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1.发明授权Polysubstituted 3-acylamino-5-phenyl-1, 4-benzodiazepin-2-one derivatives, process for their preparation and the pharmaceutical compositions containing them 失效多取代的3-酰基氨基-5-苯基-1,4-苯并二氮杂-2-酮衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US5719143A
公开(公告)日：1998-02-17
申请号：US390770
申请日：1995-02-14
申请人： Alain Badorc , Pierre Despeyroux , Daniele Gully , Paul de Cointet , Daniel Frehel , Jean-Pierre Maffrand
发明人： Alain Badorc , Pierre Despeyroux , Daniele Gully , Paul de Cointet , Daniel Frehel , Jean-Pierre Maffrand
IPC分类号： C12N9/99 , A61K31/55 , A61K31/551 , A61P1/00 , A61P3/04 , A61P25/18 , A61P25/28 , A61P43/00 , C07D243/24 , C07D243/30 , C07D401/12 , C07D403/12 , C07K5/068 , C07K14/575 , C07K14/655 , C07K14/705 , A61K31/395
CPC分类号： C07D403/12 , C07D243/24
摘要： The invention relates to the compounds of formula (I) ##STR1## in which R.sub.I, R.sub.II, X.sub.1, X.sub.2, X.sub.3 and X.sub.4 are as defined in claim 1.
摘要翻译： 本发明涉及其中RI，RII，X1，X2，X3和X4如权利要求1中所定义的式（I）化合物。
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2.发明授权Glycinamide derivatives, processes for their preparation and medicines containing them 失效甘氨酰胺衍生物，其制备方法和含有它们的药物
公开(公告)号：US5731340A
公开(公告)日：1998-03-24
申请号：US515640
申请日：1995-08-16
申请人： Jean-Pierre Bras , Paul de Cointet , Pierre Despeyroux , Daniel Frehel , Danielle Gully , Jean-Pierre Maffrand , Eric Bignon
发明人： Jean-Pierre Bras , Paul de Cointet , Pierre Despeyroux , Daniel Frehel , Danielle Gully , Jean-Pierre Maffrand , Eric Bignon
IPC分类号： C07C237/12 , A61K31/16 , A61K31/165 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/47 , A61K31/472 , A61K38/00 , A61P1/00 , A61P1/14 , A61P3/04 , A61P25/00 , A61P25/18 , A61P43/00 , C07C209/08 , C07C211/16 , C07C211/40 , C07C211/44 , C07C231/02 , C07C237/04 , C07C237/14 , C07C237/20 , C07C237/22 , C07C271/22 , C07C309/04 , C07C323/60 , C07D209/42 , C07D215/48 , C07D215/54 , C07D217/26 , C07D405/04 , C07D471/06 , A61K31/445 , A61K31/535
CPC分类号： C07D405/04 , C07C237/04 , C07C237/14 , C07C237/20 , C07C237/22 , C07C271/22 , C07C323/60 , C07D209/42 , C07D215/48 , C07D215/54 , C07D217/26 , C07D471/06 , C07C2101/02 , C07C2101/08 , C07C2101/14 , C07C2101/18
摘要： The present invention relates to compounds of formula: ##STR1## which are agonists of cholecystokinin receptors and pharmaceutical compositions containing them.
摘要翻译： 本发明涉及作为胆囊收缩素受体的激动剂和含有它们的药物组合物的下式的化合物。
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3.发明授权Substituted 4-phenylthiazole derivatives, process for their preparation and pharmaceutical compositions containing them 失效取代的4-苯基噻唑衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US5607952A
公开(公告)日：1997-03-04
申请号：US577097
申请日：1995-12-22
申请人： Alain Badorc , Marie-Fran.cedilla.oise Bordes , Paul de Cointet , Jean-Marc Herbert , Jean-Pierre Maffrand
发明人： Alain Badorc , Marie-Fran.cedilla.oise Bordes , Paul de Cointet , Jean-Marc Herbert , Jean-Pierre Maffrand
IPC分类号： C07D277/12 , A61K31/425 , A61K31/427 , A61K31/445 , A61P7/02 , A61P19/10 , A61P43/00 , C07D417/12 , C07D211/60
CPC分类号： C07D417/12
摘要： The invention concerns compounds of formula ##STR1## in which R, A, R.sub.1 and Y are as defined in claim 1. The instant compounds have an affinity for the fibrinogen receptor: the complex of the glycoproteins IIb/llIa (GP IIb/IIIa); more particularly, the subject of the present invention is new inhibitors of platelet aggregation which are antagonists of the GP IIb/IIIa receptors, of nonpeptide structure, which are active via the parenteral and oral routes.
