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公开(公告)号：US6114322A
公开(公告)日：2000-09-05
申请号：US361530
申请日：1999-07-27
申请人： Alfons Enhsen , Eugen Falk , Heiner Glombik , Siegfried Stengelin
发明人： Alfons Enhsen , Eugen Falk , Heiner Glombik , Siegfried Stengelin
IPC分类号： C12N15/09 , A61K31/55 , A61K31/554 , A61K31/675 , A61K31/70 , A61K48/00 , A61P1/16 , A61P3/06 , A61P3/10 , A61P9/10 , A61P35/00 , C07D281/00 , C07D281/10 , C07D417/04 , C07D417/10 , C07D417/12 , C07F9/6558 , C07H17/00 , C12N5/00 , C12N5/10 , C12N9/12 , C12N15/06 , C12N15/10 , C12N15/11 , C12N15/54 , C12N15/85 , C12P21/02 , C12R1/91
CPC分类号： C07D417/04 , C07D281/00 , C07H17/00 , Y02P20/55
摘要： The present invention is concerned with new hypolipidemic compounds, with processes and novel intermediates for their preparation, with pharmaceutical compositions containing them and with their use in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions, such as atherosclerosis.Compounds of the formula (I): ##STR1## wherein R.sup.1 to R.sup.10 and X are as defined in the Specification and useful as hypolipidemic compounds.
摘要翻译： 本发明涉及新的降血脂化合物，其制备方法和新的中间体，含有它们的药物组合物和它们在医药中的用途，特别是用于预防和治疗高脂血症病症如动脉粥样硬化。 式（I）的化合物：其中R 1至R 10和X如说明书中所定义并可用作降血脂化合物。
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公开(公告)号：US6020330A
公开(公告)日：2000-02-01
申请号：US41953
申请日：1998-03-13
申请人： Alfons Enhsen , Eugen Falk , Heiner Glombik , Siegfried Stengelin
发明人： Alfons Enhsen , Eugen Falk , Heiner Glombik , Siegfried Stengelin
IPC分类号： C12N15/09 , A61K31/55 , A61K31/554 , A61K31/675 , A61K31/70 , A61K48/00 , A61P1/16 , A61P3/06 , A61P3/10 , A61P9/10 , A61P35/00 , C07D281/00 , C07D281/10 , C07D417/04 , C07D417/10 , C07D417/12 , C07F9/6558 , C07H17/00 , C12N5/00 , C12N5/10 , C12N9/12 , C12N15/06 , C12N15/10 , C12N15/11 , C12N15/54 , C12N15/85 , C12P21/02 , C12R1/91
CPC分类号： C07D417/04 , C07D281/00 , C07H17/00 , Y02P20/55
摘要： The present invention is concerned with new hypolipidemic compounds, with processes and novel intermediates for their preparation, with pharmaceutical compositions containing them and with their use in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions, such as atherosclerosis.Compounds of the formula (I): ##STR1## wherein R.sup.1 to R.sup.10 and X are a defined in the specification and are useful as hypolipidemic compounds.
摘要翻译： 本发明涉及新的降血脂化合物，其制备方法和新的中间体，含有它们的药物组合物和它们在医药中的用途，特别是用于预防和治疗高脂血症病症如动脉粥样硬化。 式（I）的化合物：其中R 1至R 10和X在说明书中定义并且可用作降血脂化合物。
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3.发明授权Propanolamine derivatives linked to bile acids, processes for their preparation, pharmaceuticals comprising these compounds, and their use 有权与胆汁酸连接的丙醇胺衍生物，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US06180618B2
公开(公告)日：2001-01-30
申请号：US09408169
申请日：1999-09-29
IPC分类号： A61K3158
摘要： Compounds of formula (I) in which the radicals are as defined in the specification and claims, and physiologically tolerated and physiologically functional derivatives thereof and processes for their preparation are described. The compounds are suitable, for example, as hypolipidemic agents.
