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公开(公告)号：US20110150943A1
公开(公告)日：2011-06-23
申请号：US13037850
申请日：2011-03-01
申请人： Andreas Werner Speitling , Philip Procter , Joachim Schomburg , Christian Schultz , Wolf-Dieter Jülich , Ulrike Lindequist , Frieder Schauer , Annett Mikolasch , Katrin Manda
发明人： Andreas Werner Speitling , Philip Procter , Joachim Schomburg , Christian Schultz , Wolf-Dieter Jülich , Ulrike Lindequist , Frieder Schauer , Annett Mikolasch , Katrin Manda
IPC分类号： A61K33/06 , A61K35/74 , A61K38/44 , A61K36/05 , A61K9/00 , A61P17/02 , A61K31/785 , A61P31/04
CPC分类号： C09J175/04 , A61L24/043 , C08G18/10 , C08G18/428 , C08G18/6446 , C08L89/00 , C09J189/00 , Y10T428/2982 , C08L67/04 , C08G18/64
摘要： The invention relates to adhesives for medical applications and methods of their preparation and use.
摘要翻译： 本发明涉及用于医疗应用的粘合剂及其制备和使用方法。
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公开(公告)号：US07923003B2
公开(公告)日：2011-04-12
申请号：US12223772
申请日：2007-02-09
申请人： Andreas Werner Speitling , Philip Procter , Joachim Schomburg , Christian Schultz , Wolf Dieter Jülich , Ulrike Lindequist , Frieder Schauer , Annett Mikolasch , Katrin Manda
发明人： Andreas Werner Speitling , Philip Procter , Joachim Schomburg , Christian Schultz , Wolf Dieter Jülich , Ulrike Lindequist , Frieder Schauer , Annett Mikolasch , Katrin Manda
IPC分类号： A61K31/74 , A01N1/00 , C09J189/00 , A61F15/00
CPC分类号： C09J175/04 , A61L24/043 , C08G18/10 , C08G18/428 , C08G18/6446 , C08L89/00 , C09J189/00 , Y10T428/2982 , C08L67/04 , C08G18/64
摘要： The invention relates to a kit comprising the following individual components: (a) polymers comprising at least one free amino group, (b) bridge molecules selected from the group consisting of monocyclic ortho-dihydroxyaromates, mono-cyclic para-dihydroxyaromates, bicyclic monohydrxyaromates, polycyclic monohydroxyaromates, bicyclic dihydroxyaromates, polycyclic dihydroxyaromates, bicyclic trihydroxyaromates, polycyclic trihydroxyaromates, and mixtures thereof, and (c) polyphenoloxidases, in particular, lignolytic polyphenoloxidases, whereby the individual components b) and c) are not in contact.
摘要翻译： 本发明涉及包含以下单独组分的试剂盒：（a）包含至少一个游离氨基的聚合物，（b）选自单环邻二羟基溴酸盐，单环对二羟基溴酸盐，双环单羟基溴化物， 多环一羟基溴化物，双环二羟基溴酸盐，多环二羟基溴化物，双环三羟基溴化物，多环三羟基溴化物及其混合物，和（c）多酚氧化酶，特别是木素分解多酚氧化酶，其中各成分b）和c）不接触。
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公开(公告)号：US20090318584A1
公开(公告)日：2009-12-24
申请号：US12223772
申请日：2007-02-09
申请人： Andreas Werner Speitling , Philip Procter , Joachim Schomburg , Christian Schultz , Wolf-Dieter Jülich , Ulrike Lindequist , Frieder Schauer , Annett Mikolasch , Katrin Manda
发明人： Andreas Werner Speitling , Philip Procter , Joachim Schomburg , Christian Schultz , Wolf-Dieter Jülich , Ulrike Lindequist , Frieder Schauer , Annett Mikolasch , Katrin Manda
CPC分类号： C09J175/04 , A61L24/043 , C08G18/10 , C08G18/428 , C08G18/6446 , C08L89/00 , C09J189/00 , Y10T428/2982 , C08L67/04 , C08G18/64
摘要： The invention relates to a kit comprising the following individual components: (a) polymers comprising at least one free amino group, (b) bridge molecules selected from the group consisting of monocyclic ortho-dihydroxyaromates, mono-cyclic para-dihydroxyaromates, bicyclic monohydrxyaromates, polycyclic monohydroxyaromates, bicyclic dihydroxyaromates, polycyclic dihydroxyaromates, bicyclic trihydroxyaromates, polycyclic trihydroxyaromates, and mixtures thereof, and (c) polyphenoloxidases, in particular, lignolytic polyphenoloxidases, whereby the individual components b) and c) are not in contact.
