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公开(公告)号：US06372459B1
公开(公告)日：2002-04-16
申请号：US09624390
申请日：2000-07-27
IPC分类号： C12P1304
CPC分类号： C12P41/007 , C12N9/90
摘要： The present invention is directed to an N-acetyl amino acid racemase (AAR) as well as the gene coding for it, to a plasmid, vector and microroganism containing the gene. A method of producing enantiomer-enriched amino acids, and derivatives thereof, is also provided.
摘要翻译： 本发明涉及N-乙酰氨基酸消旋酶（AAR）以及编码它的基因，涉及含有该基因的质粒，载体和微团聚体。 还提供了产生对映体富集的氨基酸及其衍生物的方法。
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2.发明授权Acetyl amino acid racemase from amycolatopsis orientalis for racemizing carbamoyl amino acids 失效用于外消旋化氨基甲酰氨基酸的乙酰氨基酸消旋酶公开(公告)号：US06767725B2
公开(公告)日：2004-07-27
申请号：US09973712
申请日：2001-10-11
IPC分类号： C12P1304
CPC分类号： C12N9/90 , C12P41/009
摘要： The invention relates to the use of the N-acetyl amino acid racemase from Amycolatopsis orientalis subspecies lurida for the racemiszation of N-carbamoyl amino acids. This use permits the 100% preparation of optically pure amino acids starting from racemic hydantoins in an enzymatic overall process.
摘要翻译： 本发明涉及来自山莨菪属亚种的亚乙酰氨基酸消旋酶用于N-氨基甲酰氨基酸的外消旋化的用途。 这种使用允许在酶的总体方法中从外消旋乙内酰脲开始100％制备光学纯氨基酸。
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公开(公告)号：US06656710B2
公开(公告)日：2003-12-02
申请号：US09973765
申请日：2001-10-11
IPC分类号： C12P1304
CPC分类号： C12P41/007 , C12P13/04 , C12P13/12
摘要： The present invention relates to the processes of racemization and deprotection of special N-protected amino acids in the acylase/racemase system for the total conversion of special N-protected racemic amino acids into optically pure amino acids.
摘要翻译： 本发明涉及酰基转移酶/消旋酶体系中的特殊N-保护氨基酸的外消旋化和脱保护方法，用于将特殊N-保护的外消旋氨基酸总转化成光学纯氨基酸。
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公开(公告)号：US07378269B2
公开(公告)日：2008-05-27
申请号：US10651965
申请日：2003-09-02
IPC分类号： C12P41/00
CPC分类号： C12P41/007 , C12P13/04 , C12P13/12
摘要： The present invention relates to the processes of racemization and deprotection of special N-protected amino acids in the acylase/racemase system for the total conversion of special N-protected racemic amino acids into optically pure amino acids.
摘要翻译： 本发明涉及酰基转移酶/消旋酶体系中的特殊N-保护氨基酸的外消旋化和脱保护方法，用于将特殊N-保护的外消旋氨基酸总转化成光学纯氨基酸。
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公开(公告)号：US20070148742A1
公开(公告)日：2007-06-28
申请号：US10651965
申请日：2003-09-02
IPC分类号： C12P13/04
CPC分类号： C12P41/007 , C12P13/04 , C12P13/12
摘要： The present invention relates to the processes of racemization and deprotection of special N-protected amino acids in the acylase/racemase system for the total conversion of special N-protected racemic amino acids into optically pure amino acids.
摘要翻译： 本发明涉及酰基转移酶/消旋酶体系中的特殊N-保护氨基酸的外消旋化和脱保护方法，用于将特殊N-保护的外消旋氨基酸总转化成光学纯氨基酸。
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6.发明授权公开(公告)号：US07157251B2
公开(公告)日：2007-01-02
申请号：US10651938
申请日：2003-09-02
CPC分类号： C12P41/007 , C12P13/04 , C12P13/12
摘要： The present invention relates to the processes of racemization and deprotection of special N-protected amino acids in the acylase/racemase system for the total conversion of special N-protected racemic amino acids into optically pure amino acids.
