公开(公告)号：US08969529B2

公开(公告)日：2015-03-03

申请号：US13142556

申请日：2010-01-21

申请人： Alison O'Brien ,  Angela Melton-Celsa ,  Michael Smith ,  James Sinclair

发明人： Alison O'Brien ,  Angela Melton-Celsa ,  Michael Smith ,  James Sinclair

IPC分类号： C07K16/12 ,  C12P21/04 ,  C07K14/25 ,  A61K38/00 ,  A61K39/00

CPC分类号： A61K39/0283 ,  A61K38/00 ,  A61K39/0258 ,  A61K2039/505 ,  C07K7/06 ,  C07K7/08 ,  C07K14/25 ,  C07K16/1232 ,  C07K2317/34 ,  Y02A50/473

摘要： The invention is based on the discovery of the epitope in the Stx2 protein for the 11 E1O antibody. The invention features compositions containing non-full length Stx2 polypeptides that include the 11 E1O monoclonal antibody epitope. The invention also features methods of producing anti-Stx2 antibodies specific for the 11 E1O epitope of the Stx2 protein. Additionally, the invention features methods for treating a subject having, or at risk of developing, a Shiga toxin associated disease (e.g., hemolytic uremia syndrome and diseases associated with E. coli and S. dysenteriae infection) with a polypeptide that includes the 11 E1O epitope or with an anti-Stx2 antibody developed using the methods of the invention. Furthermore, the invention features the detection of Stx2 in a sample using the antibodies developed using the methods of the invention.

摘要翻译： 本发明基于11 E1O抗体的Stx2蛋白中的表位的发现。 本发明的特征在于包含非全长Stx2多肽的组合物，其包括11E1O单克隆抗体表位。 本发明还具有产生对Stx2蛋白的11E1O表位特异的抗Stx2抗体的方法。 另外，本发明的特征在于用包含11个E1O的多肽治疗具有或有发展志贺毒素相关疾病（例如，溶血性尿毒症综合征和与大肠杆菌和痢疾杆菌感染相关的疾病）的受试者的方法 表位或使用本发明的方法开发的抗Stx2抗体。 此外，本发明的特征在于使用使用本发明的方法开发的抗体检测样品中的Stx2。

公开(公告)号：US20110318357A1

公开(公告)日：2011-12-29

申请号：US13142556

申请日：2010-01-21

申请人： Alison O'Brien ,  Angela Melton-Celsa ,  Michael Smith ,  James Sinclair

发明人： Alison O'Brien ,  Angela Melton-Celsa ,  Michael Smith ,  James Sinclair

IPC分类号： A61K39/00 ,  C12N15/11 ,  C12N15/70 ,  A61K38/02 ,  C07K16/12 ,  C12N1/21 ,  A61P31/00 ,  A61P37/04 ,  C12P21/00 ,  C12N5/16 ,  G01N33/566 ,  C07K19/00 ,  A61K39/40

CPC分类号： A61K39/0283 ,  A61K38/00 ,  A61K39/0258 ,  A61K2039/505 ,  C07K7/06 ,  C07K7/08 ,  C07K14/25 ,  C07K16/1232 ,  C07K2317/34 ,  Y02A50/473

摘要： The invention is based on the discovery of the epitope in the Stx2 protein for the 11 E1O antibody. The invention features compositions containing non-full length Stx2 polypeptides that include the 11 E1O monoclonal antibody epitope. The invention also features methods of producing anti-Stx2 antibodies specific for the 11 E1O epitope of the Stx2 protein. Additionally, the invention features methods for treating a subject having, or at risk of developing, a Shiga toxin associated disease (e.g., hemolytic uremia syndrome and diseases associated with E. coli and S. dysenteriae infection) with a polypeptide that includes the 11 E1O epitope or with an anti-Stx2 antibody developed using the methods of the invention. Furthermore, the invention features the detection of Stx2 in a sample using the antibodies developed using the methods of the invention.

