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公开(公告)号：US20080125710A1
公开(公告)日：2008-05-29
申请号：US11500794
申请日：2006-08-07
申请人： Alex R. Hobson , Michael Houghton , David R. King , Joseph E. Korleski , Brian C. Lentz , Kenneth Newcomb , Peter J. Roeber , John Streeter
发明人： Alex R. Hobson , Michael Houghton , David R. King , Joseph E. Korleski , Brian C. Lentz , Kenneth Newcomb , Peter J. Roeber , John Streeter
IPC分类号： A61M25/10
CPC分类号： A61M25/10 , A61F2/958 , A61F7/123 , A61F2007/126 , A61F2250/0067 , A61L29/041 , A61L29/085 , A61L29/126 , A61L29/146 , A61M25/1002 , A61M25/1006 , A61M25/1018 , A61M25/10184 , A61M25/1027 , A61M25/1029 , A61M25/104 , A61M2025/1031 , A61M2025/105 , A61M2025/1052 , A61M2025/1075 , A61M2205/0216 , B32B1/00 , B32B1/02 , B32B1/08 , B32B5/18 , C08J7/047 , C08J2327/18 , C08J2475/04 , Y10T428/1352 , Y10T428/1386
摘要： The present invention provides a stretchable material suitable for use in an inflatable medical device. The stretchable material has at least one reinforcing polymer layer with a top and bottom side forming a porous matrix which is imbibed with a sealing material to infiltrate and substantially seal spaces of the porous matrix and extend beyond the reinforcing polymer layer to form a surface coating.
摘要翻译： 本发明提供一种适用于充气医疗装置的伸缩性材料。 可拉伸材料具有至少一个增强聚合物层，其顶部和底部形成多孔基质，该多孔基体被密封材料吸收，以渗透并基本上密封多孔基质的空间，并延伸超过增强聚合物层以形成表面涂层。
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公开(公告)号：US09180279B2
公开(公告)日：2015-11-10
申请号：US11500794
申请日：2006-08-07
申请人： Alex R. Hobson , Michael Houghton , David R. King , Joseph E. Korleski, Jr. , Brian C. Lentz , Kenneth Newcomb , Peter J. Roeber , John Streeter
发明人： Alex R. Hobson , Michael Houghton , David R. King , Joseph E. Korleski, Jr. , Brian C. Lentz , Kenneth Newcomb , Peter J. Roeber , John Streeter
CPC分类号： A61M25/10 , A61F2/958 , A61F7/123 , A61F2007/126 , A61F2250/0067 , A61L29/041 , A61L29/085 , A61L29/126 , A61L29/146 , A61M25/1002 , A61M25/1006 , A61M25/1018 , A61M25/10184 , A61M25/1027 , A61M25/1029 , A61M25/104 , A61M2025/1031 , A61M2025/105 , A61M2025/1052 , A61M2025/1075 , A61M2205/0216 , B32B1/00 , B32B1/02 , B32B1/08 , B32B5/18 , C08J7/047 , C08J2327/18 , C08J2475/04 , Y10T428/1352 , Y10T428/1386
摘要： The present invention provides a stretchable material suitable for use in an inflatable medical device. The stretchable material has at least one reinforcing polymer layer with a top and bottom side forming a porous matrix which is imbibed with a sealing material to infiltrate and substantially seal spaces of the porous matrix and extend beyond the reinforcing polymer layer to form a surface coating.
摘要翻译： 本发明提供一种适用于充气医疗装置的伸缩性材料。 可拉伸材料具有至少一个增强聚合物层，其顶部和底部形成多孔基质，该多孔基体被密封材料吸收，以渗透并基本上密封多孔基质的空间，并延伸超过增强聚合物层以形成表面涂层。
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公开(公告)号：US20080097300A1
公开(公告)日：2008-04-24
申请号：US11500793
申请日：2006-08-07
IPC分类号： A61M25/10
CPC分类号： A61M25/1002 , A61M25/1038 , A61M2025/1004 , A61M2025/1031 , A61M2025/1086
摘要： Balloons are provided which are formed of at least one balloon material with micropleats distributed about the circumference of the balloon. The micropleats reduce the profile of the balloon and pull taut upon inflation to provide an essentially radial symmetry.
