公开(公告)号：US08915960B2

公开(公告)日：2014-12-23

申请号：US13221700

申请日：2011-08-30

申请人： Alain F. Carpentier ,  William C. Brunnett ,  Louis A. Campbell ,  Da-Yu Chang ,  Steven Ford ,  John F. Migliazza ,  Anand Rao

发明人： Alain F. Carpentier ,  William C. Brunnett ,  Louis A. Campbell ,  Da-Yu Chang ,  Steven Ford ,  John F. Migliazza ,  Anand Rao

IPC分类号： A61F2/24

CPC分类号： A61F2/2445 ,  A61F2/2466 ,  A61F2230/0039 ,  A61F2230/0052

摘要： A prosthetic tricuspid remodeling annuloplasty ring for use in tricuspid valve repairs to provide annular support after reconstructive valve surgery. The ring maintains an optimal annular dimension to prevent excessive dilatation of the natural valve annulus while adapting to the dynamic motion of the tricuspid annulus during the cardiac cycle. An exemplary ring features a waveform contour and may be constructed of a titanium core having a varying cross-section for selective flexibility for good Z-axis or out-of plane movement. The “waveform” contour and selective flexibility of the different segments of this ring are designed to adapt to the complex motion of the annulus. This reduces the stress on the anatomical structures and therefore minimizes the risk of arrhythmia and ring dehiscence.

摘要翻译： 用于三尖瓣修复的假体三尖瓣重塑瓣环成形术环，以在重建瓣膜手术后提供环形支撑。 环保持最佳的环形尺寸，以防止自然瓣膜环的过度膨胀，同时适应心动周期期间三尖瓣环的动态运动。 示例性环具有波形轮廓，并且可以由具有变化横截面的钛芯构成，用于选择性的灵活性以获得良好的Z轴或平面外的运动。 该环的不同段的“波形”轮廓和选择性灵活性被设计成适应环的复杂运动。 这减少了对解剖结构的压力，从而使心律失常和环开裂的风险最小化。

公开(公告)号：US20120071970A1

公开(公告)日：2012-03-22

申请号：US13221700

申请日：2011-08-30

申请人： Alain F. Carpentier ,  William C. Brunnett ,  Louis A. Campbell ,  Da-Yu Chang ,  Steven Ford ,  John F. Migliazza ,  Anand Rao

发明人： Alain F. Carpentier ,  William C. Brunnett ,  Louis A. Campbell ,  Da-Yu Chang ,  Steven Ford ,  John F. Migliazza ,  Anand Rao

IPC分类号： A61F2/24

CPC分类号： A61F2/2445 ,  A61F2/2466 ,  A61F2230/0039 ,  A61F2230/0052

摘要： A prosthetic tricuspid remodeling annuloplasty ring for use in tricuspid valve repairs to provide annular support after reconstructive valve surgery. The ring maintains an optimal annular dimension to prevent excessive dilatation of the natural valve annulus while adapting to the dynamic motion of the tricuspid annulus during the cardiac cycle. An exemplary ring features a waveform contour and may be constructed of a titanium core having a varying cross-section for selective flexibility for good Z-axis or out-of plane movement. The “waveform” contour and selective flexibility of the different segments of this ring are designed to adapt to the complex motion of the annulus. This reduces the stress on the anatomical structures and therefore minimizes the risk of arrhythmia and ring dehiscence.

