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公开(公告)号：US08986624B2
公开(公告)日：2015-03-24
申请号：US13128184
申请日：2009-11-10
申请人： Albert Hendrik Jan Immink , Petrus Johannes Wilhelmus Van Lankvelt , Tom Philippe Jean Jacques Delaey
发明人： Albert Hendrik Jan Immink , Petrus Johannes Wilhelmus Van Lankvelt , Tom Philippe Jean Jacques Delaey
CPC分类号： G01N21/13 , G01N2201/0221 , G01N2201/0256
摘要： A measurement device includes a housing and at least one display integrated in the housing. The housing includes a recess adapted for insertion of a cartridge into the housing to deliver a sample to be measured to the device. The recess has an opening at the front of the housing and a first part of the housing for insertion of the cartridge protrudes in a direction enclosing an angle with a second part of the housing.
摘要翻译： 测量装置包括壳体和集成在壳体中的至少一个显示器。 壳体包括适于将盒插入壳体中以将要测量的样品输送到装置的凹部。 凹部在壳体的前部具有开口，并且用于插入盒的壳体的第一部分沿与壳体的第二部分包围一角度的方向突出。
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公开(公告)号：US20120107961A1
公开(公告)日：2012-05-03
申请号：US13381115
申请日：2010-06-24
申请人： Wendy Uyen Dittmer , Femke Karina De Theije , Albert Hendrik Jan Immink , Jeroen Hans Nieuwenhuis , Petrus Johannes Wilhelmus Van Lankvelt
发明人： Wendy Uyen Dittmer , Femke Karina De Theije , Albert Hendrik Jan Immink , Jeroen Hans Nieuwenhuis , Petrus Johannes Wilhelmus Van Lankvelt
IPC分类号： G01N33/566 , G01N30/00
CPC分类号： G01N33/54326 , G01N21/552 , G01N27/745 , G01N33/54366 , G01N33/54386
摘要： A sensor device (1) for detecting the presence of a target molecule (20) in a sample, is disclosed. The sensor device comprises a measurement sensor (2) comprising a first moiety (16) for forming a binding couple with a first further moiety comprising the target molecule (20) and a detectable label (40) and a reference sensor (3) comprising a second moiety (50) for forming a further binding couple with a second further moiety comprising a further detectable label (40′). The sensor device is adapted to generate a first detection signal (14) from the detection of the detectable label (40) in the first further moiety bound to the first moiety (16) and to generate a second detection signal (14′) from the detection of the further detectable label (40′) in the second further moiety bound to the second moiety (50), wherein at least during operation of the sensor device the second further moiety is expected to be present in a predefined amount such that the value of the second detection signal (14′) falls within an expected signal value window when the binding reaction of the second further moiety to the second moiety takes place as expected. An apparatus comprising such a sensor device, methods of operating the sensor device and apparatus and a sample for use with the sensor device are also disclosed.
摘要翻译： 公开了一种用于检测样品中目标分子（20）的存在的传感器装置（1）。 所述传感器装置包括测量传感器（2），所述测量传感器（2）包括用于与包含所述目标分子（20）和可检测标记（40）的第一另外部分形成结合对的第一部分（16）和包括 用于与包含另外可检测标记物（40'）的第二另外部分形成另外的结合对的第二部分（50）。 所述传感器装置适于从与所述第一部分（16）结合的所述第一另外部分中的所述可检测标记（40）的检测产生第一检测信号（14），并且从所述第一检测信号（14'）产生来自所述第一检测信号 在第二另外部分结合到第二部分（50）上的另外可检测标记物（40'）的检测，其中至少在传感器装置的操作期间预期第二另外的部分以预定量存在，使得值 当第二另外部分与第二部分的结合反应按预期进行时，第二检测信号（14'）落入预期信号值窗口内。 还公开了一种包括这种传感器装置的装置，操作传感器装置和装置的方法以及与传感器装置一起使用的样本。
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公开(公告)号：US20110093213A1
公开(公告)日：2011-04-21
申请号：US13000031
申请日：2009-06-22
CPC分类号： G01N1/02 , G01N35/00584 , G01N35/10 , G01N2001/028
摘要： The invention relates to a fluid providing apparatus (5; 34) for providing a fluid to an analyzing apparatus (17; 33) for analyzing the fluid and to the analyzing apparatus (17; 33). The fluid providing apparatus (34) comprises a casing (35), which has an introduction opening (7), through which a fluid transferring element (1) is introducible into the casing (35) for transferring the fluid to the fluid providing apparatus (34). The casing (35) comprises further a fluid releasing section (8) for releasing the fluid from the fluid transferring element (1) and a fluid transferring element detection section (36) for detecting whether the fluid transferring element (1) is introduced into the casing (35) by interacting with a fluid transferring element detection unit of the analyzing apparatus (17; 33).
