerosis; sepsis; septic shock; toxic shock syndrome; fever, and myalgias due to infection and diseases mediated by HIV-1; HIV-2; HIV-3; cytomegalovirus (CMV); influenza; adenovirus; the herpes viruses (including HSV-1, HSV-2) and herpes zoster viruses in a mammal comprising administering an effective amount of a compound of formula (I).

    摘要翻译： 本文提供了通式（I）的杂环化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐和组合物，其代谢物和前药，其中R 1， R 2，R 3，R 4和R 5如本文所述。 本文进一步描述的是用于治疗各种疾病的式（I）的杂环化合物。 以及通过在患者中施用一种或多种TNF-α，血栓烷合成酶，5-LOX和PDE4抑制剂的障碍。 本文特别描述的是用于治疗免疫疾病，炎症，疼痛障碍，类风湿性关节炎的方法; 骨质疏松症 多发性骨髓瘤 葡萄膜炎 急性和慢性粒细胞白血病; 缺血性心脏病; 动脉粥样硬化 癌症; 缺血诱导的细胞损伤; 胰腺β细胞破坏; 骨关节炎 类风湿性脊柱炎; 痛风性关节炎 炎症性肠病; 成人呼吸窘迫综合征（ARDS）; 银屑病; 克罗恩病; 过敏性鼻炎; 溃疡性结肠炎 过敏反应 接触性皮炎; 肌肉退化; 恶病质 哮喘; 骨吸收疾病; 缺血再灌注损伤; 脑外伤; 多发性硬化症 脓毒症 败血性休克 中毒性休克综合征; 发热和由于HIV-1介导的感染和疾病引起的肌痛; HIV-2; HIV-3; 巨细胞病毒（CMV）; 流感; 腺病毒 哺乳动物中的疱疹病毒（包括HSV-1，HSV-2）和带状疱疹病毒，包括施用有效量的式（I）化合物。

    Novel MAO-A inhibitors
    8.
    发明申请
    Novel MAO-A inhibitors 审中-公开
    新型MAO-A抑制剂

    公开(公告)号：US20090069313A1

    公开(公告)日：2009-03-12

    申请号：US11896902

    申请日：2007-09-06

    申请人： Debendranath Dey ,  Gajendra Singh ,  Partha Neogi ,  Uma Ramachandran ,  Chithra Santhanagopalan

    发明人： Debendranath Dey ,  Gajendra Singh ,  Partha Neogi ,  Uma Ramachandran ,  Chithra Santhanagopalan

    IPC分类号： A61K31/5377 ,  C07D277/16 ,  A61K31/426 ,  C07D209/34 ,  A61P25/24 ,  A61P25/32 ,  A61P25/08 ,  A61P25/00 ,  A61P25/34 ,  A61P25/28 ,  A61K31/404 ,  C07D413/12 ,  A61K31/422

    CPC分类号： C07D277/36 ,  C07D209/34 ,  C07D277/34 ,  C07D413/12 ,  C07D417/12

    摘要： The present invention provides a new medical use for the compounds of the formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof, as MAO-A inhibitors. Also included is a method for prophylaxis and treatment of mental disorders such as depression, in a mammal, comprising administering an effective amount of a compound of formula (I). These compounds are also effective in treating a disease, condition or disorder such as weight loss, obesity, bulimia, depression, bipolar disorders, psychoses, schizophrenia, behaviors, alcoholism, tobacco abuse, memory loss, Alzheimer's disease, dementia of aging, seizure disorders, epilepsy, attention deficit disorder, and Parkinson's disease, which is modulated by a cannabinoid receptor antagonist.