摘要翻译： 用于三尖瓣修复的假体三尖瓣重塑瓣环成形术环，以在重建瓣膜手术后提供环形支撑。 环保持最佳的环形尺寸，以防止自然瓣膜环的过度膨胀，同时适应心动周期期间三尖瓣环的动态运动。 示例性环具有波形轮廓，并且可以由具有变化横截面的钛芯构成，用于选择性的灵活性以获得良好的Z轴或平面外的运动。 该环的不同段的“波形”轮廓和选择性灵活性被设计成适应环的复杂运动。 这减少了对解剖结构的压力，从而使心律失常和环开裂的风险最小化。

公开(公告)号：US06630320B1

公开(公告)日：2003-10-07

申请号：US09567283

申请日：2000-05-08

申请人： Martin E. Davis ,  Anand Rao ,  Sylvie Gauthier ,  Yves Pouliot

发明人： Martin E. Davis ,  Anand Rao ,  Sylvie Gauthier ,  Yves Pouliot

IPC分类号： C12Q137

CPC分类号： C12P21/06 ,  A23J3/343 ,  A61K38/556

摘要： Enzymatic digests of whey protein isolates were prepared using animal, bacterial and fungal proteases, and evaluated for antihypertensive activities. The antihypertension activity was obtained with a hydrolysate of whey protein isolate prepared with a porcine trypsin. The recovered hydrolysate is used to treat hypertension in mammals such as humans and domestic pets such as dogs and cats.

摘要翻译： 使用动物，细菌和真菌蛋白酶制备乳清蛋白分离物的酶消化，并评估抗高血压活性。 用猪胰蛋白酶制备的乳清蛋白分离物的水解产物获得抗高血压活性。 回收的水解产物用于治疗哺乳动物如人和宠物如狗和猫的高血压。

公开(公告)号：US06998259B1

公开(公告)日：2006-02-14

申请号：US09702068

申请日：2000-10-30

申请人： Martin E. Davis ,  Anand Rao ,  Sylvie Gauthier ,  Yves Pouliot ,  Line Gourley ,  Anne-Francoise Allain

发明人： Martin E. Davis ,  Anand Rao ,  Sylvie Gauthier ,  Yves Pouliot ,  Line Gourley ,  Anne-Francoise Allain

IPC分类号： C12P21/06 ,  C12N9/60 ,  A01N37/18

CPC分类号： C12P21/06 ,  A23L33/18 ,  A23L33/19 ,  A23V2002/00 ,  A61K35/20 ,  A61K38/018 ,  A61K38/556 ,  A23V2200/326 ,  A23V2250/54252

摘要： Enzymatic digests of whey protein concentrates were prepared using animal, bacterial and fungal proteases, and evaluated for antihypertensive activities. The highest ACE-inhibitory activity was obtained with the purified peptide β-1g (f142–148) obtained by chemical synthesis, for which an IC50 value of 0.04 mg powder.ml−1 was found. The hydrolysates derived from BiPRO™ whey protein isolate and β-1g both gave higher antihypertensive activities (IC50 values of 0.29 to 0.90 mg powder.ml−1) than the other hydrolysates tested (IC50 values of 0.96 and 1.30 mg powder.ml−1). The recovered hydrolysate can be used to treat hypertension in mammals such as humans and domestic pets such as dogs and cats.

摘要翻译： 使用动物，细菌和真菌蛋白酶制备乳清蛋白浓缩物的酶消化，并评估抗高血压活性。 通过化学合成获得的纯化肽β-1g（f142-148）获得最高的ACE抑制活性，其中0.04mg粉末的IC 50值< / SUP>被发现。 衍生自BiPRO TM乳清蛋白分离物和β-1g的水解产物都具有较高的抗高血压活性（0.29至0.90mg粉末，比例≤0.1）比 测试其它水解产物（IC 50 S值0.96和1.30mg粉末，ml -1）。 回收的水解产物可用于治疗哺乳动物如人和宠物如狗和猫的高血压。

公开(公告)号：US20050003999A9

公开(公告)日：2005-01-06

申请号：US10291860

申请日：2002-11-08

申请人： Martin Davis ,  Anand Rao ,  Sylvie Gauthier ,  Yves Pouliot ,  Line Gourley ,  Anne-Francoise Allain

发明人： Martin Davis ,  Anand Rao ,  Sylvie Gauthier ,  Yves Pouliot ,  Line Gourley ,  Anne-Francoise Allain

IPC分类号： A23J3/34 ,  A61K38/55 ,  C12P21/06 ,  A61K38/17

CPC分类号： C12P21/06 ,  A23J3/343 ,  A61K38/556

摘要： Enzymatic digests of whey protein concentrates were prepared using animal, bacterial and fungal proteases, and evaluated for antihypertensive activities. ACE-inhibitory activity and antihypertension activity were obtained with a hydrolysate of whey protein isolate prepared with a porcine trypsin.