摘要翻译： 本发明涉及包含以下单独组分的试剂盒：（a）包含至少一个游离氨基的聚合物，（b）选自单环邻二羟基溴酸盐，单环对二羟基溴酸盐，双环单羟基溴化物， 多环一羟基溴化物，双环二羟基溴酸盐，多环二羟基溴化物，双环三羟基溴化物，多环三羟基溴化物及其混合物，和（c）多酚氧化酶，特别是木素分解多酚氧化酶，其中各成分b）和c）不接触。
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公开(公告)号：US08440209B2
公开(公告)日：2013-05-14
申请号：US13037850
申请日：2011-03-01
申请人： Andreas Speitling , Philip Procter , Joachim Schomburg , Christian Schultz , Wolf-Dieter Jülich , Ulrike Lindequist , Frieder Schauer , Annett Mikolasch , Katrin Manda
发明人： Andreas Speitling , Philip Procter , Joachim Schomburg , Christian Schultz , Wolf-Dieter Jülich , Ulrike Lindequist , Frieder Schauer , Annett Mikolasch , Katrin Manda
CPC分类号： C09J175/04 , A61L24/043 , C08G18/10 , C08G18/428 , C08G18/6446 , C08L89/00 , C09J189/00 , Y10T428/2982 , C08L67/04 , C08G18/64
摘要： The invention relates to adhesives for medical applications and methods of their preparation and use.
摘要翻译： 本发明涉及用于医疗应用的粘合剂及其制备和使用方法。
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5.发明申请SYNTHETIC BONE SUBSTITUTE, METHOD FOR PREPARING SAME AND METHOD FOR FILING A CAVITY IN A SUBSTRATE 审中-公开合成骨替代物，其制备方法和在基质中填充空穴的方法公开(公告)号：US20100305714A1
公开(公告)日：2010-12-02
申请号：US12682804
申请日：2007-10-19
申请人： Philip Procter
发明人： Philip Procter
IPC分类号： A61F2/28
CPC分类号： A61L27/58 , A61L27/46 , A61L27/56 , A61L2430/02 , C08L67/04
摘要： A synthetic bone substitute has a porous foam structure comprising a bio-resorbable polymer and a bio-ceramic filler material. A plasticizer is used for softening the porous foam structure such that the synthetic bone substitute may be compressed by an external force. Due to its elasticity, the synthetic bone substitute may restore its original form after releasing the external force. Furthermore, due to dissipation of the plasticizer, the porous foam structure can attain substantial rigidity thereby functioning as lightweight, stable bone substitute. Such a compressible bone substitute can be compressed, then inserted through a small opening hole to a cavity and once in a cavity restore its original volume and rigidity.
摘要翻译： 合成骨替代物具有包含生物可吸收聚合物和生物陶瓷填充材料的多孔泡沫结构。 使用增塑剂来软化多孔泡沫结构，使得合成骨替代物可能被外力压缩。 由于其弹性，合成骨替代物在释放外力后可恢复其原始形态。 此外，由于增塑剂的耗散，多孔泡沫结构可以获得显着的刚性，从而起到轻质稳定的骨替代物的作用。 这种可压缩的骨替代物可以被压缩，然后通过小的开孔插入到空腔中，并且一旦在空腔中恢复其原始体积和刚度。
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公开(公告)号：US5527311A
公开(公告)日：1996-06-18
申请号：US282700
申请日：1994-07-29
申请人： Philip Procter , Hans E. Harder , Nicola Bird
发明人： Philip Procter , Hans E. Harder , Nicola Bird
CPC分类号： A61B17/8085 , A61B17/7059 , A61B17/8014
摘要： The invention is an elongated plate made of deformable, body-compatible material, which is to be anteriorly attached to at least a pair of adjacent vertebrae. The plate has specially placed holes to receive bone screws to be screwed into the vertebrae.
摘要翻译： 本发明是一种由可变形的身体兼容材料制成的细长板，该材料将前端附接至至少一对相邻的椎骨。 该板已特别放置孔，以接收螺钉拧入椎骨。
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7.发明申请METHOD OF DELIVERING A BIPHOSPHONATE AND/OR STRONTIUM RANELATE BELOW THE SURFACE OF A BONE 有权在骨骼表面递送磷酸氢盐和/或锶酸盐的方法公开(公告)号：US20110172632A1
公开(公告)日：2011-07-14
申请号：US12975639
申请日：2010-12-22
申请人： Philip Procter , Anders Jönsson , Jörg Arnoldi
发明人： Philip Procter , Anders Jönsson , Jörg Arnoldi
IPC分类号： A61M5/00
CPC分类号： A61L24/0042 , A61B17/86 , A61B2017/922 , A61L24/02 , A61L2400/06 , A61L2400/16 , A61L2430/02
摘要： A method for delivering a bisphosphonate and/or strontium ranelate below the surface of a bone using a mechanical force. The method includes the steps of combining a bisphosphonate and/or strontium ranelate with a carrier to form a delivery composition and delivering an effective amount of the delivery composition below the surface of the bone with a mechanical force. Also provided is a method for strengthening a portion of a bone. This method includes the step of delivering an effective amount of a bisphosphonate and/or strontium ranelate below the surface of a portion of a bone with a mechanical force.
