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公开(公告)号：US20100120055A1
公开(公告)日：2010-05-13
申请号：US12311464
申请日：2007-09-28
申请人： Peter Hornbeck , Ailan Guo , Klarisa Rikova , Albrecht Moritz , Erik Spek , Anthony Possemato , Charles Farnsworth , Francesco Boccalatte , Jian Yu , Jefrey Mitchell , John Rush , Valerie Goss , Ting-Lei Gu , Yu Li , Matthew Stokes
发明人： Peter Hornbeck , Ailan Guo , Klarisa Rikova , Albrecht Moritz , Erik Spek , Anthony Possemato , Charles Farnsworth , Francesco Boccalatte , Jian Yu , Jefrey Mitchell , John Rush , Valerie Goss , Ting-Lei Gu , Yu Li , Matthew Stokes
CPC分类号： C12Q1/485 , A61K38/00 , A61K39/0011 , C07K14/4748 , C07K16/30 , C07K16/3007 , C07K16/40 , C07K16/44 , C07K2317/34 , C12Q1/42 , G01N33/574 , G01N33/6812 , G01N33/6842
摘要： The invention discloses 318 novel phosphorylation sites identified in carcinoma, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译： 本发明公开了在癌中鉴定的318个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。
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公开(公告)号：US20100093000A1
公开(公告)日：2010-04-15
申请号：US12148550
申请日：2008-04-18
申请人： Jessica Cherry , Charles Farnsworth , Valerie L. Goss , Ting-Lei Gu , Ailan Guo , Peter Hornbeck , Yu Li , Albrecht Moritz , Anthony Possemato , Klarisa Rikova , Matthew Stokes , Jian Yu , Erik Spek , Corinne Michaud
发明人： Jessica Cherry , Charles Farnsworth , Valerie L. Goss , Ting-Lei Gu , Ailan Guo , Peter Hornbeck , Yu Li , Albrecht Moritz , Anthony Possemato , Klarisa Rikova , Matthew Stokes , Jian Yu , Erik Spek , Corinne Michaud
CPC分类号： C07K16/44 , G01N33/574 , G01N33/57426 , G01N2333/4725 , G01N2333/98
摘要： The invention discloses novel phosphorylation sites identified in carcinoma and/or leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译： 本发明公开了在癌和/或白血病中鉴定的新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。
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3.发明申请Protein Phosphorylation by Serine/Threonine Kinases in Insulin Signaling Pathways 审中-公开胰岛素信号途径中丝氨酸/苏氨酸激酶的蛋白质磷酸化公开(公告)号：US20100304406A1
公开(公告)日：2010-12-02
申请号：US12586088
申请日：2009-09-17
申请人： Ailan Guo , Albrecht Moritz , Anthony Possemato , Charles Farnsworth , Hong Ren , Jing Zhou , John Rush , Klarisa Rikova , Matthew Stokes , Valerie Goss , Yu Li
发明人： Ailan Guo , Albrecht Moritz , Anthony Possemato , Charles Farnsworth , Hong Ren , Jing Zhou , John Rush , Klarisa Rikova , Matthew Stokes , Valerie Goss , Yu Li
IPC分类号： G01N33/567 , C07K16/18 , G01N33/68
CPC分类号： G01N33/6842 , C07K16/18 , C07K2317/34 , G01N33/6851
摘要： The invention discloses 137 novel phosphorylation sites identified in insulin signaling pathways, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译： 本发明公开了在胰岛素信号通路中鉴定的137个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体以及上述的诊断和治疗用途。
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公开(公告)号：US20090098581A1
公开(公告)日：2009-04-16
申请号：US12148547
申请日：2008-04-18
申请人： Peter Hornbeck , Ailan Guo , Ting-Lei Gu , Klarisa Rikova , Albrecht Moritz , Charles Farnsworth , Matthew Stokes , Jian Yu , Erik Spek , Yu Li , Anthony Possemato , Jessica Cherry , Valerie Goss , Jeffrey Mitchell , John Rush , Corinne Michaud
发明人： Peter Hornbeck , Ailan Guo , Ting-Lei Gu , Klarisa Rikova , Albrecht Moritz , Charles Farnsworth , Matthew Stokes , Jian Yu , Erik Spek , Yu Li , Anthony Possemato , Jessica Cherry , Valerie Goss , Jeffrey Mitchell , John Rush , Corinne Michaud
IPC分类号： G01N33/574 , C07K16/30 , G01N33/566
CPC分类号： G01N33/6842 , C07K16/30 , C07K16/44 , C07K2317/34 , G01N33/57407 , G01N33/57426
摘要： The invention discloses 482 novel phosphorylation sites identified in carcinoma and/or leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译： 本发明公开了在癌和/或白血病中鉴定的482个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。
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公开(公告)号：US20090068684A1
公开(公告)日：2009-03-12
申请号：US12079297
申请日：2008-03-26
IPC分类号： G01N33/574 , C07K16/18 , G01N33/566
CPC分类号： C07K16/44 , G01N33/573 , G01N33/57407 , G01N2333/912 , G01N2800/2871
摘要： The invention discloses 345 novel phosphorylation sites identified in carcinoma and leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译： 本发明公开了在癌和白血病中鉴定的345个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。
