公开(公告)号：US07381737B2

公开(公告)日：2008-06-03

申请号：US11238427

申请日：2005-09-29

申请人： Albert J. DelMonte ,  T. G. Murali Dhar ,  Yu Fan ,  Jack Z. Gougoutas ,  Mary F. Malley ,  Douglas D. McLeod ,  Robert E. Waltermire ,  Chenkou Wei

发明人： Albert J. DelMonte ,  T. G. Murali Dhar ,  Yu Fan ,  Jack Z. Gougoutas ,  Mary F. Malley ,  Douglas D. McLeod ,  Robert E. Waltermire ,  Chenkou Wei

IPC分类号： A61K31/4188 ,  C07D235/00

CPC分类号： C07D487/10

摘要： A process is provided for preparing spiro-hydantoin compounds of the formula II wherein Z is N or CR4b; K and L are independently O or S; Ar is an optionally substituted aryl or heteroaryl; A2 is a linker, G′ is a linker; Q is a linker; and R2, R4a, R4c, and Rh are defined in the specification. The process optionally includes the enantiomeric separation of intermediates to allow preparation of enantiomers of the spiro-hydantoin compounds of formula II. Substituted spiro-hydantoin compounds may be prepared from the spiro-hydantoin compounds of formula II. The spiro-hydantoin compound of formula II and the substituted spiro-hydantoin compounds are useful in the treatment of immune or inflammatory diseases. Also, provided are products made by the instant inventive process and crystalline forms (prepared by any process) of the substituted spiro-hydantoin compound, 5-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-ylmethyl]-thiophene-3-carboxylic acid, including solvates and salts thereof, as well as methods of use thereof. Crystalline forms of certain intermediates are provided.

摘要翻译： 提供了制备式II的螺 - 乙内酰脲化合物的方法，其中Z是N或CR 4b; K和L独立地为O或S; Ar是任选取代的芳基或杂芳基; A 2是连接体，G'是连接体; Q是一个连接符; 和R 2，R 4a，R 4c和R h H在本说明书中定义。 该方法任选地包括中间体的对映异构体分离，以允许制备式II的螺 - 乙内酰脲化合物的对映异构体。 取代的螺 - 乙内酰脲化合物可以由式II的螺 - 乙内酰脲化合物制备。 式II的螺 - 乙内酰脲化合物和取代的螺 - 乙内酰脲化合物可用于治疗免疫或炎性疾病。 此外，提供的是本发明方法制备的产物和取代的螺 - 乙内酰脲化合物的5 - [（5S，9R）-9-（4-氰基苯基）-3-（3， 5-二氯苯基）-1-甲基-2,4-二氧代-1,3,7-三氮杂螺[4.4]壬-7-基甲基] - 噻吩-3-甲酸，包括其溶剂合物及其盐，以及 使用它。 提供某些中间体的结晶形式。

公开(公告)号：US20080269499A1

公开(公告)日：2008-10-30

申请号：US12130915

申请日：2008-05-30

申请人： Albert J. DelMonte ,  T.G. Murali Dhar ,  Yu Fan ,  Jack Z. Gougoutas ,  Mary F. Malley ,  Douglas D. McLeod ,  Robert E. Waltermire ,  Chenkou Wei

发明人： Albert J. DelMonte ,  T.G. Murali Dhar ,  Yu Fan ,  Jack Z. Gougoutas ,  Mary F. Malley ,  Douglas D. McLeod ,  Robert E. Waltermire ,  Chenkou Wei

IPC分类号： C07D487/10

CPC分类号： C07D487/10

摘要： A process is provided for preparing spiro-hydantoin compounds of the formula II wherein Z is N or CR4b; K and L are independently O or S; Ar is an optionally substituted aryl or heteroaryl; A2 is a linker, G′ is a linker; Q is a linker; and R2, R4a, R4c, and Rh are defined in the specification. The process optionally includes the enantiomeric separation of intermediates to allow preparation of enantiomers of the spiro-hydantoin compounds of formula II. Substituted spiro-hydantoin compounds may be prepared from the spiro-hydantoin compounds of formula II. The spiro-hydantoin compound of formula II and the substituted spiro-hydantoin compounds are useful in the treatment of immune or inflammatory diseases. Also, provided are products made by the instant inventive process and crystalline forms (prepared by any process) of the substituted spiro-hydantoin compound, 5-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-ylmethyl]-thiophene-3-carboxylic acid, including solvates and salts thereof, as well as methods of use thereof. Crystalline forms of certain intermediates are provided.