摘要翻译： 使用动物，细菌和真菌蛋白酶制备乳清蛋白浓缩物的酶消化，并评估抗高血压活性。 用猪胰蛋白酶制备的乳清蛋白分离物的水解产物获得ACE抑制活性和抗高血压活性。

公开(公告)号：US6060093A

公开(公告)日：2000-05-09

申请号：US840435

申请日：1997-04-29

申请人： Martin E. Davis ,  Pauline M. Olson ,  Anand Rao

发明人： Martin E. Davis ,  Pauline M. Olson ,  Anand Rao

IPC分类号： A21D2/26 ,  A23C21/00 ,  A23K1/18 ,  A23L1/304 ,  A23L1/305

CPC分类号： A21D2/263 ,  A23C21/00 ,  A23K50/42 ,  A23K50/45 ,  A23L33/16 ,  A23L33/19

摘要： A regimen for calcium supplementation takes advantage of the discovery that a calcium supplement containing modified whey characterized by a calcium content of at least 3%, protein content of from 10 to 20%, and a phospholipid content of at least 2%, is of high biological value. It can be accomplished with calcium-supplemented foods that administer foods containing sufficient amounts of the modified whey to provide at least 5% of the amount of calcium required for complete nutrition on a daily basis. The regimen can benefit humans and domestic pets, in particular. More preferred levels of administration will provide at least 10% and in some cases at least 25% of the RDA for calcium for the subject.

摘要翻译： 钙补充方案的优点在于，含有钙含量至少为3％，蛋白质含量为10至20％，磷脂含量至少为2％的改性乳清的钙补充剂的含量高 生物学价值。 可以用含钙补充食品来完成，该食品管理含有足够量的改性乳清的食物，以提供每日至少5％的完全营养所需的钙量。 该方案尤其可以使人类和家养宠物受益。 更优选的给药水平将为受试者提供至少10％，在一些情况下至少25％的用于钙的RDA。

公开(公告)号：US08568476B2

公开(公告)日：2013-10-29

申请号：US13427699

申请日：2012-03-22

申请人： Anand Rao ,  Hilda Z. Fann

发明人： Anand Rao ,  Hilda Z. Fann

IPC分类号： A61F2/24

CPC分类号： A61F2/2448 ,  A61F2/2412 ,  A61F2/2427 ,  A61F2/2466

摘要： A holder for an annuloplasty ring having a template defining a proximal face opposite the distal face, and a peripheral edge about which the annuloplasty ring conforms. The annuloplasty ring anchors to the template using one or more flexible filaments. The template includes a single cutting well on its proximal face over which the flexible filament is suspended. Desirably, the single cutting well is located adjacent the peripheral edge so as to be away from any handle connections for ease of access. The flexible filament emerges above the proximal face of the template at only one location at the cutting well, thus presenting a one cut quick-release structure that is highly visible to the surgeon.

摘要翻译： 用于瓣膜成形术环的保持器，其具有限定与远端面相对的近端面的模板，以及周边边缘，瓣环成形术环围绕该周边。 瓣膜成形术环使用一个或多个柔性细丝锚定到模板上。 该模板在其近侧面上包括单个切割井，柔性细丝悬在该切割井上。 期望地，单个切割井位于周边边缘附近，以便远离任何手柄连接以便于进入。 柔性细丝仅在切割井的仅一个位置处出现在模板的近侧面上方，因此呈现出对外科医生高度可见的一切快速释放结构。