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公开(公告)号：US6020330A
公开(公告)日：2000-02-01
申请号：US41953
申请日：1998-03-13
申请人： Alfons Enhsen , Eugen Falk , Heiner Glombik , Siegfried Stengelin
发明人： Alfons Enhsen , Eugen Falk , Heiner Glombik , Siegfried Stengelin
IPC分类号： C12N15/09 , A61K31/55 , A61K31/554 , A61K31/675 , A61K31/70 , A61K48/00 , A61P1/16 , A61P3/06 , A61P3/10 , A61P9/10 , A61P35/00 , C07D281/00 , C07D281/10 , C07D417/04 , C07D417/10 , C07D417/12 , C07F9/6558 , C07H17/00 , C12N5/00 , C12N5/10 , C12N9/12 , C12N15/06 , C12N15/10 , C12N15/11 , C12N15/54 , C12N15/85 , C12P21/02 , C12R1/91
CPC分类号： C07D417/04 , C07D281/00 , C07H17/00 , Y02P20/55
摘要： The present invention is concerned with new hypolipidemic compounds, with processes and novel intermediates for their preparation, with pharmaceutical compositions containing them and with their use in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions, such as atherosclerosis.Compounds of the formula (I): ##STR1## wherein R.sup.1 to R.sup.10 and X are a defined in the specification and are useful as hypolipidemic compounds.
摘要翻译： 本发明涉及新的降血脂化合物，其制备方法和新的中间体，含有它们的药物组合物和它们在医药中的用途，特别是用于预防和治疗高脂血症病症如动脉粥样硬化。 式（I）的化合物：其中R 1至R 10和X在说明书中定义并且可用作降血脂化合物。
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公开(公告)号：US6114322A
公开(公告)日：2000-09-05
申请号：US361530
申请日：1999-07-27
申请人： Alfons Enhsen , Eugen Falk , Heiner Glombik , Siegfried Stengelin
发明人： Alfons Enhsen , Eugen Falk , Heiner Glombik , Siegfried Stengelin
IPC分类号： C12N15/09 , A61K31/55 , A61K31/554 , A61K31/675 , A61K31/70 , A61K48/00 , A61P1/16 , A61P3/06 , A61P3/10 , A61P9/10 , A61P35/00 , C07D281/00 , C07D281/10 , C07D417/04 , C07D417/10 , C07D417/12 , C07F9/6558 , C07H17/00 , C12N5/00 , C12N5/10 , C12N9/12 , C12N15/06 , C12N15/10 , C12N15/11 , C12N15/54 , C12N15/85 , C12P21/02 , C12R1/91
CPC分类号： C07D417/04 , C07D281/00 , C07H17/00 , Y02P20/55
摘要： The present invention is concerned with new hypolipidemic compounds, with processes and novel intermediates for their preparation, with pharmaceutical compositions containing them and with their use in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions, such as atherosclerosis.Compounds of the formula (I): ##STR1## wherein R.sup.1 to R.sup.10 and X are as defined in the Specification and useful as hypolipidemic compounds.
摘要翻译： 本发明涉及新的降血脂化合物，其制备方法和新的中间体，含有它们的药物组合物和它们在医药中的用途，特别是用于预防和治疗高脂血症病症如动脉粥样硬化。 式（I）的化合物：其中R 1至R 10和X如说明书中所定义并可用作降血脂化合物。
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3.发明授权Propanolamine derivatives linked to bile acids, processes for their preparation, pharmaceuticals comprising these compounds, and their use 有权与胆汁酸连接的丙醇胺衍生物，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US06180618B2
公开(公告)日：2001-01-30
申请号：US09408169
申请日：1999-09-29
IPC分类号： A61K3158
摘要： Compounds of formula (I) in which the radicals are as defined in the specification and claims, and physiologically tolerated and physiologically functional derivatives thereof and processes for their preparation are described. The compounds are suitable, for example, as hypolipidemic agents.
