公开(公告)号：US20070035060A1

公开(公告)日：2007-02-15

申请号：US11584874

申请日：2006-10-23

申请人： Andrew Harvey ,  Stephen Jens ,  Howard Kingsford ,  J. Neumann ,  Richard Formato

发明人： Andrew Harvey ,  Stephen Jens ,  Howard Kingsford ,  J. Neumann ,  Richard Formato

IPC分类号： B29C47/00

CPC分类号： A44B18/0049 ,  A44B18/0061 ,  B29C43/222 ,  B29C43/46 ,  B29C48/08 ,  B29C48/12 ,  B29C48/13 ,  B29C48/30 ,  B29C48/35 ,  B29C59/025 ,  B29C59/04 ,  B29C2043/461 ,  B29C2043/465 ,  B29C2043/486 ,  B29L2031/729

摘要： Improvements are disclosed for an apparatus for continuously molding small fastener elements integral with a base web from a flowable resin. The apparatus comprises a cylindrical mold roll rotatable about an axis and defining small fastener element-shaped mold cavities in the surface thereof, and pressure-applying means to apply operating pressure to force the resin into the cavities at a pressure zone. The pressure-applying means and mold roll define a mold gap therebetween for forming the base web. The advantageous use of relatively long mold rolls, to produce a correspondingly wide web, and the use of higher molding pressures, e.g. to form very small fastener elements, is enabled by various improvements, including means to maintain the mold gap at a desired thickness profile across the length of the molding region of the mold roll under operating pressure. In some cases the pressure-applying means includes a pressure roll, in other cases it includes a resin nozzle assembly or pressure head. In some other cases it includes a belt. Various control schemes are also disclosed, as are means to provide cooling. In some particularly useful embodiments, at least one of the rolls of the apparatus has a resiliently deformable surface. Methods of molding fastener elements directly on a sheet material, such as sandpaper, are also disclosed, as well as methods for laminating.

摘要翻译： 公开了一种用于从可流动树脂连续地模制与基底纤维一体的小型紧固件的设备的改进。 该装置包括可围绕轴线旋转并在其表面中限定小的紧固件元件形模腔的圆柱形模具辊;以及加压装置，以施加操作压力以迫使树脂在压力区域进入空腔。 压力施加装置和模具辊在它们之间形成一个模具间隙，用于形成底部网。 相对长的模具辊的有利使用，以产生相应宽的幅材，以及使用更高的成型压力，例如， 以形成非常小的紧固件元件，其可通过各种改进实现，包括在工作压力下将模具间隙保持在模具辊的模制区域的长度上期望的厚度分布的装置。 在一些情况下，压力施加装置包括压力辊，在其它情况下包括树脂喷嘴组件或压头。 在其他一些情况下，它包括皮带。 还公开了各种控制方案，作为提供冷却的手段也是如此。 在一些特别有用的实施例中，装置的至少一个辊具有可弹性变形的表面。 还公开了将紧固件元件直接模制在诸如砂纸的片材上的方法，以及层压方法。

公开(公告)号：US20140031395A1

公开(公告)日：2014-01-30

申请号：US13983476

申请日：2012-02-02

申请人： Andrew Harvey ,  Audrey Fluck ,  Bruno Giethlen ,  Dharam Paul ,  Laurent Schaeffer

发明人： Andrew Harvey ,  Audrey Fluck ,  Bruno Giethlen ,  Dharam Paul ,  Laurent Schaeffer

IPC分类号： C07D277/46 ,  C07D213/75 ,  C07C311/46 ,  C07D231/40 ,  C07C233/60

CPC分类号： A61K31/4412 ,  A61K31/167 ,  A61K31/357 ,  A61K31/415 ,  A61K31/426 ,  A61K31/4409 ,  C07C233/59 ,  C07C233/60 ,  C07C311/16 ,  C07C311/46 ,  C07C2601/02 ,  C07C2602/50 ,  C07D209/46 ,  C07D213/75 ,  C07D231/40 ,  C07D275/06 ,  C07D277/46 ,  C07D317/46

摘要： The present invention relates to compounds useful in the positive modulation of the alpha 7 nicotinic acetylcholine receptor (α7nAChR). The invention also relates to the use of these compounds in the treatment or prevention of a broad range of diseases in which the positive modulation of α7nAChR is advantageous, including neurodegenerative and neuropsychiatric diseases and also inflammatory diseases.