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公开(公告)号：US07977462B2
公开(公告)日：2011-07-12
申请号：US12148547
申请日：2008-04-18
申请人： Peter Hornbeck , Ailan Guo , Ting-Lei Gu , Klarisa Rikova , Albrecht Moritz , Charles Farnsworth , Matthew Stokes , Jian Yu , Erik Spek , Yu Li , Anthony Possemato , Jessica Cherry , Valerie Goss , Jeffrey Mitchell , John Rush , Corinne Michaud
发明人： Peter Hornbeck , Ailan Guo , Ting-Lei Gu , Klarisa Rikova , Albrecht Moritz , Charles Farnsworth , Matthew Stokes , Jian Yu , Erik Spek , Yu Li , Anthony Possemato , Jessica Cherry , Valerie Goss , Jeffrey Mitchell , John Rush , Corinne Michaud
CPC分类号： G01N33/6842 , C07K16/30 , C07K16/44 , C07K2317/34 , G01N33/57407 , G01N33/57426
摘要： The invention discloses 482 novel phosphorylation sites identified in carcinoma and/or leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译： 本发明公开了在癌和/或白血病中鉴定的482个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。
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公开(公告)号：US20110059463A1
公开(公告)日：2011-03-10
申请号：US12832974
申请日：2010-07-08
申请人： Albrecht Moritz , Jing Zhou , Anthony Possemato , Matthew Stokes , Ailan Guo , Charles Farnsworth , Klarisa Rikova , Jian Yu
发明人： Albrecht Moritz , Jing Zhou , Anthony Possemato , Matthew Stokes , Ailan Guo , Charles Farnsworth , Klarisa Rikova , Jian Yu
IPC分类号： G01N33/566 , C07K16/18
CPC分类号： G01N33/6854 , C07K16/44 , G01N2440/14
摘要： The invention discloses 726 novel phosphorylation sites identified in carcinoma and leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies that specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译： 本发明公开了在癌和白血病中鉴定的726个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。
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公开(公告)号：US20100173428A1
公开(公告)日：2010-07-08
申请号：US12683835
申请日：2010-01-07
申请人： Ailan Guo , Albrecht Moritz , Anthony Possemato , Charles Farnsworth , Hong Ren , Klarisa Rikova , John Edward Rush, II , Matthew Stokes , Meghan Tucker , Yu Li
发明人： Ailan Guo , Albrecht Moritz , Anthony Possemato , Charles Farnsworth , Hong Ren , Klarisa Rikova , John Edward Rush, II , Matthew Stokes , Meghan Tucker , Yu Li
CPC分类号： C07K16/18 , C07K16/40 , C12Q1/485 , G01N33/6872
摘要： The invention discloses 461 novel phosphorylation sites identified in basophilic Ser/Thr kinase signaling pathways, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译： 本发明公开了在嗜碱性Ser / Thr激酶信号通路中鉴定的461个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及 以上。
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公开(公告)号：US20110045603A1
公开(公告)日：2011-02-24
申请号：US12763886
申请日：2010-04-20
申请人： Ailan Guo , Albrecht Moritz , Anthony Possemato , Ting-Lei Gu , Jian Yu , Charles Lawrence Farnsworth , Corinne Michaud , Hong Ren , Jessica Ann Cherry , Jing Zhou , Valerie Lee Goss , Erik Spek , Yu Li , Meghan Ann Tucker , John Edward Rush, II , Matthew Stokes , Klarisa Rikova
发明人： Ailan Guo , Albrecht Moritz , Anthony Possemato , Ting-Lei Gu , Jian Yu , Charles Lawrence Farnsworth , Corinne Michaud , Hong Ren , Jessica Ann Cherry , Jing Zhou , Valerie Lee Goss , Erik Spek , Yu Li , Meghan Ann Tucker , John Edward Rush, II , Matthew Stokes , Klarisa Rikova
CPC分类号： C07K16/18 , C07K14/47 , C07K16/44 , G01N33/6842
摘要： The invention discloses 990 novel phosphorylation sites identified in carcinoma and leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译： 本发明公开了在癌和白血病中鉴定的990个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。
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公开(公告)号：US20110143368A1
公开(公告)日：2011-06-16
申请号：US12806766
申请日：2010-08-20
申请人： Ting-Lei Gu , Anthony Possemato , Klarisa Rikova , Jian Yu , Valerie Goss , Corinne Michaud , Charles Farnsworth , Ailan Guo , Albrecht Moritz , Yu Li
发明人： Ting-Lei Gu , Anthony Possemato , Klarisa Rikova , Jian Yu , Valerie Goss , Corinne Michaud , Charles Farnsworth , Ailan Guo , Albrecht Moritz , Yu Li
CPC分类号： C07K16/44 , C07K16/30 , C07K2317/34 , G01N33/6842
摘要： The invention discloses 142 novel phosphorylation sites identified in carcinoma, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译： 本发明公开了142个在癌中鉴定的新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。
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