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公开(公告)号：US11975156B2
公开(公告)日：2024-05-07
申请号：US18214371
申请日：2023-06-26
发明人： Vijay Agarwal , Braden Eliason , Jeremy Ling
IPC分类号： A61B7/00 , A61F7/00 , A61K9/00 , A61K31/197 , A61K41/00 , A61M21/02 , A61N7/00 , A61P35/00 , B06B1/02 , B06B1/06 , A61B17/00 , A61B17/32 , A61B18/00 , A61F7/02 , A61M21/00
CPC分类号： A61M21/02 , A61F7/0085 , A61K9/0053 , A61K31/197 , A61K41/0033 , A61K41/0061 , A61N7/00 , A61P35/00 , B06B1/0207 , B06B1/0622 , A61B2017/00084 , A61B2017/320069 , A61B2018/00023 , A61B2018/00446 , A61F2007/0056 , A61F2007/0096 , A61F2007/0288 , A61M2021/0027 , A61M2021/005 , A61N2007/003 , A61N2007/006 , A61N2007/0073 , A61N2007/0078 , A61N2007/0082 , A61N2007/0095 , B06B2201/76
摘要： Disclosed are methods of using planar or defocused acoustic waves for providing non-invasive sonodynamic therapy. The method includes acoustically coupling an array of piezoelectric transducers to a patient. A controller is configured to generate an electrical drive signal at a frequency selected from a range of frequencies, modulate the drive signal, and drive the transducer with the modulated drive signal at the frequency to produce modulated acoustic waves to produce an average acoustic intensity sufficient to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.
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公开(公告)号：US11318332B2
公开(公告)日：2022-05-03
申请号：US17399996
申请日：2021-08-11
发明人： Vijay Agarwal , Braden Eliason , Jeremy Ling
IPC分类号： A61N7/00 , A61K9/00 , A61K31/197 , A61K41/00 , A61F7/00 , A61P35/00 , B06B1/02 , B06B1/06 , A61B17/00 , A61B18/00 , A61F7/02 , A61B17/32
摘要： Methods of treating tumors by administering compounds to a patient are provided. Compounds such as pro drugs, e.g., 5-aminolevulinic acid (5-ALA), may be administered to the patient orally, by injection, intravenously, or topically, which then accumulate preferentially as compounds such as protoporphyrin IX (PpIX) in tumor cells. After such accumulation, compounds such as PpIX are then activated in various aspects to treat tumors cells, thereby treating cancer. Cancers such as glioblastoma may be treated.
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公开(公告)号：US12097392B2
公开(公告)日：2024-09-24
申请号：US18215497
申请日：2023-06-28
发明人： Vijay Agarwal , Braden Eliason , Jeremy Ling , John Ballard , Gregg Miller
CPC分类号： A61N7/00 , A61K41/0033 , A61M37/0092 , A61N7/02 , B06B1/0215 , B06B1/0625 , B06B1/0629 , B06B1/0633 , A61N2007/0021 , A61N2007/0043 , A61N2007/0073 , A61N2007/0078 , A61N2007/0086 , B06B2201/55 , B06B2201/76
摘要： Ultrasound transducer element arrays using acoustic ensonification drive patterns via a patient interface for sonosensitizer activation in sonodynamic therapy. Incoherent acoustic field generation varying phase, frequencies, and/or amplitude via controlled delivery of low intensity planar acoustic waves. Method includes generating a first and a second signal to generate respective acoustic ensonification drive patterns with phase, frequency, and amplitude and generating at least one relative phase, frequency or amplitude difference to generate a third incoherent acoustic ensonification pattern to activate a sonosensitizer. Calibration and complementary therapy procedures to improve cell susceptibility of cells to sonodynamic therapy are disclosed.
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公开(公告)号：US11872414B2
公开(公告)日：2024-01-16
申请号：US18214372
申请日：2023-06-26
发明人： Vijay Agarwal , Braden Eliason , Jeremy Ling
IPC分类号： A61N7/00 , A61K9/00 , A61K31/197 , A61K41/00 , A61P35/00 , A61F7/00 , B06B1/02 , B06B1/06 , A61B17/00 , A61B18/00 , A61F7/02 , A61B17/32
CPC分类号： A61N7/00 , A61F7/0085 , A61K9/0053 , A61K31/197 , A61K41/0033 , A61K41/0061 , A61P35/00 , B06B1/0207 , B06B1/0622 , A61B2017/00084 , A61B2017/320069 , A61B2018/00023 , A61B2018/00446 , A61F2007/0056 , A61F2007/0096 , A61F2007/0288 , A61N2007/003 , A61N2007/006 , A61N2007/0073 , A61N2007/0078 , A61N2007/0082 , A61N2007/0095 , B06B2201/76
摘要： Disclosed are methods of producing ultrasound waves for providing sonodynamic therapy. The method includes coupling a sonodynamic therapy device with an array of piezoelectric transducer elements to a skin surface. A controller is configured to generate an electrical drive signal to produce ultrasound waves to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.
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公开(公告)号：US11865372B2
公开(公告)日：2024-01-09
申请号：US18125959
申请日：2023-03-24
发明人： Vijay Agarwal , Braden Eliason , Jeremy Ling
IPC分类号： A61N7/00 , A61K9/00 , A61K41/00 , A61P35/00 , A61F7/00 , A61K31/197 , B06B1/02 , B06B1/06 , A61B17/00 , A61B18/00 , A61F7/02 , A61B17/32
CPC分类号： A61N7/00 , A61F7/0085 , A61K9/0053 , A61K31/197 , A61K41/0033 , A61K41/0061 , A61P35/00 , B06B1/0207 , B06B1/0622 , A61B2017/00084 , A61B2017/320069 , A61B2018/00023 , A61B2018/00446 , A61F2007/0056 , A61F2007/0096 , A61F2007/0288 , A61N2007/003 , A61N2007/006 , A61N2007/0073 , A61N2007/0078 , A61N2007/0082 , A61N2007/0095 , B06B2201/76
摘要： Methods of treating tumors by administering compounds to a patient are provided. Compounds such as drugs, may be administered to the patient orally, by injection, intravenously, or topically, which then accumulate preferentially as compounds such as protoporphyrin IX (PpIX) in tumor cells. After such accumulation, compounds such as PpIX are then activated in various aspects to treat tumors cells, thereby treating cancer. Cancers such as glioblastoma may be treated.
