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公开(公告)号：US20190017091A1
公开(公告)日：2019-01-17
申请号：US15699191
申请日：2017-09-08
摘要： A process for determining the viability of a biological indicator includes exposing the biological indicator to a viability detection medium, the biological indicator including test microorganisms, the exposing the biological indicator to the viability detection medium producing a gaseous reaction product when one or more of the test microorganisms are viable. The presence or absence of the gaseous reaction product produced by the biological indicator combined with the viability detection medium is detected with a sensing device, the sensing device comprising an electro-mechanical sensor, wherein the presence of the gaseous reaction product indicates the presence of viable test microorganisms and the absence of the gaseous reaction product indicates the absence of viable test microorganisms. A sterilization detection device includes a container configured to contain the biological indicator, a viability detection medium, and the sensing device.
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2.发明申请COUPLED ENZYME-BASED METHOD FOR ELECTRONIC MONITORING OF BIOLOGICAL INDICATOR 有权用于电子监测生物指示器的基于酶联的方法公开(公告)号：US20140273054A1
公开(公告)日：2014-09-18
申请号：US13832158
申请日：2013-03-15
IPC分类号： C12Q1/22
CPC分类号： C12Q1/22 , C12Q1/001 , C12Q1/006 , G01N27/327 , G01N33/52 , G01N2400/00 , Y10T436/11 , Y10T436/25375
摘要： A sterilization indicator system and method of using the system to determine efficacy of a sterilization process. The system includes a vial having a first compartment containing spores of one or more species of microorganism; a second compartment containing a growth medium with a disaccharide, an oligosaccharide or a polysaccharide in which the vial is free of monosaccharide; an enzyme, capable of acting upon the monosaccharide to yield reaction products and electron transfer, disposed on two or more electrodes adapted to carry an electrical signal resulting from the electron transfer, the pair of electrodes positioned to contact the combined contents of the first compartment and the second compartment during incubation; and an apparatus linked or linkable to the electrodes and adapted to detect and measure the electrical signal resulting from electron transfer when the enzyme acts upon the monosaccharide.
摘要翻译： 灭菌指示器系统和使用该系统来确定灭菌过程的功效的方法。 该系统包括具有包含一种或多种微生物孢子的第一隔室的小瓶; 第二隔室含有具有二糖的生长培养基，寡糖或多糖，其中小瓶不含单糖; 能够作用于单糖以产生反应产物和电子转移的酶，其设置在适于承载由电子转移产生的电信号的两个或多个电极上，该对电极定位成接触第一隔室的组合内容物，以及 孵化期间的第二隔室; 以及连接或可链接到电极的装置，并且适于在酶作用于单糖时检测和测量由电子转移产生的电信号。
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3.发明申请NON-ENZYME BASED DETECTION METHOD FOR ELECTRONIC MONITORING OF BIOLOGICAL INDICATOR 有权基于非酶的检测方法用于电子监测生物指示剂公开(公告)号：US20140262829A1
公开(公告)日：2014-09-18
申请号：US13836787
申请日：2013-03-15
IPC分类号： C12Q1/22
CPC分类号： C12Q1/22 , B01L2300/0609 , B01L2300/0816 , C12Q1/001 , C12Q1/006 , C12Q1/6816 , C12Q2527/125
摘要： A sterilization indicator system and method of using the system to determine efficacy of a sterilization process. The system may include a vial having an optional first compartment and a second compartment comprising a growth medium comprising one or more of a disaccharide, an oligosaccharide or a polysaccharide capable of conversion to a monosaccharide by germinating spores of the one or more species of microorganism, the vial being free of the monosaccharide prior to use; a strip including two or more electrodes to oxidize the monosaccharide and to carry a resulting electrical signal, and an apparatus to detect and measure the electrical signal resulting from the oxidation. Spores of a suitable biological indicator may be disposed in the first compartment and/or on the strip.
摘要翻译： 灭菌指示器系统和使用该系统来确定灭菌过程的功效的方法。 该系统可以包括具有任选的第一隔室的小瓶和包含生长培养基的第二隔室，所述生长培养基包含一种或多种能够通过发芽一种或多种微生物的孢子转化成单糖的二糖，寡糖或多糖， 使用前小瓶不含单糖; 包括两个或更多个电极以氧化单糖并携带所得电信号的条带，以及用于检测和测量由氧化产生的电信号的装置。 合适的生物指示剂的孢子可以设置在第一隔室和/或条带上。
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4.发明授权公开(公告)号：US08691562B2
公开(公告)日：2014-04-08
申请号：US13852435
申请日：2013-03-28
IPC分类号： C12M1/34
CPC分类号： G01N21/6486 , C12Q1/22
摘要： A sterilization indicator including an electronically conductive material positioned on a substrate; a biological indicator positioned on part or all of the electronically conductive material, and electronic circuitry for determining whether the membrane potential of the biological indicator changes during incubation following exposure sterilization conditions.
