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38 条记录 (耗时 0.023 秒)

    Compounds
    4.
    发明授权
    Compounds 失效
    化合物

    公开(公告)号：US06518286B1

    公开(公告)日：2003-02-11

    申请号：US09555565

    申请日：2000-06-01

    申请人： Andrew Baxter ,  Stephen Brough ,  Nicholas Kindon ,  Thomas McInally ,  Bryan Roberts ,  Stephen Thom

    发明人： Andrew Baxter ,  Stephen Brough ,  Nicholas Kindon ,  Thomas McInally ,  Bryan Roberts ,  Stephen Thom

    IPC分类号： C07D40112

    CPC分类号： C07D401/12 ,  C07D211/32 ,  C07D211/46 ,  C07D211/58 ,  C07D217/14 ,  C07D295/192 ,  C07D401/14 ,  C07D405/04 ,  C07D409/04 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D473/34 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04

    摘要： The invention provides compounds of general formula (I) wherein: R1 represents optionally substituted, C1-C12 alkyl or optionally substituted 3- to 10-membered saturated or unsaturated ring system comprising up to two ring carbon atoms that form carbonyl groups and comprising up to 4 ring heteroatoms independently selected from nitrogen, oxygen and sulfur; m is 0-1; Q represents OCH2, C1-C4 alkylene or C2-C4 alkenylene; T represents C(O)NH, or when m is 0, T may additionally represent a bond or NH, or when m is 1 and Q represents C1-C4 alkylene, T may additionally represent NH; n is 1-4; each R2 and R3 independently represents H or C1-C4 alkyl; V represents N, and W represents N or CH; X represents O, C(O), CH(OH), SO2, NH or N(C1-C6 alkyl), provided that when W represents N, then X represents either C(O) or SO2 and when W represents CH, then X is other than SO2; R4 represents optionally substituted phenyl; R5 and R6 each independently represent H, C1-C6 alkyl or hydroxyC1-C6 alkyl, or R5 and R6 together with the nitrogen atom to which they are attached form a 4- to 7-membered saturated heterocyclic ring; R7 and R8 each independently represent H or C1-C6 alkyl; and R9 represents OH or —NR7R8; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

    摘要翻译： 本发明提供了通式（I）的化合物，其中：R 1表示任选取代的C 1 -C 12烷基或任选取代的3至10元饱和或不饱和环体系，其包含至多两个形成羰基的环碳原子， 独立地选自氮，氧和硫的4个环杂原子; m为0-1; Q表示OCH 2，C 1 -C 4亚烷基或C 2 -C 4亚烯基; T表示C（O）NH，或当m为0时，T可另外表示键或NH，或当m为1且Q表示C1-C4亚烷基时，T可另外表示NH; n为1-4; 每个R 2和R 3独立地表示H或C 1 -C 4烷基; V表示N，W表示N或CH; X表示O，C（O），CH（OH），SO 2，NH或N（C 1 -C 6烷基），条件是当W表示N时，X表示C（O）或SO 2，当W表示CH时， X不是SO2; R 4表示任选取代的苯基; R 5和R 6各自独立地表示H，C 1 -C 6烷基或羟基C 1 -C 6烷基，或者R 5和R 6与它们所连接的氮原子一起形成4-至7-元饱和杂环; R 7和R 8各自独立地表示H或C 1 -C 6烷基; 并且R 9表示OH或-NR 7 R 8; 其制备方法，含有它们的药物组合物及其在治疗中的用途。

    9-substituted 8-oxoadenine compound
    10.
    发明授权
    9-substituted 8-oxoadenine compound 有权
    9-取代的8-氧代腺嘌呤化合物

    公开(公告)号：US08012964B2

    公开(公告)日：2011-09-06

    申请号：US10593691

    申请日：2005-03-24

    申请人： Ayumu Kurimoto ,  Yoshiaki Isobe ,  Stephen Brough ,  Hiroki Wada ,  Roger Bonnert ,  Thomas McInally

    发明人： Ayumu Kurimoto ,  Yoshiaki Isobe ,  Stephen Brough ,  Hiroki Wada ,  Roger Bonnert ,  Thomas McInally

    IPC分类号： C07D473/18 ,  A61K31/522 ,  A61P37/06 ,  A61P37/08 ,  A61P11/06

    CPC分类号： C07D473/18 ,  A61K31/522 ,  A61K31/5377

    摘要： The present invention provides an 8-oxoadenine compound having immunemodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group] or its pharmaceutically acceptable salt.

    摘要翻译： 本发明提供具有免疫调节活性的8-氧代腺嘌呤化合物，例如干扰素诱导活性，可用作抗病毒剂和抗变应性剂，其由下式（1）表示：[其中环A表示6-10元 芳香族碳环等，R表示卤素原子，烷基等，n表示0-2的整数，Z1表示亚烷基，X2表示氧原子，硫原子，SO2，NR5，CO，CONR5，NR5CO 等等，Y1，Y2和Y3独立地表示单键或亚烷基，X1表示氧原子，硫原子，NR4（R4是氢原子或烷基）或单键，R2表示取代或未取代的烷基 基团，R 1表示氢原子，羟基，烷氧基，烷氧基羰基或卤代烷基]或其​​药学上可接受的盐。