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1.发明申请公开(公告)号：US20070250947A1
公开(公告)日：2007-10-25
申请号：US11673351
申请日：2007-02-09
申请人： Andrey Boukharov , Zijin Du , Liang Guo , Michelle Hresko , David Kovalic , Zhaolong Li , Maolong Lu , James McCarter , Nancy Miller , Mark Vaudin , Deryck Williams , Wei Wu
发明人： Andrey Boukharov , Zijin Du , Liang Guo , Michelle Hresko , David Kovalic , Zhaolong Li , Maolong Lu , James McCarter , Nancy Miller , Mark Vaudin , Deryck Williams , Wei Wu
CPC分类号： C12N15/8285 , A01N57/16 , A23L33/105 , A23V2002/00 , A61K31/713 , C07K14/435 , C07K14/4354 , C12N15/113 , C12N15/1137 , C12N15/8261 , C12N15/8273 , C12N2310/11 , C12Q1/6888 , Y02A40/164
摘要： The invention relates to identifying and evaluating target coding sequences for control of plant parasitic nematodes by inhibiting one or more biological functions, and their use. The invention provides methods and compositions for identification of such sequences and for the control of a plant-parasitic nematode population. By feeding one or more recombinant double stranded RNA molecules provided by the invention to the nematode, a reduction in disease may be obtained through suppression of nematode gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, and the plant cells and plants obtained thereby.
摘要翻译： 本发明涉及鉴定和评估通过抑制一种或多种生物学功能及其用途来控制植物寄生线虫的靶编码序列。 本发明提供用于鉴定这种序列并控制植物寄生线虫种群的方法和组合物。 通过将本发明提供的一种或多种重组双链RNA分子送入线虫，通过抑制线虫基因表达可以获得疾病的减少。 本发明还涉及用于制备表达双链RNA分子的转基因植物以及由此获得的植物细胞和植物的方法。
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2.发明申请公开(公告)号：US20070271630A1
公开(公告)日：2007-11-22
申请号：US11360355
申请日：2006-02-23
申请人： Andrey Boukharov , Zijin Du , Liang Guo , David Kovalic , Maolong Lu , James McCarter , Nancy Miller , Mark Vaudin , Deryck Williams , Wei Wu
发明人： Andrey Boukharov , Zijin Du , Liang Guo , David Kovalic , Maolong Lu , James McCarter , Nancy Miller , Mark Vaudin , Deryck Williams , Wei Wu
IPC分类号： A01H5/00
CPC分类号： C12N15/8285 , C07K14/4354 , C12N15/8241 , C12N15/8245 , C12N15/8247 , C12N15/8274 , C12N15/8279 , Y02A40/164
摘要： The present invention is directed to controlling plant pest infestation, and particularly plant nematode infestation, by inhibiting one or more biological functions in the plant pest. The invention discloses methods and compositions for use in controlling plant pest infestation by providing one or more different recombinant double stranded RNA molecules in the diet of the pest in order to achieve a reduction in pest infestation through suppression of pest gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, to methods for detecting cells comprising the disclosed sequences, and to methods for detecting the disclosed sequences in biological samples.
摘要翻译： 本发明涉及通过抑制植物有害生物中的一种或多种生物功能来控制植物害虫侵染，特别是植物线虫侵染。 本发明公开了通过在害虫的饮食中提供一种或多种不同的重组双链RNA分子来控制植物害虫侵袭的方法和组合物，以通过抑制害虫基因表达来实现害虫侵染的减少。 本发明还涉及用于制备表达双链RNA分子的转基因植物的方法，用于检测包含所公开的序列的细胞的方法，以及用于检测生物样品中公开的序列的方法。
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公开(公告)号：US20070266461A1
公开(公告)日：2007-11-15
申请号：US11552681
申请日：2006-10-25
申请人： Michelle Verbsky , Catherine Baublite , Deryck Williams , Andrew Kloek , Jennifer Davila-Aponte , Michelle Hresko , Merry McLaird , Rodolfo Zentella
发明人： Michelle Verbsky , Catherine Baublite , Deryck Williams , Andrew Kloek , Jennifer Davila-Aponte , Michelle Hresko , Merry McLaird , Rodolfo Zentella
IPC分类号： A01H5/00
CPC分类号： C12N15/8285 , C12N15/8247 , Y02A40/164 , Y02A40/166
摘要： The present invention provides DNA constructs, transgenic plants containing such constructs, and methods of making the plants. The DNA constructs encode a polypeptide that when expressed results in the production of fatty acid compounds having anthelmintic activity. Transgenic plants expressing such a polypeptide can exhibit enhanced resistance to plant parasitic nematodes, particularly when expressed in vegetative tissues.