摘要翻译： 提供了制备式II的螺 - 乙内酰脲化合物的方法，其中Z是N或CR 4b; K和L独立地为O或S; Ar是任选取代的芳基或杂芳基; A 2是连接体，G'是连接体; Q是一个连接符; 和R 2，R 4a，R 4c和R h H在本说明书中定义。 该方法任选地包括中间体的对映异构体分离，以允许制备式II的螺 - 乙内酰脲化合物的对映异构体。 取代的螺 - 乙内酰脲化合物可以由式II的螺 - 乙内酰脲化合物制备。 式II的螺 - 乙内酰脲化合物和取代的螺 - 乙内酰脲化合物可用于治疗免疫或炎性疾病。 此外，提供的是本发明方法制备的产物和取代的螺 - 乙内酰脲化合物的5 - [（5S，9R）-9-（4-氰基苯基）-3-（3， 5-二氯苯基）-1-甲基-2,4-二氧代-1,3,7-三氮杂螺[4.4]壬-7-基甲基] - 噻吩-3-甲酸，包括其溶剂合物及其盐，以及 使用它。 提供某些中间体的结晶形式。

公开(公告)号：US20060074099A1

公开(公告)日：2006-04-06

申请号：US11238427

申请日：2005-09-29

申请人： Albert DelMonte ,  T. Dhar ,  Yu Fan ,  Jack Gougoutas ,  Mary Malley ,  Douglas McLeod ,  Robert Waltermire ,  Chenkou Wei

发明人： Albert DelMonte ,  T. Dhar ,  Yu Fan ,  Jack Gougoutas ,  Mary Malley ,  Douglas McLeod ,  Robert Waltermire ,  Chenkou Wei

IPC分类号： A61K31/4747 ,  A61K31/4188 ,  C07D487/10

CPC分类号： C07D487/10

摘要： A process is provided for preparing spiro-hydantoin compounds of the formula II wherein Z is N or CR4b; K and L are independently O or S; Ar is an optionally substituted aryl or heteroaryl; A2 is a linker, G′ is a linker; Q is a linker; and R2, R4a, R4c, and Rh are defined in the specification. The process optionally includes the enantiomeric separation of intermediates to allow preparation of enantiomers of the spiro-hydantoin compounds of formula II. Substituted spiro-hydantoin compounds may be prepared from the spiro-hydantoin compounds of formula II. The spiro-hydantoin compound of formula II and the substituted spiro-hydantoin compounds are useful in the treatment of immune or inflammatory diseases. Also, provided are products made by the instant inventive process and crystalline forms (prepared by any process) of the substituted spiro-hydantoin compound, 5-[(5S, 9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-ylmethyl]-thiophene-3-carboxylic acid, including solvates and salts thereof, as well as methods of use thereof. Crystalline forms of certain intermediates are provided.

摘要翻译： 提供了制备式II的螺 - 乙内酰脲化合物的方法，其中Z是N或CR 4b; K和L独立地为O或S; Ar是任选取代的芳基或杂芳基; A 2是连接体，G'是连接体; Q是一个连接符; 和R 2，R 4a，R 4c和R h H在本说明书中定义。 该方法任选地包括中间体的对映异构体分离，以允许制备式II的螺 - 乙内酰脲化合物的对映异构体。 取代的螺 - 乙内酰脲化合物可以由式II的螺 - 乙内酰脲化合物制备。 式II的螺 - 乙内酰脲化合物和取代的螺 - 乙内酰脲化合物可用于治疗免疫或炎性疾病。 此外，提供的是本发明方法制备的产物和取代的螺 - 乙内酰脲化合物的5 - [（5S，9R）-9-（4-氰基苯基）-3-（3， 5-二氯苯基）-1-甲基-2,4-二氧代-1,3,7-三氮杂螺[4.4]壬-7-基甲基] - 噻吩-3-甲酸，包括其溶剂合物及其盐，以及 使用它。 提供某些中间体的结晶形式。

