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    CANCER DETECTION METHOD
    1.
    发明申请
    CANCER DETECTION METHOD 审中-公开
    癌症检测方法

    公开(公告)号：US20090269744A1

    公开(公告)日：2009-10-29

    申请号：US12091835

    申请日：2006-10-26

    申请人： Alexander Krause ,  Philippe Leissner ,  Malick Paye ,  Bruno Mougin ,  Fabien Schweighoffer ,  Laurent Bracco

    发明人： Alexander Krause ,  Philippe Leissner ,  Malick Paye ,  Bruno Mougin ,  Fabien Schweighoffer ,  Laurent Bracco

    IPC分类号： C12Q1/68 ,  C07H21/00

    CPC分类号： C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/158

    摘要： The present application concerns methods and compositions which can be used to detect cancer in mammals, in particular in humans. It notably describes serum markers of cancers and their uses in diagnosis methods. It also concerns tools and/or kits which can be used to implement these methods (reagents, probes, primers, antibodies, chips, cells, etc.), their preparation and their uses. The invention can be used to detect the presence or the progression of a cancer, particularly breast cancer, including at an early stage.

    摘要翻译： 本申请涉及可用于检测哺乳动物，特别是人类中的癌症的方法和组合物。 它特别描述了癌症的血清标志物及其在诊断方法中的用途。 它还涉及可用于实施这些方法（试剂，探针，引物，抗体，芯片，细胞等）的工具和/或试剂盒，其制备及其用途。 本发明可用于检测癌症，特别是乳腺癌的存在或进展，包括早期阶段。

    Method for Breast Cancer Diagnosis
    2.
    发明申请
    Method for Breast Cancer Diagnosis 审中-公开
    乳腺癌诊断方法

    公开(公告)号：US20090123924A1

    公开(公告)日：2009-05-14

    申请号：US11988364

    申请日：2006-07-05

    申请人： Alexander Krause ,  Philippe Leissner ,  Bruno Mougin ,  Malick Paye

    发明人： Alexander Krause ,  Philippe Leissner ,  Bruno Mougin ,  Malick Paye

    IPC分类号： C12Q1/68 ,  C07H21/04

    CPC分类号： C12Q1/6886 ,  C12Q2600/178

    摘要： The invention relates to a method for the in vitro diagnosis of breast cancer in a patient who may be suffering from a breast cancer, characterized in that it comprises the following steps: a) biological material is extracted from a biological sample taken from the patient, b) the biological material is brought into contact with at least 8 specific reagents chosen from the specific reagents for the target genes with a nucleic sequence having any one of SEQ ID Nos. 1 to 8, c) the expression of said target genes is determined.

    摘要翻译： 本发明涉及可能患有乳腺癌的患者体外诊断乳腺癌的方法，其特征在于其包括以下步骤：a）从取自患者的生物样品中提取生物材料， b）生物材料与选自具有SEQ ID No.1至8中任一个的核酸序列的目标基因的特定试剂的至少8种特异性试剂接触，c）确定所述靶基因的表达 。

    Solid drill bit for machine tools
    5.
    发明授权
    Solid drill bit for machine tools 有权
    用于机床的实心钻头

    公开(公告)号：US07695221B2

    公开(公告)日：2010-04-13

    申请号：US12012097

    申请日：2008-01-31

    申请人： Jacek Kruszynski ,  Alexander Krause ,  Henry Schütt

    发明人： Jacek Kruszynski ,  Alexander Krause ,  Henry Schütt

    IPC分类号： B26D1/00 ,  B23B51/00

    CPC分类号： B23B51/048 ,  B23B2200/125 ,  B23B2200/286 ,  B23B2251/04 ,  B23B2251/50 ,  Y10S408/713 ,  Y10T407/23 ,  Y10T408/905 ,  Y10T408/9097

    摘要： A solid drill bit for machine tools has a drill bit body and two indexable inserts arranged at a radial distance from one another in respective insert seats. The inserts have an essentially quadratic contour. Their front-end main cutting edges project axially beyond the drill bit body and radially overlap one another. The outer insert has an outer insert corner and a secondary cutting edge perpendicular to the main cutting edge that projects radially beyond the circumference of the drill bit body. To permit burr-free through-drilling, the main cutting edge of the outer insert is subdivided in its longitudinal extent into a radially inner working section and a rectilinear peeling section adjoining the working section and extending to the outer insert corner. The sections enclose a setting angle of 95° to 120°. The peeling section is set at a positive setting angle of 72° to 87°.