摘要翻译： 本发明基于11 E1O抗体的Stx2蛋白中的表位的发现。 本发明的特征在于包含非全长Stx2多肽的组合物，其包括11E1O单克隆抗体表位。 本发明还具有产生对Stx2蛋白的11E1O表位特异的抗Stx2抗体的方法。 另外，本发明的特征在于用包含11个E1O的多肽治疗具有或有发展志贺毒素相关疾病（例如，溶血性尿毒症综合征和与大肠杆菌和痢疾杆菌感染相关的疾病）的受试者的方法 表位或使用本发明的方法开发的抗Stx2抗体。 此外，本发明的特征在于使用使用本发明的方法开发的抗体检测样品中的Stx2。

公开(公告)号：US20120239547A1

公开(公告)日：2012-09-20

申请号：US13482486

申请日：2012-05-29

申请人： James Sinclair ,  James A. O'Hagan ,  Edward R. Howorka ,  Jain Neena

发明人： James Sinclair ,  James A. O'Hagan ,  Edward R. Howorka ,  Jain Neena

IPC分类号： G06Q40/04

CPC分类号： G06Q40/04 ,  G06Q30/0601

摘要： An anonymous trading system includes a prime broker facility that allows a third party to trade on behalf of an institution. A deal is executed between the third party and a counter-party and a further deal is then executed between the third party and the party on whose behalf it has traded. The second deal may be for the same amount as the first deal or may be altered to include the third party's fee for conducting the first deal. Clients of the third party have prices available to them for trades made via the third party which are displayed at their trader terminals. The client sees that a better price is available though the third party than by dealing direct and selects to conduct a deal through the third party.

摘要翻译： 一个匿名的交易系统包括一个主要的经纪人设施，允许第三方代表一个机构进行交易。 第三方与对方之间签订协议，再由第三方与其交易的代理方签订进一步协议。 第二笔交易可能与第一笔交易相同，或可能被更改，以包括第三方进行第一笔交易的费用。 第三方的客户可以通过第三方在其交易终端上显示的交易获得价格。 客户认为，通过第三方可以获得更好的价格，而不是直接交易，并通过第三方进行交易。

公开(公告)号：US08209254B2

公开(公告)日：2012-06-26

申请号：US10202827

申请日：2002-07-26

申请人： Karen Ilse Setz ,  Snezhana Malkin ,  Leong Fai Mah ,  Steven J. Scully ,  Tracey Riordan ,  Edward R. Howorka ,  James Sinclair

发明人： Karen Ilse Setz ,  Snezhana Malkin ,  Leong Fai Mah ,  Steven J. Scully ,  Tracey Riordan ,  Edward R. Howorka ,  James Sinclair

IPC分类号： G06Q40/00

CPC分类号： G06Q40/04 ,  G06Q20/10 ,  G06Q40/00 ,  G06Q40/06

摘要： A computer trading system includes a quote screening function configured to accept quotes specifying a quote amount in a price where the quote amount is greater than a minimum quote amount to produce screen quote messages and to reject quotes specifying a quote amount less than the minimum quote amount. A market view generator generates market views from those quotes which specify an amount greater than or equal to the minimum quote amount. An order screening function only accepts orders specifying an amount less than a maximum transaction amount submitted in response to the market views to produce screened order messages. A transaction processor receives screened quote messages and screened order messages and matches appropriate messages with each other. The minimum quote amount is substantially equal to or greater than the maximum transaction amount whereby a screened order message can be matched entirely with one screened quote message.

摘要翻译： 计算机交易系统包括报价筛选功能，其配置为接受报价指定报价金额的报价，报价金额大于最低报价金额以生成屏幕报价信息，并拒绝报价指定小于最低报价金额的报价 。 市场视图生成器根据这些报价产生市场观点，指定金额大于或等于最低报价金额。 订单筛选功能仅接受指定小于响应市场视图而提交的最大交易金额的订单以生成筛选订单消息的订单。 交易处理器接收筛选的报价消息和筛选的订单消息并将适当的消息彼此匹配。 最小报价金额基本上等于或大于最大交易金额，从而筛选的订单消息可以完全与一个已筛选的报价消息相匹配。

公开(公告)号：US20090292635A1

公开(公告)日：2009-11-26

申请号：US12435553

申请日：2009-05-05

申请人： James Sinclair ,  James O'Hagan ,  Edward R. Howorka ,  Jain Neena

发明人： James Sinclair ,  James O'Hagan ,  Edward R. Howorka ,  Jain Neena

IPC分类号： G06Q40/00

CPC分类号： G06Q40/04 ,  G06Q30/0601

摘要： An anonymous trading system includes a prime broker facility that allows a third party to trade on behalf of an institution. A deal is executed between the third party and a counter-party and a further deal is then executed between the third party and the party on whose behalf it has traded. The second deal may be for the same amount as the first deal or may be altered to include the third party's fee for conducting the first deal. Clients of the third party have prices available to them for trades made via the third party which are displayed at their trader terminals. The client sees that a better price is available though the third party than by dealing direct and selects to conduct a deal through the third party.

