公开(公告)号：US06598371B1

公开(公告)日：2003-07-29

申请号：US09806559

申请日：2001-03-30

申请人： Allan Draisey

发明人： Allan Draisey

IPC分类号： A61K928

CPC分类号： B29C65/18 ,  A61J3/07 ,  B29C51/268 ,  B29C65/04 ,  B29C65/72 ,  B29C66/1122 ,  B29C66/43 ,  B29C66/71 ,  B29C66/73791 ,  B29C66/73793 ,  B29C66/81423 ,  B29C66/81431 ,  B29C66/8242 ,  B29C66/83221 ,  B29C66/8491 ,  B29C66/919 ,  B29C69/02 ,  B29K2001/00 ,  B29K2995/0062 ,  B29K2001/08

摘要： The invention relates to a device for filling with high accuracy a finely divided powdered medicament having a particle size smaller than 10 &mgr;m into cavities having a size corresponding to the volume of powder to be filled, wherein said device comprises oscillating and rotating means for breaking down aggregates formed in the finely divided powdered medicament and filling and for compacting it in said cavities. The invention also includes a method of filling with high accuracy of a finely divided powdered medicament having a particle size smaller than 10 &mgr;m and to fill said finely divided powdered medicament into cavities, wherein the finely divided powdered medicament is transported and compacted in said cavities by oscillating and rotating means.

摘要翻译： 本发明涉及一种用于将具有小于10um的粒度的细碎粉末状药物高精度地填充到具有与要填充的粉末的体积相对应的尺寸的空腔中的装置，其中所述装置包括用于分解的振荡和旋转装置 在细粉末状药物中形成的聚集体，并填充并压缩在所述空腔中。 本发明还包括一种以高精度填充粒度小于10um的细碎粉末药物并将细碎粉末状药物填充到空腔中的方法，其中细碎的粉末状药物通过在所述空腔中输送和压实 摆动和旋转装置。

公开(公告)号：US07490456B2

公开(公告)日：2009-02-17

申请号：US10510771

申请日：2003-04-01

申请人： Allan Draisey ,  Ryan Grimes ,  David John Smith ,  George Bernard Tidy

发明人： Allan Draisey ,  Ryan Grimes ,  David John Smith ,  George Bernard Tidy

IPC分类号： B65B47/04

CPC分类号： B29C66/83413 ,  A61J3/07 ,  B29C49/0047 ,  B29C65/04 ,  B29C65/7435 ,  B29C65/7455 ,  B29C65/749 ,  B29C66/1122 ,  B29C66/43 ,  B29C66/71 ,  B29C66/73521 ,  B29C66/73793 ,  B29C66/8122 ,  B29C66/81423 ,  B29C66/81431 ,  B29C66/81871 ,  B29C66/83415 ,  B29C66/83417 ,  B29C66/83513 ,  B29C66/849 ,  B29C2049/4655 ,  B29C2795/002 ,  B29K2995/0062 ,  B29L2031/7174 ,  B65B9/042 ,  B65B51/22 ,  B65B61/00 ,  Y10S53/02 ,  Y10T156/1052 ,  Y10T156/1054 ,  B29K2909/02 ,  B29K2001/08 ,  B29K2003/00

摘要： Capsules, for example for the delivery of pharmaceuticals, are produced from two films (18) of a water-soluble polymeric material, by deforming the films to form a multiplicity of recesses, and filling the recesses, using two adjacent rotary dies (14, 15; 42) with recesses (16) into which the films (18) are deformed. The dies (14, 15; 42) act as electrodes for welding the films together by dielectric welding to form filled capsules (30). The capsules (30) can be separated from the resulting web either by coating at least one of the dies (14) with an electrical insulator (21), or by transferring the web from the dies (14, 15; 42) to a second pair of dies which cut the capsules (30) free. The polymeric material may be gelatin, or a water-soluble cellulose derivative such as hydroxypropyl methyl cellulose, and may also contain a plasticiser.

