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公开(公告)号：US20080319184A1
公开(公告)日：2008-12-25
申请号：US11883661
申请日：2006-02-01
IPC分类号： C07H21/02
CPC分类号： A61K31/7084 , C07H21/00 , C07H21/02 , C07H21/04
摘要： The present invention provides the use of analogues and derivatives of dinucleoside polyphosphates with formula (I) or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in one or more of: the treatment of ischemia, inducing ischemic tolerance, modulating cerebral ischemia, to delay the onset of a hypoxic depolarisation stage when ischemic events are initiated; as a neurological protection agent; as a tissue protection agent; the treatment of pain; and the treatment of inflammation, wherein X, is selected from wherein X1 and X2 are independently selected from H, Cl, Br and F; each Y is independently selected from S and O; each Z is independently selected from —CX3X4—,—NH—,—O—; wherein X3 and X4 are selected from H, Cl, Br and F; B1 and B2 are independently selected from adenine, guanine, xanthine, thymine, uracil, cytosine and inosine; S1 and S2 are independently selected from ribose, open chain ribose, 2′-deoxyribose, 3′deoxyribose and arabinofuranoside. V is selected from 0, 1, 2, 3, 4 and 5; W is selected from 0, 1, 2, 3, 4 and 5; and V plus W is an integer from 2 to 6.
摘要翻译： 本发明提供了式（I）的二核苷多聚磷酸酯类似物和衍生物或其药学上可接受的盐在制备用于以下一种或多种中的一种或多种药物中的用途：治疗缺血，诱导缺血耐受，调节脑 缺血，当缺血事件发生时延迟缺氧去极化阶段的发作; 作为神经保护剂; 作为组织保护剂; 治疗疼痛; 和炎症的治疗，其中X选自其中X 1和X 2独立地选自H，Cl，Br和F; 每个Y独立地选自S和O; 每个Z独立地选自-CX 3 X 4 - ， - NH - ， - O-; 其中X3和X4选自H，Cl，Br和F; B1和B2独立地选自腺嘌呤，鸟嘌呤，黄嘌呤，胸腺嘧啶，尿嘧啶，胞嘧啶和肌苷; S1和S2独立地选自核糖，开链核糖，2'-脱氧核糖，3'-脱氧核糖和阿拉伯呋喃糖苷。 V选自0，1，2，3，4和5; W选自0，1，2，3，4和5; V加W为2〜6的整数。
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公开(公告)号：US20080063701A1
公开(公告)日：2008-03-13
申请号：US11172641
申请日：2005-07-01
IPC分类号： A61K31/7105 , A61K9/127 , A61P43/00 , C12N5/06
CPC分类号： A61K9/1272 , A61K48/00 , A61K48/0091 , A61K2121/00 , C12N15/88 , Y10T428/2984
摘要： The present invention relates to a non-viral delivery vector comprising a liposome, wherein one or more lipids of the liposome are coupled, reversibly or irreversibly, to one or more polymers, and wherein the liposome comprises siRNA.
摘要翻译： 本发明涉及包含脂质体的非病毒递送载体，其中所述脂质体的一种或多种脂质可逆地或不可逆地与一种或多种聚合物偶联，并且其中所述脂质体包含siRNA。
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公开(公告)号：US20130129636A1
公开(公告)日：2013-05-23
申请号：US13511126
申请日：2010-11-19
申请人： Nazila Kamaly , Tammy Louise Kalber , Gavin David Kenny , Maya Thanou , Andrew David Miller , Jimmy Bell
发明人： Nazila Kamaly , Tammy Louise Kalber , Gavin David Kenny , Maya Thanou , Andrew David Miller , Jimmy Bell
IPC分类号： A61K49/18
CPC分类号： A61K49/1812 , B82Y5/00 , Y10S977/773
摘要： The present invention provides novel liposomes comprising Gd.DOTA.DSA (gadolinium(III)2-{4,7-bis-carboxymethyl-10-[(N,N-distearylamidomethyl-N′-amido-methyl]-1,4,7,10-tetra-azacyclododec-1-yl}-acetic acid), characterised in that said liposome further comprises a neutral, fully saturated phospholipid component (e.g. DSPC (1,2-distearoyl-sn-glycero-3-phosphocholine]), which are of particular use in the preparation of magnetic resonance contrast agents for enhancing a magnetic resonance image of tumours in a mammal.
摘要翻译： 本发明提供了包含Gd.DOTA.DSA（钆（III）2- {4,7-双 - 羧甲基-10 - [（N，N-二硬脂酰氨基甲基-N'-酰氨基 - 甲基] 7,10-四氮杂环十二烷-1-基} - 乙酸），其特征在于所述脂质体还包含中性完全饱和的磷脂组分（例如DSPC（1,2-二硬脂酰-sn-甘油-3-磷酸胆碱）） ，其特别用于制备用于增强哺乳动物肿瘤的磁共振图像的磁共振造影剂。
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公开(公告)号：US08468054B1
公开(公告)日：2013-06-18
申请号：US12861273
申请日：2010-08-23
CPC分类号： G06Q10/00 , H04M2203/1058
摘要： Identification technology, in which a request related to generating conveyable information for a particular vendor is received based on user input provided by a particular user and mappings stored in a database are searched using an identifier associated with the particular vendor. At least one rule useful in generating conveyable information for the particular vendor is determined based on results of the searching and identification information for a type of conveyable information requested by the particular user is determined. Conveyable information is generated by applying the determined at least one rule to the determined identification information. A mobile device outputs the generated conveyable information to enable identification of the type of conveyable information requested by the particular user to a system of the particular vendor through the output of the mobile device.