摘要翻译： 本发明涉及可用于阳性调节α7烟碱乙酰胆碱受体（α7nAChR）的化合物。 本发明还涉及这些化合物在治疗或预防广泛范围的疾病中的用途，其中α7nAChR的阳性调节是有利的，包括神经变性和神经精神疾病以及炎性疾病。

公开(公告)号：US07961969B2

公开(公告)日：2011-06-14

申请号：US11942810

申请日：2007-11-20

申请人： Ewan Findlay ,  Andrew Harvey ,  Bertrand Lucotte ,  Gonzalo Muyo

发明人： Ewan Findlay ,  Andrew Harvey ,  Bertrand Lucotte ,  Gonzalo Muyo

IPC分类号： G06K9/40

CPC分类号： G06T5/003

摘要： PSF coding has become well known in recent years. Although it enables significant increases in the depth of field, defocus introduces artifacts in images that are a major detraction from the final image quality. A method is described that enables the deduction or defocus and consequently the removal of these artifacts. The principle of the disclosed techniques involves iteratively adjusting the restoration algorithm according to a chosen image metric and choosing the defocus parameter that yields the image the lowest level of artifact.

摘要翻译： 近年来，PSF编码已经成为众所周知的。 虽然它能够显着提高景深，但散焦会在图像中引入伪像，这是最终图像质量的主要障碍。 描述了一种能够减少或散焦并因此去除这些伪影的方法。 所公开技术的原理涉及根据所选择的图像度量迭代地调整恢复算法，并且选择产生图像最低级别的伪影的散焦参数。

公开(公告)号：US20050237532A1

公开(公告)日：2005-10-27

申请号：US10518418

申请日：2003-06-19

申请人： John Edward Perrigo Beale ,  Andrew Harvey ,  David Fletcher-Holmes

发明人： John Edward Perrigo Beale ,  Andrew Harvey ,  David Fletcher-Holmes

IPC分类号： G01J3/28 ,  G01J3/453 ,  G01B9/02

CPC分类号： G01J3/4537 ,  G01J3/0205 ,  G01J3/2823

摘要： The present invention relates to an imaging apparatus and comprises input and output polarisers, a first polarising beam splitter and at least one additional polarising beam splitter, a light sensitive detector and focussing means arranged on an axis. The input polariser resolves incident light into a single linear polarisation state. The first polarising beam splitter receives light from the input polarises, and resolves it into equal magnitude orthogonally polarised rays which are mutually spaced and have a path difference therebetween. The or each additional polarising beam splitter is arranged to receive light from the first polarising beam splitter. The transmission axis of the output polariser is parallel to or perpendicular to the transmission axis of the input polarises to resolve the orthogonally polarised light rays having past through the or each additional polarising beam splitter into the same or perpendicular polarisation state as light resolved by the, first polariser. The first polarising beam splitter, the or each additional polarising beam splitter and the focussing means are mutually spaced such that said mutually spaced rays are brought to coincidence whereby interference fringes are produced, the detector being arranged to detect the interference fringes. One beam splitter is mounted for movement perpendicular to said axis, whereas the other beam splitter(s) is/are rigidly mounted against movement.

