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    Biosensor desiccant system having enhanced measurement performance
    1.
    发明授权
    Biosensor desiccant system having enhanced measurement performance 有权
    具有增强的测量性能的生物传感器干燥剂系统

    公开(公告)号：US09233788B2

    公开(公告)日：2016-01-12

    申请号：US13553203

    申请日：2012-07-19

    申请人： Amy H. Chu ,  Mary Ellen Warchal-Windham

    发明人： Amy H. Chu ,  Mary Ellen Warchal-Windham

    IPC分类号： G01N27/327 ,  B65D81/26 ,  C12Q1/00 ,  B65B55/00 ,  G01N33/487

    CPC分类号： G01N27/3272 ,  B65B55/00 ,  B65D81/266 ,  C12Q1/005 ,  G01N33/48778

    摘要： A biosensor system for determining the concentration of an analyte in a sample includes a plurality of test sensors, and includes a container including a desiccant and the plurality of test sensors, sealed in the container. When the container is stored for two weeks at a temperature of 50° C., and each test sensor is subsequently removed from the container, connected through the at least two conductors to a measurement device and then contacted with one of a plurality of samples including an analyte, where the plurality of samples has analyte concentrations that span the range of 50 mg/dL-600 mg/dL, and the analyte concentration in each sample is determined by the test sensor and the measuring device, the bias of each determined analyte concentration may be within ±10 mg/dL or ±10%, and the coefficient of variation of the determined analyte concentrations may be at most 2.5%.

    摘要翻译： 用于确定样品中分析物浓度的生物传感器系统包括多个测试传感器，并且包括密封在容器中的包括干燥剂和多个测试传感器的容器。 当容器在50℃的温度下储存两周时，并且随后将每个测试传感器从容器中取出，通过至少两个导体连接到测量装置，然后与多个样品中的一个接触，包括 分析物，其中多个样品具有跨越50mg / dL-600mg / dL范围的分析物浓度，并且每个样品中的分析物浓度由测试传感器和测量装置确定，每个确定的分析物的偏差 浓度可能在±10 mg / dL或±10％以内，测定的分析物浓度的变异系数可以达到2.5％以下。

    Biosensor Desiccant System Having Enhanced Measurement Performance
    4.
    发明申请
    Biosensor Desiccant System Having Enhanced Measurement Performance 有权
    具有增强测量性能的生物传感器干燥剂系统

    公开(公告)号：US20130186755A1

    公开(公告)日：2013-07-25

    申请号：US13553203

    申请日：2012-07-19

    申请人： Amy H. Chu ,  Mary Ellen Warchal-Windham

    发明人： Amy H. Chu ,  Mary Ellen Warchal-Windham

    IPC分类号： B65D81/26 ,  B65B55/00 ,  C12Q1/00

    CPC分类号： G01N27/3272 ,  B65B55/00 ,  B65D81/266 ,  C12Q1/005 ,  G01N33/48778

    摘要： A biosensor system for determining the concentration of an analyte in a sample includes a plurality of test sensors, and includes a container including a desiccant and the plurality of test sensors, sealed in the container. When the container is stored for two weeks at a temperature of 50° C., and each test sensor is subsequently removed from the container, connected through the at least two conductors to a measurement device and then contacted with one of a plurality of samples including an analyte, where the plurality of samples has analyte concentrations that span the range of 50 mg/dL-600 mg/dL, and the analyte concentration in each sample is determined by the test sensor and the measuring device, the bias of each determined analyte concentration may be within ±10 mg/dL or ±10%, and the coefficient of variation of the determined analyte concentrations may be at most 2.5%.