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公开(公告)号：US11730980B2
公开(公告)日：2023-08-22
申请号：US17399964
申请日：2021-08-11
发明人： Vijay Agarwal , Braden Eliason , Jeremy Ling
CPC分类号： A61N7/00 , A61K9/0053 , A61K31/197 , A61K41/0033 , A61K41/0061 , A61P35/00 , A61B2017/00084 , A61B2018/00023 , A61B2018/00446 , A61F2007/0288 , A61N2007/0073 , A61N2007/0078 , A61N2007/0095
摘要： Disclosed are methods of using planar acoustic waves for providing non-invasive sonodynamic therapy. The method includes acoustically coupling an array of flat piezoelectric transducers to a patient. A controller is configured to generate an electrical drive signal at a frequency selected from a range of frequencies, modulate the drive signal, and drive the transducer with the modulated drive signal at the frequency to produce a modulated planar acoustic wave to produce an average acoustic intensity sufficient to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.
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公开(公告)号：US11724132B2
公开(公告)日：2023-08-15
申请号：US17960443
申请日：2022-10-05
发明人： Vijay Agarwal , Braden Eliason , Jeremy Ling
CPC分类号： A61N7/00 , A61K9/0053 , A61K31/197 , A61K41/0033 , A61K41/0061 , A61P35/00 , A61B2017/00084 , A61B2018/00023 , A61B2018/00446 , A61F2007/0288 , A61N2007/0073 , A61N2007/0078 , A61N2007/0095
摘要： Disclosed are methods of obtaining zero vergence ultrasound waves for providing sonodynamic therapy with ultrasound waves. The method includes coupling a sonodynamic therapy device with an array of flat piezoelectric transducers to a skin surface. A controller is configured to generate an electrical drive signal at a frequency, modulate the drive signal, and drive the transducer with the modulated drive signal at the frequency to produce a zero vergence ultrasound wave to produce an average acoustic intensity sufficient to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.
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公开(公告)号：US11617904B2
公开(公告)日：2023-04-04
申请号：US17733868
申请日：2022-04-29
发明人： Vijay Agarwal , Braden Eliason , Jeremy Ling
IPC分类号： A61N7/00 , A61K9/00 , A61K41/00 , A61P35/00 , A61F7/00 , A61K31/197 , B06B1/02 , B06B1/06 , A61B17/00 , A61B18/00 , A61F7/02 , A61B17/32
摘要： Methods of treating tumors by administering compounds to a patient are provided. Compounds such as pro drugs, e.g., 5-aminolevulinic acid (5-ALA), may be administered to the patient orally, by injection, intravenously, or topically, which then accumulate preferentially as compounds such as protoporphyrin IX (PpIX) in tumor cells. After such accumulation, compounds such as PpIX are then activated in various aspects to treat tumors cells, thereby treating cancer. Cancers such as glioblastoma may be treated.
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公开(公告)号：US11980777B2
公开(公告)日：2024-05-14
申请号：US18214386
申请日：2023-06-26
发明人： Vijay Agarwal , Braden Eliason , Jeremy Ling
IPC分类号： A61N7/00 , A61B17/00 , A61B17/32 , A61B18/00 , A61F7/00 , A61F7/02 , A61K9/00 , A61K31/197 , A61K41/00 , A61P35/00 , B06B1/02 , B06B1/06
CPC分类号： A61N7/00 , A61F7/0085 , A61K9/0053 , A61K31/197 , A61K41/0033 , A61K41/0061 , A61P35/00 , B06B1/0207 , B06B1/0622 , A61B2017/00084 , A61B2017/320069 , A61B2018/00023 , A61B2018/00446 , A61F2007/0056 , A61F2007/0096 , A61F2007/0288 , A61N2007/003 , A61N2007/006 , A61N2007/0073 , A61N2007/0078 , A61N2007/0082 , A61N2007/0095 , B06B2201/76
摘要： Disclosed are methods of producing randomized ultrasound waves for providing sonodynamic therapy. The method includes coupling a sonodynamic therapy device with an array of piezoelectric transducer elements to a skin surface. A controller is configured to generate an electrical drive signal to produce ultrasound waves to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.
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公开(公告)号：US11491353B2
公开(公告)日：2022-11-08
申请号：US17400011
申请日：2021-08-11
发明人： Vijay Agarwal , Braden Eliason , Jeremy Ling
IPC分类号： A61N7/00 , A61K9/00 , A61K31/197 , A61K41/00 , B06B1/02 , B06B1/06 , A61P35/00 , A61F7/00 , A61B17/00 , A61B18/00 , A61F7/02 , A61B17/32
摘要： Disclosed are methods of obtaining zero vergence ultrasound waves for providing sonodynamic therapy with ultrasound waves that do not converge and do not diverge. The method includes coupling a sonodynamic therapy device with an array of flat piezoelectric transducers to a skin surface. A controller is configured to generate an electrical drive signal at a frequency, modulate the drive signal, and drive the transducer with the modulated drive signal at the frequency to produce a zero vergence ultrasound wave to produce an average acoustic intensity sufficient to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.
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