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    Compound
    2.
    发明申请
    Compound 审中-公开
    复合

    公开(公告)号：US20050287202A1

    公开(公告)日：2005-12-29

    申请号：US11159938

    申请日：2005-06-23

    申请人： Andrew Miller ,  Michael Keller ,  Michael Jorgensen ,  Eric Perouzel

    发明人： Andrew Miller ,  Michael Keller ,  Michael Jorgensen ,  Eric Perouzel

    IPC分类号： A61K9/127 ,  A61K47/48 ,  A61K48/00

    CPC分类号： A61K47/644

    摘要： The present invention provides a process for preparing a modified lipid of the formula comprising reacting (I) a compound of the formula; and (ii) a compound of the formula wherein component (ii) is formulated as a liposome; wherein B is a lipid; wherein A is a moiety of interest (MOI) and is a hydrocarbyl group; wherein X is an optional linker group; wherein R1 is H or a hydrocarbyl group; and wherein R2 is a lone pair, H or a hydrocarbyl group. The moiety of interest A may be selected from a carbohydrate moiety, a polymer, a peptide, a glycoprotein, a small biomolecule (such as a folic acid derivative) and a bioconjugate linker.

    摘要翻译： 本发明提供制备下式的改性脂质的方法，包括使（I）式（I）化合物与 和（ii）下式的化合物其中组分（ii）被配制为脂质体; 其中B是脂质; 其中A是感兴趣部分（MOI）并且是烃基; 其中X是任选的连接基团; 其中R 1是H或烃基; 并且其中R 2是孤对的，H或烃基。 感兴趣的部分A可以选自碳水化合物部分，聚合物，肽，糖蛋白，小生物分子（如叶酸衍生物）和生物缀合物接头。

    Compound
    3.
    发明申请
    Compound 审中-公开
    复合

    公开(公告)号：US20050064023A1

    公开(公告)日：2005-03-24

    申请号：US10496970

    申请日：2002-12-04

    申请人： Michael Jorgensen ,  Michael Keller ,  Adrew Miller ,  Eric Perouzel

    发明人： Michael Jorgensen ,  Michael Keller ,  Adrew Miller ,  Eric Perouzel

    IPC分类号： A61K47/44 ,  A61K9/00 ,  A61K9/127 ,  A61K47/48 ,  A61K48/00 ,  C07J41/00

    CPC分类号： C07J41/0055 ,  A61K9/1272 ,  A61K47/54 ,  A61K47/541 ,  A61K47/543 ,  A61K47/544

    摘要： The present invention provides a delivery vehicle for a therapeutic agent comprising a modified lipid and a therapeutic agent; wherein the modified lipid comprises a lipid and a delivery, targeting or stabilising moiety (DTS moiety); wherein the lipid is linked to the DTS moiety via a linker which is stable in biological fluid and which is unstable in defined conditions; and wherein the DTS moiety is linked to the lipid alter formation of a complex of lipid and therapeutic agent.

    摘要翻译： 本发明提供了包含改性脂质和治疗剂的治疗剂的递送载体; 其中所述修饰的脂质包含脂质和递送，靶向或稳定部分（DTS部分）; 其中所述脂质通过在生物流体中稳定且在限定条件下不稳定的接头连接到DTS部分; 并且其中DTS部分与脂质和治疗剂复合体的脂质变化形成有关。

    Lipid
    4.
    发明申请
    Lipid 审中-公开
    脂质

    公开(公告)号：US20100297023A1

    公开(公告)日：2010-11-25

    申请号：US12520261

    申请日：2007-12-21

    申请人： Andrew David Miller ,  Patrick Arbuthnot ,  Michael Jorgensen ,  Michael Keller ,  Nazila Kamaly ,  Abderrahim Aissaoui ,  Maya Thanou

    发明人： Andrew David Miller ,  Patrick Arbuthnot ,  Michael Jorgensen ,  Michael Keller ,  Nazila Kamaly ,  Abderrahim Aissaoui ,  Maya Thanou

    IPC分类号： A61K47/18 ,  C07C237/22 ,  A61K31/713 ,  A61K48/00 ,  A61K49/10 ,  C12N5/02

    CPC分类号： C07C237/22 ,  A01K2267/0337 ,  A61K9/1272 ,  A61K47/34 ,  A61K47/543 ,  A61K47/6907 ,  A61K47/6911 ,  A61K48/0025 ,  C12N15/111 ,  C12N15/88 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2730/10111 ,  Y10T428/2984

