公开(公告)号：US20140180391A1

公开(公告)日：2014-06-26

申请号：US13741154

申请日：2012-09-09

申请人： Amir Dagan ,  Moshe Elazar ,  Nitai Hanani ,  Gal Ariav ,  Oded Meiri ,  Igor Gindin ,  Vadim Bernshtein ,  Nir Armory ,  Yossi Gross ,  Offer Glasberg

发明人： Amir Dagan ,  Moshe Elazar ,  Nitai Hanani ,  Gal Ariav ,  Oded Meiri ,  Igor Gindin ,  Vadim Bernshtein ,  Nir Armory ,  Yossi Gross ,  Offer Glasberg

IPC分类号： A61F2/82 ,  A61B5/04 ,  A61N1/05

CPC分类号： A61N1/40 ,  A61B5/0215 ,  A61B5/04 ,  A61B5/0402 ,  A61B5/0816 ,  A61F2/82 ,  A61F2/915 ,  A61F2002/8483 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0002 ,  A61F2250/0018 ,  A61N1/05 ,  A61N1/0514 ,  A61N1/0558 ,  A61N1/056 ,  A61N1/057 ,  A61N1/36053 ,  A61N1/3756 ,  A61N2001/0585

摘要： Apparatus and methods are provided for use with a blood vessel of a subject, including a stent (20) configured to be placed in the blood vessel. The stent includes at least first (32), second (34), and third (36) strut portions disposed along the stent. The first and second strut portions are coupled to one another at a first junction (37A) that facilitates bending of the first and second strut portions with respect to one another. The second and third strut portions are coupled to one another at a second junction (37B) that facilitates bending of the second and third strut portions with respect to one another. At least one electrode (22) is disposed on at least an outer surface of the stent. Other applications are also described.

摘要翻译： 提供了与被检体的血管一起使用的装置和方法，包括构造成放置在血管中的支架（20）。 所述支架包括沿支架设置的至少第一（32），第二（34）和第三（36）支柱部分。 第一和第二支柱部分在促进第一和第二支柱部分相对于彼此的弯曲的第一接合部（37A）处彼此联接。 第二和第三支柱部分在促进第二和第三支柱部分相对于彼此的弯曲的第二接合部（37B）处彼此联接。 至少一个电极（22）设置在支架的至少外表面上。 还描述了其它应用。

公开(公告)号：US09526637B2

公开(公告)日：2016-12-27

申请号：US13741154

申请日：2012-09-09

申请人： Amir Dagan ,  Moshe Elazar ,  Nitai Hanani ,  Gal Ariav ,  Oded Meiri ,  Igor Gindin ,  Vadim Bernshtein ,  Nir Armony ,  Yossi Gross ,  Offer Glasberg

发明人： Amir Dagan ,  Moshe Elazar ,  Nitai Hanani ,  Gal Ariav ,  Oded Meiri ,  Igor Gindin ,  Vadim Bernshtein ,  Nir Armony ,  Yossi Gross ,  Offer Glasberg

IPC分类号： A61F2/82 ,  A61F2/915 ,  A61N1/375 ,  A61N1/36 ,  A61B5/04 ,  A61N1/05 ,  A61F2/848

CPC分类号： A61N1/40 ,  A61B5/0215 ,  A61B5/04 ,  A61B5/0402 ,  A61B5/0816 ,  A61F2/82 ,  A61F2/915 ,  A61F2002/8483 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0002 ,  A61F2250/0018 ,  A61N1/05 ,  A61N1/0514 ,  A61N1/0558 ,  A61N1/056 ,  A61N1/057 ,  A61N1/36053 ,  A61N1/3756 ,  A61N2001/0585

摘要： Apparatus and methods are provided for use with a blood vessel of a subject, including a stent (20) configured to be placed in the blood vessel. The stent includes at least first (32), second (34), and third (36) strut portions disposed along the stent. The first and second strut portions are coupled to one another at a first junction (37A) that facilitates bending of the first and second strut portions with respect to one another. The second and third strut portions are coupled to one another at a second junction (37B) that facilitates bending of the second and third strut portions with respect to one another. At least one electrode (22) is disposed on at least an outer surface of the stent. Other applications are also described.