摘要翻译： 本发明涉及一种用于向用于分析流体和分析装置（17; 33）的分析装置（17; 33）提供流体的流体提供装置（5; 34）。 流体提供装置（34）包括具有引入开口（7）的壳体（35），流体转移元件（1）可以通过该导入开口引入到壳体（35）中，用于将流体传送到流体提供装置 34）。 壳体（35）还包括用于从流体传送元件（1）释放流体的流体释放部分（8）和用于检测流体传递元件（1）是否被引入到流体传输元件 壳体（35）通过与分析装置（17; 33）的流体转移元件检测单元相互作用。
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公开(公告)号：US20100117772A1
公开(公告)日：2010-05-13
申请号：US12528844
申请日：2008-02-29
CPC分类号： G01N27/745 , B82Y25/00 , G01R33/0213 , G01R33/093 , G01R33/12 , G01R33/1269
摘要： The invention relates to an electromagnetic system for biosensors, in which the system can switch quickly between high magnetic gradients, without the need of movement of mechanical elements. This is realized by two independent electromagnetic units (1,1′ 2, 2′) which are separated in the region of the pole shoes over a gap, in which a sample volume is arranged by a cartridge (3), and in which the sensor surfaces of the biosensor are located at one or more inner surfaces of the cartridge (3).
摘要翻译： 本发明涉及用于生物传感器的电磁系统，其中系统可以在高磁梯度之间快速切换，而不需要机械元件的移动。 这通过两个独立的电磁单元（1,1'，2,2'）实现，这两个独立的电磁单元（1,1'2,2'）在极靴的区域中在一个间隙上分开，其中样品体积由盒（3）布置，其中 生物传感器的传感器表面位于盒（3）的一个或多个内表面。
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公开(公告)号：US08237434B2
公开(公告)日：2012-08-07
申请号：US12528844
申请日：2008-02-29
CPC分类号： G01N27/745 , B82Y25/00 , G01R33/0213 , G01R33/093 , G01R33/12 , G01R33/1269
摘要： An electromagnetic system for biosensors including two independent electromagnetic units separated in the region of pole shoes of the electromagnetic units positioned under a gap, a cartridge positioned in the gap providing a sample volume and a biosensor having a sensor surface located at one or more inner surfaces of the cartridge proximate to the pole shoes.
摘要翻译： 一种用于生物传感器的电磁系统，包括在定位在间隙下方的电磁单元的极靴区域中分离的两个独立的电磁单元，位于提供样品体积的间隙中的盒，以及具有位于一个或多个内表面的传感器表面的生物传感器 的墨盒靠近极靴。
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公开(公告)号：US09557328B2
公开(公告)日：2017-01-31
申请号：US13381115
申请日：2010-06-24
申请人： Wendy Uyen Dittmer , Femke Karina De Theije , Albert Hendrik Jan Immink , Jeroen Hans Nieuwenhuis , Petrus Johannes Wilhelmus Van Lankvelt
发明人： Wendy Uyen Dittmer , Femke Karina De Theije , Albert Hendrik Jan Immink , Jeroen Hans Nieuwenhuis , Petrus Johannes Wilhelmus Van Lankvelt
IPC分类号： G01N33/543 , G01N27/74 , G01N21/552
CPC分类号： G01N33/54326 , G01N21/552 , G01N27/745 , G01N33/54366 , G01N33/54386
摘要： A sensor device (1) for detecting the presence of a target molecule (20) in a sample, is disclosed. The sensor device comprises a measurement sensor (2) comprising a first moiety (16) for forming a binding couple with a first further moiety comprising the target molecule (20) and a detectable label (40) and a reference sensor (3) comprising a second moiety (50) for forming a further binding couple with a second further moiety comprising a further detectable label (40′). The sensor device is adapted to generate a first detection signal (14) from the detection of the detectable label (40) in the first further moiety bound to the first moiety (16) and to generate a second detection signal (14′) from the detection of the further detectable label (40′) in the second further moiety bound to the second moiety (50), wherein at least during operation of the sensor device the second further moiety is expected to be present in a predefined amount such that the value of the second detection signal (14′) falls within an expected signal value window when the binding reaction of the second further moiety to the second moiety takes place as expected. An apparatus comprising such a sensor device, methods of operating the sensor device and apparatus and a sample for use with the sensor device are also disclosed.
