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1.发明授权Method for increasing shelf-life of a serum conjugated bilirubin reference composition and composition produced thereby 失效提高血清结合胆红素参考组合物的保存期限的方法及由此制备的组合物
公开(公告)号：US4344864A
公开(公告)日：1982-08-17
申请号：US202269
申请日：1980-10-30
CPC分类号： G01N33/728 , G01N33/96 , Y10T436/103332
摘要： A stable blood serum conjugated bilirubin reference composition characterized in that the composition possess a pH of from about 8.2 to bout 9.2 and comprises (a) a sulfhydryl compound in an amount sufficient to enhance the stability of the conjugated bilirubin and (b) a chelating agent in an amount sufficient to bind all the metals present in the blood serum moiety of the composition. This blood serum conjugated bilirubin composition when stored in a gas impervious vial under an inert atmosphere has an excellent shelf life.
摘要翻译： 一种稳定的血清结合胆红素参照组合物，其特征在于所述组合物具有约8.2至约9.2的pH，并且包含（a）足以提高共轭胆红素稳定性的量的巯基化合物和（b）螯合剂 其量足以结合存在于组合物的血清部分中的所有金属。 当在惰性气氛下储存在不透气小瓶中时，该血清共轭胆红素组合物具有优良的保质期。
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公开(公告)号：US07879331B2
公开(公告)日：2011-02-01
申请号：US11232527
申请日：2005-09-22
IPC分类号： A61K39/395
CPC分类号： C07K14/765
摘要： An efficacious large-scale alcohol-free plasma fractionation production process which produces a high-yielding, non-denatured, double viral-inactivated intravenous human immune gamma globulin (IgG) product. The process employs sodium citrate in two initial fractionation steps, followed by diafiltration to remove sodium citrate.
摘要翻译： 有效的大规模无酒精血浆分离生产方法，产生高产，非变性，双病毒灭活的静脉注射人免疫球蛋白（IgG）产品。 该方法在两个初始分馏步骤中使用柠檬酸钠，随后进行渗滤以除去柠檬酸钠。
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3.发明授权Process for preparing a biological composition for use as a reference control in diagnostic analysis 失效制备生物组合物的方法，用作诊断分析中的参考对照
公开(公告)号：US4158544A
公开(公告)日：1979-06-19
申请号：US925483
申请日：1978-07-17
申请人： Allan L. Louderback
发明人： Allan L. Louderback
CPC分类号： G01N33/96 , G01N2333/75 , G01N2333/974 , G01N2496/05 , Y10T436/106664 , Y10T436/107497 , Y10T436/108331
摘要： A process for making a biological composition for use as a blood serum reference composition in diagnostic analysis. The process comprises:(a) adding calcium to citrated plasma and mixing well to form decitrated plasma;(b) adding thrombin to the decitrated plasma and mixing well to form a clot of fibrin;(c) performing at least one freeze-thaw routine on the clot to cause the fibrin to contract;(d) removing the fibrin to thereby obtain serum;(e) molecular washing and ultrafiltering the serum and thereby obtaining concentrated serum; and(f) adding to the concentrated serum at least one alkylene polyol having from 2-5 carbon atoms in an amount such that said composition's non-biological component comprises from about 40 to about 85 weight percent water and from about 15 to about 60 weight percent of said alkylene polyol.
摘要翻译： 在诊断分析中制备用作血清参考组合物的生物组合物的方法。 该过程包括：
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4.发明授权
公开(公告)号：US3977995A
公开(公告)日：1976-08-31
申请号：US515760
申请日：1974-10-17
CPC分类号： G01N33/96 , G01N15/1404 , G01N2333/805 , G01N2496/10 , Y10T436/101666 , Y10T436/105831 , Y10T436/107497 , Y10T436/108331
摘要： A calibrating fluid for automated instruments for blood cell counting and hemoglobin determination comprising a sterile solution of oxyhemoglobin or other derivative products of hemoglobin and containing latex particles.
摘要翻译： 用于血细胞计数和血红蛋白测定的自动化仪器的校准流体，包括氧合血红蛋白或血红蛋白的其它衍生产物和含有胶乳颗粒的无菌溶液。
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5.发明授权Augmented solvent/detergent method for inactivating enveloped and non-enveloped viruses 有权用于灭活包膜和非包膜病毒的增强溶剂/洗涤剂方法公开(公告)号：US06881573B2
公开(公告)日：2005-04-19
申请号：US10661329
申请日：2003-09-12
申请人： Allan L. Louderback
发明人： Allan L. Louderback
IPC分类号： A61K39/395 , C07K16/34 , C07H21/04
CPC分类号： C07K16/34 , A61K39/39591
摘要： A process for making Solvent Detergent (SD) treatment effective against non-enveloped viruses. The process stipulates using prequalified concentrations of formaldehyde and phenol with SD treatments. In particular, serial or combined use of 100 to 10,000 parts per million of formaldehyde and/or 100 to 10,000 parts per million of phenol with an associated SD treatment process are disclosed.