摘要翻译： 提供气球，其由至少一个球囊材料形成，其中微球体围绕气球的圆周分布。 微孔减少气囊的轮廓并且在膨胀时拉紧以提供基本上径向的对称性。
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公开(公告)号：US20100262178A1
公开(公告)日：2010-10-14
申请号：US12824343
申请日：2010-06-28
CPC分类号： A61M29/02 , A61M25/1029 , A61M2025/1075 , A61M2025/1084
摘要： The present invention provides a balloon which achieves diameters greater than 6 mm for securement to a catheter. The balloon includes an elastomeric generally hollow pressure expandable body which exhibits essentially radial symmetry and constant length when expanded under an internally applied minimum working pressure from an uninflated state.
摘要翻译： 本发明提供一种实现直径大于6mm的气囊，用于固定到导管。 气囊包括弹性体大体中空压力可膨胀体，其在内部施加的最小工作压力下从未充气状态膨胀时，其基本上呈径向对称性和恒定长度。
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公开(公告)号：US07785290B2
公开(公告)日：2010-08-31
申请号：US11501190
申请日：2006-08-07
IPC分类号： A61M31/00
CPC分类号： A61M29/02 , A61M25/1029 , A61M2025/1075 , A61M2025/1084
摘要： The present invention provides a balloon which achieves diameters greater than 6 mm for securement to a catheter. The balloon includes an elastomeric generally hollow pressure expandable body which exhibits essentially radial symmetry and constant length when expanded under an internally applied minimum working pressure from an uninflated state.
摘要翻译： 本发明提供一种实现直径大于6mm的气囊，用于固定到导管。 气囊包括弹性体大体中空压力可膨胀体，其在内部施加的最小工作压力下从未充气状态膨胀时，其基本上呈径向对称性和恒定长度。
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公开(公告)号：US20080097301A1
公开(公告)日：2008-04-24
申请号：US11501190
申请日：2006-08-07
IPC分类号： A61M25/10
CPC分类号： A61M29/02 , A61M25/1029 , A61M2025/1075 , A61M2025/1084
摘要： The present invention provides a balloon which achieves diameters greater than 6 mm for securement to a catheter. The balloon includes an elastomeric generally hollow pressure expandable body which exhibits essentially radial symmetry and constant length when expanded under an internally applied minimum working pressure from an uninflated state.
摘要翻译： 本发明提供一种实现直径大于6mm的气囊，用于固定到导管。 气囊包括弹性体大体中空压力可膨胀体，其在内部施加的最小工作压力下从未充气状态膨胀时，其基本上呈径向对称性和恒定长度。
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公开(公告)号：US08585640B2
公开(公告)日：2013-11-19
申请号：US12824343
申请日：2010-06-28
IPC分类号： A61M31/00
CPC分类号： A61M29/02 , A61M25/1029 , A61M2025/1075 , A61M2025/1084
摘要： The present invention provides a balloon which achieves diameters greater than 6 mm for securement to a catheter. The balloon includes an elastomeric generally hollow pressure expandable body which exhibits essentially radial symmetry and constant length when expanded under an internally applied minimum working pressure from an uninflated state.
摘要翻译： 本发明提供一种实现直径大于6mm的气囊，用于固定到导管。 气囊包括弹性体大体中空压力可膨胀体，其在内部施加的最小工作压力下从未充气状态膨胀时，其基本上呈径向对称性和恒定长度。
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公开(公告)号：US20120141529A1
公开(公告)日：2012-06-07
申请号：US13355192
申请日：2012-01-20
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译： 描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。 特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法 以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。 还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。 本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。
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公开(公告)号：US08142793B2
公开(公告)日：2012-03-27
申请号：US12383425
申请日：2009-03-24
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译： 描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。 特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法 以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。 还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。 本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。
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公开(公告)号：US20110014652A1
公开(公告)日：2011-01-20
申请号：US12383419
申请日：2009-03-24
IPC分类号： C12P21/02
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译： 描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。 特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法 以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。 还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。 本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。
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