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1.发明授权公开(公告)号：US09434713B2
公开(公告)日：2016-09-06
申请号：US14040412
申请日：2013-09-27
发明人： Wilfried Braje , Thorsten Oost , Astrid Netz , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch
IPC分类号： A61K31/497 , C07D401/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D421/00 , C07D211/68 , C07D211/80 , C07D213/02 , C07D401/14
CPC分类号： C07D401/14
摘要： The present invention relates to novel 5,6-disubstituted oxindole derivatives and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising such derivatives, and to the use of such derivatives for the manufacture of a medicament, and methods of treating disorders in a subject in need thereof, such as vasopressin-dependent disorders, using 5,6-disubstituted oxindole derivatives.
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2.发明授权Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases 有权氨基甲酸酯取代的羟吲哚衍生物及其用于治疗加压素依赖性疾病的用途公开(公告)号：US09422264B2
公开(公告)日：2016-08-23
申请号：US14252425
申请日：2014-04-14
发明人： Astrid Netz , Thorsten Oost , Hervé Geneste , Wilfried Braje , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch
IPC分类号： A61K31/496 , A61K31/4545 , C07D401/04 , C07D401/14
CPC分类号： C07D401/14 , C07D401/04
摘要： The present invention relates to novel carbamate-substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-dependent disorders.
摘要翻译： 本发明涉及新的氨基甲酸酯取代的羟基吲哚衍生物，包含它们的药物组合物及其用于治疗加压素依赖性病症的用途。
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3.发明授权Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them 有权杂芳基取代的1,3-二氢吲哚-2-酮衍生物和含有它们的药物公开(公告)号：US09487505B2
公开(公告)日：2016-11-08
申请号：US14037026
申请日：2013-09-25
发明人： Wilfried Lubisch , Wilfried Hornberger , Thorsten K. Oost , Daryl Richard Sauer , Liliane Unger , Wolfgang Wernet , Hervé Geneste
IPC分类号： A01N43/38 , C07D403/14 , C07D401/04 , C07D403/04 , C07D403/12 , C07D405/14 , C07D409/04 , C07D401/14 , C07D413/14 , C07D417/14
CPC分类号： C07D403/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/14
摘要： The present invention relates to novel 1,3-dihydroindol-2-one (oxindole) derivatives of the formula (I) in which A, R3, R4, R5, R6 and R7 are defined according to claim 1, and to medicaments containing them for the treatment of diseases. In particular, the novel oxindole derivatives can be used for the control and/or prophylaxis of various vasopressin-dependent or oxytocin-dependent diseases.
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4.发明申请CARBAMATE-SUBSTITUTED OXINDOLE DERIVATIVES AND USE THEREOF FOR THE TREATMENT OF VASOPRESSIN-DEPENDENT DISEASES 有权碳水化合物取代的氧化衍生物及其用于治疗依赖性依赖性疾病的用途公开(公告)号：US20140315914A1
公开(公告)日：2014-10-23
申请号：US14252425
申请日：2014-04-14
发明人： Astrid Netz , Thorsten Oost , Hervé Geneste , Wilfried Braje , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch
IPC分类号： C07D401/04
CPC分类号： C07D401/14 , C07D401/04
摘要： The present invention relates to novel carbamate-substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-dependent disorders.
摘要翻译： 本发明涉及新的氨基甲酸酯取代的羟基吲哚衍生物，包含它们的药物组合物及其用于治疗加压素依赖性病症的用途。
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5.发明申请SUBSTITUTED OXINDOLE-DERIVATIVES AND THE USE THEREOF FOR THE TREATMENT OF VASOPRESSIN-DEPENDENT ILLNESSES 有权取代的氧化衍生物及其用于治疗依赖于依赖性依赖性的药物公开(公告)号：US20140303138A1
公开(公告)日：2014-10-09
申请号：US14095162
申请日：2013-12-03
发明人： Wilfried Braje , Astrid Netz , Thorsten Oost , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch
IPC分类号： C07D401/14 , C07D209/34 , C07D401/04
CPC分类号： C07D401/14 , C07D209/34 , C07D401/04
摘要： The present invention relates to novel substituted oxindole derivatives of the formula (I), pharmaceutical agents containing said derivatives, and the use thereof for the treatment of vasopressin-dependent illnesses.
摘要翻译： 本发明涉及式（I）的新型取代羟吲哚衍生物，含有所述衍生物的药物及其用于治疗加压素依赖性疾病的用途。
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6.发明申请CARBAMATE-SUBSTITUTED OXINDOLE DERIVATIVES AND USE THEREOF FOR THE TREATMENT OF VASOPRESSIN-DEPENDENT DISEASES 审中-公开碳水化合物取代的氧化衍生物及其用于治疗依赖性依赖性疾病的用途公开(公告)号：US20160362394A1
公开(公告)日：2016-12-15
申请号：US15244283
申请日：2016-08-23
发明人： Astrid Netz , Thorsten Oost , Hervé Geneste , Wilfried Braje , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch
IPC分类号： C07D401/14
CPC分类号： C07D401/14 , C07D401/04
摘要： The present invention relates to novel carbamate-substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-dependent disorders.