摘要翻译： 公开了一种用于检测样品中目标分子（20）的存在的传感器装置（1）。 所述传感器装置包括测量传感器（2），所述测量传感器（2）包括用于与包含所述目标分子（20）和可检测标记（40）的第一另外部分形成结合对的第一部分（16）和包括 用于与包含另外可检测标记物（40'）的第二另外部分形成另外的结合对的第二部分（50）。 所述传感器装置适于从与所述第一部分（16）结合的所述第一另外部分中的所述可检测标记（40）的检测产生第一检测信号（14），并且从所述第一检测信号（14'）产生来自所述第一检测信号 在第二另外部分结合到第二部分（50）上的另外可检测标记物（40'）的检测，其中至少在传感器装置的操作期间预期第二另外的部分以预定量存在，使得值 当第二另外部分与第二部分的结合反应按预期进行时，第二检测信号（14'）落入预期信号值窗口内。 还公开了一种包括这种传感器装置的装置，操作传感器装置和装置的方法以及与传感器装置一起使用的样本。
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公开(公告)号：US09134201B2
公开(公告)日：2015-09-15
申请号：US13000031
申请日：2009-06-22
CPC分类号： G01N1/02 , G01N35/00584 , G01N35/10 , G01N2001/028
摘要： The invention relates to a fluid providing apparatus (5; 34) for providing a fluid to an analyzing apparatus (17; 33) for analyzing the fluid and to the analyzing apparatus (17; 33). The fluid providing apparatus (34) comprises a casing (35), which has an introduction opening (7), through which a fluid transferring element (1) is introducible into the casing (35) for transferring the fluid to the fluid providing apparatus (34). The casing (35) comprises further a fluid releasing section (8) for releasing the fluid from the fluid transferring element (1) and a fluid transferring element detection section (36) for detecting whether the fluid transferring element (1) is introduced into the casing (35) by interacting with a fluid transferring element detection unit of the analyzing apparatus (17; 33).
摘要翻译： 本发明涉及一种用于向用于分析流体和分析装置（17; 33）的分析装置（17; 33）提供流体的流体提供装置（5; 34）。 流体提供装置（34）包括具有引入开口（7）的壳体（35），流体转移元件（1）可以通过该导入开口引入到壳体（35）中，用于将流体传送到流体提供装置 34）。 壳体（35）还包括用于从流体传送元件（1）释放流体的流体释放部分（8）和用于检测流体传递元件（1）是否被引入到流体传输元件 壳体（35）通过与分析装置（17; 33）的流体转移元件检测单元相互作用。
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公开(公告)号：US09040285B2
公开(公告)日：2015-05-26
申请号：US13140175
申请日：2009-12-07
申请人： Albert Hendrik Jan Immink , Albert F. Gootzen , Dirk Jan Nelly Vananderoye , Petrus Johannes Wilhelmus Van Lankvelt
发明人： Albert Hendrik Jan Immink , Albert F. Gootzen , Dirk Jan Nelly Vananderoye , Petrus Johannes Wilhelmus Van Lankvelt
IPC分类号： C12M1/34 , G01N33/543 , G01N21/03 , G01N21/11 , G01N21/552
CPC分类号： G01N33/54373 , B01L2200/027 , B01L2200/04 , B01L2300/048 , B01L2300/0627 , B01L2300/0816 , B01L2300/087 , B01L2300/14 , B01L2400/0481 , G01N21/03 , G01N21/11 , G01N21/552 , G01N2021/0346
摘要： A sensing device including an inlet port for receiving a fluid, a measurement chamber for sensing the fluid, a fluid channel coupling the inlet port and the measurement chamber for transporting the fluid from the inlet port to the measurement chamber, and a fluid stop unit for stopping and controllably releasing the flow of fluid between the inlet port and the measurement chamber.
