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1.发明授权公开(公告)号：US09434713B2
公开(公告)日：2016-09-06
申请号：US14040412
申请日：2013-09-27
发明人： Wilfried Braje , Thorsten Oost , Astrid Netz , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch
IPC分类号： A61K31/497 , C07D401/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D421/00 , C07D211/68 , C07D211/80 , C07D213/02 , C07D401/14
CPC分类号： C07D401/14
摘要： The present invention relates to novel 5,6-disubstituted oxindole derivatives and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising such derivatives, and to the use of such derivatives for the manufacture of a medicament, and methods of treating disorders in a subject in need thereof, such as vasopressin-dependent disorders, using 5,6-disubstituted oxindole derivatives.
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2.发明授权Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases 有权氨基甲酸酯取代的羟吲哚衍生物及其用于治疗加压素依赖性疾病的用途公开(公告)号：US09422264B2
公开(公告)日：2016-08-23
申请号：US14252425
申请日：2014-04-14
发明人： Astrid Netz , Thorsten Oost , Hervé Geneste , Wilfried Braje , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch
IPC分类号： A61K31/496 , A61K31/4545 , C07D401/04 , C07D401/14
CPC分类号： C07D401/14 , C07D401/04
摘要： The present invention relates to novel carbamate-substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-dependent disorders.
摘要翻译： 本发明涉及新的氨基甲酸酯取代的羟基吲哚衍生物，包含它们的药物组合物及其用于治疗加压素依赖性病症的用途。
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3.发明申请CARBAMATE-SUBSTITUTED OXINDOLE DERIVATIVES AND USE THEREOF FOR THE TREATMENT OF VASOPRESSIN-DEPENDENT DISEASES 有权碳水化合物取代的氧化衍生物及其用于治疗依赖性依赖性疾病的用途公开(公告)号：US20140315914A1
公开(公告)日：2014-10-23
申请号：US14252425
申请日：2014-04-14
发明人： Astrid Netz , Thorsten Oost , Hervé Geneste , Wilfried Braje , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch
IPC分类号： C07D401/04
CPC分类号： C07D401/14 , C07D401/04
摘要： The present invention relates to novel carbamate-substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-dependent disorders.
摘要翻译： 本发明涉及新的氨基甲酸酯取代的羟基吲哚衍生物，包含它们的药物组合物及其用于治疗加压素依赖性病症的用途。
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4.发明申请SUBSTITUTED OXINDOLE-DERIVATIVES AND THE USE THEREOF FOR THE TREATMENT OF VASOPRESSIN-DEPENDENT ILLNESSES 有权取代的氧化衍生物及其用于治疗依赖于依赖性依赖性的药物公开(公告)号：US20140303138A1
公开(公告)日：2014-10-09
申请号：US14095162
申请日：2013-12-03
发明人： Wilfried Braje , Astrid Netz , Thorsten Oost , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch
IPC分类号： C07D401/14 , C07D209/34 , C07D401/04
CPC分类号： C07D401/14 , C07D209/34 , C07D401/04
摘要： The present invention relates to novel substituted oxindole derivatives of the formula (I), pharmaceutical agents containing said derivatives, and the use thereof for the treatment of vasopressin-dependent illnesses.