摘要翻译： 识别技术，其中基于由特定用户提供的用户输入接收与特定供应商相关的生成可传送信息的请求，并使用与特定供应商相关联的标识符来搜索存储在数据库中的映射。 基于针对特定用户请求的可传送信息的类型的搜索和识别信息的结果来确定用于为特定供应商生成可传送信息的至少一个规则。 通过将确定的至少一个规则应用于所确定的识别信息来生成可传送信息。 移动设备输出所生成的可传送信息，以通过移动设备的输出来识别由特定用户请求的可传送信息的类型到特定供应商的系统。
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公开(公告)号：US08178713B2
公开(公告)日：2012-05-15
申请号：US10518427
申请日：2003-06-16
CPC分类号： C07C329/06 , A61K9/1272 , C07C323/52 , C07F9/10
摘要： The present invention provides a lipid compound comprising at least one non-polar moiety and a polar moiety, wherein each or at least one non-polar moiety is of the formula X—Y—Z—, wherein X is a hydrocarbyl chain, Y is selected from at least one of S, Se, SO2, SO, and O, and Z is an optional hydrocarbyl group, wherein the polar moiety is of the formula —[C(O)]mPHG, wherein PHG is a polar head group, and wherein m is the number of non-polar moieties.
摘要翻译： 本发明提供了包含至少一个非极性部分和极性部分的脂质化合物，其中每个或至少一个非极性部分具有式X-Y-Z-，其中X是烃基链，Y是 选自S，Se，SO 2，SO和O中的至少一个，Z是任选的烃基，其中极性部分具有式 - [C（O）] m PHG，其中PHG是极性头基， 并且其中m是非极性部分的数目。
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公开(公告)号：US20100297023A1
公开(公告)日：2010-11-25
申请号：US12520261
申请日：2007-12-21
申请人： Andrew David Miller , Patrick Arbuthnot , Michael Jorgensen , Michael Keller , Nazila Kamaly , Abderrahim Aissaoui , Maya Thanou
发明人： Andrew David Miller , Patrick Arbuthnot , Michael Jorgensen , Michael Keller , Nazila Kamaly , Abderrahim Aissaoui , Maya Thanou
IPC分类号： A61K47/18 , C07C237/22 , A61K31/713 , A61K48/00 , A61K49/10 , C12N5/02
CPC分类号： C07C237/22 , A01K2267/0337 , A61K9/1272 , A61K47/34 , A61K47/543 , A61K47/6907 , A61K47/6911 , A61K48/0025 , C12N15/111 , C12N15/88 , C12N2310/14 , C12N2320/32 , C12N2730/10111 , Y10T428/2984
摘要： The present invention provides a lipid of the formula (I) R3R4N—[Y]q—(CpH2p)—X-Linker-NR1R2 (I) wherein R3 and R4 are independently selected from H and hydrocarbyl groups; q is an integer selected from 1 to 10; Y represents a group (CnH2n)NR5, wherein (i) when q is 1, n is 2, or (ii) when q is greater than 1, each Y may be the same or different and each n is an integer independently selected from 1 to 10, with the proviso that for at least one unit Y, n is 2, and (iii) each R5 is independently selected from H and hydrocarbyl groups; p is an integer selected from 1 to 10; X is an optional group selected from —NR7—, —C(═O)—NR8—, —NR9—C(═O)—, —C(═O)—, —O—, and NR10—C(=0)0-, wherein each R7, R8, R9 and R10 is independently selected from H and hydrocarbyl groups, Linker is an optional group selected from amino acid residues, peptide residues and groups of the formula —(OCH2CH2)1-10, —NR6-(CvH2v)—C(═O)—, wherein R6 is H or a hydrocarbyl group and v is an integer selected from 1 to 11, and —C(=0)-(CH2)0-10—CH2—C(=0)-; R1 is selected from acyclic groups having from 4 to 30 carbon atoms; and R2 is selected from H and acyclic groups having from 4 to 30 carbon atoms. Said lipids can be used in a delivery vehicle (e.g. micelle or liposome) for the delivery of one or more (therapeutic or diagnostic) agents.
摘要翻译： 本发明提供式（I）R3R4N- [Y] q-（CpH2p）-X-连接子-NR1R2（I）的脂质，其中R3和R4独立地选自H和烃基; q是选自1至10的整数; Y表示基团（C n H 2n）NR 5，其中（i）当q为1时，n为2，或（ii）当q大于1时，每个Y可以相同或不同，并且每个n是独立地选自 1至10，条件是对于至少一个单元Y，n为2，和（iii）每个R 5独立地选自H和烃基; p是选自1至10的整数; X是选自-NR 7 - ， - C（= O）-NR 8 - ， - NR 9 -C（= O） - ， - C（= O） - ， - O-和NR 10 -C（= O ）0-，其中每个R 7，R 8，R 9和R 10独立地选自H和烃基，连接子是选自氨基酸残基，肽残基和式 - （OCH 2 CH 2）1-10，-NR 6 - （CvH2v）-C（= O） - ，其中R6是H或烃基，v是选自1至11的整数，和-C（= O） - （CH 2）0-10-CH 2 -C = 0） - ; R1选自具有4至30个碳原子的无环基团; 并且R 2选自H和具有4至30个碳原子的无环基。 所述脂质可用于递送载体（例如胶束或脂质体）中以递送一种或多种（治疗或诊断）试剂。
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