摘要翻译： 本发明涉及一种成像装置，包括输入和输出偏振器，第一偏振分束器和至少一个附加偏振分束器，光敏检测器和布置在轴上的聚焦装置。 输入偏振器将入射光分解为单线性偏振状态。 第一偏振分束器从输入偏振器接收光，并将其分解成相等的正交偏振光线，它们彼此间隔开并且在它们之间具有路径差。 该或每个附加的偏振分束器布置成接收来自第一偏振分束器的光。 输出偏振器的透射轴平行于或垂直于输入偏振器的透射轴，以将已经通过该或每个附加的偏振光束分离器的正交偏振光束解析为与由该光束分辨的光分解的相同或垂直的偏振状态， 第一个偏振器 第一偏振分束器，或每个附加的偏振分束器和聚焦装置相互间隔开，使得所述相互间隔的射线变得一致，从而产生干涉条纹，检测器被布置成检测干涉条纹。 一个分束器安装成垂直于所述轴线移动，而另一个分束器被刚性地安装成抵抗运动。

公开(公告)号：US20050158430A1

公开(公告)日：2005-07-21

申请号：US11016939

申请日：2004-12-20

申请人： Richard Wiesman ,  Dick Atkinson ,  Andrew Harvey

发明人： Richard Wiesman ,  Dick Atkinson ,  Andrew Harvey

IPC分类号： A23B4/16 ,  A23L3/015 ,  C12H1/06

CPC分类号： A23B4/16 ,  A23B4/00 ,  A23L3/0155 ,  A23L3/3445 ,  A23V2002/00 ,  A23V2200/10 ,  A23V2250/112

摘要： A food treatment system and method with a pressurization zone, a dwell zone, and a depressurization zone. A linear pocket feeder includes a number of sealed chambers each housing a food product driven through the pressurization zone, the dwell zone, and the depressurization zone in sequence. The pressurization zone includes at least one purge region to prevent dilution of treatment fluid and also treatment fluid injection regions to pressurize the sealed chambers in a controlled fashion. The depressurization zone includes treatment fluid ejection regions to depressurize the sealed chambers and remove the treatment fluid therefrom in a controlled fashion. The treatment fluid injection regions are in fluid communication with the treatment fluid ejection regions to conserve treatment fluid and to minimize power required for pressurization.

摘要翻译： 具有加压区，停留区和减压区的食品处理系统和方法。 线性袋式进料器包括多个密封室，每个密封室依次容纳通过加压区，停留区和减压区驱动的食品。 加压区包括至少一个吹扫区域，以防止处理流体的稀释以及处理流体注入区域以受控的方式对密封室进行加压。 减压区包括处理流体喷射区域以使密封室减压并以受控的方式从其中去除处理流体。 处理流体注射区域与处理流体喷射区域流体连通以节省处理流体并最小化加压所需的功率。

公开(公告)号：US06330599B1

公开(公告)日：2001-12-11

申请号：US09174046

申请日：1998-10-16

申请人： Andrew Harvey

发明人： Andrew Harvey

IPC分类号： G06F15173

CPC分类号： H04L29/06 ,  H04L45/00 ,  H04L45/586 ,  H04L63/08 ,  H04L69/18

摘要： A method and system for providing a virtual interface between a router and a network, in which the router is not connected to the network using a local interface. A method and system in which a router may be dynamically decoupled from a first network and coupled to a second network, without losing state information associated with the coupling to either network. The router comprises a virtual interface to the network, at which state information for the physical interface to the network is recorded, and a binding between the virtual interface and a physical interface, the latter of which is coupled to the network. Dynamic binding of the virtual interface to the physical interface comprises an authentication step. A method and system in which a router can be dynamically coupled to one of a plurality of local networks of differing types, such as one local network using an ethernet technique and one local network using a token ring technique. The router comprises one virtual interface for each local network interface, a physical interface comprising a PC Card (PCMCIA card) controller, and one PC Card (PCMCIA card) network interface. A router is dynamically coupled to and decoupled from a set of networks sequentially, so that an administrator or an administrative program at the router may issue administrative and/or set-up commands to each of the networks. The administrative commands comprise configuration commands, so that an administrator may configure a plurality of networks from a single source location.

