利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

8 条记录 (耗时 0.032 秒)

    Antiarrhythmic piperidin-1-yl-2,2-dialkylpropanone arylsulfonamide derivatives
    6.
    发明授权
    Antiarrhythmic piperidin-1-yl-2,2-dialkylpropanone arylsulfonamide derivatives 失效
    抗心律失常哌啶-1-基-2,2-二烷基丙酮芳基磺酰胺衍生物

    公开(公告)号：US5541201A

    公开(公告)日：1996-07-30

    申请号：US460029

    申请日：1995-06-02

    申请人： Albert A. Carr ,  Richard C. Dage ,  David A. Hay ,  John E. Koerner ,  Tung Li

    发明人： Albert A. Carr ,  Richard C. Dage ,  David A. Hay ,  John E. Koerner ,  Tung Li

    IPC分类号： C07D211/22 ,  C07D211/32 ,  A61K31/445

    CPC分类号： C07D211/32 ,  C07D211/22

    摘要： The invention is directed to a new class of antiarrhythmic agents of the formula: ##STR1## in which R is represented by hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, CF.sub.3, SR.sub.1, NHC(O)R.sub.2, NH.sub.2, or OH; R.sub.1 is hydrogen or C.sub.1-4 alkyl; R.sub.2 is C.sub.1-4 alkyl; X is represented by CO or CHOH; R.sub.3 and R.sub.4 are each independently represented by methyl, ethyl, n-propyl, or R.sub.3 and R.sub.4 together with the carbon atom to which they each are attached form a C.sub.5 or C.sub.6 cycloalkyl; and Alk is a C.sub.1-4 alkyl; or a pharmaceutically acceptable addition salt thereof.

    摘要翻译： 本发明涉及一类新的抗心律不齐药物，其分子式为：其中R由氢，卤素，C 1-4烷基，C 1-4烷氧基，CF 3，SR 1，NHC（O）R 2，NH 2 ，或OH; R1是氢或C1-4烷基; R2是C1-4烷基; X由CO或CHOH表示; R 3和R 4各自独立地由甲基，乙基，正丙基或者R 3和R 4与它们各自连接的碳原子一起形成C5或C6环烷基; 和Alk是C 1-4烷基; 或其药学上可接受的加成盐。