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公开(公告)号:US07732378B2
公开(公告)日:2010-06-08
申请号:US10489341
申请日:2002-09-16
申请人: Andrew Hugin Thompson , Christian Hamon , Jurgen Schafer , Karsten Kuhn , Joseph Schwarz , Thomas Neumann
发明人: Andrew Hugin Thompson , Christian Hamon , Jurgen Schafer , Karsten Kuhn , Joseph Schwarz , Thomas Neumann
IPC分类号: C40B40/00
CPC分类号: G01N33/6848 , G01N33/68 , G01N33/6851 , G01N2458/15 , H01J49/04
摘要: Provided is a set of two or more mass labels, each label in the set comprising a mass marker moiety attached via a cleavable linker having at least one amide bond to a mass normalization moiety, wherein the aggregate mass of each label in the set may be the same or different and the mass of the mass marker moiety of each label in the set may be the same or different, and wherein in any group of labels within the set having a mass marker moiety of a common mass each label has an aggregate mass different from all other labels in that group, and wherein in any group of labels within the set having a common aggregate mass each label has a mass marker moiety having a mass different from that of all other mass marker moieties in that group, such that all of the mass labels in the set are distinguishable from each other by mass spectrometry, and wherein the mass marker moiety comprises an amino acid and the mass normalization moiety comprises an amino acid.
摘要翻译: 提供了一组两个或更多个质量标签,该组中的每个标签包含通过具有至少一个酰胺键与质量标准化部分连接的质量标记部分,其中该组中每个标签的总质量可以是 相同或不同,组中每个标记物的质量标记物部分的质量可以相同或不同,并且其中在具有共同质量的质量标记物部分的组中的任何标签组中,每个标签具有总体质量 不同于该组中的所有其它标记,并且其中在组中具有共同聚集体的任何标签组中,每个标记具有与该组中所有其他质量标记部分的质量不同的质量标记部分,使得全部 组中的质量标记物通过质谱法彼此区分,并且其中质量标记物部分包含氨基酸,质量标准化部分包含氨基酸。
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公开(公告)号:US20050048489A1
公开(公告)日:2005-03-03
申请号:US10489341
申请日:2002-09-16
申请人: Andrew Thompson , Christian Hamon , Jurgen Schafer , Karsten Kuhn , Joseph Schwarz , Thomas Neumann
发明人: Andrew Thompson , Christian Hamon , Jurgen Schafer , Karsten Kuhn , Joseph Schwarz , Thomas Neumann
IPC分类号: G01N27/62 , B01J20/281 , G01N30/04 , G01N30/72 , G01N30/88 , G01N33/48 , G01N33/483 , G01N33/50 , G01N33/53 , G01N33/58 , G01N33/68 , H01J49/04 , C12Q1/68 , C07H21/04
CPC分类号: G01N33/6848 , G01N33/68 , G01N33/6851 , G01N2458/15 , H01J49/04
摘要: Provided is a set of two or more mass labels, each label in the set comprising a mass marker moiety attached via a cleavable linker having at least one amide bond to a mass normalisation moiety, wherein the aggregate mass of each label in the set may be the same or different and the mass of the mass marker moiety of each label in the set may be the same or different, and wherein in any group of labels within the set having a mass marker moiety of a common mass each label has an aggregate mass different from all other labels in that group, and wherein in any group of labels within the set having a common aggregate mass each label has a mass marker moiety having a mass different from that of all other mass marker moieties in that group, such that all of the mass labels in the set are distinguishable from each other by mass spectromety, and wherein the mass marker moiety comprises an amino acid and the mass normalisation moiety comprises an amino acid.
摘要翻译: 提供了一组两个或更多个质量标签,该组中的每个标签包含通过具有至少一个酰胺键与质量标准化部分连接的质量标记部分,其中该组中每个标签的总质量可以是 相同或不同,组中每个标记物的质量标记物部分的质量可以相同或不同,并且其中在具有共同质量的质量标记物部分的组中的任何标签组中,每个标签具有总体质量 不同于该组中的所有其它标记,并且其中在组中具有共同聚集体的任何标签组中,每个标记具有与该组中所有其他质量标记部分的质量不同的质量标记部分,使得全部 组中的质量标记物通过质谱可以彼此区分,并且其中质量标记物部分包含氨基酸,质量标准化部分包含氨基酸。
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3.
