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公开(公告)号：US08658093B2
公开(公告)日：2014-02-25
申请号：US12167292
申请日：2008-07-03
IPC分类号： G01N1/26
CPC分类号： G01N33/54366 , B01L3/5027 , B01L3/502761 , B01L2200/0647 , B01L2200/0668 , B01L2300/0636 , B01L2300/069 , B01L2300/0816 , B01L2300/0864 , G01N33/54326 , G01N2400/00
摘要： System and methods for detecting analytes such as pathogenic cells are described. The methods allow for the direct measurement of analytes such as pathogenic organisms without the need for sample preparation and/or PCR. The devices can be used individually as point-of-use sensors for airborne pathogens and other pathogenic organisms in foods and agriculture products.
摘要翻译： 描述了用于检测分析物如致病细胞的系统和方法。 这些方法允许直接测量分析物如病原体，而不需要样品制备和/或PCR。 这些装置可以单独用作食品和农产品中的空气传播病原体和其他致病生物的使用点传感器。
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公开(公告)号：US08062611B2
公开(公告)日：2011-11-22
申请号：US11252915
申请日：2005-10-18
IPC分类号： B01L3/00
CPC分类号： F16K99/0001 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0415 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0661 , B01L2400/0677 , B01L2400/0683 , B01L2400/082 , B01L2400/084 , B01L2400/086 , F16K99/003 , F16K99/0036 , F16K99/0057 , F16K2099/0084 , Y10S422/901 , Y10T137/0318 , Y10T137/0324 , Y10T137/1624 , Y10T137/1812 , Y10T137/2191 , Y10T137/8376 , Y10T137/8593 , Y10T137/85978 , Y10T436/143333 , Y10T436/2575
摘要： A fluid processing device is provided that includes a substrate, a plurality of fluid retainment regions formed in or on the substrate, and a barrier at least partially separating two or more of the fluid retainment regions. The barrier includes a mixture of a sequestering material and a reaction component. The reaction component can be at least one of a reactant, a reagent, a catalyst, an initiator, a promoter, a cofactor, an enzyme, a salt, or a combination thereof. The sequestering material can be a porous material, a dissolvable material, or both.
摘要翻译： 提供了一种流体处理装置，其包括衬底，形成在衬底中或衬底上的多个流体保持区域，以及至少部分地分离两个或更多个流体保持区域的屏障。 屏障包括螯合材料和反应组分的混合物。 反应组分可以是反应物，试剂，催化剂，引发剂，助催化剂，辅因子，酶，盐或其组合中的至少一种。 隔离材料可以是多孔材料，可溶解材料或两者。
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公开(公告)号：US07480042B1
公开(公告)日：2009-01-20
申请号：US11173609
申请日：2005-06-30
申请人： J. Michael Phillips , Aldrich N. K. Lau , Mark F. Oldham , Kevin S. Bodner , Steven J. Boege , Donald R. Sandell , David H. Tracy
发明人： J. Michael Phillips , Aldrich N. K. Lau , Mark F. Oldham , Kevin S. Bodner , Steven J. Boege , Donald R. Sandell , David H. Tracy
IPC分类号： G01J1/10
CPC分类号： G01N21/278 , B82Y15/00 , G01J1/10 , G01N21/01 , G01N21/4785 , G01N21/6452 , G01N21/76 , G01N2201/06113 , G01N2201/0612 , G01N2201/062 , G01N2201/0691 , G01N2201/0697 , Y10S977/943 , Y10S977/949
摘要： Systems, and components thereof, for detecting and/or analyzing light. These systems can include, among others, optical reference standards for calibrating, validating, and/or monitoring light-detection systems, before, during, and/or after sample analysis.
摘要翻译： 系统及其组件，用于检测和/或分析光。 样品分析之前，期间和/或之后，这些系统可以包括用于校准，验证和/或监测光检测系统的光学参考标准。
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4.发明授权
公开(公告)号：US5571448A
公开(公告)日：1996-11-05
申请号：US416556
申请日：1995-04-04
申请人： Mark F. Wartenberg , Harriette Atkins , Robert H. Reamey , Laurence Welsh , James Strain , Janusz Wojtowicz , Wayne Montoya , Paul S. Drzaic , John Havens , Akira Tomita , Aldrich N. K. Lau
发明人： Mark F. Wartenberg , Harriette Atkins , Robert H. Reamey , Laurence Welsh , James Strain , Janusz Wojtowicz , Wayne Montoya , Paul S. Drzaic , John Havens , Akira Tomita , Aldrich N. K. Lau
IPC分类号： G02F1/1334 , C09K19/02 , C09K19/54 , C09K19/58 , G02F1/1333 , G02F1/137 , G02F1/13
CPC分类号： C09K19/544 , C09K19/54 , C09K19/58 , G02F1/1334
摘要： A liquid crystal display is made from an encapsulated liquid crystal structure comprising a liquid crystal composition dispersed in a containment medium. Selected additives may be added to the encapsulated liquid crystal structure to improve performance characteristics such as the operating field, the hysteresis, and the voltage holding ratio.