公开(公告)号：US20140379806A1

公开(公告)日：2014-12-25

申请号：US14344849

申请日：2012-08-13

申请人： Jian Zhang ,  Yu Fan ,  Weijian Jin ,  Lin Zhao

发明人： Jian Zhang ,  Yu Fan ,  Weijian Jin ,  Lin Zhao

IPC分类号： H04L29/08 ,  G06F17/30

CPC分类号： H04L67/22 ,  G06F16/9535 ,  G06Q10/10 ,  G06Q30/02 ,  G06Q50/01

摘要： Provided is a data matching method and device. The method includes: marking each micro-blog user in a first category of micro-blog users according to characteristic information and category of the micro-blog user; obtaining characteristic information and category of a second micro-blog user; and selecting a micro-blog user matching the characteristic information and category of the second micro-blog user from the first category of micro-blog users and recommending the selected micro-blog user to the second micro-blog user. By the method and device, a message source interesting the user may be recommended.

摘要翻译： 提供了一种数据匹配方法和装置。 该方法包括：根据微博用户的特征信息和类别，将微博用户列为第一类微博用户; 获取第二微博用户的特征信息和类别; 并从第一类微博用户中选择与第二微博用户的特征信息和类别相匹配的微博用户，并向第二微博用户推荐所选择的微博用户。 通过方法和设备，可能推荐用户感兴趣的消息来源。

公开(公告)号：US08603324B2

公开(公告)日：2013-12-10

申请号：US12725939

申请日：2010-03-17

申请人： Yu Fan ,  Xiaojun Bao ,  Gang Shi ,  Haiyan Liu

发明人： Yu Fan ,  Xiaojun Bao ,  Gang Shi ,  Haiyan Liu

IPC分类号： C10G51/06

CPC分类号： C10G45/38 ,  C10G45/08 ,  C10G45/64 ,  C10G45/68 ,  C10G65/00 ,  C10G65/043 ,  C10G65/046 ,  C10G65/06 ,  C10G2300/104 ,  C10G2300/1044 ,  C10G2300/202 ,  C10G2300/305 ,  C10G2300/4018 ,  C10G2400/02

摘要： The present invention relates to a method of hydro-upgrading inferior gasoline through ultra-deep desulfurization and octane number recovery. The method comprises the following steps: cutting inferior full-range gasoline into light fraction gasoline and heavy fraction gasolines; contacting the light fraction gasoline successively with a catalyst for selective diene removal and a catalyst for desulfurization and hydrocarbon multi-branched-chain hydroisomerization; contacting the heavy fraction gasoline with the catalyst for selective hydrodesulfurization in a first reactor, and contacting the reaction effluent from the first reactor with a catalyst for supplemental desulfurization and hydrocarbon aromatization/single-branched-chain hydroisomerization in a second reactor; and blending the treated light fraction gasoline and the heavy fraction gasoline to obtain the ultra-clean gasoline product. The hydro-upgrading method of the invention is suitable for hydro-upgrading inferior gasoline, especially for hydro-upgrading inferior FCC gasoline with ultra-high sulfur content and high olefin content to obtain excellent hydro-upgrading effects.

摘要翻译： 本发明涉及通过超深脱硫和辛烷值回收来升级劣质汽油的方法。 该方法包括以下步骤：将低级全程汽油切割成轻馏分汽油和重馏分汽油; 将轻馏分汽油依次与用于选择性二烯除去的催化剂和用于脱硫和烃多支链加氢异构化的催化剂接触; 使重馏分汽油与第一反应器中的选择性加氢脱硫催化剂接触，并使来自第一反应器的反应流出物与第二反应器中用于补充脱硫和烃芳构化/单支链加氢异构化的催化剂接触; 并混合处理的轻馏分汽油和重馏分汽油，得到超清洁汽油产品。 本发明的加氢改质方法适用于加氢改质劣质汽油，特别是用于加氢改质超高硫含量和高烯烃含量的低级FCC汽油，以获得优异的加氢改质效果。

公开(公告)号：US20120010402A1

公开(公告)日：2012-01-12

申请号：US12977275

申请日：2010-12-23

申请人： David K. Leahy ,  Yu Fan ,  Lopa V. Desai ,  Ronald L. Hanson ,  Thorsten Rosner ,  Guanglin Luo

