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    Isoindoles having cardiovascular activity
    1.
    发明授权
    Isoindoles having cardiovascular activity 失效
    异吲哚酮具有心血管活性

    公开(公告)号：US5376673A

    公开(公告)日：1994-12-27

    申请号：US117162

    申请日：1993-09-17

    申请人： Alberto Sala ,  Silvio Levi ,  Francesca Benedini ,  Roberta Cereda ,  Piero Soldato

    发明人： Alberto Sala ,  Silvio Levi ,  Francesca Benedini ,  Roberta Cereda ,  Piero Soldato

    IPC分类号： A61K31/40 ,  A61K31/403 ,  A61K31/4035 ,  A61P9/08 ,  A61P9/10 ,  C07D209/48

    CPC分类号： C07D209/48

    摘要： Isoindole compounds of the formula (I) ##STR1## wherein R.sub.1 represents hydrogen; C.sub.1 -C.sub.6 alkyl; benzyl optionally substituted with halogen, hydroxy, C.sub.1 -C.sub.6 alkoxy, methylenedioxy; C.sub.2 -C.sub.8 aliphatic acyl; benzoyl optionally substituted with halogen, hydroxy, C.sub.1 -C.sub.6 alkoxy, C.sub.2 -C.sub.6 alkanoyl, C.sub.2 -C.sub.6 alkanoyloxy, C.sub.1 -C.sub.4 alkyl, trifluoromethyl, methylenedioxy;R.sub.2 -R.sub.3 are selected independently from hydrogen; halogen; C.sub.1 -C.sub.4 alkyl; trifluoromethyl; hydroxy; nitro; amino; mono or di C.sub.1 -C.sub.4 alkylamino; cyano; C.sub.1 -C.sub.6 alkoxy; C.sub.2 -C.sub.6 alkoxycarbonyl;Y is ethylene, or a straight or branched alkylene chain containing from 3 to 6 carbon atoms, and the salts thereof of pharmaceutically acceptable acids. The compounds possess antianginal activity and are used in the preparation of medicaments for antianginal therapy.

    摘要翻译： 式（I）的异吲哚化合物其中R 1表示氢; C1-C6烷基; 任选被卤素取代的苄基，羟基，C 1 -C 6烷氧基，亚甲二氧基; C 2 -C 8脂族酰基; 任选被卤素取代的苯甲酰基，羟基，C 1 -C 6烷氧基，C 2 -C 6烷酰基，C 2 -C 6烷酰氧基，C 1 -C 4烷基，三氟甲基，亚甲二氧基; R2-R3独立地选自氢; 卤素; C 1 -C 4烷基; 三氟甲基 羟基; 硝基 氨基; 单或二C1-C4烷基氨基; 氰基; C1-C6烷氧基; C2-C6烷氧基羰基; Y是乙烯，或含有3至6个碳原子的直链或支链亚烷基链及其药学上可接受的酸的盐。 该化合物具有抗心绞痛活性，并用于制备用于抗心绞痛治疗的药物。