摘要翻译： 一个匿名的交易系统包括一个主要的经纪人设施，允许第三方代表一个机构进行交易。 第三方与对方之间签订协议，再由第三方与其交易的代理方签订进一步协议。 第二笔交易可能与第一笔交易相同，或可能被更改，以包括第三方进行第一笔交易的费用。 第三方的客户可以通过第三方在其交易终端上显示的交易获得价格。 客户认为，通过第三方可以获得更好的价格，而不是直接交易，并通过第三方进行交易。

公开(公告)号：US20070072257A1

公开(公告)日：2007-03-29

申请号：US11605814

申请日：2006-11-29

申请人： Paul Negulescu ,  Alec Harootunian ,  Philip Salzmann ,  Javier Flores ,  James Sinclair ,  Minh Vuong ,  Ashvani Singh ,  Fred VanGoor

发明人： Paul Negulescu ,  Alec Harootunian ,  Philip Salzmann ,  Javier Flores ,  James Sinclair ,  Minh Vuong ,  Ashvani Singh ,  Fred VanGoor

IPC分类号： C12M1/34 ,  C12Q1/02

CPC分类号： B01L3/5085 ,  B01L3/50255 ,  B01L2300/0645 ,  B01L2300/0829

摘要： A device for characterizing the biological properties of cells can include a plurality of dual-compartment assay chambers wherein the compartments of each chamber are separated by a cell layer across which ions can flow. The biological properties of the cell layer in the presence or absence of experimental compounds can be determined by measuring an electrical gradient across the layer. A individual dual-compartment chamber of this type may be referred to as an “Ussing chamber.”

公开(公告)号：US20060200448A1

公开(公告)日：2006-09-07

申请号：US11405152

申请日：2006-04-17

申请人： David Edmunds ,  Robert Minns ,  James Sinclair

发明人： David Edmunds ,  Robert Minns ,  James Sinclair

IPC分类号： G06F17/30

CPC分类号： G06F17/30539

摘要： This invention addresses the need for dealing with complex planning calculations based on data warehouse or Planning Data Repository (PDR) data where some aggregated data or forecast data might be changed without directly manipulating the underlying data, and where there may be several relationships linking the data. The system is able to deal with complex relationships along more than one axis or dimension. A number of iterations are typically used involving both back-solving and ‘forward-solving’. The subset of cells that needs to be recalculated is identified before steps of back-solving and/or forward-solving using parent/child tables. The scanning of these tables looking for potential dependencies is much simpler and faster than to looking at the actual formulae or functions relating the cells. The step of creating the parent/child tables is carried out in advance of the actual calculation by parsing all the relationships (formulae and functions) and summarising the dependencies between cells in the parent/child tables.

摘要翻译： 本发明解决了处理基于数据仓库或规划数据存储库（PDR）数据的复杂规划计算的需要，其中可以改变一些聚合数据或预测数据而不直接操纵底层数据，以及可能存在几个关联数据的关系 。 该系统能够处理沿着多个轴或维度的复杂关系。 通常使用多次迭代，包括反求解和“前向解决”。 需要重新计算的单元的子集在使用父/子表的反求解和/或前向解析的步骤之前被识别。 寻找潜在依赖关系的这些表的扫描比查看与单元格相关的实际公式或功能更简单和更快。 通过解析所有关系（公式和函数）并总结父/子表中的单元格之间的依赖关系，在实际计算之前执行创建父/子表的步骤。

公开(公告)号：US08577784B2

公开(公告)日：2013-11-05

申请号：US13482486

申请日：2012-05-29

申请人： James Sinclair ,  James A. O'Hagan ,  Edward R. Howorka ,  Neena Jain

发明人： James Sinclair ,  James A. O'Hagan ,  Edward R. Howorka ,  Neena Jain

IPC分类号： G06Q40/00

CPC分类号： G06Q40/04 ,  G06Q30/0601

摘要： An anonymous trading system includes a prime broker facility that allows a third party to trade on behalf of an institution. A deal is executed between the third party and a counter-party and a further deal is then executed between the third party and the party on whose behalf it has traded. The second deal may be for the same amount as the first deal or may be altered to include the third party's fee for conducting the first deal. Clients of the third party have prices available to them for trades made via the third party which are displayed at their trader terminals. The client sees that a better price is available though the third party than by dealing direct and selects to conduct a deal through the third party.