发明人： David K. Leahy ,  Yu Fan ,  Lopa V. Desai ,  Ronald L. Hanson ,  Thorsten Rosner ,  Guanglin Luo

IPC分类号： C07D471/04 ,  C07D221/04 ,  C07F7/18 ,  C07D243/04 ,  C07D498/10

CPC分类号： C07D401/14 ,  C07D221/04 ,  C07D471/04 ,  C07D498/10 ,  C07D498/20

摘要： The disclosure generally relates to the novel compounds of formula I, including their salts, which are CGRP receptor antagonists. The disclosure also relates to pharmaceutical compositions and methods for using the compounds in the treatment of CGRP related disorders including migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases such as asthma, and chronic obstructive pulmonary disease (COPD).

摘要翻译： 本发明一般涉及式I的新化合物，包括它们的盐，它们是CGRP受体拮抗剂。 本公开还涉及用于治疗CGRP相关疾病（包括偏头痛和其他头痛，神经源性血管舒张，神经源性炎症，热损伤，循环休克，与更年期相关的潮红，气道炎症性疾病如哮喘）的药物组合物和方法， 和慢性阻塞性肺疾病（COPD）。

公开(公告)号：US07692511B2

公开(公告)日：2010-04-06

申请号：US12077811

申请日：2008-03-21

申请人： Yinon Degani ,  Yu Fan ,  Charley Chunlei Gao ,  Kunquan Sun ,  Liguo Sun ,  Jian Cheng

发明人： Yinon Degani ,  Yu Fan ,  Charley Chunlei Gao ,  Kunquan Sun ,  Liguo Sun ,  Jian Cheng

IPC分类号： H03H7/42 ,  H01P3/08

CPC分类号： H01F17/0013 ,  H01F27/2804 ,  H01F2017/0046 ,  H03H7/42

摘要： Balun transformers are described wherein multiple transformer loops are implemented in a stacked design with the primary and secondary loops overlying one another. By aligning the loops in a vertical direction, instead of offsetting the loops, the area of the device is reduced. Multiple transformer loops are nested on each level, and the transformer loops on a given level are connected together using a crossover located on a different level.

摘要翻译： 描述了平衡 - 不平衡变压器，其中多个变压器回路以堆叠设计实现，其中主回路和次级回路彼此重叠。 通过在垂直方向上对准环路，而不是抵消环路，设备的面积减小。 多个变压器回路嵌套在每个级别上，并且给定级别上的变压器环路使用位于不同级别的交叉连接在一起。

公开(公告)号：US20080061405A1

公开(公告)日：2008-03-13

申请号：US11980062

申请日：2007-10-30

申请人： Yinon Degani ,  Yu Fan ,  Charley Gao ,  Kunguan Sun ,  Liguo Sun

发明人： Yinon Degani ,  Yu Fan ,  Charley Gao ,  Kunguan Sun ,  Liguo Sun

IPC分类号： H01L23/552

CPC分类号： H01L23/552 ,  H01L23/5225 ,  H01L23/66 ,  H01L2223/6622 ,  H01L2224/16 ,  H01L2924/00011 ,  H01L2924/00014 ,  H01L2924/01079 ,  H01L2924/1461 ,  H01L2924/19011 ,  H01L2924/19103 ,  H01L2924/3025 ,  H01L2924/00 ,  H01L2224/0401

摘要： The specification describes a thin film Integrated Passive Device (IPD) design that achieves isolation between conductive runners by shielding the top and bottom regions of a noisy runner with metal shield plates. The shield plates are derived from metal interconnect layers. The invention can be implemented by merely modifying the mask pattern for the metal interconnect layers. No added elements or steps are needed to fabricate the IPDs. The invention is suitable for use in Multi-Chip Modules (MCMs) or other arrangements where digital circuits and RF circuits are in close proximity.