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5.发明授权
公开(公告)号：US5427713A
公开(公告)日：1995-06-27
申请号：US28497
申请日：1993-03-09
申请人： Mark F. Wartenberg , Harriette Atkins , Robert H. Reamey , Laurence Welsh , James Strain , Janusz Wojtowicz , Wayne Montoya , Paul S. Drzaic , John Havens , Akira Tomita , Aldrich N. K. Lau
发明人： Mark F. Wartenberg , Harriette Atkins , Robert H. Reamey , Laurence Welsh , James Strain , Janusz Wojtowicz , Wayne Montoya , Paul S. Drzaic , John Havens , Akira Tomita , Aldrich N. K. Lau
IPC分类号： G02F1/1334 , C09K19/02 , C09K19/54 , C09K19/58 , G02F1/1333 , G02F1/137 , G02F1/13
CPC分类号： C09K19/544 , C09K19/54 , C09K19/58 , G02F1/1334
摘要： A liquid crystal display is made from an encapsulated liquid crystal structure comprising a liquid crystal composition dispersed in a containment medium. Selected additives may be added to the encapsulated liquid crystal structure to improve performance characteristics such as the operating field, the hysteresis, and the voltage holding ratio.
摘要翻译： 液晶显示器由包含分散在容纳介质中的液晶组合物的胶囊化液晶结构制成。 可以将所选择的添加剂加入到封装的液晶结构中，以改善操作场，滞后和电压保持率等性能特征。
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6.发明授权Methods for generating pH/ionic concentration gradient near electrode surfaces for modulating biomolecular interactions 有权用于在电极表面附近产生用于调节生物分子相互作用的pH /离子浓度梯度的方法公开(公告)号：US09075041B2
公开(公告)日：2015-07-07
申请号：US13543300
申请日：2012-07-06
IPC分类号： G01N33/50 , G01N27/327 , G01N33/53
CPC分类号： G01N33/50 , G01N27/3275 , G01N33/5306
摘要： Methods of modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest from a biological sample in a biosensor having a multisite array of test sites. In particular, the methods modulate the pH or ionic concentration gradient near the electrodes in such biosensor. The methods of modulating the binding interactions provide a biosensor and analytic methods for more accurately measuring an analyte of interest in a biological sample.
摘要翻译： 在生物传感器中调节生物样品中生物分子探针或检测剂与目的分析物之间的结合相互作用的方法，该生物传感器具有多个测试位点阵列。 特别地，该方法调节这种生物传感器中电极附近的pH或离子浓度梯度。 调节结合相互作用的方法提供了生物传感器和分析方法，用于更精确地测量生物样品中感兴趣的分析物。
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公开(公告)号：US08312890B1
公开(公告)日：2012-11-20
申请号：US11252914
申请日：2005-10-18
申请人： Aldrich N. K. Lau
发明人： Aldrich N. K. Lau
IPC分类号： F16K17/14
CPC分类号： F16K99/0001 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0415 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0661 , B01L2400/0677 , B01L2400/0683 , B01L2400/082 , B01L2400/084 , B01L2400/086 , F16K99/003 , F16K99/0036 , F16K99/0057 , F16K2099/0084 , Y10S422/901 , Y10T137/0318 , Y10T137/0324 , Y10T137/1624 , Y10T137/1812 , Y10T137/2191 , Y10T137/8376 , Y10T137/8593 , Y10T137/85978 , Y10T436/143333 , Y10T436/2575
摘要： A fluid processing device, system, and method for processing a fluid, are provided. The device includes a substrate, a plurality of fluid retainment regions formed in or on the substrate, and a barrier at least partially separating two or more of the fluid retainment regions, wherein the barrier can include a solvent-dissolvable, LCST-free material.