摘要翻译： 使用机械力在骨表面下方递送二膦酸盐和/或雷奈酸锶的方法。 该方法包括以下步骤：将二膦酸盐和/或雷奈酸锶与载体组合以形成递送组合物并用机械力将有效量的递送组合物递送到骨表面下方。 还提供了一种用于加强骨的一部分的方法。 该方法包括用机械力在骨的一部分表面下方输送有效量的二膦酸盐和/或雷奈酸锶的步骤。
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8.发明授权Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone 有权在骨表面下方递送二膦酸盐和/或雷奈酸锶的方法公开(公告)号：US08882740B2
公开(公告)日：2014-11-11
申请号：US12975639
申请日：2010-12-22
申请人： Philip Procter , Anders Jönsson , Jörg Arnoldi
发明人： Philip Procter , Anders Jönsson , Jörg Arnoldi
CPC分类号： A61L24/0042 , A61B17/86 , A61B2017/922 , A61L24/02 , A61L2400/06 , A61L2400/16 , A61L2430/02
摘要： A method for delivering a bisphosphonate and/or strontium ranelate below the surface of a bone using a mechanical force. The method includes the steps of combining a bisphosphonate and/or strontium ranelate with a carrier to form a delivery composition and delivering an effective amount of the delivery composition below the surface of the bone with a mechanical force. Also provided is a method for strengthening a portion of a bone. This method includes the step of delivering an effective amount of a bisphosphonate and/or strontium ranelate below the surface of a portion of a bone with a mechanical force.
摘要翻译： 使用机械力在骨表面下方递送二膦酸盐和/或雷奈酸锶的方法。 该方法包括以下步骤：将二膦酸盐和/或雷奈酸锶与载体组合以形成递送组合物并用机械力将有效量的递送组合物递送到骨表面下方。 还提供了一种用于加强骨的一部分的方法。 该方法包括用机械力在骨的一部分表面下方输送有效量的二膦酸盐和/或雷奈酸锶的步骤。
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公开(公告)号：US08814920B2
公开(公告)日：2014-08-26
申请号：US12532549
申请日：2008-03-19
申请人： Philip Procter
发明人： Philip Procter
CPC分类号： A61L27/502 , A61B17/80 , A61B17/8625 , A61B17/866 , A61B2017/00004 , A61L27/48 , A61L27/58 , A61L31/129 , A61L31/141 , A61L31/148 , A61L2430/02
摘要： An implantation device for fixating a bone has a main body. The main body has a peripheral region and comprises a polymeric material. The peripheral region comprises the polymeric material and a plasticizer. In particular, the peripheral region may be adapted to be fixed to a bone. A method for producing the implantation device includes the steps of forming an implantation device using polymer material, and dipping at least a portion of the implantation device into a plasticizer in such a way that a peripheral region of the implantation device is plasticized.
摘要翻译： 用于固定骨的植入装置具有主体。 主体具有周边区域并且包括聚合材料。 外围区域包括聚合物材料和增塑剂。 特别地，周边区域可以适于固定在骨骼上。 一种用于制造植入装置的方法包括以下步骤：使用聚合物材料形成植入装置，并将植入装置的至少一部分浸入增塑剂中，使得植入装置的周边区域被塑化。
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公开(公告)号：US20100036441A1
公开(公告)日：2010-02-11
申请号：US12532549
申请日：2008-03-19
申请人： Philip Procter
发明人： Philip Procter
IPC分类号： A61B17/86
CPC分类号： A61L27/502 , A61B17/80 , A61B17/8625 , A61B17/866 , A61B2017/00004 , A61L27/48 , A61L27/58 , A61L31/129 , A61L31/141 , A61L31/148 , A61L2430/02
摘要： An implantation device for fixating a bone has a main body. The main body has a peripheral region and comprises a polymeric material. The peripheral region comprises the polymeric material and a plasticizer. In particular, the peripheral region may be adapted to be fixed to a bone. A method for producing the implantation device includes the steps of forming an implantation device using polymer material, and dipping at least a portion of the implantation device into a plasticizer in such a way that a peripheral region of the implantation device is plasticized.
摘要翻译： 用于固定骨的植入装置具有主体。 主体具有周边区域并且包括聚合材料。 外围区域包括聚合物材料和增塑剂。 特别地，周边区域可以适于固定在骨骼上。 一种用于制造植入装置的方法包括以下步骤：使用聚合物材料形成植入装置，并将植入装置的至少一部分浸入增塑剂中，使得植入装置的周边区域被塑化。
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