    摘要翻译： 用于确定样品中分析物浓度的生物传感器系统包括多个测试传感器，并且包括密封在容器中的包括干燥剂和多个测试传感器的容器。 当容器在50℃的温度下储存两周时，并且随后将每个测试传感器从容器中取出，通过至少两个导体连接到测量装置，然后与多个样品中的一个接触，包括 分析物，其中多个样品具有跨越50mg / dL-600mg / dL范围的分析物浓度，并且每个样品中的分析物浓度由测试传感器和测量装置确定，每个确定的分析物的偏差 浓度可能在±10 mg / dL或±10％以内，测定的分析物浓度的变异系数可以达到2.5％以下。

    Transient decay amperometry
    5.
    发明授权
    Transient decay amperometry 有权
    瞬态衰变电流分析法

    公开(公告)号：US08470604B2

    公开(公告)日：2013-06-25

    申请号：US13210738

    申请日：2011-08-16

    申请人： Huan-Ping Wu ,  Steven C. Charlton ,  Amy H. Chu ,  Andrew J. Edelbrock ,  Sung-Kwon Jung ,  Dijia Huang

    发明人： Huan-Ping Wu ,  Steven C. Charlton ,  Amy H. Chu ,  Andrew J. Edelbrock ,  Sung-Kwon Jung ,  Dijia Huang

    IPC分类号： G01N27/333 ,  G01N33/66

    CPC分类号： C12Q1/54 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/1495 ,  C12Q1/004 ,  G01N27/3271 ,  G01N27/3272

    摘要： A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the −0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay.

    摘要翻译： 生物传感器系统使用没有Cottrell衰变的电化学过程来确定生物样品的分析物浓度。 生物传感器系统产生具有瞬时衰减的输出信号，其中输出信号不与时间的平方根成反比。 瞬态衰减大于或小于Cottrell衰变的-0.5衰减常数。 瞬时衰减可能由相对较短的潜伏期，相对小的样品储存容量，电极表面与传感器条的盖之间的相对小的距离和/或相对于试剂层的平均初始厚度的相对短的激发而产生。 生物传感器系统从具有瞬时衰减的输出信号确定分析物浓度。

    Reagent Composition and Methods of Using and Forming the Same
    6.
    发明申请
    Reagent Composition and Methods of Using and Forming the Same 有权
    试剂组合物及其使用和形成方法

    公开(公告)号：US20080199937A1

    公开(公告)日：2008-08-21

    申请号：US11885237

    申请日：2006-03-03

    申请人： Amy H. Chu ,  Hope G. Spradlin

    发明人： Amy H. Chu ,  Hope G. Spradlin

    IPC分类号： C12N9/24 ,  C12M1/34

    CPC分类号： C12Q1/006 ,  C12Q1/004 ,  G01N27/3271

    摘要： A reagent composition containing GDH-PQQ as an enzyme-co-factor and screen-printed on working and counter electrodes of electrochemical biosensors, maintains activity of the enzyme reagents by proper selection of components. A preferred composition includes hydrophilic polymers, amorphous untreated silica, buffers, surfactants, and a mediator For example, the biosensor is useful in the amperometric determination of glucose.

    摘要翻译： 包含GDH-PQQ作为酶辅因子并丝网印刷在电化学生物传感器的工作和对电极上的试剂组合物通过适当选择组分保持酶试剂的活性。 优选的组合物包括亲水性聚合物，无定形未处理二氧化硅，缓冲液，表面活性剂和介体。例如，生物传感器可用于葡萄糖的电流测定。

    Transient decay amperometry
    8.
    发明授权
    Transient decay amperometry 有权
    瞬态衰变电流分析法

    公开(公告)号：US08026104B2

    公开(公告)日：2011-09-27

    申请号：US11875942

    申请日：2007-10-21

    申请人： Huan-Ping Wu ,  Steven C. Charlton ,  Amy H. Chu ,  Andrew J. Edelbrock ,  Sung-Kwon Jung ,  Dijia Huang

    发明人： Huan-Ping Wu ,  Steven C. Charlton ,  Amy H. Chu ,  Andrew J. Edelbrock ,  Sung-Kwon Jung ,  Dijia Huang

    IPC分类号： G01N27/00 ,  G01N27/413

    CPC分类号： C12Q1/54 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/1495 ,  C12Q1/004 ,  G01N27/3271 ,  G01N27/3272

    摘要： A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the −0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay.

