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    Structure modeled on a biological tissue and method for producing said structure
    1.
    发明授权
    Structure modeled on a biological tissue and method for producing said structure 有权
    以生物组织为模型的结构及其制造方法

    公开(公告)号：US09375305B2

    公开(公告)日：2016-06-28

    申请号：US13877721

    申请日：2011-09-30

    申请人： Andreas Schober ,  Michael Gebinoga ,  Uta Fernekorn ,  Frank Weise ,  Jörg Hampl ,  Julia Katzmann ,  Thomas Klar

    发明人： Andreas Schober ,  Michael Gebinoga ,  Uta Fernekorn ,  Frank Weise ,  Jörg Hampl ,  Julia Katzmann ,  Thomas Klar

    IPC分类号： G01N33/48 ,  G01N33/50 ,  A61F2/02 ,  G05B19/4099 ,  G06F19/24 ,  G06F19/12

    CPC分类号： A61F2/02 ,  G05B19/4099 ,  G05B2219/49019 ,  G05B2219/49031 ,  G06F19/12 ,  G06F19/24

    摘要： The present invention relates to a method for producing a structure modeled on a biological tissue. The invention also relates to a structure which can be produced using the method according to the invention. According to an embodiment of the invention, a precursor of a biopolymer is locally irradiated with electromagnetic radiation in a targeted manner, wherein the irradiation, in particular the selection of the areas to be irradiated, is effected according to data which describe a structural construction at least components of the extracellular matrix of the biological tissue. In this case, the electromagnetic radiation is such that two-photon or multi-photon absorption takes place in the irradiated areas of the precursor and results in the precursor being polymerized to form the biopolymer in the irradiated areas, with the result being that the precursor is at least partially solidified there.

    摘要翻译： 本发明涉及一种用于生产以生物组织为模型的结构的方法。 本发明还涉及可以使用根据本发明的方法制造的结构。 根据本发明的一个实施方案，生物聚合物的前体以目标方式用电磁辐射局部照射，其中照射，特别是对待照射区域的选择，是根据描述在 生物组织的细胞外基质的最少组分。 在这种情况下，电磁辐射使得在前体的照射区域中发生双光子或多光子吸收，并导致前体聚合以在照射区域中形成生物聚合物，结果是前体 在那里至少部分固化。

    STRUCTURE MODELED ON A BIOLOGICAL TISSUE AND METHOD FOR PRODUCING SAID STRUCTURE
    2.
    发明申请
    STRUCTURE MODELED ON A BIOLOGICAL TISSUE AND METHOD FOR PRODUCING SAID STRUCTURE 有权
    生物组织建模结构和生产结构的方法

    公开(公告)号：US20130197668A1

    公开(公告)日：2013-08-01

    申请号：US13877721

    申请日：2011-09-30

    申请人： Andreas Schober ,  Michael Gebinoga ,  Uta Fernekorn ,  Frank Weise ,  Jörg Hampl ,  Julia Katzmann ,  Thomas Klar

    发明人： Andreas Schober ,  Michael Gebinoga ,  Uta Fernekorn ,  Frank Weise ,  Jörg Hampl ,  Julia Katzmann ,  Thomas Klar

    IPC分类号： A61F2/02

    CPC分类号： A61F2/02 ,  G05B19/4099 ,  G05B2219/49019 ,  G05B2219/49031 ,  G06F19/12 ,  G06F19/24

    摘要： The present invention relates to a method for producing a structure modeled on a biological tissue. The invention also relates to a structure which can be produced using the method according to the invention. According to an embodiment of the invention, a precursor of a biopolymer is locally irradiated with electromagnetic radiation in a targeted manner, wherein the irradiation, in particular the selection of the areas to be irradiated, is effected according to data which describe a structural construction at least components of the extracellular matrix of the biological tissue. In this case, the electromagnetic radiation is such that two-photon or multi-photon absorption takes place in the irradiated areas of the precursor and results in the precursor being polymerized to form the biopolymer in the irradiated areas, with the result being that the precursor is at least partially solidified there.

    摘要翻译： 本发明涉及一种用于生产以生物组织为模型的结构的方法。 本发明还涉及可以使用根据本发明的方法制造的结构。 根据本发明的一个实施方案，生物聚合物的前体以目标方式用电磁辐射局部照射，其中照射，特别是对待照射区域的选择，是根据描述在 生物组织的细胞外基质的最少组分。 在这种情况下，电磁辐射使得在前体的照射区域中发生双光子或多光子吸收，并导致前体聚合以在照射区域中形成生物聚合物，结果是前体 在那里至少部分固化。

    Method for producing a support carrying immobilized viruses, and the use of such a support
    5.
    发明申请
    Method for producing a support carrying immobilized viruses, and the use of such a support 审中-公开
    用于制备携带固定化病毒的载体的方法，以及使用这种载体

    公开(公告)号：US20060063260A1

    公开(公告)日：2006-03-23

    申请号：US11219122

    申请日：2005-09-02

    申请人： Hansjuergen Volkmer ,  Frank Weise ,  Thomas Joos

    发明人： Hansjuergen Volkmer ,  Frank Weise ,  Thomas Joos

    IPC分类号： C12N15/86 ,  C12N15/74

    CPC分类号： G01N33/54386 ,  B01J19/0046 ,  B01J2219/00533 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00725 ,  B01J2219/0074 ,  G01N33/566 ,  G01N33/56911 ,  G01N33/56966 ,  G01N2333/005

    摘要： A method for producing a support possessing a functionalized surface which is suitable for immobilizing viruses and carrying viruses which are immobilized on the functionalized surface and which are preferably infectious, as well as the use of such supports, are described. In this connection, a support material is initially provided and at least one surface of the support material is then coated, preferably with a nitrocellulose material, in order to form the functionalized surface. In a following step, a solution which contains viruses, which are preferably infectious, is applied to the functionalized surface, after which the viruses are subsequently enabled to adhere to the functionalized surface over a period of from preferably 10 minutes to 36 hours. After that, the surface is, where appropriate, covered with a fluid.

    摘要翻译： 描述了一种制备具有功能化表面的支持物的方法，该功能化表面适用于固定在功能化表面上并且优选感染的病毒和携带病毒，以及使用这种载体。 在这方面，首先提供支撑材料，然后涂覆支撑材料的至少一个表面，优选用硝酸纤维素材料涂覆以形成官能化表面。 在随后的步骤中，将含有优选感染性病毒的溶液施用于官能化表面，之后随后使病毒能够在优选10分钟至36小时的时间内粘附到官能化表面。 之后，在适当的情况下，表面被流体覆盖。