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    Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
    1.
    发明授权
    Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists 失效
    取代的氮杂双环己烷衍生物作为毒蕈碱受体拮抗剂

    公开(公告)号：US07592359B2

    公开(公告)日：2009-09-22

    申请号：US10552617

    申请日：2003-04-10

    申请人： Anita Mehta ,  Arundutt Viswanatham Silamkoti ,  Jang Bahadur Gupta

    发明人： Anita Mehta ,  Arundutt Viswanatham Silamkoti ,  Jang Bahadur Gupta

    IPC分类号： A61K31/445 ,  A61P11/00 ,  A61P13/00 ,  C07D211/22

    CPC分类号： C07D209/52 ,  C07D405/06

    摘要： This invention generally relates to derivatives of substituted azabicyclo hexanes. The compounds of this invention can function as muscarinic receptor antagonists, and can be used for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to a process for the preparation of the compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the methods of treating the diseases mediated through muscarinic receptors.

    摘要翻译： 本发明一般涉及取代的氮杂双环己烷的衍生物。 本发明化合物可用作毒蕈碱受体拮抗剂，可用于治疗通过毒蕈碱受体介导的呼吸道，尿路和胃肠道系统的各种疾病。 本发明还涉及制备本发明化合物的方法，含有本发明化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。

    3,6-disubstituted azabicyclo [3.1.0] hexane deriviatives useful as muscarinic receptor antagonists
    2.
    发明授权
    3,6-disubstituted azabicyclo [3.1.0] hexane deriviatives useful as muscarinic receptor antagonists 失效
    可用作毒蕈碱受体拮抗剂的3,6-二取代的氮杂双环[3.1.0]己烷衍生物

    公开(公告)号：US07410993B2

    公开(公告)日：2008-08-12

    申请号：US10524081

    申请日：2002-08-09

    申请人： Anita Mehta ,  Arundutt V. Silamkoti ,  Miriyala Bruhaspathy ,  Jang Bahadur Gupta

    发明人： Anita Mehta ,  Arundutt V. Silamkoti ,  Miriyala Bruhaspathy ,  Jang Bahadur Gupta

    IPC分类号： A61K31/403 ,  C07D209/52

    CPC分类号： C07D209/02 ,  C07D209/52

    摘要： This invention generally relates to the derivatives of 3,6 disubstituted azabicyclo[3.1.0] hexanes. The compounds of this invention are muscarinic receptor antagonists which are useful, inter-alia, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to a process for the preparation of the compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the methods for treating the diseases mediated through muscarinic receptors.

    摘要翻译： 本发明一般涉及3,6-二取代的氮杂双环[3.1.0]己烷的衍生物。 本发明的化合物是毒蕈碱受体拮抗剂，其特别用于治疗通过毒蕈碱受体介导的呼吸，尿和胃肠道系统的各种疾病。 本发明还涉及制备本发明化合物的方法，含有本发明化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。

    3,6-disubstituted azabicyclo [3.1.0] hexane derivatives useful as muscarinic receptor antagonists
    5.
    发明授权
    3,6-disubstituted azabicyclo [3.1.0] hexane derivatives useful as muscarinic receptor antagonists 失效
    用作毒蕈碱受体拮抗剂的3,6-二取代的氮杂双环[3.1.0]己烷衍生物

    公开(公告)号：US07399779B2

    公开(公告)日：2008-07-15

    申请号：US10520573

    申请日：2002-07-08

    申请人： Anita Mehta ,  Arundutt V. Silamkoti ,  Jang Bahadur Gupta

    发明人： Anita Mehta ,  Arundutt V. Silamkoti ,  Jang Bahadur Gupta

    IPC分类号： A61K31/403 ,  C07D209/52

    CPC分类号： C07D401/12 ,  C07D209/52 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

    摘要： This invention generally relates to the derivatives of novel 3,6 disubstituted azabicyclo[3.1.0]hexanes. The compounds of this invention are muscarinic receptor antagonists which are useful, inter-alia for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to pharmaceutical compositions containing the compounds of the present invention and the methods of treating the diseases mediated through muscarinic receptors.

    摘要翻译： 本发明一般涉及新的3,6-二取代的氮杂双环[3.1.0]己烷的衍生物。 本发明的化合物是毒蕈碱受体拮抗剂，其特别用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病。 本发明还涉及含有本发明化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。

    Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
    6.
    发明授权
    Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists 失效
    取代的氮杂双环己烷衍生物作为毒蕈碱受体拮抗剂

    公开(公告)号：US07517905B2

    公开(公告)日：2009-04-14

    申请号：US10552456

    申请日：2003-04-09

    申请人： Anita Mehta ,  Bruhaspathy Miriyala ,  Sudershan Kumar Arora ,  Jang Bahadur Gupta

    发明人： Anita Mehta ,  Bruhaspathy Miriyala ,  Sudershan Kumar Arora ,  Jang Bahadur Gupta

    IPC分类号： A61K31/403 ,  C07D209/52

    CPC分类号： C07D209/52

    摘要： This invention relates to the derivatives of substituted azabicyclo hexanes. The compounds of this invention can function as muscarinic receptor antagonists and can be used for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to a process for the preparation of the compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the methods of treating the diseases mediated through muscarinic receptors.