    摘要： The present invention provides a lipid of the formula (I) R3R4N—[Y]q—(CpH2p)—X-Linker-NR1R2 (I) wherein R3 and R4 are independently selected from H and hydrocarbyl groups; q is an integer selected from 1 to 10; Y represents a group (CnH2n)NR5, wherein (i) when q is 1, n is 2, or (ii) when q is greater than 1, each Y may be the same or different and each n is an integer independently selected from 1 to 10, with the proviso that for at least one unit Y, n is 2, and (iii) each R5 is independently selected from H and hydrocarbyl groups; p is an integer selected from 1 to 10; X is an optional group selected from —NR7—, —C(═O)—NR8—, —NR9—C(═O)—, —C(═O)—, —O—, and NR10—C(=0)0-, wherein each R7, R8, R9 and R10 is independently selected from H and hydrocarbyl groups, Linker is an optional group selected from amino acid residues, peptide residues and groups of the formula —(OCH2CH2)1-10, —NR6-(CvH2v)—C(═O)—, wherein R6 is H or a hydrocarbyl group and v is an integer selected from 1 to 11, and —C(=0)-(CH2)0-10—CH2—C(=0)-; R1 is selected from acyclic groups having from 4 to 30 carbon atoms; and R2 is selected from H and acyclic groups having from 4 to 30 carbon atoms. Said lipids can be used in a delivery vehicle (e.g. micelle or liposome) for the delivery of one or more (therapeutic or diagnostic) agents.

    摘要翻译： 本发明提供式（I）R3R4N- [Y] q-（CpH2p）-X-连接子-NR1R2（I）的脂质，其中R3和R4独立地选自H和烃基; q是选自1至10的整数; Y表示基团（C n H 2n）NR 5，其中（i）当q为1时，n为2，或（ii）当q大于1时，每个Y可以相同或不同，并且每个n是独立地选自 1至10，条件是对于至少一个单元Y，n为2，和（iii）每个R 5独立地选自H和烃基; p是选自1至10的整数; X是选自-NR 7 - ， - C（= O）-NR 8 - ， - NR 9 -C（= O） - ， - C（= O） - ， - O-和NR 10 -C（= O ）0-，其中每个R 7，R 8，R 9和R 10独立地选自H和烃基，连接子是选自氨基酸残基，肽残基和式 - （OCH 2 CH 2）1-10，-NR 6 - （CvH2v）-C（= O） - ，其中R6是H或烃基，v是选自1至11的整数，和-C（= O） - （CH 2）0-10-CH 2 -C = 0） - ; R1选自具有4至30个碳原子的无环基团; 并且R 2选自H和具有4至30个碳原子的无环基。 所述脂质可用于递送载体（例如胶束或脂质体）中以递送一种或多种（治疗或诊断）试剂。

    Ultra Low Frequency-Based Radio Transmission System
    6.
    发明申请
    Ultra Low Frequency-Based Radio Transmission System 审中-公开
    超低频无线电传输系统

    公开(公告)号：US20100056045A1

    公开(公告)日：2010-03-04

    申请号：US12202966

    申请日：2008-09-02

    申请人： Michael Jorgensen ,  Curt Andersson

    发明人： Michael Jorgensen ,  Curt Andersson

    IPC分类号： H04B7/24

    CPC分类号： H04B7/15507 ,  H01Q1/007

    摘要： An ultra low frequency transmission system can provide communications, for example, messages, to an individual or a group in areas of a building where conventional transmission reception is limited. A communication system for a structure includes a transmitter and an antenna network extending substantially throughout the structure. The antenna network includes a first portion and a second portion. At least one location in the structure can receive a transmission from the first portion and the second portion of the antenna network. The antenna network is configured to receive the transmission from the transmitter and to communicate the transmission throughout the antenna network to at least one receiver configured to receive the transmission from the transmitter via the antenna network. The antenna network transmits the transmission using an ultra low frequency to the at least one receiver.