公开(公告)号:US20100129431A1
公开(公告)日:2010-05-27
申请号:US12276809
申请日:2008-11-24
申请人: Joseph Schwarz , Michael Weisspapir
发明人: Joseph Schwarz , Michael Weisspapir
IPC分类号: A61K9/127 , A61K31/122 , A61P31/00
CPC分类号: A61K31/122 , A61K9/0019 , A61K9/1075 , A61K47/14 , A61K47/44
摘要: The invention describes the use of an injectable form of Idebenone to induce protect from neuronal damage, improve recovery after brain trauma; stroke, intoxication, neurodegenerative diseases, memory loss or neuropathology associated with neuroinflammation or infection damage and to restore cognitive function, suppress disorientation, alcoholic and drug abuse associated syndromes and other signs of neuronal damage.
摘要翻译: 本发明描述了可注射形式的艾地苯醌诱导保护免受神经元损伤的使用,改善脑损伤后的恢复; 中风,中毒,神经变性疾病,与神经炎症或感染损伤相关的记忆丧失或神经病理学,并恢复认知功能,抑制定向障碍,酒精和药物滥用相关综合征和其他神经元损伤征兆。
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公开(公告)号:US20090061009A1
公开(公告)日:2009-03-05
申请号:US11846980
申请日:2007-08-29
申请人: Joseph Schwarz , Michael Weisspapir , Hai Yan Gao
发明人: Joseph Schwarz , Michael Weisspapir , Hai Yan Gao
IPC分类号: A61K9/14 , A61K31/70 , A61K31/7048 , A61K31/496 , A61K31/545 , A61K38/02 , A61K38/12 , A61K31/7036 , A61K38/14 , A61K31/5383 , A61K31/704 , A61P31/04
CPC分类号: A61K31/545 , A61K9/0019 , A61K9/5153 , A61K9/5192 , A61K31/496 , A61K31/5383 , A61K31/70 , A61K31/7036 , A61K31/704 , A61K31/7048 , Y02A50/475 , Y02A50/481
摘要: The invention is intended for a treatment of severe infections using an injectable drug-delivery system comprising nanoparticles of a biodegradable polymer with incorporated antibacterial drug.
摘要翻译: 本发明旨在用于使用包含具有掺入的抗菌药物的生物可降解聚合物的纳米颗粒的可注射药物递送系统来治疗严重感染。
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公开(公告)号:US20080287532A1
公开(公告)日:2008-11-20
申请号:US11750925
申请日:2007-05-18
申请人: Joseph Schwarz , Michael Weisspapir
发明人: Joseph Schwarz , Michael Weisspapir
IPC分类号: A61K31/341 , A61P25/28 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00 , A61P37/08 , A61P9/00 , C07D307/32
CPC分类号: A61K31/341 , C07D307/32 , C07D307/33
摘要: The present invention relates to oxacyclopentene-2 derivatives as compounds possessing antiinflammatory, neuroprotective, immunomodulatory and cardiovascular activities in mammals.
摘要翻译: 本发明涉及作为在哺乳动物中具有抗炎,神经保护,免疫调节和心血管活性的化合物的氧杂环戊烯-2衍生物。
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公开(公告)号:US20060241175A1
公开(公告)日:2006-10-26
申请号:US11454921
申请日:2006-06-19
申请人: Joseph Schwarz , Michael Weisspapir
发明人: Joseph Schwarz , Michael Weisspapir
IPC分类号: A61K31/355 , A61K31/125 , A61K31/045
CPC分类号: A61K31/045 , A61K9/0014 , A61K31/125 , A61K31/355 , A61K47/08 , A61K47/10
摘要: A vehicle for topical delivery which contains a liquid eutectic mixture of hydrophobic compounds.
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公开(公告)号:US20050158348A1
公开(公告)日:2005-07-21
申请号:US11080812
申请日:2005-03-16
申请人: Joseph Schwarz , Michael Weisspapir
发明人: Joseph Schwarz , Michael Weisspapir
IPC分类号: A61K47/46 , A61K9/00 , A61K31/00 , A61K31/05 , A61K31/125 , A61K31/192 , A61K31/405 , A61K31/60 , A61K45/00 , A61K47/08 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/34 , A61K47/44 , A61P25/04 , A61P29/00
CPC分类号: A61K47/10 , A61K9/0014 , A61K31/00 , A61K31/05 , A61K31/125 , A61K47/08
摘要: A vehicle for topical application which contains a liquid eutectic mixture of hydrophobic compounds to improve solubility of pharmaceutically active component and enhance topical and transdermal delivery.