摘要翻译： 描述了其中基团如说明书和权利要求书中所定义的式（I）化合物及其生理学耐受性和生理功能性衍生物及其制备方法。 该化合物例如可用作降血脂药物。
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4.发明授权Substituted 1,3-diaryl-2-pyrid-2-yl-3-(pyrid-2-ylamino)propanol derivatives, process for their preparation, pharmaceuticals comprising these compounds and their use 有权取代的1,3-二芳基-2-吡啶-2-基-3-（吡啶-2-基氨基）丙醇衍生物，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US06596728B1
公开(公告)日：2003-07-22
申请号：US09410083
申请日：1999-10-01
申请人： Reinhard Kirsch , Alfons Enhsen , Heiner Glombik , Werner Kramer , Eugen Falk
发明人： Reinhard Kirsch , Alfons Enhsen , Heiner Glombik , Werner Kramer , Eugen Falk
IPC分类号： A61K31505
CPC分类号： C07D213/74 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/04
摘要： Substituted 1,3-diaryl-2-pyridin-2-yl-3-(pyridin-2-ylamino)propanol derivatives of the formula (I), and salts thereof, in which the radicals have the meanings given in the specification, and physiologically tolerated salts thereof and processes for their preparation are described. The compounds are suitable, for example, as hypolipidemic agents.
摘要翻译： 取代的式（I）的1,3-二芳基-2-吡啶-2-基-3-（吡啶-2-基氨基）丙醇衍生物及其盐，其中基团具有本说明书中给出的含义，和 描述了其生理学耐受的盐及其制备方法。 该化合物例如可用作降血脂药物。
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5.发明授权Benzothiepine 1, 1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use 有权苯并噻吩1,1-二氧化物衍生物，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US07019023B2
公开(公告)日：2006-03-28
申请号：US10606771
申请日：2003-06-27
申请人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
发明人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
IPC分类号： A61K31/38
CPC分类号： C07K5/06086 , A61K38/00 , C07D337/08 , C08G65/329
摘要： Substituted benzothiepine 1,1-dioxide derivatives of formula I: in which R1, R2, R3, R4, R5 and Z have the meanings indicated, and their physiologically tolerable salts and physiologically functional derivatives and a process for their preparation are described. The compounds are suitable, for example, as hypolipidemics.
摘要翻译： 取代的式I的苯并噻吩1,1-二氧化物衍生物：其中R 1，R 2，R 3，R 4， Z和Z具有所示的含义，并描述了它们的生理上可耐受的盐和生理功能衍生物及其制备方法。 该化合物例如可用作降血脂药物。
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公开(公告)号：US5486626A
公开(公告)日：1996-01-23
申请号：US206321
申请日：1994-03-07
申请人： Alfons Enhsen , Heiner Glombik , Werner Kramer , Gunther Wess
发明人： Alfons Enhsen , Heiner Glombik , Werner Kramer , Gunther Wess
CPC分类号： C07J43/003 , C07J41/0011 , C07J9/005
摘要： Process for the preparation of 3.beta.-aminocholanic acid derivativesA process for the preparation of 3.beta.-aminocholanic acid derivatives of the formula II ##STR1## wherein R(1), R(2) and R(3) have the meanings given, starting from the corresponding 3.beta.-hydroxycholanic acid esters, is described.
摘要翻译： 制备3β-氨基胆胺酸衍生物的方法制备式II的3β-氨基胆胺酸衍生物的方法其中R（1），R（2）和R（3）具有给定的含义 ，从相应的3β-羟基胆酸酯开始。
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7.发明授权Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use 有权苯并噻吩1,1-二氧化物衍生物，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US06441022B1
公开(公告)日：2002-08-27
申请号：US09773772
申请日：2001-02-02
申请人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
发明人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
IPC分类号： A61K3138
CPC分类号： C07K5/06086 , A61K38/00 , C07D337/08 , C08G65/329
摘要： Substituted benzothiepine 1,1-dioxide derivatives of formula I: in which R1, R2, R3, R4, R5 and Z have the meanings indicated, and their physiologically tolerable salts and physiologically functional derivatives and a process for their preparation are described. The compounds are suitable, for example, as hypolipidemics.
