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    METHODS EMPLOYING INSECT MODELS FOR DETERMINING INTESTINAL ABSORPTION OF CHEMICAL COMPOUNDS
    3.
    发明申请
    METHODS EMPLOYING INSECT MODELS FOR DETERMINING INTESTINAL ABSORPTION OF CHEMICAL COMPOUNDS 有权
    用于确定化学化合物的吸收吸收的方法

    公开(公告)号：US20120122144A1

    公开(公告)日：2012-05-17

    申请号：US13387083

    申请日：2010-08-10

    申请人： Peter Aadal Nielsen ,  Gunnar Andersson ,  Olga Andersson

    发明人： Peter Aadal Nielsen ,  Gunnar Andersson ,  Olga Andersson

    IPC分类号： C12Q1/02 ,  A01K67/00

    CPC分类号： G01N33/5085

    摘要： There is provided insect screening models to determine gastrointestinal absorption of different chemical compounds in vertebrates, and in particular humans, in order to improve the compound screening procedures/processes in the early drug discovery process. This offers many advantages relative to prior technologies since insect models are more reliable tools for the decision-making process than the existing in vitro models, and will speed up the drug screening process and reduce the late phase attrition rate. Moreover, it will reduce the number of mammals sacrificed during the drug discovery phase.

    摘要翻译： 为了改善早期药物发现过程中的化合物筛选程序/过程，提供了用于确定脊椎动物，特别是人类中不同化合物的胃肠道吸收的昆虫筛选模型。 与现有技术相比，昆虫模型是决策过程的可靠工具，而不仅仅是现有的体外模型，因此与现有技术相比具有很多优势，并且将加速药物筛选过程并降低后期的磨耗率。 此外，它将减少在药物发现阶段牺牲的哺乳动物的数量。

    SCREENING METHODS EMPLOYING INSECTS WITH BLOOD BRAIN BARRIER
    4.
    发明申请
    SCREENING METHODS EMPLOYING INSECTS WITH BLOOD BRAIN BARRIER 有权
    使用血液脑屏障的筛选方法

    公开(公告)号：US20110171682A1

    公开(公告)日：2011-07-14

    申请号：US13060619

    申请日：2009-09-16

    申请人： Peter Aadal Nielsen ,  Gunnar Andersson

    发明人： Peter Aadal Nielsen ,  Gunnar Andersson

    IPC分类号： C12Q1/24 ,  C12Q1/02

    CPC分类号： G01N33/5085

    摘要： There is provided insect models that are aimed to reflect vertebrate blood-brain barrier (BBB) penetration. Investigation of BBB penetration is extremely important in drug discovery; successful CNS drugs have to cross the BBB, while BBB penetration may cause unwanted side effects for peripheral acting drugs. Specifically, the present invention relates to the use of insects in screening for substances with a biological effect on the brain or central nervous system and/or effect on a disease or disorder of the brain or central nervous system. It further relates to use of such insects in screening for substances that have a desired biological activity and which do not cross the blood brain barrier.

    摘要翻译： 提供旨在反映脊椎动物血脑屏障（BBB）渗透的昆虫模型。 BBB穿透的调查在药物发现中是非常重要的; 成功的CNS药物必须穿过BBB，而BBB渗透可能会对外周作用药物造成不良副作用。 具体地，本发明涉及昆虫在对脑或中枢神经系统具有生物学作用的物质的筛选和/或对脑或中枢神经系统疾病或病症的影响中的应用。 它进一步涉及这种昆虫在筛选具有所需生物学活性并且不会穿过血脑屏障的物质的用途。

    Control system for a transformer or reactor
    5.
    发明申请
    Control system for a transformer or reactor 有权
    变压器或电抗器的控制系统

    公开(公告)号：US20070225945A1

    公开(公告)日：2007-09-27

    申请号：US11385434

    申请日：2006-03-21

    申请人： Bengt-Olof Stenestam ,  Gunnar Andersson

    发明人： Bengt-Olof Stenestam ,  Gunnar Andersson

    IPC分类号： G06F19/00 ,  G06F17/40

    CPC分类号： G01R31/3274 ,  G01R31/027 ,  H01F29/04 ,  H01H2009/0061 ,  H02H7/055

    摘要： A universal control and diagnostic system for a transformer that may be retrofit with existing control and tap-changer equipment, the system providing for remote monitoring and control of the equipment and for measuring various criteria associated with the tap-changer to substantially minimize damage to the equipment during a maneuver and for substantially avoiding carbonization of a connected contact.