摘要翻译: 用于局部应用的载体,其含有疏水化合物的液体共晶混合物以改善药物活性成分的溶解度并增强局部和透皮递送。
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8.
公开(公告)号:US20110070305A1
公开(公告)日:2011-03-24
申请号:US12566419
申请日:2009-09-24
申请人: Joseph Schwarz , Michael Weisspapir
发明人: Joseph Schwarz , Michael Weisspapir
IPC分类号: A61K9/28 , C07D487/04 , A61K31/4188 , A61P25/24 , A61P25/22 , A61P25/18
CPC分类号: A61K31/4188 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2846
摘要: The invention relates to a sustained release pharmaceutical composition, containing mebicar, for the treatment of anxiety, depression and other psychiatric and neurological disorders.
摘要翻译: 本发明涉及用于治疗焦虑,抑郁和其他精神和神经障碍的含有mebicar的缓释药物组合物。
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公开(公告)号:US20090169635A1
公开(公告)日:2009-07-02
申请号:US11968084
申请日:2007-12-31
申请人: Joseph Schwarz , Michael Weisspapir , Hai Yan Gao
发明人: Joseph Schwarz , Michael Weisspapir , Hai Yan Gao
CPC分类号: A61K9/5153 , A61K9/0019
摘要: Colloidal compositions, loaded with non-covalently bonded antibiotics, can be efficiently used for the treatment of severe bacterial pneumonia and other serious lung infections such as tuberculosis. Such formulations, comprised of biodegradable nanoparticles or nanocapsules with incorporated antibiotics, show a significant increase in antibacterial activity, extended and sustained drug release and a decrease in frequency of the drug administration. Antibiotics of various types, such as aminoglycosides, glycopeptides and others can be successfully incorporated into a nanoparticulate colloidal delivery system.
摘要翻译: 装载非共价键合抗生素的胶体组合物可以有效地用于治疗严重的细菌性肺炎和其他严重的肺部感染如结核病。 由可生物降解的纳米颗粒组成的这种制剂或具有掺入的抗生素的纳米胶囊显示出抗菌活性,延长和持续的药物释放以及药物施用频率的降低的显着增加。 各种类型的抗生素,例如氨基糖苷类,糖肽等可以成功掺入到纳米颗粒胶体递送系统中。
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公开(公告)号:US20060222716A1
公开(公告)日:2006-10-05
申请号:US11197309
申请日:2005-08-05
申请人: Joseph Schwarz , Michael Weisspapir
发明人: Joseph Schwarz , Michael Weisspapir
IPC分类号: A61K38/14 , A61K31/7048 , A61K31/7034 , A61K31/545 , A61K31/496 , A61K9/14
CPC分类号: A61K9/5123 , A61K9/5192 , A61K31/4709 , A61K31/496 , A61K31/5383 , A61K31/545 , A61K31/7036 , A61K31/7048 , A61K31/7052
摘要: The invention provides a drug carrier that includes a solid lipid nanoparticle (SLN), wherein the SLN includes tocopherol or a derivative thereof. The invention also provides a pharmaceutical composition that includes a SLN and a biologically active compound, wherein the SLN comprises tocopherol or a derivative thereof. The present invention further provides a colloidal drug delivery system that includes solid lipid nanoparticles (SLNs), wherein the SLNs comprise tocopherol or a derivative thereof. Also provided are methods for preparing the drug carrier, pharmaceutical composition, and colloidal drug delivery system of the invention.
摘要翻译: 本发明提供了包含固体脂质纳米颗粒(SLN)的药物载体,其中SLN包括生育酚或其衍生物。 本发明还提供了包含SLN和生物活性化合物的药物组合物,其中SLN包含生育酚或其衍生物。 本发明还提供了包含固体脂质纳米颗粒(SLN)的胶体药物递送系统,其中所述SLN包含生育酚或其衍生物。 还提供了制备本发明的药物载体,药物组合物和胶体药物递送系统的方法。
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