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    Method for fixing a protein on a pyrrole-based polymer and use thereof for making a sensor
    1.
    发明授权
    Method for fixing a protein on a pyrrole-based polymer and use thereof for making a sensor 有权
    将蛋白质固定在吡咯类聚合物上的方法及其制造传感器的用途

    公开(公告)号：US07998726B2

    公开(公告)日：2011-08-16

    申请号：US10533950

    申请日：2003-11-20

    申请人： Andre Roget ,  Thierry Livache ,  Yves Levy

    发明人： Andre Roget ,  Thierry Livache ,  Yves Levy

    IPC分类号： C12M1/34 ,  G01N33/53 ,  G01N33/551 ,  G01N33/544 ,  G01N33/547

    CPC分类号： C08G73/0611 ,  C08G61/124 ,  G01N33/54353

    摘要： The aim of the present invention is to provide a method for attaching a protein to a conductive polymer, that can be used in particular for producing a sensor or a multisensor, for example a biochip.This aim, and also others, are achieved, in accordance with the invention, by means of a method for attaching a protein to a pyrrole polymer, comprising the following steps: coupling of the protein to be attached with pyrrole so as to obtain a first solution of a protein-pyrrole coupling compound, preparation of a second solution of pyrrole not containing the protein, mixing of said first solution with said second solution so as to obtain an electropolymerization solution, electropolymerization of the pyrrole and of the protein coupled to the pyrrole on a conductive support using said electropolymerization solution.

    摘要翻译： 本发明的目的是提供一种将蛋白质连接到导电聚合物上的方法，其特别可用于生产传感器或多传感器，例如生物芯片。 根据本发明，通过将蛋白质与吡咯聚合物连接的方法，其目的以及其它目的以及其它目的，也包括以下步骤：将待连接的蛋白质与吡咯偶联以获得第一 蛋白质 - 吡咯偶联化合物的溶液，制备不含有蛋白质的吡咯的第二溶液，将所述第一溶液与所述第二溶液混合，得到电聚合溶液，吡咯和与吡咯偶联的蛋白质的电聚合 在使用所述电聚合溶液的导电载体上。

    Method for fixing a protein on a pyrrole-based polymer and use thereof for making a sensor
    2.
    发明申请
    Method for fixing a protein on a pyrrole-based polymer and use thereof for making a sensor 有权
    将蛋白质固定在吡咯类聚合物上的方法及其制造传感器的用途

    公开(公告)号：US20060035208A1

    公开(公告)日：2006-02-16

    申请号：US10533950

    申请日：2003-11-20

    申请人： Andre Roget ,  Thierry Livache ,  Yves Levy

    发明人： Andre Roget ,  Thierry Livache ,  Yves Levy

    IPC分类号： C12Q1/00 ,  G01N33/53 ,  C08G63/91 ,  C08G63/48

    CPC分类号： C08G73/0611 ,  C08G61/124 ,  G01N33/54353

    摘要： The aim of the present invention is to provide a method for attaching a protein to a conductive polymer, that can be used in particular for producing a sensor or a multisensor, for example a biochip. This aim, and also others, are achieved, in accordance with the invention, by means of a method for attaching a protein to a pyrrole polymer, comprising the following steps: coupling of the protein to be attached with pyrrole so as to obtain a first solution of a protein-pyrrole coupling compound, preparation of a second solution of pyrrole not containing the protein, mixing of said first solution with said second solution so as to obtain an electropolymerization solution, electropolymerization of the pyrrole and of the protein coupled to the pyrrole on a conductive support using said electropolymerization solution.

    摘要翻译： 本发明的目的是提供一种将蛋白质连接到导电聚合物上的方法，其特别可用于生产传感器或多传感器，例如生物芯片。 根据本发明，通过将蛋白质与吡咯聚合物连接的方法，其目的以及其它目的以及其它目的，也包括以下步骤：将待连接的蛋白质与吡咯偶联以获得第一 蛋白质 - 吡咯偶联化合物的溶液，不含蛋白质的吡咯的第二溶液的制备，将所述第一溶液与所述第二溶液混合，得到电解聚合溶液，吡咯和与吡咯偶联的蛋白质的电聚合 在使用所述电聚合溶液的导电载体上。

    Method for characterizing a surface, and device therefor
    5.
    发明授权
    Method for characterizing a surface, and device therefor 有权
    表面表征方法及其装置

    公开(公告)号：US07678584B2

    公开(公告)日：2010-03-16

    申请号：US11592221

    申请日：2006-11-03

    申请人： Philippe Guedon ,  Yves Levy

    发明人： Philippe Guedon ,  Yves Levy

    IPC分类号： G01N33/552

    CPC分类号： B82Y15/00 ,  G01N21/552 ,  G01N21/553

    摘要： The present invention relates to a method of characterizing a surface and to a device for implementing this method. In particular, this method makes it possible to measure, qualitatively and/or quantitatively, interactions that may be physical, chemical, biochemical or biological.

    摘要翻译： 本发明涉及一种表征表面的方法以及用于实施该方法的装置。 特别地，该方法使得可以测量，定性和/或定量的可能是物理，化学，生物化学或生物学的相互作用。

    COMPOSITIONS AND METHODS TO IMMUNIZE AGAINST HEPATITIS C VIRUS
    6.
    发明申请
    COMPOSITIONS AND METHODS TO IMMUNIZE AGAINST HEPATITIS C VIRUS 审中-公开
    免疫HEPATITIS C病毒的组合物和方法

    公开(公告)号：US20120301465A1

    公开(公告)日：2012-11-29

    申请号：US13430206

    申请日：2012-03-26

    申请人： Helene Dutartre ,  Yves Levy ,  Jacques F. Banchereau ,  Gerard Zurawski

    发明人： Helene Dutartre ,  Yves Levy ,  Jacques F. Banchereau ,  Gerard Zurawski

    IPC分类号： A61K39/395 ,  A61P37/04 ,  A61P31/12 ,  C07K19/00 ,  C12N5/0784

    CPC分类号： C12N5/0639 ,  A61K39/12 ,  A61K39/29 ,  A61K2039/6056 ,  C07K14/005 ,  C07K16/2851 ,  C07K16/2878 ,  C07K2319/00 ,  C07K2319/33 ,  C12N2770/24222 ,  C12N2770/24234

    摘要： Compositions comprising viral antigens and antigenic peptides corresponding to or derived from Hepatitis C virus (HCV) proteins or fragments thereof, fused to heavy and/or light chain of antibodies, or fragments thereof specific for dendritic cells (DCs) are described herein. Included herein are immunostimulatory compositions (HCV vaccines, HCV antigen presenting dendritic cells, etc.) and methods for increasing effectiveness of HCV antigen presentation by an antigen presenting cell, for a treatment, a prophylaxis or a combination thereof against hepatitis C in a human subject, and methods of providing immunostimulation by activation of one or more dendritic cells, methods to treat or prevent hepatitis C.

    摘要翻译： 本文描述了包含与针对树突状细胞（DC）特异性的抗体的重链和/或轻链或其片段融合的丙型肝炎病毒（HCV）蛋白或其片段的病毒抗原和抗原肽的组合物。 本文包括免疫刺激组合物（HCV疫苗，呈递树突细胞的HCV抗原等）以及用于增加抗原呈递细胞的HCV抗原呈递的有效性的方法，用于治疗，预防或其组合以抗人类受试者中的丙型肝炎 ，以及通过激活一种或多种树突状细胞提供免疫刺激的方法，治疗或预防丙型肝炎的方法。