摘要翻译： 该规范描述了一种薄膜集成无源器件（IPD）设计，通过屏蔽带有金属屏蔽板的噪声转轮的顶部和底部区域来实现导电流道之间的隔离。 屏蔽板衍生自金属互连层。 本发明可以通过仅修改金属互连层的掩模图案来实现。 不需要添加元素或步骤来制造IPD。 本发明适用于数字电路和RF电路非常接近的多芯片模块（MCM）或其他布置。

公开(公告)号：US20060255434A1

公开(公告)日：2006-11-16

申请号：US11127889

申请日：2005-05-12

申请人： Yinon Degani ,  Yu Fan ,  Charley Gao ,  Kunguan Sun ,  Liguo Sun

发明人： Yinon Degani ,  Yu Fan ,  Charley Gao ,  Kunguan Sun ,  Liguo Sun

IPC分类号： H01L23/552

CPC分类号： H01L23/552 ,  H01L23/5225 ,  H01L23/66 ,  H01L2223/6622 ,  H01L2224/16 ,  H01L2924/00011 ,  H01L2924/00014 ,  H01L2924/01079 ,  H01L2924/1461 ,  H01L2924/19011 ,  H01L2924/19103 ,  H01L2924/3025 ,  H01L2924/00 ,  H01L2224/0401

摘要： The specification describes a thin film Integrated Passive Device (IPD) design that achieves isolation between conductive runners by shielding the top and bottom regions of a noisy runner with metal shielding plates. The shielding plates are derived from metal interconnect layers. The invention can be implemented by merely modifying the mask pattern for the metal interconnect layers. No added elements or steps are needed to fabricate the IPDs. The invention is suitable for use in Multi-Chip Modules (MCMs) or other arrangements where digital circuits and RF circuits are in close proximity.

摘要翻译： 该规范描述了薄膜集成无源器件（IPD）设计，通过屏蔽带有金属屏蔽板的噪声转轮的顶部和底部区域来实现导电流道之间的隔离。 屏蔽板衍生自金属互连层。 本发明可以通过仅修改金属互连层的掩模图案来实现。 不需要添加元素或步骤来制造IPD。 本发明适用于数字电路和RF电路非常接近的多芯片模块（MCM）或其他布置。

公开(公告)号：US08597494B2

公开(公告)日：2013-12-03

申请号：US12726151

申请日：2010-03-17

申请人： Yu Fan ,  Xiaojun Bao ,  Gang Shi ,  Haiyan Liu

发明人： Yu Fan ,  Xiaojun Bao ,  Gang Shi ,  Haiyan Liu

IPC分类号： C10G51/06

CPC分类号： C10G65/06 ,  C10G45/08 ,  C10G45/38 ,  C10G45/64 ,  C10G45/68 ,  C10G65/00 ,  C10G65/043 ,  C10G65/046

摘要： The present invention relates to a method for producing ultra-clean gasoline. The invention provides a method of hydro-upgrading inferior gasoline through deep desulfurization and octane number recovery, which comprises the following steps: cutting inferior full-range gasoline into the light and heavy fraction gasolines; contacting the light fraction gasoline successively with a catalyst for selective diene removal and a catalyst for desulfurization and hydrocarbon aromatization/single-branched-chain hydroisomerization; contacting the heavy fraction gasoline with a catalyst for selective hydrodesulfurization, and contacting the reaction effluent with a catalyst for supplemental desulfurization and hydrocarbon multi-branched-chain hydroisomerization; and blending the treated light and heavy fraction gasolines to obtain the ultra-clean gasoline product. The method of the invention is suitable for hydro-upgrading inferior gasoline, especially for hydro-upgrading inferior FCC gasoline with ultra-high sulfur content and high olefin content to obtain excellent hydro-upgrading effects.

摘要翻译： 本发明涉及一种生产超清洁汽油的方法。 本发明提供了一种通过深度脱硫和辛烷值回收来升级劣质汽油的方法，包括以下步骤：将低级全程汽油切割成轻重汽油; 将轻馏分汽油依次与用于选择性二烯除去的催化剂和用于脱硫和烃芳构化/单支链加氢异构化的催化剂接触; 使重馏分汽油与催化剂接触以进行选择性加氢脱硫，并将反应流出物与用于补充脱硫和烃多支链加氢异构化的催化剂接触; 并混合经处理的轻质和重馏分汽油，得到超清洁汽油产品。 本发明的方法适用于升级劣质汽油，特别是用于加氢改造具有超高硫含量和高烯烃含量的劣质FCC汽油，以获得优异的水力升级效果。