摘要翻译： 提供了与被检体的血管一起使用的装置和方法，包括构造成放置在血管中的支架（20）。 所述支架包括沿支架设置的至少第一（32），第二（34）和第三（36）支柱部分。 第一和第二支柱部分在促进第一和第二支柱部分相对于彼此的弯曲的第一接合部（37A）处彼此联接。 第二和第三支柱部分在促进第二和第三支柱部分相对于彼此的弯曲的第二接合部（37B）处彼此联接。 至少一个电极（22）设置在支架的至少外表面上。 还描述了其它应用。

公开(公告)号：US08855783B2

公开(公告)日：2014-10-07

申请号：US13294062

申请日：2011-11-10

申请人： Amir Dagan ,  Yossi Gross ,  Yotam Reisner ,  Offer Glasberg ,  Nitai Hanani ,  Gal Ariav ,  Oded Meiri

发明人： Amir Dagan ,  Yossi Gross ,  Yotam Reisner ,  Offer Glasberg ,  Nitai Hanani ,  Gal Ariav ,  Oded Meiri

IPC分类号： A61N1/378 ,  A61N1/36 ,  A61N1/372 ,  A61N1/05 ,  A61F2/01

CPC分类号： A61N1/372 ,  A61F2002/016 ,  A61N1/0556 ,  A61N1/36053 ,  A61N1/36117 ,  A61N1/3615 ,  A61N1/37217 ,  A61N1/378 ,  A61N1/3787

摘要： Apparatus is provided, including (1) an external device, configured for placement outside of a body of a subject and to sense a factor of the subject, and to generate a signal in response to the sensed factor, and (2) an implant, which comprises a wireless receiver for receiving the signal, and at least one electrode, the implant configured to drive the electrode to apply current to an aortic and/or vagal site of the subject in response to the signal.

摘要翻译： 提供了一种设备，包括：（1）外部设备，被配置为放置在对象的身体外部并感测被摄体的因子，并且响应于感测到的因素而产生信号，以及（2）植入物， 其包括用于接收信号的无线接收器，以及至少一个电极，所述植入物配置成驱动所述电极，以响应于所述信号将电流施加到所述受试者的主动脉和/或迷走神瘤部位。

公开(公告)号：US08649863B2

公开(公告)日：2014-02-11

申请号：US12973484

申请日：2010-12-20

申请人： Yossi Gross ,  Amir Dagan ,  Yotam Reisner ,  Offer Glasberg ,  Nitai Hanani ,  Gal Ariav

发明人： Yossi Gross ,  Amir Dagan ,  Yotam Reisner ,  Offer Glasberg ,  Nitai Hanani ,  Gal Ariav

IPC分类号： A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/36542 ,  A61N1/368

摘要： Apparatus and methods are provided for use with a heart of a subject, including a set of one or more electrodes. A control unit paces the heart by driving a first electric current via the electrode set into tissue of the subject, in accordance with a first set of parameters. The control unit stimulates nitric oxide production by a portion of the heart by driving a second electric current via the electrode set into the portion of the heart, in accordance with a second set of parameters. Other embodiments are also described.

摘要翻译： 提供了与受试者的心脏一起使用的装置和方法，包括一组一个或多个电极。 根据第一组参数，控制单元通过经由电极组的第一电流驱动到对象的组织中而使心脏跳动。 根据第二组参数，控制单元通过经由电极组的第二电流驱动心脏的一部分来刺激一部分心脏的一氧化氮产生。 还描述了其它实施例。

公开(公告)号：US20100305392A1

公开(公告)日：2010-12-02

申请号：US12792227

申请日：2010-06-02

申请人： Yossi Gross ,  Amir Dagan ,  Yotam Reisner ,  Offer Glasberg ,  Nitai Hanani ,  Gal Ariav

发明人： Yossi Gross ,  Amir Dagan ,  Yotam Reisner ,  Offer Glasberg ,  Nitai Hanani ,  Gal Ariav

IPC分类号： A61M1/10 ,  A61N1/36

CPC分类号： A61N1/05 ,  A61M1/106 ,  A61M1/1072 ,  A61M1/1086 ,  A61M1/125 ,  A61M2205/33 ,  A61M2205/3303 ,  A61N1/36114 ,  A61N1/36564 ,  A61N1/3962

摘要： Apparatus and methods are described including identifying a subject as suffering from a condition selected from the group consisting of congestive heart failure, diastolic heart failure, and hypertension. In response to the identifying, an electrode is placed on a vagus nerve of the subject at a vagal site that is between (a) a vagal bifurcation with a thoracic cardiac branch of the subject, and (b) thoracic vagal branching into the esophageal plexus of the subject. The subject is treated by driving a current into the vagal site, via the electrode. Other embodiments are also described.