    摘要翻译： 超低频传输系统可以在传统的发射接收受限的建筑物的区域中向个人或群体提供例如消息的通信。 用于结构的通信系统包括基本上贯穿整个结构延伸的发射机和天线网络。 天线网络包括第一部分和第二部分。 结构中的至少一个位置可以从天线网络的第一部分和第二部分接收传输。 天线网络被配置为从发射机接收传输，并且将整个天线网络中的传输通信至被配置为经由天线网络从发射机接收传输的至少一个接收机。 天线网络使用超低频率传输至少一个接收机。

    SYSTEM AND METHOD FOR DETERMINING FUZZY CAUSE AND EFFECT RELATIONSHIPS IN AN INTELLIGENT WORKLOAD MANAGEMENT SYSTEM
    7.
    发明申请
    SYSTEM AND METHOD FOR DETERMINING FUZZY CAUSE AND EFFECT RELATIONSHIPS IN AN INTELLIGENT WORKLOAD MANAGEMENT SYSTEM 失效
    用于确定智能原因的系统和方法以及智能工作负载管理系统中的影响关系

    公开(公告)号：US20120130936A1

    公开(公告)日：2012-05-24

    申请号：US12952314

    申请日：2010-11-23

    申请人： Jeremy Brown ,  Jason Allen Sabin ,  Nathaniel Brent Kranendonk ,  Kal A. Larsen ,  Lloyd Leon Burch ,  Michael Fairbanks ,  Michael Jorgensen ,  Thomas Larry Biggs

    发明人： Jeremy Brown ,  Jason Allen Sabin ,  Nathaniel Brent Kranendonk ,  Kal A. Larsen ,  Lloyd Leon Burch ,  Michael Fairbanks ,  Michael Jorgensen ,  Thomas Larry Biggs

    IPC分类号： G06N5/02 ,  G06N7/02

    CPC分类号： G06N7/02 ,  G06N5/048 ,  G06Q10/0633

    摘要： The system and method for determining fuzzy cause and effect relationships in an intelligent workload management system described herein may combine potential causes and effects captured from various different sources associated with an information technology infrastructure with substantially instantaneous feedback mechanisms and other knowledge sources. As such, fuzzy correlation logic may then be applied to the combined information to determine potential cause and effect relationships and thereby diagnose problems and otherwise manage interactions that occur in the infrastructure. For example, information describing potential causes and potential effects associated with an operational state of the infrastructure may be captured and combined, and any patterns among the information that describes the multiple potential causes and effects may then be identified. As such, fuzzy logic may the be applied to any such patterns to determine possible relationships among the potential causes and the potential effects associated with the infrastructure operational state.

    摘要翻译： 用于确定本文描述的智能工作负载管理系统中的模糊因果关系的系统和方法可以将从与信息技术基础设施相关联的各种不同来源捕获的潜在原因和效果与基本上即时的反馈机制和其他知识源组合。 因此，然后可以将模糊相关逻辑应用于组合信息以确定潜在的因果关系，从而诊断问题并以其他方式管理基础设施中发生的交互。 例如，可以捕获和组合描述与基础设施的操作状态相关联的潜在原因和潜在效果的信息，并且然后可以识别描述多个潜在原因和效果的信息中的任何模式。 因此，模糊逻辑可以应用于任何这样的模式，以确定潜在原因与与基础设施操作状态相关联的潜在效应之间的可能关系。

    Supercapacitor Device For Ultra Low Frequency Transmission System
    9.
    发明申请
    Supercapacitor Device For Ultra Low Frequency Transmission System 审中-公开
    超低频传输系统超级电容器

    公开(公告)号：US20100056048A1

    公开(公告)日：2010-03-04

    申请号：US12202930

    申请日：2008-09-02

    申请人： Michael Jorgensen ,  Curt Andersson

    发明人： Michael Jorgensen ,  Curt Andersson

    IPC分类号： H04B7/00 ,  H02J7/00

    CPC分类号： H04B1/034 ,  H04B1/3883

    摘要： Ultra low frequency transmissions can be used to penetrate obstructions to areas where other operation of other communication devices may be limited, such as in a mine, tunnel, or other underground location. A portable device that includes a supercapacitor, a transmitter, and an antenna can be used to communicate using ultra low frequency transmissions. In one aspect, a communication device comprises a supercapacitor; a transmitter powered by the supercapacitor; and an antenna connected to the transmitter for sending messages. In another aspect, a method for communicating comprises the steps of receiving a message to be transmitted, powering a transmitter from a charged supercapacitor, and transmitting the message via an antenna.

    摘要翻译： 可以使用超低频传输来穿透其他通信设备的其它操作可能受到限制的区域的障碍物，例如在矿井，隧道或其他地下位置。 可以使用包括超级电容器，发射器和天线的便携式设备来使用超低频传输。 一方面，通信装置包括超级电容器; 由超级电容器供电的发射器; 和连接到发射机的天线用于发送消息。 在另一方面，一种用于通信的方法包括以下步骤：接收要发送的消息，从充电的超级电容器向发射机供电，以及经由天线发送所述消息。