摘要翻译： 例如用于递送药物的胶囊由两个水溶性聚合物材料薄膜（18）制成，通过使膜变形以形成多个凹部，并使用两个相邻的旋转模具（14,14）填充凹部， 15; 42），其中薄膜（18）变形到其中的凹部（16）。 模具（14,15; 42）用作电极，用于通过电介质焊接将膜焊接在一起以形成填充胶囊（30）。 胶囊（30）可以通过用电绝缘体（21）涂覆至少一个模具（14）或通过将纤维网从模具（14,15; 42）转移到第二个模具 一对切割胶囊（30）的模具是自由的。 聚合物材料可以是明胶，或水溶性纤维素衍生物如羟丙基甲基纤维素，也可以含有增塑剂。

公开(公告)号：US06755010B2

公开(公告)日：2004-06-29

申请号：US10220805

申请日：2002-09-06

申请人： Allan Draisey

发明人： Allan Draisey

IPC分类号： B65B4702

CPC分类号： B29C65/7435 ,  A61J3/07 ,  B29C65/04 ,  B29C66/1122 ,  B29C66/43 ,  B29C66/71 ,  B29C66/73143 ,  B29C66/73793 ,  B29C66/83411 ,  B29C66/83413 ,  B29C66/83513 ,  B29C66/849 ,  B65B51/22 ,  B29K2001/00

摘要： Capsules, for example for the delivery of pharmaceuticals, are produced from two films (18) of a water-soluble polymeric material, by deforming the films to form a multiplicity of recesses, and filling the recesses with a flowable filling material. This is performed using two adjacent rotary dies (14, 15), with recesses (16) into which the films (18) are deformed. The dies (14, 15) also act as electrodes for welding the films together by dielectric welding to form filled capsules (30). The capsules (30) can readily be separated from the resulting web. The polymeric material may be gelatin, or a water-soluble cellulose derivative such as hydroxypropyl methyl cellulose, and may also contain a plasticizer.

摘要翻译： 例如用于输送药物的胶囊由两种水溶性聚合物材料薄膜（18）制成，通过使膜变形以形成多个凹部，并用可流动的填充材料填充凹部。 这是使用两个相邻的旋转模具（14,15）执行的，其中薄膜（18）变形成凹部（16）。 模具（14,15）还用作通过电介质焊接将膜焊接在一起以形成填充胶囊（30）的电极。 胶囊（30）可以容易地从所得到的纤维网分离。 聚合物材料可以是明胶，或水溶性纤维素衍生物如羟丙基甲基纤维素，也可以含有增塑剂。

公开(公告)号：US06923980B2

公开(公告)日：2005-08-02

申请号：US10220621

申请日：2001-03-15

申请人： Allan Draisey ,  Richard Martin Rencourt ,  Ryan Grimes

发明人： Allan Draisey ,  Richard Martin Rencourt ,  Ryan Grimes

IPC分类号： B29C51/10 ,  B29C65/04 ,  B65B9/04 ,  A61K47/00 ,  B29C39/10 ,  B32B31/00

CPC分类号： B29C51/10 ,  B29C65/04 ,  B29C66/112 ,  B29C66/131 ,  B29C66/53461 ,  B29C66/71 ,  B29C66/73793 ,  B29C66/8242 ,  B29C66/8322 ,  B29C66/9534 ,  B29C2791/001 ,  B29C2791/006 ,  B29C2793/0009 ,  B29C2793/009 ,  B29K2001/00 ,  B29K2995/0062 ,  B29L2031/7174 ,  B65B9/042 ,  Y10T29/49128 ,  Y10T29/49149 ,  Y10T29/49798

摘要： Capsules, for example for the delivery of pharmaceuticals, are produced from at least three films (12, 13, 14) of a water-soluble polymeric material, by deforming two of the films (12, 14) to form a multiplicity of recesses, and filling the recesses (18, 32) with a flowable filling material. A film (13) is used to cover the recesses (18) in at least one of the films (12), and is welded to it by dielectric welding. The films with filled recesses are then brought together and welded together by dielectric welding to form filled capsules, which are cut or punched out of the welded film. The polymeric material may be gelatin, or a water-soluble cellulose derivative such as hydroxypropyl methyl cellulose, and may also contain a plasticiser.