    摘要翻译： 用于变压器的通用控制和诊断系统，可以使用现有的控制和分接开关设备进行改造，该系统提供对设备的远程监控和控制，并用于测量与分接开关相关的各种标准，从而大大减少对 在机动操作期间设备，并大大避免连接的接触件的碳化。

    Tap changer condition diagnosing
    6.
    发明授权
    Tap changer condition diagnosing 有权
    分接开关状态诊断

    公开(公告)号：US07089145B2

    公开(公告)日：2006-08-08

    申请号：US10450578

    申请日：2001-12-14

    申请人： Bengt-Olof Stenestam ,  Gunnar Andersson

    发明人： Bengt-Olof Stenestam ,  Gunnar Andersson

    IPC分类号： G01K1/00

    CPC分类号： G01R31/027 ,  G01R31/3274 ,  G01R31/333 ,  H01F29/04 ,  H01H2009/0061

    摘要： A method and apparatus for condition diagnosing of a tap changer immersed in a cooling fluid, controlling and regulating an inductive power device, such as a transformer or reactor. The diagnosing method compares and evaluates expected heat exchanges between the tap changer and ambient air and the inductive power device, an expected amount of heat generated by the tap changer during operation, together with an actual temperature of the fluid. From the actual temperature, expected heat exchanges and expected generated heat, the heat balance in the system may be obtained and is used for disgnosing the operation conditions of the tap changer. The results from the condition diagnosing may be used as indicators that can alarm operators or may be sent as a data signal to remote and/or portable display means, such as a computer.

    摘要翻译： 用于状态诊断浸入冷却流体中的抽头变换器的方法和装置，控制和调节诸如变压器或反应器的感应功率器件。 诊断方法比较和评估分接开关与环境空气和感应功率器件之间期望的热交换，在分接开关在运行期间产生的预期热量以及流体的实际温度。 从实际的温度，预期的热交换和期望的产生的热量，可以获得系统中的热平衡，并用于断开分接开关的操作条件。 来自状态诊断的结果可以用作可以将报警操作者或作为数据信号发送到诸如计算机的远程和/或便携式显示装置的指示器。

    Gas filter unit
    7.
    发明授权
    Gas filter unit 失效
    气体过滤器单元

    公开(公告)号：US5914413A

    公开(公告)日：1999-06-22

    申请号：US930377

    申请日：1997-10-23

    申请人： Gunnar Andersson ,  Bo Engvall ,  Bo Lindvert ,  Goran Strom

    发明人： Gunnar Andersson ,  Bo Engvall ,  Bo Lindvert ,  Goran Strom

    IPC分类号： B01D46/02 ,  B01D29/13

    CPC分类号： B01D46/023 ,  B01D46/02 ,  Y10S55/12 ,  Y10S55/31

    摘要： The invention concerns a gas filter unit or cartridge type, including a filter material put together to form one or several filter bags, and a support frame of essentially U-shaped cross-sectional configuration, including a web portion and two lateral leg members in adjoining relationship, the filter material closest to the mouths of the filter bags being clamped in position between said lateral leg members. In accordance with the invention, the frame includes profile sections of a flexible material, preferably a plastics material, at least one of said lateral leg members being hingedly interconnected with the web portion, in addition to which locking means are provided to retain the corresponding lateral leg member in its clamping position in which it is pivoted into engagement with the other lateral leg member.

    摘要翻译： PCT No.PCT / SE96 / 00354 Sec。 371日期：1997年10月23日 102（e）日期1997年10月23日PCT 1996年3月21日PCT公布。 公开号WO96 / 29138 日期1996年9月26日本发明涉及一种气体过滤器单元或盒式，包括放置在一起以形成一个或多个过滤袋的过滤材料，以及基本上呈U形横截面构造的支撑框架，包括腹板部分和两个 相邻关系的侧腿部件，最靠近过滤袋口部的过滤材料被夹持在所述侧腿部件之间。 根据本发明，框架包括柔性材料的轮廓部分，优选为塑料材料，所述横向腿部构件中的至少一个与腹板部分铰接地互连，除此之外还设有锁定装置以保持相应的侧面 腿部构件处于其夹紧位置，在该位置中，该构件枢转成与另一侧向腿构件接合。

    INSECT-BASED EX VIVO MODEL FOR TESTING BLOOD-BRAIN BARRIER PENETRATION AND METHOD FOR EXPOSING INSECT BRAIN TO NANOPARTICLES
    8.
    发明申请
    INSECT-BASED EX VIVO MODEL FOR TESTING BLOOD-BRAIN BARRIER PENETRATION AND METHOD FOR EXPOSING INSECT BRAIN TO NANOPARTICLES 有权
    用于测试血脑屏障穿刺的基于INSECT的VIVO模型和将脑膜暴露于纳米颗粒的方法