摘要翻译： 一种消毒指示器，包括位于基板上的电子导电材料; 位于部分或全部电子导电材料上的生物指示剂，以及用于确定在暴露灭菌条件之后孵育期间生物指示物的膜电位是否改变的电子电路。
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公开(公告)号：US10301631B2
公开(公告)日：2019-05-28
申请号：US16001203
申请日：2018-06-06
IPC分类号： C12Q1/22 , C12Q1/34 , C12Q1/68 , C12N15/75 , A61L2/28 , C12M1/34 , C12Q1/689 , C12M1/12 , C12Q1/6897 , C12N9/38
摘要： This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed.
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公开(公告)号：US10183087B2
公开(公告)日：2019-01-22
申请号：US14936775
申请日：2015-11-10
IPC分类号： C11D3/02 , C11D1/75 , C11D3/395 , C11D3/39 , A61L2/18 , C11D1/722 , A01N37/02 , A01N37/16 , A01N59/00 , A01N59/02 , C11D1/66 , C11D1/72 , C11D3/00 , C11D3/386 , C11D3/48 , C11D1/88 , C11D1/90 , C11D3/04 , C11D3/20 , C11D3/22 , C11D3/28 , C11D3/30 , C11D3/33 , C11D3/36 , C11D3/37 , C11D7/10 , C11D7/26 , C11D7/32 , C11D7/36 , C11D11/00 , A61B1/005 , A61B1/12 , B08B3/08
摘要： The disclosed invention relates to a two-part liquid composition for cleaning and disinfecting a substrate, comprising: (A) a disinfectant medium comprising peracetic acid; and (B) a supplemental medium comprising a non-enzymatic cleaner, a corrosion inhibitor, and a chelator. The supplemental medium (B) may further comprise an enzymatic cleaner, a surfactant, a buffer, a pH modifier, or a mixture of two or more thereof. The substrate may be a medical device, for example, an endoscope.
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公开(公告)号：US10017772B2
公开(公告)日：2018-07-10
申请号：US15618158
申请日：2017-06-09
IPC分类号： C12Q1/22 , C12Q1/34 , C12Q1/68 , C12N15/75 , C12M1/12 , C12N9/38 , A61L2/28 , C12M1/34 , C12Q1/6897 , C12Q1/689
摘要： This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed.
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公开(公告)号：US20170211122A1
公开(公告)日：2017-07-27
申请号：US15375256
申请日：2016-12-12
CPC分类号： C12Q1/22 , A61L2/28 , C12M1/3407 , C12M41/46 , G01N27/221
摘要： This invention relates to a capacitor comprising two electrical conductors separated by a dielectric, the dielectric comprising microorganisms. The dielectric may comprise a biological indicator. This invention relates to a process for determining whether the microorganisms are alive or dead. The number of microorganisms can be determined. This invention relates to a process for testing the efficacy of a sterilization process using the capacitor.
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公开(公告)号：US09695428B2
公开(公告)日：2017-07-04
申请号：US15204079
申请日：2016-07-07
CPC分类号： C12N15/75 , A61L2/28 , C12M1/34 , C12M37/06 , C12N9/2471 , C12Q1/22 , C12Q1/34 , C12Q1/689 , C12Q1/6897 , C12Y302/01023
摘要： This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed.
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公开(公告)号：US20170128605A1
公开(公告)日：2017-05-11
申请号：US14936775
申请日：2015-11-10
IPC分类号： A61L2/18 , A01N37/02 , A01N59/00 , A01N59/02 , C11D3/386 , C11D3/00 , C11D1/66 , C11D1/72 , C11D1/75 , A01N37/16 , C11D3/48
CPC分类号： A61L2/18 , A01N37/02 , A01N37/16 , A01N59/00 , A01N59/02 , A61B1/005 , A61B1/125 , A61L2/186 , A61L2202/17 , A61L2202/24 , B08B3/08 , C11D1/66 , C11D1/662 , C11D1/72 , C11D1/722 , C11D1/75 , C11D1/88 , C11D1/90 , C11D3/0073 , C11D3/046 , C11D3/2068 , C11D3/2075 , C11D3/2082 , C11D3/2086 , C11D3/225 , C11D3/28 , C11D3/30 , C11D3/33 , C11D3/361 , C11D3/364 , C11D3/365 , C11D3/3707 , C11D3/38618 , C11D3/38627 , C11D3/38636 , C11D3/3947 , C11D3/48 , C11D7/10 , C11D7/263 , C11D7/265 , C11D7/3218 , C11D7/3245 , C11D7/3281 , C11D7/36 , C11D11/0041
摘要： The disclosed invention relates to a two-part liquid composition for cleaning and disinfecting a substrate, comprising: (A) a disinfectant medium comprising peracetic acid; and (B) a supplemental medium comprising a non-enzymatic cleaner, a corrosion inhibitor, and a chelator. The supplemental medium (B) may further comprise an enzymatic cleaner, a surfactant, a buffer, a pH modifier, or a mixture of two or more thereof. The substrate may be a medical device, for example, an endoscope.
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