利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

21 条记录 (耗时 0.031 秒)

    Thiazolineazetidinone derivatives
    9.
    发明授权
    Thiazolineazetidinone derivatives 失效
    噻唑啉氮杂环丁酮衍生物

    公开(公告)号：US4172078A

    公开(公告)日：1979-10-23

    申请号：US860857

    申请日：1977-12-15

    申请人： Ronald G. Micetich ,  Chia-Cheng Shaw ,  Peter K. Wolfert

    发明人： Ronald G. Micetich ,  Chia-Cheng Shaw ,  Peter K. Wolfert

    IPC分类号： C07D513/04 ,  C07D277/08

    CPC分类号： C07D513/04 ,  Y02P20/55

    摘要： Thiazolineazetidinone derivatives of the formulae 1,2, and 3. ##STR1## wherein R is derived from the commonly known carboxamido groups present in penicillins, R.sup.1 is a carboxy protecting group commonly used in penicillin chemistry, and R.sup.2 is Cl, Br, I, CN, lower alkoxy, lower acyloxy, SCN, SCH.sub.3, S-phenyl, S-heteroaryl such as 5-mercaptotetrazole or 2-mercapto-5-methyl-1,3,4-thiadiazole, NO.sub.3, N.sub.3, NH-phenyl, and N(CH.sub.3).sub.2 with the proviso that R.sup.2 in the compounds of formula 1 is limited to Cl, Br, I, and lower acyloxy, and a process for preparing said compounds from 2-(substituted methyl) penicillin sulfoxides followed by treatment with a base.The compounds of formulae 1,2, and 3 are useful as intermediates in the synthesis of cephalosporins.

    摘要翻译： 式1,2和3的噻唑啉氮杂环丁酮衍生物。其中R衍生自青霉素中常见的羧酰胺基，R1是青霉素化学通常使用的羧基保护基，R2是Cl，Br ，I，CN，低级烷氧基，低级酰氧基，SCN，SCH3，S-苯基，S-杂芳基如5-巯基四唑或2-巯基-5-甲基-1,3,4-噻二唑，NO 3，N 3，NH- 苯基和N（CH 3）2，条件是式1化合物中的R 2限于Cl，Br，I和低级酰氧基，以及由2-（取代的甲基）青霉素亚砜制备所述化合物的方法， 用基地治疗。