    摘要翻译： 本发明涉及取代的氮杂双环己烷的衍生物。 本发明的化合物可用作毒蕈碱受体拮抗剂，可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病。 本发明还涉及制备本发明化合物的方法，含有本发明化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。

    1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
    7.
    发明授权
    1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists 失效
    1-取代-3-吡咯烷衍生物作为毒蕈碱受体拮抗剂

    公开(公告)号：US07465751B2

    公开(公告)日：2008-12-16

    申请号：US10540245

    申请日：2002-12-23

    申请人： Anita Mehta ,  Jang Bahadur Gupta ,  Pakala Kumara Savithru Sarma

    发明人： Anita Mehta ,  Jang Bahadur Gupta ,  Pakala Kumara Savithru Sarma

    IPC分类号： A61K31/4015 ,  A61K31/4025 ,  C07D207/48 ,  C07D207/12

    CPC分类号： C07D405/12 ,  C07D207/12 ,  C07D207/14

    摘要： This invention generally relates to the derivatives of 1-substituted-3-pyrroli dines having the structure of Formula (I): The compounds of this invention can function as muscarinic receptor antagonists, and can be used for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to a process for the preparation of the compounds of the present invention. pharmaceutical compositions containing the compounds of the present invention and the methods for treating the diseases mediated through muscarinic receptors.

    摘要翻译： 本发明一般涉及具有式（I）结构的1-取代-3-吡咯烷二醇衍生物：本发明化合物可用作毒蕈碱受体拮抗剂，可用于治疗各种呼吸疾病 ，通过毒蕈碱受体介导的尿路和胃肠道系统。 本发明还涉及制备本发明化合物的方法。 含有本发明化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。

    Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives as muscarinic receptor antagonists
    8.
    发明授权
    Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives as muscarinic receptor antagonists 失效
    含有3,6-二取代的氮杂二环（3.1.0）己烷衍生物的氟磺酰氨基作为毒蕈碱受体拮抗剂

    公开(公告)号：US07288562B2

    公开(公告)日：2007-10-30

    申请号：US10525439

    申请日：2002-08-23

    申请人： Anita Mehta ,  Jang Bahadur Gupta

    发明人： Anita Mehta ,  Jang Bahadur Gupta

    IPC分类号： A61K31/403 ,  C07D209/52

    CPC分类号： C07D209/94 ,  C07D209/52

    摘要： This invention generally relates to the derivatives of novel 3,6 disubstituted azabicyclo[3.1.0] hexane's. The compounds of this invention are MUSCARINIC receptor antagonists which are useful, inter-ail for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through MUSCARINIC receptors. The invention also relates to processes for the preparation of the compounds of the invention, pharmaceutical compositions containing the compounds of the present invention and the methods of treating the diseases mediated through MUSCARINIC receptors.

    摘要翻译： 本发明一般涉及新的3,6-二取代的氮杂双环[3.1.0]己烷的衍生物。 本发明的化合物是毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，尿和胃肠道系统的各种疾病。 本发明还涉及制备本发明化合物的方法，含有本发明化合物的药物组合物和通过MUSCARINIC受体介导的疾病的治疗方法。

    Flavaxate derivatives as muscarinic receptor antagonists
    9.
    发明授权
    Flavaxate derivatives as muscarinic receptor antagonists 失效
    泛黄酸衍生物作为毒蕈碱受体拮抗剂

    公开(公告)号：US07501443B2

    公开(公告)日：2009-03-10

    申请号：US10540062

    申请日：2002-12-23

    申请人： Anita Mehta ,  Sanjay Kumar Srivastava ,  Jang Bahadur Gupta

    发明人： Anita Mehta ,  Sanjay Kumar Srivastava ,  Jang Bahadur Gupta

    IPC分类号： A61K31/46 ,  C07D211/18

    CPC分类号： C07D209/52 ,  A61K31/352 ,  C07D405/12

    摘要： This invention generally relates to the derivatives of 3.6-disubstituted azabicyclo [3.1.0] hexanes of the following formula [IA]. The compounds of this invention can function as muscarinic receptor antagonists, and can be used for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to a process for the preparation of the compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the :h1ethods for treating the diseases mediated through muscarinic receptors.

    摘要翻译： 本发明一般涉及下式[IA]的3.6-二取代的氮杂二环[3.1.0]己烷的衍生物。 本发明化合物可用作毒蕈碱受体拮抗剂，可用于治疗通过毒蕈碱受体介导的呼吸道，尿路和胃肠道系统的各种疾病。 本发明还涉及制备本发明化合物的方法，含有本发明化合物的药物组合物和：用于治疗通过毒蕈碱受体介导的疾病的方法。