摘要翻译： 一种用于在路由器和网络之间提供虚拟接口的方法和系统，其中路由器未使用本地接口连接到网络。 一种方法和系统，其中路由器可以从第一网络动态解耦并耦合到第二网络，而不会丢失与耦合到任一网络的状态信息。 路由器包括到网络的虚拟接口，在该虚拟接口处记录用于到网络的物理接口的状态信息，以及虚拟接口和物理接口之间的绑定，后者耦合到网络。 虚拟接口与物理接口的动态绑定包括认证步骤。 一种方法和系统，其中路由器可以动态耦合到不同类型的多个本地网络之一，例如使用以太网技术的一个本地网络和使用令牌环技术的一个本地网络。 该路由器包括用于每个本地网络接口的一个虚拟接口，包括PC卡（PCMCIA卡）控制器和一个PC卡（PCMCIA卡）网络接口的物理接口。 路由器被顺序地耦合到一组网络并从一组网络去耦，使得路由器上的管理员或管理程序可以向每个网络发布管理和/或建立命令。 管理命令包括配置命令，使得管理员可以从单个源位置配置多个网络。

公开(公告)号：US20140336198A1

公开(公告)日：2014-11-13

申请号：US14118170

申请日：2012-05-16

申请人： Andrew Harvey ,  Agnes Bombrun ,  Rachel Cooke ,  Isabelle Jeanclaude-Etter ,  Nathan Kuchel ,  Jerome Molette ,  Jorgen Mould ,  Dharam Paul ,  Rajinder Singh ,  Cristina Donini ,  Veronique Colovray ,  Thomas Avery ,  Julia Crossman ,  Justin Ripper

发明人： Andrew Harvey ,  Agnes Bombrun ,  Rachel Cooke ,  Isabelle Jeanclaude-Etter ,  Nathan Kuchel ,  Jerome Molette ,  Jorgen Mould ,  Dharam Paul ,  Rajinder Singh ,  Cristina Donini ,  Veronique Colovray ,  Thomas Avery ,  Julia Crossman ,  Justin Ripper

IPC分类号： C07D451/04 ,  C07D405/12 ,  C07D411/12 ,  C07D213/64 ,  C07D413/12 ,  C07D237/08 ,  C07D241/18 ,  C07D213/40 ,  C07D401/12

CPC分类号： C07D213/40 ,  C07C217/90 ,  C07D209/52 ,  C07D211/16 ,  C07D211/26 ,  C07D211/38 ,  C07D213/16 ,  C07D213/61 ,  C07D213/64 ,  C07D213/70 ,  C07D213/89 ,  C07D231/12 ,  C07D233/56 ,  C07D237/08 ,  C07D239/24 ,  C07D239/34 ,  C07D241/12 ,  C07D241/18 ,  C07D309/14 ,  C07D401/12 ,  C07D405/12 ,  C07D411/12 ,  C07D413/12 ,  C07D451/04

摘要： The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.

摘要翻译： 本发明涉及可用于调节细胞中钾通道活性的化合物，特别是在T细胞中发现的Kv1.3通道的活性。 本发明还涉及这些化合物在治疗或预防自身免疫性和炎性疾病，包括多发性硬化症中的用途，含有这些化合物的药物组合物及其制备方法。

公开(公告)号：US20060254621A1

公开(公告)日：2006-11-16

申请号：US11488754

申请日：2006-07-19

申请人： Peter Carhuff ,  Edward Dickinson ,  Andrew Harvey ,  Edward Kolvek ,  Takeshi Masu

发明人： Peter Carhuff ,  Edward Dickinson ,  Andrew Harvey ,  Edward Kolvek ,  Takeshi Masu

IPC分类号： B08B9/00

CPC分类号： B08B9/0321 ,  B67D1/07 ,  Y10T137/4259

摘要： The present invention relates to a method for dispensing of a microbiologically sensitive fluid, in particular low acid food fluid, in a hygienic manner so as to avoid micro-organism growth in the line dispensing the fluid as well as in any mechanical components of a dispensing unit that may enter into contact with the fluid. The invention hygienically supplies microbiologically sensitive fluid from a removable container that has a terminal connecting portion to a dispensing unit. The unit includes a coupling mechanism adapted to connect the terminal connecting portion and a component for delivering a cleaning or rinsing fluid within the terminal connecting portion. Thus, during cleaning or rinsing, the cleaning or rinsing fluid can be discharged within the terminal connecting portion up to a closing point of the container assembly, thus demarcating a closing point, downstream of which is a part that is maintained clean, and upstream of which is a part of the container that is maintained sterile.