    摘要翻译： 用于机床的固体钻头具有钻头体和两个可转位刀片，其相对于相应刀片座中彼此径向间隔布置。 刀片具有基本上二次曲线。 它们的前端主切削刃轴向突出超过钻头体并且彼此径向重叠。 外部插入件具有外部插入角和与主切削刃垂直的辅助切削刃，其径向突出超过钻头体的圆周。 为了允许无毛刺穿孔，外刀片的主切削刃在其纵向范围内被细分成径向内部工作部分和邻接工作部分并延伸到外部刀片拐角的直线剥离部分。 这些部分的设置角度为95°至120°。 剥离部设定为72°〜87°的正设定角度。

    Solid drill bit for machine tools
    6.
    发明申请
    Solid drill bit for machine tools 有权
    用于机床的实心钻头

    公开(公告)号：US20080131217A1

    公开(公告)日：2008-06-05

    申请号：US12012097

    申请日：2008-01-31

    申请人： Jacek Kruszynski ,  Alexander Krause ,  Henry Schutt

    发明人： Jacek Kruszynski ,  Alexander Krause ,  Henry Schutt

    IPC分类号： B23B27/00 ,  B23B51/00 ,  B23B27/16 ,  B23P15/28

    CPC分类号： B23B51/048 ,  B23B2200/125 ,  B23B2200/286 ,  B23B2251/04 ,  B23B2251/50 ,  Y10S408/713 ,  Y10T407/23 ,  Y10T408/905 ,  Y10T408/9097

    摘要： A solid drill bit for machine tools has a drill bit body and two indexable inserts arranged at a radial distance from one another in respective insert seats. The inserts have an essentially quadratic contour. Their front-end main cutting edges project axially beyond the drill bit body and radially overlap one another. The outer insert has an outer insert corner and a secondary cutting edge perpendicular to the main cutting edge that projects radially beyond the circumference of the drill bit body. To permit burr-free through-drilling, the main cutting edge of the outer insert is subdivided in its longitudinal extent into a radially inner working section and a rectilinear peeling section adjoining the working section and extending to the outer insert corner. The sections enclose a setting angle of 95° to 120°. The peeling section is set at a positive setting angle of 72° to 87°.

    摘要翻译： 用于机床的固体钻头具有钻头体和两个可转位刀片，其相对于相应刀片座中彼此径向间隔布置。 刀片具有基本上二次曲线。 它们的前端主切削刃轴向突出超过钻头体并且彼此径向重叠。 外部插入件具有外部插入角和与主切削刃垂直的辅助切削刃，其径向突出超过钻头体的圆周。 为了允许无毛刺穿孔，外刀片的主切削刃在其纵向范围内被细分成径向内部工作部分和邻接工作部分并延伸到外部刀片拐角的直线剥离部分。 这些部分的设置角度为95°至120°。 剥离部设定为72°〜87°的正设定角度。

    Solid drill bit for machine tools
    7.
    发明授权
    Solid drill bit for machine tools 有权
    用于机床的实心钻头

    公开(公告)号：US07201542B2

    公开(公告)日：2007-04-10

    申请号：US10275418

    申请日：2001-04-06

    申请人： Andree Fritsch ,  Hans Haidinger ,  Alexander Krause ,  Jacek Kruszynski ,  Helmut Morlok ,  Frank Roeser ,  Henry Schuett ,  Miltiadis Theodorou

    发明人： Andree Fritsch ,  Hans Haidinger ,  Alexander Krause ,  Jacek Kruszynski ,  Helmut Morlok ,  Frank Roeser ,  Henry Schuett ,  Miltiadis Theodorou

    IPC分类号： B23B51/02 ,  B23B51/00

    CPC分类号： B23B51/048 ,  B23B2200/245 ,  B23B2251/125 ,  Y10S408/713 ,  Y10T408/905 ,  Y10T408/906 ,  Y10T408/909

    摘要： A solid drill bit for machine tools. has a bit body and two movable inserts located a radial distance apart in insert seats of the bit body. The inserts have a rectangular or quadratic contour, project axially over the bit body with their major cutting edges and overlap in their working area. The outer movable insert projects radially beyond the periphery of the bit body with its outer cutting edge corner and with the adjoining minor cutting edge. Starting from the cutting edge corner, the minor cutting edge is inclined in the direction of the bit body at a setting angle of less than 3.2 °. The minor cutting edge has a guiding edge that is slidingly supported against the wall of the bore over at least part of its length due to a radially outwardly oriented thrust force.