摘要翻译： 一个匿名的交易系统包括一个主要的经纪人设施，允许第三方代表一个机构进行交易。 第三方与对方之间签订协议，再由第三方与其交易的代理方签订进一步协议。 第二笔交易可能与第一笔交易相同，或可能被更改，以包括第三方进行第一笔交易的费用。 第三方的客户可以通过第三方在其交易终端上显示的交易获得价格。 客户认为，通过第三方可以获得更好的价格，而不是直接交易，并通过第三方进行交易。

公开(公告)号：US08516995B2

公开(公告)日：2013-08-27

申请号：US12843956

申请日：2010-07-27

申请人： James Sinclair

发明人： James Sinclair

IPC分类号： F02M59/36

CPC分类号： F02D41/3845 ,  F02D41/1401 ,  F02D41/1402 ,  F02D41/1482 ,  F02D41/1483 ,  F02D41/221 ,  F02D2041/1409 ,  F02D2041/1422 ,  F02D2041/225 ,  F02D2200/0602 ,  F02D2250/31 ,  F02M59/368

摘要： A method and apparatus for controlling a fuel pump assembly comprising a plurality of pump elements, each pump element comprising a cam-driven plunger to perform at least one pumping event per engine revolution and a control valve. Each pumping event corresponds to an associated cam lobe of the associated cam. The method comprises, for each pumping event of each pump element, controlling the control valve of said pump element in response to an output control signal derived from at least one previous pumping event. Fuel pressure is measured within a rail volume and compared with a demanded rail pressure value to derive a rail pressure error. A proportional term and an integral term for the rail pressure error are derived and combined to derive the output control signal. Monitoring of the integral term for each pumping event provides a means for identifying and diagnosing a fault condition.

摘要翻译： 一种用于控制包括多个泵元件的燃料泵组件的方法和装置，每个泵元件包括凸轮驱动的柱塞，用于每发动机转速执行至少一个泵送事件和控制阀。 每个泵送事件对应于相关凸轮的相关凸轮凸角。 该方法包括对于每个泵元件的每个泵送事件，响应于从至少一个先前泵送事件导出的输出控制信号来控制所述泵浦元件的控制阀。 在轨道容积内测量燃料压力，并与要求的轨道压力值进行比较以导出轨道压力误差。 导出与压力误差的比例项和积分项，并组合起来导出输出控制信号。 监测每个泵送事件的积分项提供了识别和诊断故障状况的手段。

公开(公告)号：US08275693B2

公开(公告)日：2012-09-25

申请号：US12435553

申请日：2009-05-05

申请人： James Sinclair ,  James O'Hagan ,  Edward R. Howorka ,  Neena Jain

发明人： James Sinclair ,  James O'Hagan ,  Edward R. Howorka ,  Neena Jain

IPC分类号： G06Q40/00

CPC分类号： G06Q40/04 ,  G06Q30/0601

摘要： An anonymous trading system includes a prime broker facility that allows a third party to trade on behalf of an institution. A deal is executed between the third party and a counter-party and a further deal is then executed between the third party and the party on whose behalf it has traded. The second deal may be for the same amount as the first deal or may be altered to include the third party's fee for conducting the first deal. Clients of the third party have prices available to them for trades made via the third party which are displayed at their trader terminals. The client sees that a better price is available though the third party than by dealing direct and selects to conduct a deal through the third party.

摘要翻译： 一个匿名的交易系统包括一个主要的经纪人设施，允许第三方代表一个机构进行交易。 第三方与对方之间签订协议，再由第三方与其交易的代理方签订进一步协议。 第二笔交易可能与第一笔交易相同，或可能被更改，以包括第三方进行第一笔交易的费用。 第三方的客户可以通过第三方在其交易终端上显示的交易获得价格。 客户认为，通过第三方可以获得更好的价格，而不是直接交易，并通过第三方进行交易。