摘要翻译： 描述了装置和方法，包括将受试者识别为患有选自充血性心力衰竭，舒张性心力衰竭和高血压的病症。 响应于识别，将电极放置在受试者的迷走神经上，该迷走神经位于（a）迷走神经分叉与受试者的胸部心脏分支之间，（b）分支到食管丛的迷走迷走神经 的主题。 通过电极驱动电流进入迷走神经部位进行治疗。 还描述了其它实施例。

公开(公告)号：US20110137370A1

公开(公告)日：2011-06-09

申请号：US12957799

申请日：2010-12-01

申请人： Yossi Gross ,  Amir Dagan ,  Yotam Reisner ,  Offer Glasberg ,  Nitai Hanani ,  Gal Ariav

发明人： Yossi Gross ,  Amir Dagan ,  Yotam Reisner ,  Offer Glasberg ,  Nitai Hanani ,  Gal Ariav

IPC分类号： A61N1/05

CPC分类号： A61N1/36114 ,  A61M1/106 ,  A61M1/1072 ,  A61M1/1086 ,  A61M1/125 ,  A61M2205/33 ,  A61M2205/3303 ,  A61N1/05 ,  A61N1/0556 ,  A61N1/0558 ,  A61N1/36117 ,  A61N1/36564 ,  A61N1/3962

摘要： Apparatus and methods are provided, including an electrode that is placed in contact with an artery of a subject. A control unit drives the electrode to perform a function with respect to the artery, the function selected from the group consisting of: driving a current into the artery, and sensing an electrical parameter of the artery. A transmitter is placed in a vein of the subject that is in a vicinity of the artery, the transmitter being wiredly connected to the control unit. The control unit is configured to drive the electrode by wirelessly transmitting a signal via the transmitter. Other embodiments are also described.

摘要翻译： 提供了设备和方法，包括与受试者的动脉接触放置的电极。 控制单元驱动电极相对于动脉执行功能，所述功能选自包括：将电流驱动到动脉中并感测动脉的电参数。 发射器放置在处于动脉附近的受试者的静脉中，发射器被有线地连接到控制单元。 控制单元被配置为通过经由发送器无线地发送信号来驱动电极。 还描述了其它实施例。

公开(公告)号：US09649487B2

公开(公告)日：2017-05-16

申请号：US13968868

申请日：2013-08-16

申请人： Yossi Gross ,  Amir Dagan ,  Yotam Reisner ,  Offer Glasberg ,  Nitai Hanani ,  Gal Ariav

发明人： Yossi Gross ,  Amir Dagan ,  Yotam Reisner ,  Offer Glasberg ,  Nitai Hanani ,  Gal Ariav

IPC分类号： A61N1/05 ,  A61N1/36 ,  A61F2/82 ,  A61N1/365

CPC分类号： A61N1/05 ,  A61F2/82 ,  A61N1/0514 ,  A61N1/0521 ,  A61N1/056 ,  A61N1/36 ,  A61N1/36564

摘要： Apparatus and methods are described including a mechanical support element that is placed inside a first vein of a subject. At least one electrode disposed on the mechanical support element is placed inside the first vein, in a vicinity of a site upstream of a bifurcation with a second vein of the subject. A control unit enhances downstream blood flow from the first vein by driving the at least one electrode to divert blood downstream into the second vein by constricting the first vein at the upstream site, by driving the at least one electrode to apply a current to the vicinity of the site. The mechanical support element prevents the first vein from collapsing by providing mechanical support to the vein. Other embodiments are also described.

公开(公告)号：US08626299B2

公开(公告)日：2014-01-07

申请号：US12957799

申请日：2010-12-01

申请人： Yossi Gross ,  Amir Dagan ,  Yotam Reisner ,  Offer Glasberg ,  Nitai Hanani ,  Gal Ariav

发明人： Yossi Gross ,  Amir Dagan ,  Yotam Reisner ,  Offer Glasberg ,  Nitai Hanani ,  Gal Ariav

IPC分类号： A61N1/00

CPC分类号： A61N1/36114 ,  A61M1/106 ,  A61M1/1072 ,  A61M1/1086 ,  A61M1/125 ,  A61M2205/33 ,  A61M2205/3303 ,  A61N1/05 ,  A61N1/0556 ,  A61N1/0558 ,  A61N1/36117 ,  A61N1/36564 ,  A61N1/3962

摘要： Apparatus and methods are provided, including an electrode that is placed in contact with an artery of a subject. A control unit drives the electrode to perform a function with respect to the artery, the function selected from the group consisting of: driving a current into the artery, and sensing an electrical parameter of the artery. A transmitter is placed in a vein of the subject that is in a vicinity of the artery, the transmitter being wiredly connected to the control unit. The control unit is configured to drive the electrode by wirelessly transmitting a signal via the transmitter. Other embodiments are also described.