摘要翻译： 本发明提供DNA构建体，含有这种构建体的转基因植物，以及制备植物的方法。 DNA构建体编码多肽，当表达导致产生具有驱肠虫活性的脂肪酸化合物时。 表达这种多肽的转基因植物可以表现出对植物寄生线虫的增强的抗性，特别是当在营养组织中表达时。
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公开(公告)号：US20050260674A1
公开(公告)日：2005-11-24
申请号：US11191375
申请日：2005-07-28
申请人： Michelle Hresko , Merry McLaird , Deryck Williams , Anita Frevert , Brandi Chiapelli , Catherine Baublite , Andrew Kloek , Jennifer Davila-Aponte , John Bradley , Siqun Xu
发明人： Michelle Hresko , Merry McLaird , Deryck Williams , Anita Frevert , Brandi Chiapelli , Catherine Baublite , Andrew Kloek , Jennifer Davila-Aponte , John Bradley , Siqun Xu
IPC分类号： A61K38/17 , C07H21/04 , C07K1/00 , C07K14/00 , C07K14/435 , C07K14/705 , C07K17/00 , C12N20060101 , C12N15/00 , C12P21/06 , C12Q1/68
CPC分类号： C07K14/705
摘要： Nucleic acid molecules from nematodes encoding PAN and ZP domain containing receptor polypeptides are described. PANZP polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PANZP nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
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公开(公告)号：US20050260673A1
公开(公告)日：2005-11-24
申请号：US11191374
申请日：2005-07-28
申请人： Michelle Hresko , Merry McLaird , Deryck Williams , Anita Frevert , Brandi Chiapelli , Catherine Baublite , Andrew Kloek , Jennifer Davila-Aponte , John Bradley , Siqun Xu
发明人： Michelle Hresko , Merry McLaird , Deryck Williams , Anita Frevert , Brandi Chiapelli , Catherine Baublite , Andrew Kloek , Jennifer Davila-Aponte , John Bradley , Siqun Xu
IPC分类号： A61K38/17 , C07H21/04 , C07K1/00 , C07K14/00 , C07K14/435 , C07K14/705 , C07K17/00 , C12N20060101 , C12N15/00 , C12P21/06 , C12Q1/68
CPC分类号： C07K14/705
摘要： Nucleic acid molecules from nematodes encoding PAN and ZP domain containing receptor polypeptides are described. PANZP polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PANZP nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
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公开(公告)号：US20070169222A1
公开(公告)日：2007-07-19
申请号：US11552603
申请日：2006-10-25
申请人： Michelle Verbsky , Catherine Baublite , Andrew Kloek , Jennifer Davila-Aponte , Michelle Hresko , Merry McLaird , Rodolfo Zentella , Deryck Williams
发明人： Michelle Verbsky , Catherine Baublite , Andrew Kloek , Jennifer Davila-Aponte , Michelle Hresko , Merry McLaird , Rodolfo Zentella , Deryck Williams
CPC分类号： C12N9/0071 , C11B1/00 , C12N9/0073 , C12N15/8223 , C12N15/8247 , C12N15/8285 , Y02A40/164
摘要： The present invention provides DNA constructs, transgenic plants containing such constructs, and methods of making the plants. The DNA constructs encode a polypeptide that when expressed results in the production of fatty acid compounds having anthelmintic activity. Transgenic plants expressing such a polypeptide can exhibit enhanced resistance to plant parasitic nematodes, particularly when expressed in vegetative tissues. Transgenic plants expressing such a polypeptide can also be useful for non-pesticidal industrial uses.