摘要翻译： 制备溶剂洗涤剂（SD）治疗对非包膜病毒有效的方法。 该方法规定使用甲醛和苯酚的预标准浓度进行SD处理。 特别地，公开了连续或组合使用100至10,000份/百万份甲醛和/或100至10,000份/百万份苯酚和相关的SD处理方法。
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公开(公告)号：US4833165A
公开(公告)日：1989-05-23
申请号：US105340
申请日：1987-10-07
申请人： Allan L. Louderback
发明人： Allan L. Louderback
CPC分类号： C12N7/00 , A61K31/05 , A61K31/115 , A61K35/18 , A61L2/0088 , C12N2740/14063 , Y10S530/829
摘要： HTLV-III virus in blood or blood components is inactivated by treatment with about 0.1-5% of phenol, formaldehyde, or mixtures thereof, at a temperature of about 2.degree.-40.degree. C. for at least about 5 minutes.
摘要翻译： 通过用大约0.1-5％的苯酚，甲醛或其混合物在约2°-40℃的温度下处理血液或血液成分中的HTLV-III病毒灭活至少约5分钟。
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公开(公告)号：US4324687A
公开(公告)日：1982-04-13
申请号：US162065
申请日：1980-06-23
CPC分类号： G01N33/96 , G01N2496/05 , G01N2496/80 , Y10T436/101666 , Y10T436/108331
摘要： A blood biochemistry control standard for the quality control of the analytical measurement of blood biochemistry components is disclosed. The control standard comprises an aqueous suspension of red blood cells which have been stabilized by mild treatment with aldehyde and saline and then slowly equilibrated with at least one additionally incorporated non-gaseous biochemical analyte in a concentration of clinical significance.
摘要翻译： 公开了血液生物化学成分分析测量质量控制的血液生化控制标准。 对照标准包括红细胞的水性悬浮液，其通过用醛和盐水轻度处理而稳定，然后用至少一种额外掺入的非气体生化分析物以临床意义的浓度缓慢平衡。
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公开(公告)号：US4324685A
公开(公告)日：1982-04-13
申请号：US132609
申请日：1980-03-21
申请人： Allan L. Louderback
发明人： Allan L. Louderback
CPC分类号： G01N33/96 , G01N2496/05 , Y10T436/106664 , Y10T436/108331 , Y10T436/109163
摘要： An improved blood serum reference composition of the type comprising blood serum having constituents of known values, characterized in that said composition further comprises a water soluble amine chloride. The water soluble amine chloride is employed to adjust the negative electrolyte balance of said reference composition without interfering with presently employed blood serum clinical assay procedures or analytical equipment used therein.
摘要翻译： 包含具有已知值成分的血清的改进的血清参考组合物，其特征在于所述组合物还包含水溶性胺氯化物。 使用水溶性氯化胺调节所述参考组合物的负电解质平衡，而不干扰目前使用的血清临床测定程序或其中使用的分析设备。
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公开(公告)号：US4126575A
公开(公告)日：1978-11-21
申请号：US853928
申请日：1977-11-22
申请人： Allan L. Louderback
发明人： Allan L. Louderback
CPC分类号： G01N33/96 , G01N2496/05 , G01N2496/70 , Y10T436/101666 , Y10T436/102499 , Y10T436/107497 , Y10T436/108331
摘要： A stable blood control standard for the quality control of the measurement of blood pH and gases in the clinical laboratory and method of making the same is disclosed. The blood control standard comprises a sealed receptacle containing specially treated red cells and a gaseous head space at least equal to about the volume of the red cells. The special treatment comprises thoroughly washing and separating the red cells from the plasma components and followed by mildly treating the cells with aldehyde and retaining the cells in a buffered solution. The special treatment also includes treating at least a portion of the red cells with carbon monoxide. The head space comprises from 0-15% CO.sub.2, 0-25% O.sub.2 and the balance N.sub.2 and/or inert gas.
摘要翻译： 公开了临床实验室血液pH和气体测量质量控制的稳定血液控制标准及其制备方法。 血液控制标准包括密封容器，其容纳特别处理的红细胞和至少等于红细胞体积的气体头部空间。 特殊处理包括从血浆成分中彻底洗涤和分离红细胞，然后用醛轻度处理细胞并将细胞保留在缓冲溶液中。 特殊处理还包括用一氧化碳处理至少一部分红细胞。 顶部空间包含0-15％的二氧化碳，0-25％的O 2和余量为N 2和/或惰性气体。
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公开(公告)号：US07879332B2
公开(公告)日：2011-02-01
申请号：US11358431
申请日：2006-02-21
申请人： Gene Zurlo , Dennis Curtin , Allan L. Louderback
发明人： Gene Zurlo , Dennis Curtin , Allan L. Louderback
IPC分类号： A61K39/395
CPC分类号： A61M1/3693 , A61K2035/124 , A61M1/3486 , A61M1/3696 , A61M2202/0419
摘要： An efficacious large-scale alcohol-free plasma fractionation production process which produces a high-yielding, non-denatured, double viral-inactivated intravenous human immune gamma globulin (IgG) product. The process employs one or more salts from a group of salts comprising sodium citrate, sodium acetate, sodium gluconate, ammonium sulfate, sodium chloride, sodium sulfate and ammonium chloride in two initial fractionation steps, followed by diafiltration to remove those salts employed. A process which employs alcohol via the process of the disclosed inventive method is also disclosed.
摘要翻译： 有效的大规模无酒精血浆分离生产方法，产生高产，非变性，双病毒灭活的静脉注射人免疫球蛋白（IgG）产品。 该方法在两个初始分馏步骤中使用一种或多种盐，所述盐包括柠檬酸钠，乙酸钠，葡糖酸钠，硫酸铵，氯化钠，硫酸钠和氯化铵，然后进行渗滤除去所用的盐。 还公开了通过所公开的本发明方法的方法使用醇的方法。
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