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1.发明授权
公开(公告)号：US5212534A
公开(公告)日：1993-05-18
申请号：US796414
申请日：1991-11-22
CPC分类号： H04J3/0682 , H04B10/2725 , H04J14/0246 , H04J14/0247 , H04J14/025 , H04J14/0252 , H04J14/0282 , H04J14/0226
摘要： In an optical communication system with a passive star coupler, measurement between a station and a central node should not interfere with the operation of other stations. Distance measurement is accomplished by determining the echo delay using a wavelength not being used by other stations. The system uses combined wavelength- and time-division multiplexing. One wavelength is always kept free for measurements if possible. For the measurement, the same data format as that employed during normal operation can be used. Measurement can be continuously repeated unchanged during operation.
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公开(公告)号：US5917019A
公开(公告)日：1999-06-29
申请号：US18628
申请日：1998-02-04
摘要： The present invention provides an isolated altered vertebrate telomere repeat binding factor (A-TRFs). Also included are the corresponding nucleic acids that encode the A-TRFs of the present invention, as well as the heterodimers formed by the association of an A-TRF with a TRF. In addition, pharmaceutical compositions containing the A-TRFs for treatment of diseases such as ataxia telangiectasia are also included. Methods of making, purifying and using the A-TRFs of the present invention are described. In addition, drug screening assays to identify drugs that mimic and/or complement the effect of the A-TRFs are presented.
摘要翻译： 本发明提供了分离的改变的脊椎动物端粒重复结合因子（A-TRF）。 还包括编码本发明的A-TRF的相应核酸以及通过A-TRF与TRF缔合形成的异源二聚体。 此外，还包括含有用于治疗诸如共济失调毛细血管扩张症的疾病的A-TRF的药物组合物。 描述制造，纯化和使用本发明的A-TRF的方法。 此外，提出了用于鉴定模拟和/或补充A-TRF的作用的药物的药物筛选试验。
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公开(公告)号：US6022709A
公开(公告)日：2000-02-08
申请号：US209605
申请日：1998-12-11
摘要： The present invention provides an isolated altered vertebrate telomere repeat binding factor (A-TRF) that hinders the binding of a TRF to its specific telomere repeat sequence. Also included are the corresponding nucleic acids that encode the A-TRFs of the present invention, as well as the heterodimers formed by the association of an A-TRF with a TRF. In addition, pharmaceutical compositions containing the A-TRFs for treatment of diseases such as ataxia telangiectasia are also included. Methods of making, purifying and using the A-TRFs of the present invention are described. In addition, drug screening assays to identify drugs that mimic and/or complement the effect of the A-TRFs are presented.
摘要翻译： 本发明提供了阻碍TRF与其特异性端粒重复序列结合的分离的改变的脊椎动物端粒重复结合因子（A-TRF）。 还包括编码本发明的A-TRF的相应核酸以及通过A-TRF与TRF缔合形成的异源二聚体。 此外，还包括含有用于治疗诸如共济失调毛细血管扩张症的疾病的A-TRF的药物组合物。 描述制造，纯化和使用本发明的A-TRF的方法。 此外，提出了用于鉴定模拟和/或补充A-TRF的作用的药物的药物筛选试验。
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公开(公告)号：US6020166A
公开(公告)日：2000-02-01
申请号：US273378
申请日：1999-03-22
摘要： The present invention provides an isolated altered vertebrate telomere repeat binding factor (A-TRFs). Also included are the corresponding nucleic acids that encode the A-TRFs of the present invention, as well as the heterodimers formed by the association of an A-TRF with a TRF. In addition, pharmaceutical compositions containing the A-TRFs for treatment of diseases such as ataxia telangiectasia are also included. Methods of making, purifying and using the A-TRFs of the present invention are described. In addition, drug screening assays to identify drugs that mimic and/or complement the effect of the A-TRFs are presented.
摘要翻译： 本发明提供了分离的改变的脊椎动物端粒重复结合因子（A-TRF）。 还包括编码本发明的A-TRF的相应核酸以及通过A-TRF与TRF缔合形成的异源二聚体。 此外，还包括含有用于治疗诸如共济失调毛细血管扩张症的疾病的A-TRF的药物组合物。 描述制造，纯化和使用本发明的A-TRF的方法。 此外，提出了用于鉴定模拟和/或补充A-TRF的作用的药物的药物筛选试验。
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公开(公告)号：US5859183A
公开(公告)日：1999-01-12
申请号：US800264
申请日：1997-02-13
IPC分类号： A61K38/00 , C07K14/47 , C07K4/12 , C07K14/435
摘要： The present invention provides an isolated altered vertebrate telomere repeat binding factor (A-TRF) that hinders the binding of a TRF to its specific telomere repeat sequence. Also included are the corresponding nucleic acids that encode the A-TRFs of the present invention, as well as the heterodimers formed by the association of an A-TRF with a TRF. In addition, pharmaceutical compositions containing the A-TRFs for treatment of diseases such as ataxia telangiectasia are also included. Methods of making, purifying and using the A-TRFs of the present invention are described. In addition, drug screening assays to identify drugs that mimic and/or complement the effect of the A-TRFs are presented.
摘要翻译： 本发明提供了阻碍TRF与其特异性端粒重复序列结合的分离的改变的脊椎动物端粒重复结合因子（A-TRF）。 还包括编码本发明的A-TRF的相应核酸以及通过A-TRF与TRF缔合形成的异源二聚体。 此外，还包括含有用于治疗诸如共济失调毛细血管扩张症的疾病的A-TRF的药物组合物。 描述制造，纯化和使用本发明的A-TRF的方法。 此外，提出了用于鉴定模拟和/或补充A-TRF的作用的药物的药物筛选试验。
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