摘要翻译： 描述了其中基团如说明书和权利要求书中所定义的式（I）化合物及其生理学耐受性和生理功能性衍生物及其制备方法。 该化合物例如可用作降血脂药物。
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4.发明授权Substituted 1,3-diaryl-2-pyrid-2-yl-3-(pyrid-2-ylamino)propanol derivatives, process for their preparation, pharmaceuticals comprising these compounds and their use 有权取代的1,3-二芳基-2-吡啶-2-基-3-（吡啶-2-基氨基）丙醇衍生物，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US06596728B1
公开(公告)日：2003-07-22
申请号：US09410083
申请日：1999-10-01
申请人： Reinhard Kirsch , Alfons Enhsen , Heiner Glombik , Werner Kramer , Eugen Falk
发明人： Reinhard Kirsch , Alfons Enhsen , Heiner Glombik , Werner Kramer , Eugen Falk
IPC分类号： A61K31505
CPC分类号： C07D213/74 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/04
摘要： Substituted 1,3-diaryl-2-pyridin-2-yl-3-(pyridin-2-ylamino)propanol derivatives of the formula (I), and salts thereof, in which the radicals have the meanings given in the specification, and physiologically tolerated salts thereof and processes for their preparation are described. The compounds are suitable, for example, as hypolipidemic agents.
摘要翻译： 取代的式（I）的1,3-二芳基-2-吡啶-2-基-3-（吡啶-2-基氨基）丙醇衍生物及其盐，其中基团具有本说明书中给出的含义，和 描述了其生理学耐受的盐及其制备方法。 该化合物例如可用作降血脂药物。
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5.发明授权Arylcycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals 有权芳基环烷基取代的链烷酸衍生物，其制备方法及其作为药物的用途公开(公告)号：US07872034B2
公开(公告)日：2011-01-18
申请号：US12013806
申请日：2008-01-14
申请人： Christian Stapper , Stefanie Keil , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Dirk Gretzke , Hans-Ludwig Schaefer , Wolfgang Wendler
发明人： Christian Stapper , Stefanie Keil , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Dirk Gretzke , Hans-Ludwig Schaefer , Wolfgang Wendler
IPC分类号： A61K31/421 , C07D263/32 , A61P3/10
CPC分类号： C07D263/32 , C07D413/02
摘要： The invention relates to arylcycloalkyl-substituted alkanoic acid derivatives and to their physiologically acceptable salts and physiologically functional derivatives.What is described are compounds of the formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable, for example, for the treatment and/or prevention of disorders of the fatty acid metabolism and glucose utilization disorders and also disorders in which insulin resistance is involved.
摘要翻译： 本发明涉及芳基环烷基取代的链烷酸衍生物及其生理上可接受的盐和生理功能衍生物。 描述的是式I化合物，其中基团如所定义，以及它们的生理上可接受的盐及其制备方法。 该化合物例如适用于治疗和/或预防脂肪酸代谢紊乱和葡萄糖利用障碍以及涉及胰岛素抵抗的疾病。
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6.发明授权Diarylcycloalkyl derivatives, processes for their preparation and their use as pharmceuticals 有权二芳基环烷基衍生物，其制备方法及其作为药剂学的用途公开(公告)号：US07399777B2
公开(公告)日：2008-07-15
申请号：US11097345
申请日：2005-04-04
申请人： Heiner Glombik , Eugen Falk , Wendelin Frick , Stefanie Keil , Hans-Ludwig Schäfer , Lothar Schwink , Wolfgang Wendler
发明人： Heiner Glombik , Eugen Falk , Wendelin Frick , Stefanie Keil , Hans-Ludwig Schäfer , Lothar Schwink , Wolfgang Wendler
IPC分类号： C07D263/32 , A61K31/421
CPC分类号： C07D263/32 , C07D413/12
摘要： Diarylcycloalkyl derivatives and their physiologically acceptable salts and physiologically functional derivatives are disclosed. The compounds include those of formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds typically have lipid- and/or triglyceride-lowering properties and are suitable, for example, for the treatment of disorders of lipid metabolism, of type II diabetes, and of syndrome X.
摘要翻译： 公开了二芳基环烷基衍生物及其生理上可接受的盐和生理功能衍生物。 化合物包括其中基团如所定义的式I化合物及其生理上可接受的盐及其制备方法。 化合物通常具有降低脂质和/或甘油三酯的性质，并且适合于例如用于治疗脂质代谢紊乱，II型糖尿病和X综合症。
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7.发明授权Cycloalkyl-substituted amino acid derivatives, processes for their preparation and their use as pharmaceuticals 有权环烷基取代的氨基酸衍生物，其制备方法及其作为药物的用途公开(公告)号：US07365084B2
公开(公告)日：2008-04-29
申请号：US10788997
申请日：2004-02-27
申请人： Christian Stapper , Stefanie Keil , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Dirk Gretzke , Hans-Ludwig Schaefer , Wolfgang Wendler
发明人： Christian Stapper , Stefanie Keil , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Dirk Gretzke , Hans-Ludwig Schaefer , Wolfgang Wendler
IPC分类号： C07D413/02 , C07D263/30 , A61K31/4439 , A61K31/422
CPC分类号： C07D263/32 , C07D413/02
摘要： Provided herein are cycloalkyl-substituted amino acid derivatives, processes for their preparation and their use as pharmaceuticals.