    摘要翻译： 本发明提供了作为MAO-A抑制剂的式（I）化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐和组合物，其代谢物和前药的新医学用途 。 还包括在哺乳动物中预防和治疗精神障碍如抑郁症的方法，包括施用有效量的式（I）化合物。 这些化合物在治疗疾病，病症或病症如体重减轻，肥胖，贪食症，抑郁症，双相性精神障碍，精神病，精神分裂症，行为，酒精中毒，吸烟，记忆丧失，阿尔茨海默病，老年痴呆，癫痫发作障碍 ，癫痫，注意力缺陷障碍和由大麻素受体拮抗剂调节的帕金森病。

    MULTI-SEAMED WARMING DEVICES WITH ADHESIVE DISPOSED THEREON AND METHODS OF WARMING
    9.
    发明申请
    MULTI-SEAMED WARMING DEVICES WITH ADHESIVE DISPOSED THEREON AND METHODS OF WARMING 审中-公开
    具有粘合剂处理的多层加热装置及其加热方法

    公开(公告)号：US20070256678A1

    公开(公告)日：2007-11-08

    申请号：US11745838

    申请日：2007-05-08

    申请人： Daniel Yim ,  Uma Ramachandran

    发明人： Daniel Yim ,  Uma Ramachandran

    IPC分类号： A61F7/00

    CPC分类号： A61F7/034 ,  A61F7/03 ,  A61F2007/0001 ,  A61F2007/0226 ,  A61F2007/023 ,  A61F2007/0258 ,  A61F2007/0268

    摘要： Self-contained disposable single-use heat-generating apparatuses and methods for providing heat are disclosed that have adhesive formed on at least a portion thereof. One exemplary apparatus includes a heat-generating pack having a first bag layer defined by a first surface area bonded to a second bag layer defined by a second surface area and creating one or a multiple pouches therebetween. A heat-generating agent is disposed within the pouch(es) and adapted to consume air at a predetermined consumption rate in an exothermic reaction. At least a portion of one of the first surface area and the second surface area comprises an air permeable surface area having a predetermined airflow rate such that the heat-generating agent remains substantially evenly distributed within the pouches.

    摘要翻译： 公开了在其至少一部分上形成有粘合剂的独立的一次性一次性发热装置和用于提供热量的方法。 一个示例性装置包括具有由第一表面区域限定的第一袋层的发热包装，该第一表面区域由第二表面区域限定的第二袋层结合并在其间形成一个或多个袋。 发泡剂设置在袋内并适于在放热反应中以预定的消耗速率消耗空气。 第一表面区域和第二表面区域中的一个的至少一部分包括具有预定气流速率的透气表面区域，使得发热剂基本均匀地分布在袋内。

    WARMING DEVICES WITH ELASTIC DISPOSED THEREIN AND METHODS OF WARMING
    10.
    发明申请
    WARMING DEVICES WITH ELASTIC DISPOSED THEREIN AND METHODS OF WARMING 审中-公开
    具有弹性处理的加热装置和加热方法

    公开(公告)号：US20070256679A1

    公开(公告)日：2007-11-08

    申请号：US11745850

    申请日：2007-05-08

    申请人： Daniel Yim ,  Uma Ramachandran

    发明人： Daniel Yim ,  Uma Ramachandran

    IPC分类号： A61F7/00

    CPC分类号： A61F7/034 ,  A61F7/03 ,  A61F2007/0001 ,  A61F2007/0226 ,  A61F2007/023

    摘要： Self-contained disposable single-use heat-generating apparatuses and methods for providing heat are disclosed that have elastic member formed on at least a portion thereof. One exemplary apparatus includes a heat-generating pack having a first bag layer defined by a first surface area bonded to a second bag layer defined by a second surface area and creating one or a multiple pouches therebetween, an elastic member being disposed between at least two pouches. A heat-generating agent is disposed within the pouch(es) and adapted to consume air at a predetermined consumption rate in an exothermic reaction. At least a portion of one of the first surface area and the second surface area comprises an air permeable surface area having a predetermined airflow rate such that the heat-generating agent remains substantially evenly distributed within the pouches.

    摘要翻译： 公开了在其至少一部分上形成有弹性构件的独立的一次性一次性发热装置和用于提供热量的方法。 一个示例性的装置包括一个发热包，其具有第一袋层，该第一袋层由第一表面区域限定，第一表面区域与由第二表面区域限定的第二袋层结合，并在其间形成一个或多个袋，弹性构件设置在至少两个 小袋子 发泡剂设置在袋内并适于在放热反应中以预定的消耗速率消耗空气。 第一表面区域和第二表面区域中的一个的至少一部分包括具有预定气流速率的透气表面区域，使得发热剂基本均匀地分布在袋内。