摘要翻译： 本发明涉及酰基转移酶/消旋酶体系中的特殊N-保护氨基酸的外消旋化和脱保护方法，用于将特殊N-保护的外消旋氨基酸总转化成光学纯氨基酸。
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公开(公告)号：US07070963B2
公开(公告)日：2006-07-04
申请号：US10309294
申请日：2002-12-04
申请人： Stefan Verseck , Karlheinz Drauz , Andreas Bommarius , Maria-Regina Kula , Lutz Krieg , Heike Slusarczyk , Marion Ansorge-Schumacher
发明人： Stefan Verseck , Karlheinz Drauz , Andreas Bommarius , Maria-Regina Kula , Lutz Krieg , Heike Slusarczyk , Marion Ansorge-Schumacher
摘要： The present invention relates to an amidase enzyme, nucleic acids encoding the amidase, as well as methods of employing the nucleic acids and/or amidase to produce, for example, enantiomericallyenriched compounds such as D-amino acids.
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公开(公告)号：US20080171389A1
公开(公告)日：2008-07-17
申请号：US10593357
申请日：2005-03-10
申请人： Stefan Verseck , Klaus Liebeton , Jurgen Eck
发明人： Stefan Verseck , Klaus Liebeton , Jurgen Eck
CPC分类号： C12N9/88 , C12Y402/01084
摘要： The present invention is concerned with the preparation of novel nitrile hydratases. These latter are preferably obtained from nonculturable organisms by means of a PCR-based screening, in metagenome DNA libraries, using special degenerate primers.
摘要翻译： 本发明涉及新型腈水合酶的制备。 这些后者优选通过基于PCR的筛选从使用特殊简并引物的宏基因组DNA文库中获得来自非可培养生物体。
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公开(公告)号：US07491521B2
公开(公告)日：2009-02-17
申请号：US11892085
申请日：2007-08-20
申请人： Steffen Osswald , Stefan Verseck , Uta Deiting , Christoph Weckbecker , Klaus Huthmacher , Michael Binder , Maria-Regina Kula , Konrad Odendahl
发明人： Steffen Osswald , Stefan Verseck , Uta Deiting , Christoph Weckbecker , Klaus Huthmacher , Michael Binder , Maria-Regina Kula , Konrad Odendahl
摘要： The invention relates to a Rhodococcus polynucleotide cluster which contains nucleotide sequences which encode polypeptides having the activity of a nitrile hydratase, of an auxiliary protein P15K which activates this enzyme and of a cobalt transporter, to transformed microorganisms in which the nucleotide sequences encoding these proteins are present in increased quantity, and to the use of the transformed microorganisms for preparing amides from nitriles.
摘要翻译： 本发明涉及一种红球菌多核苷酸簇，其含有编码具有腈水合酶活性的多肽，辅酶P15K，其活化该酶和钴转运蛋白的核苷酸序列，转化微生物，其中编码这些蛋白质的核苷酸序列为 存在增加的量，以及使用转化的微生物从腈制备酰胺。
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公开(公告)号：US07288402B2
公开(公告)日：2007-10-30
申请号：US11083327
申请日：2005-03-18
申请人： Steffen Osswald , Stefan Verseck , Uta Deiting , Christoph Weckbecker , Klaus Huthmacher , Michael Binder , Maria-Regina Kula , Konrad Odendahl
发明人： Steffen Osswald , Stefan Verseck , Uta Deiting , Christoph Weckbecker , Klaus Huthmacher , Michael Binder , Maria-Regina Kula , Konrad Odendahl
摘要： The invention relates to a Rhodococcus polynucleotide cluster which contains nucleotide sequences which encode polypeptides having the activity of a nitrile hydratase, of an auxiliary protein P15K which activates this enzyme and of a cobalt transporter, to transformed microorganisms in which the nucleotide sequences encoding these proteins are present in increased quantity, and to the use of the transformed microorganisms for preparing amides from nitriles.
摘要翻译： 本发明涉及一种红球菌多核苷酸簇，其含有编码具有腈水合酶活性的多肽，辅酶P15K，其活化该酶和钴转运蛋白的核苷酸序列，转化微生物，其中编码这些蛋白质的核苷酸序列为 存在增加的量，以及使用转化的微生物从腈制备酰胺。
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