摘要翻译： 提供了设备和方法，包括与受试者的动脉接触放置的电极。 控制单元驱动电极相对于动脉执行功能，所述功能选自包括：将电流驱动到动脉中并感测动脉的电参数。 发射器放置在处于动脉附近的受试者的静脉中，发射器被有线地连接到控制单元。 控制单元被配置为通过经由发送器无线地发送信号来驱动电极。 还描述了其它实施例。

公开(公告)号：US08538535B2

公开(公告)日：2013-09-17

申请号：US12851214

申请日：2010-08-05

申请人： Yossi Gross ,  Amir Dagan ,  Yotam Reisner ,  Offer Glasberg ,  Nitai Hanani ,  Gal Ariav

发明人： Yossi Gross ,  Amir Dagan ,  Yotam Reisner ,  Offer Glasberg ,  Nitai Hanani ,  Gal Ariav

IPC分类号： A61N1/00

CPC分类号： A61N1/05 ,  A61F2/82 ,  A61N1/0514 ,  A61N1/0521 ,  A61N1/056 ,  A61N1/36 ,  A61N1/36564

摘要： Apparatus and methods are described including a mechanical support element that is placed inside a first vein of a subject. At least one electrode disposed on the mechanical support element is placed inside the first vein, in a vicinity of a site upstream of a bifurcation with a second vein of the subject. A control unit enhances downstream blood flow from the first vein by driving the at least one electrode to divert blood downstream into the second vein by constricting the first vein at the upstream site, by driving the at least one electrode to apply a current to the vicinity of the site. The mechanical support element prevents the first vein from collapsing by providing mechanical support to the vein. Other embodiments are also described.

摘要翻译： 描述的装置和方法包括放置在受试者的第一静脉内部的机械支撑元件。 设置在机械支撑元件上的至少一个电极被放置在第一静脉的内部，在与受试者的第二静脉分叉的上游位置附近。 控制单元通过驱动所述至少一个电极来增强来自所述第一静脉的下游血液流动，以通过在所述上游部位收缩所述第一静脉来将血液下游转移到所述第二静脉中，通过驱动所述至少一个电极以向所述附近施加电流 的网站。 机械支撑元件通过向静脉提供机械支撑来防止第一静脉塌陷。 还描述了其它实施例。

公开(公告)号：US20120035711A1

公开(公告)日：2012-02-09

申请号：US12851214

申请日：2010-08-05

申请人： Yossi GROSS ,  Amir Dagan ,  Yotam Reisner ,  Offer Glasberg ,  Nitai Hanani ,  Gal Ariav

发明人： Yossi GROSS ,  Amir Dagan ,  Yotam Reisner ,  Offer Glasberg ,  Nitai Hanani ,  Gal Ariav

IPC分类号： A61F2/82 ,  A61N1/00

CPC分类号： A61N1/05 ,  A61F2/82 ,  A61N1/0514 ,  A61N1/0521 ,  A61N1/056 ,  A61N1/36 ,  A61N1/36564

摘要： Apparatus and methods are described including a mechanical support element that is placed inside a first vein of a subject. At least one electrode disposed on the mechanical support element is placed inside the first vein, in a vicinity of a site upstream of a bifurcation with a second vein of the subject. A control unit enhances downstream blood flow from the first vein by driving the at least one electrode to divert blood downstream into the second vein by constricting the first vein at the upstream site, by driving the at least one electrode to apply a current to the vicinity of the site. The mechanical support element prevents the first vein from collapsing by providing mechanical support to the vein. Other embodiments are also described.

摘要翻译： 描述的装置和方法包括放置在受试者的第一静脉内部的机械支撑元件。 设置在机械支撑元件上的至少一个电极被放置在第一静脉的内部，在与受试者的第二静脉分叉的上游位置附近。 控制单元通过驱动所述至少一个电极来增强来自所述第一静脉的下游血液流动，以通过在所述上游部位收缩所述第一静脉来将血液下游转移到所述第二静脉中，通过驱动所述至少一个电极以向所述附近施加电流 的网站。 机械支撑元件通过向静脉提供机械支撑来防止第一静脉塌陷。 还描述了其它实施例。