摘要翻译： 本文提供环烷基取代的氨基酸衍生物，其制备方法及其作为药物的用途。
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8.发明授权Cycloalkylmethoxy-substituted acetic acid derivatives, processes for their preparation and their use as pharmaceuticals 有权环烷基甲氧基取代的乙酸衍生物，其制备方法及其作为药物的用途公开(公告)号：US07259177B2
公开(公告)日：2007-08-21
申请号：US10788996
申请日：2004-02-27
申请人： Christian Stapper , Stefanie Keil , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Dirk Gretzke , Hans-Ludwig Schaefer , Wolfgang Wendler
发明人： Christian Stapper , Stefanie Keil , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Dirk Gretzke , Hans-Ludwig Schaefer , Wolfgang Wendler
IPC分类号： A61K31/42 , C07D263/30
CPC分类号： C07D263/32 , C07D413/02
摘要： Provided herein are novel compounds of formula I below: in which the radicals are as defined, their physiologically acceptable salts, processes for their preparation, as well as methods of treating and/or preventing disorders of disorders of fatty acid metabolism and glucose utilization disorders, and also of disorders in which insulin resistance is involved, in a patient.
摘要翻译： 本文提供了下文式I的新化合物：其中基团如所定义，其生理学上可接受的盐，其制备方法，以及治疗和/或预防脂肪酸代谢紊乱和葡萄糖利用障碍疾病的方法， 以及患有胰岛素抵抗的疾病。
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9.发明授权Cycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals 有权环烷基取代的链烷酸衍生物，其制备方法及其作为药物的用途公开(公告)号：US07173151B2
公开(公告)日：2007-02-06
申请号：US10789324
申请日：2004-02-27
申请人： Christian Stapper , Heiner Glombik , Eugen Falk , Dirk Gretzke , Jochen Goerlitzer , Stefanie Keil , Hans-Ludwig Schaefer , Wolfgang Wendler
发明人： Christian Stapper , Heiner Glombik , Eugen Falk , Dirk Gretzke , Jochen Goerlitzer , Stefanie Keil , Hans-Ludwig Schaefer , Wolfgang Wendler
IPC分类号： C07C229/00 , C07C61/28 , C07C61/16 , C07C62/00 , C07C62/30
CPC分类号： C07C275/28 , C07C275/10 , C07C275/24 , C07C275/26 , C07C2601/14
摘要： The invention relates to arylcycloalkyl-substituted derivatives and to their physiologically acceptable salts and physiologically functional derivatives.What is described are compounds of the formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistence is involved.
摘要翻译： 本发明涉及芳基环烷基取代的衍生物及其生理上可接受的盐和生理功能衍生物。 描述的是式I化合物，其中基团如所定义，以及它们的生理上可接受的盐及其制备方法。 所述化合物适用于治疗和/或预防脂肪酸代谢紊乱和葡萄糖利用障碍以及涉及胰岛素抵抗的疾病。
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10.发明授权Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals 有权具有生物异丝氨酸羧酸基团的环烷基衍生物，其制备方法及其作为药物的用途公开(公告)号：US07148246B2
公开(公告)日：2006-12-12
申请号：US10789865
申请日：2004-02-27
申请人： Dirk Gretzke , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Stefanie Keil , Hans-Ludwig Schaefer , Christian Stapper , Wolfgang Wendler
发明人： Dirk Gretzke , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Stefanie Keil , Hans-Ludwig Schaefer , Christian Stapper , Wolfgang Wendler
IPC分类号： C07D277/04 , C07D209/54 , C07D257/04 , C07D413/00 , A61K31/42
CPC分类号： C07D417/12 , C07D263/32 , C07D413/12
摘要： Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals The invention relates to cycloalkyl derivatives having bioisosteric carboxylic acid groups and to their physiologically acceptable salts and physiologically functional derivatives. What is described are compounds of the formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistence is involved.
摘要翻译： 具有生物硅烷酸羧酸基团的环烷基衍生物及其制备方法及其作为药物的用途本发明涉及具有生物硅烷酸羧酸基团的环烷基衍生物及其生理上可接受的盐和生理功能衍生物。 所描述的是式I化合物，其中自由基如所定义，以及它们的生理上可接受的盐及其制备方法。 所述化合物适用于治疗和/或预防脂肪酸代谢紊乱和葡萄糖利用障碍以及涉及胰岛素抵抗的疾病。
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