    公开(公告)号：US20140154725A1

    公开(公告)日：2014-06-05

    申请号：US13881566

    申请日：2011-09-30

    申请人： Peter Aadal Nielsen ,  Gunnar Andersson ,  Olga Andersson

    发明人： Peter Aadal Nielsen ,  Gunnar Andersson ,  Olga Andersson

    IPC分类号： G01N33/50

    CPC分类号： G01N33/5058 ,  G01N33/5085

    摘要： There is provided an ex-vivo insect screening model to accurately determine blood-brain barrier penetration of different nanoparticles in order to improve the compound screening procedures/processes in the early drug discovery process. This object offers many advantages relative to prior technologies since insect models are more reliable tools for the decision-making process than the existing in vitro models, and will speed up the drug screening process and reduce the late phase attrition rate. Moreover, it will reduce the number of mammals sacrificed during the drug discovery phase.

    摘要翻译： 提供了一种离体昆虫筛选模型，以准确地确定不同纳米颗粒的血脑屏障穿透，以改善早期药物发现过程中的复合筛选程序/过程。 与现有技术相比，该目标提供了许多优点，因为昆虫模型是决策过程中比现有体外模型更可靠的工具，并且将加速药物筛选过程并减少后期磨耗率。 此外，它将减少在药物发现阶段牺牲的哺乳动物的数量。

    INSECT-BASED EX VIVO MODEL FOR TESTING BLOOD-BRAIN BARRIER PENETRATION AND METHOD FOR EXPOSING INSECT BRAIN TO CHEMICAL COMPOUNDS
    9.
    发明申请
    INSECT-BASED EX VIVO MODEL FOR TESTING BLOOD-BRAIN BARRIER PENETRATION AND METHOD FOR EXPOSING INSECT BRAIN TO CHEMICAL COMPOUNDS 有权
    用于测试血脑屏障穿刺的基于INSECT的VIVO模型和将化学物质暴露于化学化合物的方法

    公开(公告)号：US20120122145A1

    公开(公告)日：2012-05-17

    申请号：US13387088

    申请日：2010-08-10

    申请人： Peter Aadal ,  Gunnar Andersson ,  Olga Andersson

    发明人： Peter Aadal ,  Gunnar Andersson ,  Olga Andersson

    IPC分类号： C12Q1/02 ,  A01K67/00

    CPC分类号： G01N33/5085

    摘要： There is provided an ex-vivo insect screening model to accurately determine blood-brain barrier penetration of different chemical compounds in order to improve the compound screening procedures/processes in the early drug discovery process. This object offers many advantages relative to prior technologies since insect models are more reliable tools for the decision-making process than the existing in vitro models, and will speed up the drug screening process and reduce the late phase attrition rate. Moreover, it will reduce the number of mammals sacrificed during the drug discovery phase.

    摘要翻译： 提供了一种离体昆虫筛选模型，以准确确定不同化合物的血脑屏障渗透，以改善早期药物发现过程中的复合筛选程序/过程。 与现有技术相比，该目标提供了许多优点，因为昆虫模型是决策过程中比现有体外模型更可靠的工具，并且将加速药物筛选过程并减少后期磨耗率。 此外，它将减少在药物发现阶段牺牲的哺乳动物的数量。

    Control system for a transformer or reactor
    10.
    发明授权
    Control system for a transformer or reactor 有权
    变压器或电抗器的控制系统

    公开(公告)号：US07444266B2

    公开(公告)日：2008-10-28

    申请号：US11385434

    申请日：2006-03-21

    申请人： Bengt-Olof Stenestam ,  Gunnar Andersson

    发明人： Bengt-Olof Stenestam ,  Gunnar Andersson

    IPC分类号： G06F11/30 ,  G06F15/00 ,  G21C17/00

    CPC分类号： G01R31/3274 ,  G01R31/027 ,  H01F29/04 ,  H01H2009/0061 ,  H02H7/055

    摘要： A universal control and diagnostic system for a transformer that may be retrofit with existing control and tap-changer equipment, the system providing for remote monitoring and control of the equipment and for measuring various criteria associated with the tap-changer to substantially minimize damage to the equipment during a maneuver and for substantially avoiding carbonization of a connected contact.

    摘要翻译： 用于变压器的通用控制和诊断系统，可以使用现有的控制和分接开关设备进行改造，该系统提供对设备的远程监控和控制，并用于测量与分接开关相关的各种标准，从而大大减少对 在机动操作期间设备，并大大避免连接的接触件的碳化。