摘要翻译： 本发明涉及以卫生方式分配微生物敏感流体，特别是低酸食物流体的方法，以避免在分配流体的管线以及分配任何机械组分中的微生物生长 可能与流体接触的单元。 本发明卫生地从具有终端连接部分到分配单元的可移除容器提供微生物敏感流体。 该单元包括适于连接端子连接部分和用于在终端连接部分内输送清洁或冲洗流体的部件的联接机构。 因此，在清洁或冲洗期间，清洁或冲洗流体可以在终端连接部分内排出直到容器组件的关闭点，从而划分关闭点，其下游是保持清洁的部分，并且在上游 它是保持无菌的容器的一部分。

公开(公告)号：US20060190575A1

公开(公告)日：2006-08-24

申请号：US11404397

申请日：2006-04-14

申请人： Andrew Harvey ,  Ikramullah Mohammad ,  Leo Pereira ,  Tohru Kao

发明人： Andrew Harvey ,  Ikramullah Mohammad ,  Leo Pereira ,  Tohru Kao

IPC分类号： G06F15/177

CPC分类号： H04L67/303 ,  H04L67/025 ,  H04L67/125

摘要： A system and an apparatus are disclosed for carrying out automatic network device provisioning and configuration. A configuration service receives a request from a network device to provide configuration information. The configuration service retrieves a template describing the device configuration, where the template associates one symbolic reference to one parameter that may receive values specific to particular devices. Based at least on the symbolic reference and the request, the configuration service retrieves a value of the parameter that is specific to the network device. A device-specific instance of the configuration information is created and stored based at least one the template and the value of the parameter. The configuration information is stored in XML format and conforms to an XML DTD.

摘要翻译： 公开了一种用于执行自动网络设备供应和配置的系统和装置。 配置服务从网络设备接收请求以提供配置信息。 配置服务检索描述设备配置的模板，其中模板将一个符号引用与可能接收特定设备特定值的一个参数相关联。 至少基于符号引用和请求，配置服务检索特定于网络设备的参数的值。 基于模板和参数值中的至少一个创建并存储配置信息的设备特定实例。 配置信息以XML格式存储，并符合XML DTD。

公开(公告)号：US20060045028A1

公开(公告)日：2006-03-02

申请号：US10932976

申请日：2004-09-02

申请人： Masum Hasan ,  Andrew Harvey ,  Leo Pereira

发明人： Masum Hasan ,  Andrew Harvey ,  Leo Pereira

IPC分类号： H04L12/28

CPC分类号： H04L41/0886 ,  H04L41/0879 ,  H04L41/12

摘要： Systems and methods are provided for generating an Internetworking Operating System (IOS) Command Line Interface (CLI) configuration model and a logical topology from an IOS CLI configuration base. The method includes representing structure and cross-CLI dependencies in a formal specification format, such as Extended Backus-Naur Form (EBNF), and translating the representation into a machine-processable structure and code referred to as the IOS CLI Dependency Tree (ICDT). The ICDT is the configuration model. The ICDT optionally may be manipulated to generate configuration models in other formats, such as Java classes or XSD (extensible markup language Schema Definition). The method further includes generating the logical topology from the ICDT.

摘要翻译： 提供了系统和方法，用于从IOS CLI配置库生成互联操作系统（IOS）命令行界面（CLI）配置模型和逻辑拓扑。 该方法包括以正式规范格式（例如Extended Backus-Naur Form（EBNF））表示结构和交叉CLI依赖性，并将表示转换为称为IOS CLI依赖关系树（ICDT）的机器可处理结构和代码， 。 ICDT是配置模型。 ICDT可选择地被操纵以生成其他格式的配置模型，例如Java类或XSD（可扩展标记语言模式定义）。 该方法还包括从ICDT生成逻辑拓扑。