摘要翻译： 本发明涉及式（I）的化合物，其中R，A，R 1和Y如权利要求1中所定义。本发明化合物对纤维蛋白原受体具有亲和力：糖蛋白IIb / IIa（GP IIb / IIIa）; 更特别地，本发明的主题是作为非肽结构的GP IIb / IIIa受体的拮抗剂的新的血小板聚集抑制剂，其通过肠胃外和口服途径是活性的。
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公开(公告)号：US5481005A
公开(公告)日：1996-01-02
申请号：US348150
申请日：1994-11-28
申请人： Jean Wagnon , Paul de Cointet , Dino Nisato , Claude Plouzane , Claudine Serradeil-Legal , Bernard Tonnerre
发明人： Jean Wagnon , Paul de Cointet , Dino Nisato , Claude Plouzane , Claudine Serradeil-Legal , Bernard Tonnerre
IPC分类号： C07C311/08 , C07C311/13 , C07C311/21 , C07D209/42 , C07D401/06 , C07D401/12 , C07D403/06 , C07D417/06 , C07D207/04
CPC分类号： C07D401/06 , C07C311/08 , C07C311/13 , C07C311/21 , C07D209/42 , C07D401/12 , C07D403/06 , C07D417/06
摘要： The invention relates to N-sulfonyl derivatives of formulae (I) and (I)' ##STR1## to their preparation, and to pharmaceutical compositions in which they are present. The compounds of formulae (I) and (I)' have an affinity for the vasopressin and ocytocin receptors.
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5.发明授权N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present 失效N-磺酰基二氢吲哚衍生物，其制备方法及其存在的药物组合物
公开(公告)号：US5338755A
公开(公告)日：1994-08-16
申请号：US923839
申请日：1992-08-03
申请人： Jean Wagnon , Paul de Cointet , Dino Nisato , Claude Plouzane , Claudine Serradeil-Legal , Bernard Tonnerre
发明人： Jean Wagnon , Paul de Cointet , Dino Nisato , Claude Plouzane , Claudine Serradeil-Legal , Bernard Tonnerre
IPC分类号： C07C311/08 , C07C311/13 , C07C311/21 , C07D209/42 , C07D401/06 , C07D401/12 , C07D403/06 , C07D417/06 , A61K31/40 , A61K31/405 , C07D209/04
CPC分类号： C07D401/06 , C07C311/08 , C07C311/13 , C07C311/21 , C07D209/42 , C07D401/12 , C07D403/06 , C07D417/06
摘要： The invention relates to N-sulfonyl derivatives of formulae (I)" and (I)' ##STR1## and to pharmaceutical compositions in which they are present. The compounds have an affinity for the vasopressin and ocytocin receptors.
摘要翻译： 本发明涉及式（I）“和（I）'（I）'的N-磺酰基衍生物及其存在的药物组合物。 这些化合物对血管升压素和卵母细胞受体具有亲和力。
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公开(公告)号：US5578633A
公开(公告)日：1996-11-26
申请号：US458614
申请日：1995-06-02
申请人： Jean Wagnon , Paul de Cointet , Dino Nisato , Claude Plouzane , Claudine Serradeil-Legal , Bernard Tonnerre
发明人： Jean Wagnon , Paul de Cointet , Dino Nisato , Claude Plouzane , Claudine Serradeil-Legal , Bernard Tonnerre
IPC分类号： C07C311/08 , C07C311/13 , C07C311/21 , C07D209/42 , C07D401/06 , C07D401/12 , C07D403/06 , C07D417/06 , A61K31/40 , C07D209/04
CPC分类号： C07D401/06 , C07C311/08 , C07C311/13 , C07C311/21 , C07D209/42 , C07D401/12 , C07D403/06 , C07D417/06
摘要： The invention relates to N-sulfonyl derivatives of formulae (I) and (I)' ##STR1## to their preparation, and to pharmaceutical compositions in which they are present. The compounds of formulae (I) and (I)' have an affinity for the vasopressin and ocytocin receptors.
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7.发明授权N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present 失效N-磺酰基二氢吲哚衍生物，其制备方法及其存在的药物组合物
公开(公告)号：US5397801A
公开(公告)日：1995-03-14
申请号：US240360
申请日：1994-05-10
申请人： Jean Wagnon , Paul de Cointet , Dino Nisato , Claude Plouzane , Claudine Serradeil-Legal , Bernard Tonnerre
发明人： Jean Wagnon , Paul de Cointet , Dino Nisato , Claude Plouzane , Claudine Serradeil-Legal , Bernard Tonnerre
IPC分类号： C07C311/08 , C07C311/13 , C07C311/21 , C07D209/42 , C07D401/06 , C07D401/12 , C07D403/06 , C07D417/06 , A61K31/40 , C07D209/10 , C07D413/06
CPC分类号： C07D401/06 , C07C311/08 , C07C311/13 , C07C311/21 , C07D209/42 , C07D401/12 , C07D403/06 , C07D417/06
摘要： The invention relates to N-sulfonyl derivatives of formulae (I) and (I)' ##STR1## to their preparation, and to pharmaceutical compositions in which they are present. The compounds of formulae (I) and (I)' have an affinity for the vasopressin and ocytocin receptors.
摘要翻译： 本发明涉及式（I）和（I）的制备方法的N-磺酰基衍生物及其制备的药物组合物。 式（I）和（I）的化合物对加压素和卵母细胞受体具有亲和力。
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