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公开(公告)号：US20100105040A1
公开(公告)日：2010-04-29
申请号：US12507045
申请日：2009-07-21
CPC分类号： G01N27/44704 , B01L3/5023 , B01L3/502707 , B01L3/502753 , B01L7/52 , B01L2200/10 , B01L2200/12 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2400/0418 , B01L2400/0421
摘要： Microfluidic devices that incorporate a porous polymer electrode assemblies, including microfluidic device useful for detection of nucleic acids, as well as methods of using the microfluidic devices.
摘要翻译： 包含多孔聚合物电极组件的微流体装置，包括可用于检测核酸的微流体装置，以及使用微流体装置的方法。
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公开(公告)号：US20100092867A1
公开(公告)日：2010-04-15
申请号：US12504488
申请日：2009-07-16
CPC分类号： G01N27/3335
摘要： Porous polymer electrode assemblies are useful in the detection or quantification of a variety of analytes. By preparing a porous monolith, and applying a conductive polymer to the monolith, a porous matrix is prepared that combines favorable conductive properties, by virtue of the presence of the conductive polymer, with the porous character of the underlying monolith. The resulting porous electrode can be used for qualitative or quantitative analysis, and the capture and/or release of selected charged materials, such as nucleic acids. The pores of the electrode matrix may also be filled with nonconductive material, yielding electrodes having a plurality of discrete conductive surfaces.
摘要翻译： 多孔聚合物电极组件可用于检测或定量各种分析物。 通过制备多孔整料并将导电聚合物施加到整料上，制备出多孔基质，其通过导电聚合物的存在与下面的整料的多孔特征结合有利的导电性能。 所得的多孔电极可用于定性或定量分析，以及所选择的带电材料（例如核酸）的捕获和/或释放。 电极基体的孔也可以用非导电材料填充，产生具有多个离散导电表面的电极。
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公开(公告)号：US20090142772A1
公开(公告)日：2009-06-04
申请号：US12167292
申请日：2008-07-03
CPC分类号： G01N33/54366 , B01L3/5027 , B01L3/502761 , B01L2200/0647 , B01L2200/0668 , B01L2300/0636 , B01L2300/069 , B01L2300/0816 , B01L2300/0864 , G01N33/54326 , G01N2400/00
摘要： System and methods for detecting analytes such as pathogenic cells are described. The methods allow for the direct measurement of analytes such as pathogenic organisms without the need for sample preparation and/or PCR. The devices can be used individually as point-of-use sensors for airborne pathogens and other pathogenic organisms in foods and agriculture products.
摘要翻译： 描述了用于检测分析物如致病细胞的系统和方法。 这些方法允许直接测量分析物如病原体，而不需要样品制备和/或PCR。 这些装置可以单独用作食品和农产品中的空气传播病原体和其他致病生物的使用点传感器。
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公开(公告)号：US20110318740A1
公开(公告)日：2011-12-29
申请号：US13149697
申请日：2011-05-31
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , C12Q1/6846 , C12Q2522/101 , C12Q2561/109 , C12Q2565/519 , C12Q1/686
摘要： Disclosed, for example, are methods for detecting at least one target polynucleotide comprising cleaving a flap from a polynucleotide probe that is hybridized to a complementary target polynucleotide, and hybridizing the cleaved flap to a complementary capture probe immobilized on a surface, wherein said cleaving and/or hybridizing occurs in the presence of a single strand binding protein that is capable of binding single-stranded DNA, but that can bind neither the flap nor the capture probe. The cleaved flap and the complementary capture probe may each comprise PNA, RNA, LNA, L-DNA or other modified nucleotides or chimeras thereof that do not significantly bind to the single strand binding protein.
摘要翻译： 例如，公开了用于检测至少一种靶多核苷酸的方法，所述至少一种靶多核苷酸包括从互补靶多核苷酸杂交的多核苷酸探针切割瓣，并将切割的瓣与固定在表面上的互补捕获探针杂交，其中所述切割和 /或杂交发生在能够结合单链DNA的单链结合蛋白存在下，但是既不结合皮瓣也不能结合捕获探针。 切割的瓣和互补捕获探针可以各自包含不显着结合单链结合蛋白的PNA，RNA，LNA，L-DNA或其它修饰的核苷酸或嵌合体。
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公开(公告)号：US08658093B2
公开(公告)日：2014-02-25
申请号：US12167292
申请日：2008-07-03
IPC分类号： G01N1/26
CPC分类号： G01N33/54366 , B01L3/5027 , B01L3/502761 , B01L2200/0647 , B01L2200/0668 , B01L2300/0636 , B01L2300/069 , B01L2300/0816 , B01L2300/0864 , G01N33/54326 , G01N2400/00
摘要： System and methods for detecting analytes such as pathogenic cells are described. The methods allow for the direct measurement of analytes such as pathogenic organisms without the need for sample preparation and/or PCR. The devices can be used individually as point-of-use sensors for airborne pathogens and other pathogenic organisms in foods and agriculture products.
摘要翻译： 描述了用于检测分析物如致病细胞的系统和方法。 这些方法允许直接测量分析物如病原体，而不需要样品制备和/或PCR。 这些装置可以单独用作食品和农产品中的空气传播病原体和其他致病生物的使用点传感器。
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