摘要翻译： 本发明提供了DNA构建体，含有这种构建体的转基因植物和制备植物的方法。 DNA构建体编码多肽，当表达导致产生具有驱肠虫活性的脂肪酸化合物时。 表达这种多肽的转基因植物可以表现出对植物寄生线虫的增强的抗性，特别是当在营养组织中表达时。 表达这种多肽的转基因植物也可用于非农药工业用途。
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公开(公告)号：US20050198695A1
公开(公告)日：2005-09-08
申请号：US11091969
申请日：2005-03-28
申请人： Deryck Williams , Brandy Salmon , Andrew Kloek
发明人： Deryck Williams , Brandy Salmon , Andrew Kloek
CPC分类号： C07K14/4354 , G01N33/573 , G01N2500/04
摘要： Nucleic acid molecules from nematodes encoding ATP synthase subunit E polypeptides are described. ATP synthase subunit E-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of ATP synthase subunit E-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
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公开(公告)号：US20050172358A1
公开(公告)日：2005-08-04
申请号：US10912534
申请日：2004-08-04
申请人： Michelle Verbsky , Catherine Baublite , Andrew Kloek , Jennifer Davila-Aponte , Michelle Hresko , Merry McLaird , Rodolfo Zentella , Deryck Williams
发明人： Michelle Verbsky , Catherine Baublite , Andrew Kloek , Jennifer Davila-Aponte , Michelle Hresko , Merry McLaird , Rodolfo Zentella , Deryck Williams
CPC分类号： C12N9/0071 , C11B1/00 , C12N9/0073 , C12N15/8223 , C12N15/8247 , C12N15/8285 , Y02A40/164
摘要： The present invention provides DNA constructs, transgenic plants containing such constructs, and methods of making the plants. The DNA constructs encode a polypeptide that when expressed results in the production of fatty acid compounds having anthelmintic activity. Transgenic plants expressing such a polypeptide can exhibit enhanced resistance to plant parasitic nematodes, particularly when expressed in vegetative tissues. Transgenic plants expressing such a polypeptide can also be useful for non-pesticidal industrial uses.
摘要翻译： 本发明提供了DNA构建体，含有这种构建体的转基因植物和制备植物的方法。 DNA构建体编码多肽，当表达导致产生具有驱肠虫活性的脂肪酸化合物时。 表达这种多肽的转基因植物可以表现出对植物寄生线虫的增强的抗性，特别是当在营养组织中表达时。 表达这种多肽的转基因植物也可用于非农药工业用途。
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公开(公告)号：US20070009981A1
公开(公告)日：2007-01-11
申请号：US11326080
申请日：2006-01-05
申请人： Deryck Williams , Merry McLaird , Michelle Hresko , Anita Frevert-Thompson , Ronald Worthington , Andrew Kloek , Jennifer Davila-Aponte , John Bradley , Siqun Xu
发明人： Deryck Williams , Merry McLaird , Michelle Hresko , Anita Frevert-Thompson , Ronald Worthington , Andrew Kloek , Jennifer Davila-Aponte , John Bradley , Siqun Xu
CPC分类号： C12N9/1007
摘要： Nucleic acid molecules from nematodes encoding phosphoethanolamine n-methyltransferase polypeptides are described. PEAMT-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PEAMT-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
摘要翻译： 描述了编码磷酸乙醇胺正甲基转移酶多肽的线虫的核酸分子。 还提供了PEAMT样多肽序列，载体，宿主细胞和用于产生PEAMT样核苷酸和多肽的重组方法也是如此。 还描述了用于鉴定抑制剂和/或激活剂的筛选方法以及用于抗体生产的方法。
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公开(公告)号：US20050282222A1
公开(公告)日：2005-12-22
申请号：US11191588
申请日：2005-07-28
申请人： Michelle Hresko , Merry McLaird , Deryck Williams , Anita Frevert , Brandi Chiapelli , Catherine Baublite , Andrew Kloek , Jennifer Davila-Aponte , John Bradley , Siqun Xu
发明人： Michelle Hresko , Merry McLaird , Deryck Williams , Anita Frevert , Brandi Chiapelli , Catherine Baublite , Andrew Kloek , Jennifer Davila-Aponte , John Bradley , Siqun Xu
IPC分类号： A61K38/17 , C07H21/04 , C07K1/00 , C07K14/00 , C07K14/435 , C07K14/705 , C07K17/00 , C12N20060101 , C12N15/00 , C12P21/06 , C12Q1/68
CPC分类号： C07K14/705
摘要： Nucleic acid molecules from nematodes encoding PAN and ZP domain containing receptor polypeptides are described. PANZP polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PANZP nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
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