摘要翻译： 例如用于递送药物的胶囊通过使两个膜（12,14）变形以形成多个凹部，由至少三种水溶性聚合物材料的薄膜（12,13,14）产生， 以及用可流动的填充材料填充所述凹部（18,32）。 膜（13）用于覆盖至少一个膜（12）中的凹部（18），并且通过电介质焊接将其焊接到其上。 然后将具有填充凹槽的膜通过电介质焊接在一起并焊接在一起，以形成从焊接膜切割或冲压的填充胶囊。 聚合物材料可以是明胶，或水溶性纤维素衍生物如羟丙基甲基纤维素，也可以含有增塑剂。

公开(公告)号：US20050138899A1

公开(公告)日：2005-06-30

申请号：US10510771

申请日：2003-04-01

申请人： Allan Draisey ,  Ryan Grimes ,  David Smith ,  George Tidy

发明人： Allan Draisey ,  Ryan Grimes ,  David Smith ,  George Tidy

IPC分类号： A61J3/07 ,  B29C49/00 ,  B29C65/04 ,  B29C65/74 ,  B65B9/04 ,  B65B51/22

CPC分类号： B29C66/83413 ,  A61J3/07 ,  B29C49/0047 ,  B29C65/04 ,  B29C65/7435 ,  B29C65/7455 ,  B29C65/749 ,  B29C66/1122 ,  B29C66/43 ,  B29C66/71 ,  B29C66/73521 ,  B29C66/73793 ,  B29C66/8122 ,  B29C66/81423 ,  B29C66/81431 ,  B29C66/81871 ,  B29C66/83415 ,  B29C66/83417 ,  B29C66/83513 ,  B29C66/849 ,  B29C2049/4655 ,  B29C2795/002 ,  B29K2995/0062 ,  B29L2031/7174 ,  B65B9/042 ,  B65B51/22 ,  B65B61/00 ,  Y10S53/02 ,  Y10T156/1052 ,  Y10T156/1054 ,  B29K2909/02 ,  B29K2001/08 ,  B29K2003/00

摘要： Capsules, for example for the delivery of pharmaceuticals, are produced from two films (18) of a water-soluble polymeric material, by deforming the films to form a multiplicity of recesses, and filling the recesses, using two adjacent rotary dies (14, 15; 42) with recesses (16) into which the films (18) are deformed. The dies (14, 15; 42) act as electrodes for welding the films together by dielectric welding to form filled capsules (30). The capsules (30) can be separated from the resulting web either by coating at least one of the dies (14) with an electrical insulator (21), or by transferring the web from the dies (14, 15; 42) to a second pair of dies which cut the capsules (30) free. The polymeric material may be gelatin, or a water-soluble cellulose derivative such as hydroxypropyl methyl cellulose, and may also contain a plasticiser.

摘要翻译： 例如用于输送药物的胶囊由两种水溶性聚合物材料薄膜（18）制成，通过使膜变形以形成多个凹部，并使用两个相邻的旋转模具（14,14）填充凹部， 15; 42），其中薄膜（18）变形到其中的凹部（16）。 模具（14,15; 42）用作电极，用于通过电介质焊接将膜焊接在一起以形成填充胶囊（30）。 胶囊（30）可以通过用电绝缘体（21）涂覆至少一个模具（14）或通过将纤维网从模具（14,15; 42）转移到第二 一对切割胶囊（30）的模具是自由的。 聚合物材料可以是明胶，或水溶性纤维素衍生物如羟丙基甲基纤维素，也可以含有增塑剂。