摘要翻译： 一种感测装置，包括用于接收流体的入口端口，用于感测流体的测量室，连接入口端口和测量室的流体通道，用于将流体从入口输送到测量室;以及流体停止单元， 停止并可控制地释放入口和测量室之间的流体流。
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公开(公告)号：US08190372B2
公开(公告)日：2012-05-29
申请号：US12528086
申请日：2007-06-25
申请人： Josephus Arnoldus Henricus Maria Kahlman , Petrus Johannes Wilhelmus Van Lankvelt , Jeroen Hans Nieuwenhuis , Allbert Hendrik Jan Immink
发明人： Josephus Arnoldus Henricus Maria Kahlman , Petrus Johannes Wilhelmus Van Lankvelt , Jeroen Hans Nieuwenhuis , Allbert Hendrik Jan Immink
IPC分类号： G01N33/543
CPC分类号： G01N33/54373 , B82Y25/00 , G01N27/745 , G01N33/54326 , G01R33/07 , G01R33/093 , G01R33/12 , G01R33/1269 , G01R33/1276
摘要： A sensor device for sensing magnetic particles, the sensor device including a substrate and a sensing unit provided on and/or in and/or near the substrate. The sensing unit is configured to sense a detection signal indicative of the presence of the magnetic particles. The sensor device further includes a magnetic field control unit which may be provided off the substrate and is configured to generate a time-dependent magnetic field for interaction with the magnetic particles.
摘要翻译： 用于感测磁性颗粒的传感器装置，所述传感器装置包括衬底和设置在衬底上和/或衬底中和/或附近的感测单元。 感测单元被配置为感测指示磁性颗粒的存在的检测信号。 传感器装置还包括磁场控制单元，该磁场控制单元可以设置在基板之外并被配置为产生与磁性颗粒相互作用的时间依赖磁场。
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公开(公告)号：US20100324828A1
公开(公告)日：2010-12-23
申请号：US12528086
申请日：2007-06-25
申请人： Josephus Arnoldus Henricus Maria Kahlman , Petrus Johannes Wilhelmus Van Lankvelt , Jeroen Hans Nieuwenhuis , Allbert Hendrik Jan Immink
发明人： Josephus Arnoldus Henricus Maria Kahlman , Petrus Johannes Wilhelmus Van Lankvelt , Jeroen Hans Nieuwenhuis , Allbert Hendrik Jan Immink
IPC分类号： G01N33/543 , G01R33/06
CPC分类号： G01N33/54373 , B82Y25/00 , G01N27/745 , G01N33/54326 , G01R33/07 , G01R33/093 , G01R33/12 , G01R33/1269 , G01R33/1276
摘要： A sensor device (50) for sensing magnetic particles (15), the sensor device (50) comprising a substrate (25) and a sensing unit (11, 20) provided on and/or in and/or near the substrate (25) and being adapted for sensing a detection signal indicative of the presence of the magnetic particles (15), and a magnetic field control unit (30 to 34) provided off the substrate (25) and being adapted for generating a time-dependent magnetic field for interaction with the magnetic particles (15).
摘要翻译： 一种用于感测磁性颗粒（15）的传感器装置（50），所述传感器装置（50）包括衬底（25）和设置在衬底（25）上和/或之上和/或附近的感测单元（11,20） 并适于感测表示磁性颗粒（15）的存在的检测信号;以及设置在基板（25）之外的磁场控制单元（30至34），并适于产生时间依赖性的磁场，用于 与磁性颗粒（15）的相互作用。
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