摘要翻译： 描述式I的取代苯并噻吩1,1-二氧化物衍生物：其中R1，R2，R3，R4，R5和Z具有所示含义，并描述了其生理上可耐受的盐和生理功能衍生物及其制备方法。 该化合物例如可用作降血脂药物。
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8.发明授权Bile acid derivatives, process for their preparation and use of these compounds as pharmaceuticals 失效胆酸衍生物，其制备方法和这些化合物用作药物
公开(公告)号：US5428182A
公开(公告)日：1995-06-27
申请号：US074753
申请日：1993-06-10
申请人： Alfons Enhsen , Heiner Glombik , Werner Kramer , Gunther Wess
发明人： Alfons Enhsen , Heiner Glombik , Werner Kramer , Gunther Wess
IPC分类号： A61K31/575 , A61P1/00 , A61P3/00 , A61P3/06 , A61P7/00 , C07H9/00 , C07J9/00 , C07J41/00 , C07J51/00
CPC分类号： C07J41/0055 , C07J41/0005 , C07J9/005
摘要： Bile acid derivatives of the formula IZ(X--GS)nin which GS, X, Z and n have the meanings indicated in the specification, and a process for the preparation of these compounds are described. The compounds are pharmacologically active and can, therefore, be used as pharmaceuticals, in particular as a hypolipidemic.
摘要翻译： 描述了其中GS，X，Z和n具有本说明书中指出的含义的式I Z（X-GS）n的胆汁酸衍生物及其制备方法。 这些化合物是药理活性的，因此可以用作药物，特别是降血脂药。
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9.发明授权Propanolamine derivatives, processes for their preparation, pharmaceuticals comprising these compounds, and their use 失效丙醇胺衍生物，其制备方法，包含这些化合物的药物及其用途
公开(公告)号：US5874451A
公开(公告)日：1999-02-23
申请号：US53513
申请日：1998-04-02
IPC分类号： C07D239/47 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4427 , A61K31/4436 , A61K31/444 , A61K31/47 , A61K31/505 , A61P3/04 , A61P3/06 , C07D213/00 , C07D213/30 , C07D213/38 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/80 , C07D239/00 , C07D261/00 , C07D277/00 , C07D401/12 , C07D409/12 , C07D409/14 , C07D411/12 , C07D413/12 , C07D417/12 , C07D213/02 , C07D401/02
CPC分类号： C07D213/74 , C07D213/80 , C07D401/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The invention relates to substituted propanolamine derivatives and their acid addition salts.Propanolamine derivatives of formula I, ##STR1## in which R.sup.1 to R.sup.8 have the meanings indicated in the specification, and their physiologically tolerable salts and processes for their preparation are described. The compounds are suitable, for example, as hypolipidemics.
摘要翻译： 本发明涉及取代的丙醇胺衍生物及其酸加成盐。 描述了其中R1至R8具有本说明书中所示含义的式I的丙醇胺衍生物及其生理上可耐受的盐及其制备方法。 该化合物例如可用作降血脂药物。
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10.发明授权Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use 有权苯并噻吩1,1-二氧化物衍生物，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US06221897B1
公开(公告)日：2001-04-24
申请号：US09398315
申请日：1999-09-20
申请人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
发明人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
IPC分类号： A61K3138
CPC分类号： C07K5/06086 , A61K38/00 , C07D337/08 , C08G65/329
摘要： Substituted benzothiepine 1,1-dioxide derivatives of formula I: in which R1, R2, R3, R4, R5 and Z have the meanings indicated, and their physiologically tolerable salts and physiologically functional derivatives and a process for their preparation are described. The compounds are suitable, for example, as hypolipidemics.
摘要翻译： 描述式I的取代苯并噻吩1,1-二氧化物衍生物：其中R1，R2，R3，R4，R5和Z具有所示含义，并描述了其生理上可耐受的盐和生理功能衍生物及其制备方法。 该化合物例如可用作降血脂药物。
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