摘要翻译： 提供了一种用于处理流体的流体处理装置，系统和方法。 该装置包括衬底，形成在衬底中或衬底上的多个流体保持区域，以及至少部分地分离两个或更多个流体保持区域的屏障，其中该阻挡层可包括溶剂可溶解的不含LCST的材料。
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公开(公告)号：US20100136701A1
公开(公告)日：2010-06-03
申请号：US12627799
申请日：2009-11-30
CPC分类号： F16K99/0001 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0415 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0661 , B01L2400/0677 , B01L2400/0683 , B01L2400/082 , B01L2400/084 , B01L2400/086 , F16K99/003 , F16K99/0036 , F16K99/0057 , F16K2099/0084 , Y10S422/901 , Y10T137/0318 , Y10T137/0324 , Y10T137/1624 , Y10T137/1812 , Y10T137/2191 , Y10T137/8376 , Y10T137/8593 , Y10T137/85978 , Y10T436/143333 , Y10T436/2575
摘要： A diagnostic device is provided that includes a plurality of retainment regions, with the retainment regions that are separated by at least one dissolvable barrier. The retainment regions can be interconnected through at least one fluid processing passageway. A retainment region can include a container such as a retainment region, well, chamber, or other receptacle, or a retainment region such as a surface on which the material is retained. The retainment regions can include a reaction retainment region, one or more reagent retainment regions, each containing unreacted reagents, and a sample retainment region. A pressure-actuated valve can be positioned in each fluid processing passageway interconnecting the one or more reagent retainment regions with the respective intermediate retainment regions interposed between each of the one or more reagent retainment regions and the reaction retainment region. The dissolvable barrier can be a fluid flow modulator in the at least one fluid processing passageway.
摘要翻译： 提供了一种诊断装置，其包括多个保持区域，其中保留区域被至少一个可溶解屏障隔开。 保持区域可以通过至少一个流体处理通道相互连接。 保持区域可以包括诸如保持区域，孔，腔室或其它容器的容器，或诸如保持材料的表面的保持区域。 保留区域可以包括反应保留区域，一个或多个试剂保留区域，每个含有未反应的试剂和样品保留区域。 压力致动阀可以定位在每个流体处理通道中，其将一个或多个试剂保留区域与插入在一个或多个试剂保留区域中的每一个和反应保留区域之间的各个中间保留区域互连。 可溶解屏障可以是至少一个流体处理通道中的流体流动调节器。
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公开(公告)号：US20100133104A1
公开(公告)日：2010-06-03
申请号：US12627824
申请日：2009-11-30
CPC分类号： F16K99/0001 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0415 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0661 , B01L2400/0677 , B01L2400/0683 , B01L2400/082 , B01L2400/084 , B01L2400/086 , F16K99/003 , F16K99/0036 , F16K99/0057 , F16K2099/0084 , Y10S422/901 , Y10T137/0318 , Y10T137/0324 , Y10T137/1624 , Y10T137/1812 , Y10T137/2191 , Y10T137/8376 , Y10T137/8593 , Y10T137/85978 , Y10T436/143333 , Y10T436/2575
摘要： A diagnostic device is provided that includes a plurality of retainment regions interconnected through at least one fluid processing passageway or separated by at least one barrier. A fluid flow modulator can be provided in the fluid processing passageway if a fluid processing passageway is provided. The barrier and/or fluid flow modulator can comprise a polysaccharide, a derivative of a polysaccharide, or a combination thereof. For example, the barrier can comprise a chitosan material.
摘要翻译： 提供了诊断装置，其包括通过至少一个流体处理通道互连或由至少一个屏障隔开的多个保持区域。 如果提供流体处理通道，流体流动调节器可以设置在流体处理通道中。 阻隔和/或流体流动调节器可以包含多糖，多糖的衍生物或其组合。 例如，阻挡层可以包含壳聚糖材料。
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10.发明授权High speed, high resolution compositions, methods, and kits for capillary electrophoresis 有权用于毛细管电泳的高速，高分辨率组合物，方法和试剂盒公开(公告)号：US06706162B1
公开(公告)日：2004-03-16
申请号：US09668960
申请日：2000-09-25
申请人： Karl O. Voss , Aldrich N. K. Lau
发明人： Karl O. Voss , Aldrich N. K. Lau
IPC分类号： B01D5702
CPC分类号： G01N27/44747 , B01D53/02 , G01N27/44791
摘要： The invention provides compositions, methods and kits for high speed, high resolution of analytes by capillary electrophoresis starting with uncoated capillaries. The compositions comprise a sieving component, comprising a non-crosslinked acrylamide polymer, and a surface interaction component, comprising at least one uncharged and non-crosslinked water-soluble silica-adsorbing polymer. Methods for employing the novel compositions in capillary electrophoresis are provided. Kits comprising the novel compositions for use in the novel methods are also provided.
摘要翻译： 本发明提供了用未经涂覆的毛细管从毛细管电泳开始高分辨率分析物的组合物，方法和试剂盒。 组合物包含筛分组分，其包含非交联的丙烯酰胺聚合物和包含至少一种不带电和非交联的水溶性二氧化硅吸附聚合物的表面相互作用组分。 提供了在毛细管电泳中使用新型组合物的方法。 还提供了包含用于新颖方法的新型组合物的试剂盒。
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