    摘要翻译： 用于机床的坚固钻头。 具有一个位体和两个可移动的插入件，位于距离钻头体的插入座中的径向距离处。 刀片具有矩形或二次轮廓，轴向位于钻头主体上并具有主切削刃，并在其工作区域重叠。 外可移动刀片的外切削刃角度与相邻的次切削刃径向超过钻头体的周边。 从切削刃角度开始，副切削刃在钻头体的方向上以小于3.2°的设定角度倾斜。 小切削刃具有引导边缘，其由于径向向外定向的推力而滑动地支撑在孔的至少部分长度上的孔的壁上。

    Solid drill bit for machine tools
    8.
    发明授权
    Solid drill bit for machine tools 失效
    用于机床的实心钻头

    公开(公告)号：US07351017B2

    公开(公告)日：2008-04-01

    申请号：US10522647

    申请日：2003-07-26

    申请人： Jacek Kruszynski ,  Alexander Krause ,  Henry Schutt

    发明人： Jacek Kruszynski ,  Alexander Krause ,  Henry Schutt

    IPC分类号： B23B51/00

    CPC分类号： B23B51/048 ,  B23B2200/125 ,  B23B2200/286 ,  B23B2251/04 ,  B23B2251/50 ,  Y10S408/713 ,  Y10T407/23 ,  Y10T408/905 ,  Y10T408/9097

    摘要： A solid drill bit for machine tools has a drill bit body and two indexable inserts arranged at a radial distance from one another in respective insert seats. The inserts have an essentially quadratic contour. Their front-end main cutting edges project axially beyond the drill bit body and radially overlap one another. The outer insert has an outer insert corner and a secondary cutting edge perpendicular to the main cutting edge that projects radially beyond the circumference of the drill bit body. To permit burr-free through-drilling, the main cutting edge of the outer insert is subdivided in its longitudinal extent into a radially inner working section and a rectilinear peeling section adjoining the working section and extending to the outer insert corner. The sections enclose a setting angle of 95° to 120°. The peeling section is set at a positive setting angle of 720° to 87°.

    摘要翻译： 用于机床的固体钻头具有钻头体和两个可转位刀片，其相对于相应刀片座中彼此径向间隔布置。 刀片具有基本上二次曲线。 它们的前端主切削刃轴向突出超过钻头体并且彼此径向重叠。 外部插入件具有外部插入角和与主切削刃垂直的辅助切削刃，其径向突出超过钻头体的圆周。 为了允许无毛刺穿孔，外刀片的主切削刃在其纵向范围内被细分成径向内部工作部分和邻接工作部分并延伸到外部刀片拐角的直线剥离部分。 这些部分的设置角度为95°至120°。 剥离部设定为720°〜87°的正设定角度。

    Method for the diagnosis/prognosis of neuroblastoma
    9.
    发明申请
    Method for the diagnosis/prognosis of neuroblastoma 审中-公开
    神经母细胞瘤诊断/预后的方法

    公开(公告)号：US20060263784A1

    公开(公告)日：2006-11-23

    申请号：US10572905

    申请日：2004-10-01

    申请人： Valerie Combaret ,  Alexander Krause ,  Alain Puisieux ,  Bruno Lacroix

    发明人： Valerie Combaret ,  Alexander Krause ,  Alain Puisieux ,  Bruno Lacroix

    IPC分类号： C12Q1/68 ,  C12M1/34

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118

    摘要： The present invention relates to a method for neuroblastoma prognosis in a patient suffering from neuroblastoma, characterized in that it comprises the following steps: a. biological material is extracted from a biological sample taken from the patient, b. the biological material is brought into contact with at least one specific reagent chosen from the reagents specific for the target genes exhibiting a nucleic acid sequence having any one of SEQ ID Nos. 1 to 37, it being understood that, when the target gene exhibits a nucleic acid sequence having one of SEQ ID Nos. 11, 17 or 37, the biological material is brought into contact with at least two specific reagents chosen from the reagents specific for the target genes exhibiting a nucleic acid sequence having any one of SEQ ID Nos. 1 to 37, c. the expression of at least one of said target genes is determined, it being understood that, when the target gene exhibits a nucleic acid sequence having one of SEQ ID Nos. 11, 17 or 37, the expression of at least two of said target genes is determined.

    摘要翻译： 本发明涉及神经母细胞瘤患者神经母细胞瘤预后的方法，其特征在于包括以下步骤：a。 生物材料从取自患者的生物样品中提取，b。 使生物材料与选自对具有SEQ ID No.1至37中任一项所示的核酸序列的靶基因特异性的试剂中的至少一种特异性试剂接触，应理解，当靶基因表现出 具有SEQ ID No.11,17或37之一的核酸序列，使生物材料与至少两种特异性试剂接触，所述试剂选自对具有SEQ ID NO：11,17或37中任一项所示的核酸序列的靶基因特异性的试剂 1至37，c。 确定至少一个所述靶基因的表达，应当理解，当靶基因表现出具有SEQ ID No.11,17或37之一的核酸序列时，至少两个所述靶基因的表达 决心，决意，决定。