    摘要翻译： 生物传感器系统使用没有Cottrell衰变的电化学过程来确定生物样品的分析物浓度。 生物传感器系统产生具有瞬时衰减的输出信号，其中输出信号不与时间的平方根成反比。 瞬态衰减大于或小于Cottrell衰变的-0.5衰减常数。 瞬时衰减可能由相对较短的潜伏期，相对小的样品储存容量，电极表面与传感器条的盖之间的相对小的距离和/或相对于试剂层的平均初始厚度的相对短的激发而产生。 生物传感器系统从具有瞬时衰减的输出信号确定分析物浓度。

    Methods of determining the concentration of an analyte in a fluid test sample
    9.
    发明授权
    Methods of determining the concentration of an analyte in a fluid test sample 有权
    确定流体测试样品中分析物浓度的方法

    公开(公告)号：US07132041B2

    公开(公告)日：2006-11-07

    申请号：US10770199

    申请日：2004-02-02

    申请人： Yingping Deng ,  Amy H. Chu

    发明人： Yingping Deng ,  Amy H. Chu

    IPC分类号： G01N27/26 ,  G01N33/50 ,  C12Q1/26

    CPC分类号： C12Q1/006 ,  G01N27/3274

    摘要： A method of determining the concentration of an analyte in a fluid test sample that includes providing an electrochemical sensor adapted to measure the analyte in the test sample. The test sample sufficiently covers a counter and working electrode of the electrochemical sensor. A first potential is applied between the counter and working electrodes for a first predetermined time period and the current is measured and the time is recorded. After the first potential is removed or substantially reduced, a second potential is applied between the counter and working electrodes and the current is measured. The concentration of the analyte is determined in the test sample as a function of the current measured. An index is calculated and compared to at least one predetermined parameter to identify when a bias, if any, exceeds a threshold. An error signal or analyte concentration is displayed depending on the comparison.

    摘要翻译： 确定流体测试样品中分析物浓度的方法，其包括提供适于测量测试样品中的分析物的电化学传感器。 测试样品充分覆盖电化学传感器的计数器和工作电极。 在第一预定时间段内在计数器和工作电极之间施加第一电位，并且测量电流并记录时间。 在去除或显着减小第一电位之后，在计数器和工作电极之间施加第二电位，并测量电流。 在测试样品中测定分析物的浓度作为测量电流的函数。 计算索引并将其与至少一个预定参数进行比较，以识别偏差（如果有的话）何时超过阈值。 根据比较显示错误信号或分析物浓度。

    Analyte detection device and process
    10.
    发明授权
    Analyte detection device and process 失效
    分析物检测装置及工艺

    公开(公告)号：US06190918B1

    公开(公告)日：2001-02-20

    申请号：US08400786

    申请日：1995-03-06

    申请人： Amy H. Chu ,  Michael J. Wilcox

    发明人： Amy H. Chu ,  Michael J. Wilcox

    IPC分类号： G01N3348

    CPC分类号： C12Q1/54 ,  G01N33/525 ,  Y10T436/144444 ,  Y10T436/25375

    摘要： The present invention provides a device and a process for detecting an analyte in a biological fluid. The device comprises a separating matrix for separating analyte from the fluid and means for detecting the analyte, where the separating matrix contains HEPES buffer, preferably in an amount between 70 and 150 millimolar. The process comprises applying the sample to the device having a separating matrix and then detecting analyte in the sample using the detection means. The presence of HEPES in the separation layer shortened the detection time.

    摘要翻译： 本发明提供一种用于检测生物流体中的分析物的装置和方法。 该装置包括用于从流体中分离分析物的分离基质和用于检测分析物的装置，其中分离基质含有HEPES缓冲液，优选为70至150毫摩尔。 该方法包括将样品施加到具有分离基质的装置中，然后使用检测装置检测样品中的分析物。 分离层中HEPES的存在缩短了检测时间。