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21 条记录 (耗时 0.012 秒)

    Method for preparing organic hyponitrites
    5.
    发明授权
    Method for preparing organic hyponitrites 失效
    制备有机次硝酸盐的方法

    公开(公告)号：US4460513A

    公开(公告)日：1984-07-17

    申请号：US436634

    申请日：1982-10-25

    申请人： G. David Mendenhall

    发明人： G. David Mendenhall

    IPC分类号： C07C203/00 ,  C07C77/00 ,  C07C77/02

    CPC分类号： C07C291/00

    摘要： Tertiary organic hyponitrite usable as initiators for polymerizing ethylenically unsaturated compounds are prepared by reacting an alkali metal, alkaline earth, ammonium or substituted ammonium salt of hyponitrite, such as sodium hyponitrite, with a tertiary organic halide, such as tert-butyl chloride, in the presence of one or more weak Friedel-Crafts catalysts, such as ferric or zinc chloride, and in a solution of a neutral solvent.

    摘要翻译： 可用作聚合烯键式不饱和化合物的引发剂的三级有机次硝酸盐是通过将低亚硝酸盐如次亚硝酸钠的碱金属，碱土金属，铵或取代的铵盐与叔有机卤化物如叔丁基氯反应制备的 存在一种或多种弱的Friedel-Crafts催化剂，例如三价铁或氯化锌，以及在中性溶剂的溶液中。

    METHODS FOR MODULATING RNA SPLICING
    10.
    发明公开
    METHODS FOR MODULATING RNA SPLICING 审中-公开

    公开(公告)号：US20230272367A1

    公开(公告)日：2023-08-31

    申请号：US18316871

    申请日：2023-05-12

    申请人： PTC THERAPEUTICS, INC.

    发明人： Anuradha Bhattacharyya ,  Amal Dakka ,  Kerstin Effenberger ,  Vijayalakshmi Gabbeta ,  Wencheng Li ,  Nikolai Naryshkin ,  Christopher Trotta ,  Kari Wiedinger

    IPC分类号： C12N15/10 ,  C07C255/00 ,  C07C291/00

    CPC分类号： C12N15/10 ,  C12N15/102 ,  C07C255/00 ,  C07C291/00

    摘要： In one aspect, described herein is an intronic recognition element for splicing modifier (iREMS) that can be recognized by a compound provided herein. In another aspect, described herein are methods for modulating the amount of a product of a gene, wherein a precursor RNA transcript transcribed from the gene contains an intronic REMS, and the methods utilizing a compound described herein. More particularly, described herein are methods for modulating the amount of an RNA transcript or protein product encoded by a gene, wherein a precursor RNA transcript transcribed from the gene comprises an intronic REMS, and the methods utilizing a compound described herein. In another aspect, provided herein are artificial gene constructs comprising an intronic REMS, and uses of those artificial gene constructs to modulate protein production. In another aspect, provided herein are methods for altering endogenous genes to comprise an intronic REMS, and the use of a compound described herein to modulate protein produced from such altered endogenous genes.