摘要翻译： 本发明涉及新的氨基甲酸酯取代的羟基吲哚衍生物，包含它们的药物组合物及其用于治疗加压素依赖性病症的用途。
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7.发明申请GUANIDINE COMPOUNDS AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5 RECEPTORS 审中-公开胍基化合物及其作为5-HT5受体的结合合作伙伴使用公开(公告)号：US20170037016A1
公开(公告)日：2017-02-09
申请号：US15332744
申请日：2016-10-24
发明人： Astrid Netz , Wilhelm Amberg , Udo Lange , Michael Ochse , Charles W. Hutchins , Francisco-Xavier Garcia-Ladona , Wolfgang Wernet , Andreas Kling
IPC分类号： C07D277/48 , C07D277/82 , C07D333/36 , C07D417/04 , C07D235/30 , C07D513/04 , C07D263/48 , C07D417/12 , C07D277/60
CPC分类号： C07D277/48 , C07D231/56 , C07D235/30 , C07D237/22 , C07D249/14 , C07D261/14 , C07D263/28 , C07D263/48 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D333/36 , C07D417/04 , C07D417/12 , C07D513/04
摘要： The present invention relates to guanidine compounds of the general formula I corresponding enantiomeric, diastereomeric and/or tautomeric forms thereof as well as pharmaceutically acceptable salts thereof. The present compound further relates to the use of guanidine compounds as binding partners for 5-HT5 receptors for the treatment of diseases which are modulated by a 5-HT5 receptor activity, in particular for the treatment of neurodegenerative and neuropsychiatric disorders as well as the associated signs, symptoms and dysfunctions.
摘要翻译： 相应的对映异构体，非对映异构体和/或互变异构形式以及其药学上可接受的盐。 本发明化合物还涉及胍化合物作为5-HT 5受体的结合伴侣的用途，用于治疗由5-HT 5受体活性调节的疾病，特别是用于治疗神经变性和神经精神障碍以及相关的 体征，症状和功能障碍。
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8.发明申请5-HALOGEN-SUBSTITUTED OXINDOLE DERIVATIVES AND USE THEREOF FOR TREATING VASOPRESSIN-DEPENDENT DISEASES 审中-公开5-取代的氧化衍生物及其用于治疗依赖性依赖性疾病的用途公开(公告)号：US20150158845A1
公开(公告)日：2015-06-11
申请号：US14554734
申请日：2014-11-26
发明人： Wilfried Braje , Thorsten Oost , Astrid Netz , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch
IPC分类号： C07D401/14
CPC分类号： C07D401/14
摘要： The present invention relates to novel 5-halogen-substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-dependent disorders.
摘要翻译： 本发明涉及新的5-卤素取代的羟基吲哚衍生物，包含它们的药物组合物及其用于治疗加压素依赖性病症的用途。
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9.发明申请HETEROARYL-SUBSTITUTED 1,3-DIHYDROINDOL-2-ONE DERIVATIVES AND MEDICAMENTS CONTAINING THEM 审中-公开异取代的1,3-二氢吲哚-2-酮衍生物和含有它们的药物公开(公告)号：US20170050959A1
公开(公告)日：2017-02-23
申请号：US15345204
申请日：2016-11-07
发明人： Wilfried Lubisch , Wilfried Hornberger , Thorsten K. Oost , Daryl Richard Sauer , Liliane Unger , Wolfgang Wernet , Hervé Geneste
IPC分类号： C07D417/14 , C07D403/14 , C07D401/04 , C07D413/14 , C07D409/04 , C07D401/14 , C07D405/14
CPC分类号： C07D417/14 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D513/04
摘要： The present invention relates to novel 1,3-dihydroindol-2-one (oxindole) derivatives of the formula (I) in whichA, R3, R4, R5, R6 and R7 are defined according to claim 1, and to medicaments containing them for the treatment of diseases. In particular, the novel oxindole derivaties can be used for the control and/or prophylaxis of various vasopressin-dependent or oxytocin-dependent diseases.
摘要翻译： A，R3，R4，R5，R6和R7如权利要求1所定义，以及含有它们用于治疗疾病的药物。 特别地，新羟吲哚衍生物可用于控制和/或预防各种加压素依赖性或催产素依赖性疾病。
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公开(公告)号：US09475782B2
公开(公告)日：2016-10-25
申请号：US13683296
申请日：2012-11-21
发明人： Astrid Netz , Wilhelm Amberg , Udo Lange , Michael Ochse , Charles W. Hutchins , Francisco-Xavier Garcia-Ladona , Wolfgang Wernet , Andreas Kling
IPC分类号： C07D277/48 , C07D277/82 , C07D333/36 , C07D263/48 , C07D277/60 , C07D235/30 , C07D513/04 , C07D417/12 , C07D417/04 , C07D231/56 , C07D237/22 , C07D249/14 , C07D261/14 , C07D263/28 , C07D285/08 , C07D285/135
CPC分类号： C07D277/48 , C07D231/56 , C07D235/30 , C07D237/22 , C07D249/14 , C07D261/14 , C07D263/28 , C07D263/48 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D333/36 , C07D417/04 , C07D417/12 , C07D513/04
摘要： The present invention relates to guanidine compounds of the general formula I corresponding enantiomeric, diastereomeric and/or tautomeric forms thereof as well as pharmaceutically acceptable salts thereof. The present compound further relates to the use of guanidine compounds as binding partners for 5-HT5 receptors for the treatment of diseases which are modulated by a 5-HT5 receptor activity, in particular for the treatment of neurodegenerative and neuropsychiatric disorders as well as the associated signs, symptoms and dysfunctions.
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