摘要翻译： 本发明涉及式（I）的新型取代羟吲哚衍生物，含有所述衍生物的药物及其用于治疗加压素依赖性疾病的用途。
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公开(公告)号：US20220259226A1
公开(公告)日：2022-08-18
申请号：US17660355
申请日：2022-04-22
发明人： Wilfried Braje , George Doherty , Katja Jantos , Cheng Ji , Andrew Judd , Aaron Kunzer , Anthony Mastracchio , Xiaohong Song , Andrew Souers , Gerard Sullivan , Zhi-Fu Tao , Chunqiu Lai , Jesse Teske , Michael Wendt , Patrick Brady , Xilu Wang , Thomas Penning , Yujia Dai , Jane Gong , Roberto Risi , Yiyun Yu , Guidong Zhu
IPC分类号： C07D498/18 , A61P35/00 , C07D519/00 , C07D495/18 , C07D495/16 , A61K31/519 , C07D491/16 , C07D498/16
摘要： The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
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公开(公告)号：US20200010480A1
公开(公告)日：2020-01-09
申请号：US16575114
申请日：2019-09-18
发明人： Patrick B. Brady , Wilfried Braje , Yujia Dai , George A. Doherty , Jane Gong , Katja Jantos , Cheng Ji , Andrew S. Judd , Aaron R. Kunzer , Chunqiu Lai , Anthony Mastracchio , Roberto M. Risi , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Jesse A. Teske , Xilu Wang , Michael D. Wendt , Yiyun Yu , Guidong Zhu , Thomas D. Penning
IPC分类号： C07D498/18 , A61P35/00 , C07D519/00 , C07D495/18 , C07D495/16
摘要： The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
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公开(公告)号：US20190071443A1
公开(公告)日：2019-03-07
申请号：US16179050
申请日：2018-11-02
发明人： Hannes Koolman , Wilfried Braje , Helmut Mack , Andreas Haupt , Ana Lucia Relo , Karla Drescher , Margaretha Henrica Maria Bakker , Viktor Lakics , Carolin Hoft , Ruxu Xu , Xiaona Zhao
IPC分类号： C07D471/06 , C07D487/16 , C07D487/06
摘要： The present invention relates to tricyclic quinoline and quinoxaline derivatives, to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, and to a method for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor.
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公开(公告)号：US20190055264A1
公开(公告)日：2019-02-21
申请号：US15998688
申请日：2018-08-15
发明人： Patrick B. Brady , Wilfried Braje , Yujia Dai , George A. Doherty , Jane Gong , Katja Jantos , Cheng Ji , Andrew S. Judd , Aaron R. Kunzer , Chunqiu Lai , Anthony Mastracchio , Roberto M. Risi , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Jesse A. Teske , Xilu Wang , Michael D. Wendt , Yiyun Yu , Guidong Zhu , Thomas D. Penning
IPC分类号： C07D498/18 , C07D495/18 , C07D519/00 , A61P35/00
摘要： The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
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公开(公告)号：US09994568B2
公开(公告)日：2018-06-12
申请号：US14868835
申请日：2015-09-29
发明人： Hannes Koolman , Wilfried Braje , Helmut Mack , Andreas Haupt , Ana Lucia Relo , Karla Drescher , Margaretha Henrica Maria Bakker , Viktor Lakics , Carolin Hoft
IPC分类号： A61K31/519 , A61K31/52 , C07D403/12 , C07D405/12 , C07D473/34 , C07D487/04 , C07D471/06 , C07D487/06
CPC分类号： C07D471/06 , C07D487/06
摘要： The present invention relates to tricyclic quinoline and quinoxaline derivatives, to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, and to a method for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor.
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公开(公告)号：US09701679B2
公开(公告)日：2017-07-11
申请号：US14503198
申请日：2014-09-30
发明人： Ying Wang , Jason T. Brewer , Irini Akritopoulou-Zanze , Stevan W. Djuric , Bhadra Shelat , Frauke Pohlki , Wilfried Braje , Ana-Lucia Relo
IPC分类号： C07D487/04 , C07D471/04 , C07D471/14 , C07D491/04 , C07D498/04 , C07D487/14
CPC分类号： C07D487/04 , C07D471/04 , C07D471/14 , C07D487/14 , C07D491/04 , C07D498/04 , Y02E60/321
摘要： The present application relates to 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,4]benzodiazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazepine, 2,3,4,4a,5,6,7,11b-octahydro-1H-pyrido[3,4-d][2]benzazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1]benzazepine, 1,2,3,4,4a,5-hexahydro-7H-pyrazino[1,2-a][4,1]benzoxazepine, and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[2,1-d][1,5]benzoxazepine, and 5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, X1, X2, X3, X4, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
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