利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

9 条记录 (耗时 0.019 秒)

    Manicure file
    3.
    发明申请
    Manicure file 审中-公开
    修指甲档案

    公开(公告)号：US20060130864A1

    公开(公告)日：2006-06-22

    申请号：US11017610

    申请日：2004-12-21

    申请人： Anne Jensen

    发明人： Anne Jensen

    IPC分类号： A45D29/18

    CPC分类号： A45D29/04 ,  A45D2029/045

    摘要： A manicure file where a part of it is made from thermo hardened armoured glass with an abrasive surface from 1-10 um (micrometer) where the glass is build into a hard plastic handle and have extra a plastic case as a protection

    摘要翻译： 一个修指甲文件，其中一部分由热硬化的装甲玻璃制成，其研磨表面为1-10微米（微米），玻璃制成硬塑料手柄，并具有额外的塑料外壳作为保护

    Polynucleotides encoding S99T interferon gamma polypeptide variants and means of expression
    4.
    发明申请
    Polynucleotides encoding S99T interferon gamma polypeptide variants and means of expression 失效
    编码S99T干扰素γ多肽变体的多核苷酸和表达手段

    公开(公告)号：US20050249703A1

    公开(公告)日：2005-11-10

    申请号：US11158848

    申请日：2005-06-22

    申请人： Anne Jensen

    发明人： Anne Jensen

    IPC分类号： A61K38/00 ,  C07K14/57 ,  C07H21/04 ,  C12N15/00 ,  C12N15/09

    CPC分类号： C07K14/57 ,  A61K38/00

    摘要： The present invention relates to novel interferon gamma polypeptide variants having interferon gamma (IFNG) activity, methods for their preparation, pharmaceutical compositions comprising the polypeptide variants and their use in the treatment of diseases, in particular for the treatment of interstitial pulmonary diseases, such as idiopathic pulmonary fibrosis. These novel polypeptide variants all comprise the substitution S99T as compared to the amino acid sequence of huIFNG or fragments thereof. By performing this mutation the naturally occurring N-glycosylation site present at position 97 is significantly better utilized. Preferably, the variants comprise further modifications, e.g. in order to increase the AUC of such variants when administered subcutaneously.

    摘要翻译： 本发明涉及具有干扰素γ（IFNG）活性的新型干扰素γ多肽变体，其制备方法，包含多肽变体的药物组合物及其在治疗疾病中的用途，特别是用于治疗间质性肺疾病，例如 特发性肺纤维化。 与huIFNG或其片段的氨基酸序列相比，这些新型多肽变体全部包含取代S99T。 通过进行该突变，存在于位置97处的天然存在的N-糖基化位点被显着地更好地利用。 优选地，变体包括进一步的修饰，例如。 以便在皮下施用时增加这些变体的AUC。

    NAIL FILE
    5.
    发明申请
    NAIL FILE 审中-公开
    指甲锉

    公开(公告)号：US20090025744A1

    公开(公告)日：2009-01-29

    申请号：US12180690

    申请日：2008-07-28

    申请人： Anne Jensen

    发明人： Anne Jensen

    IPC分类号： A45D29/04

    CPC分类号： A45D29/04

    摘要： A nail file, including a file sheet and a handle, wherein at least the file sheet is made of biscuit porcelain, the file sheet containing an abrasive agent.

    摘要翻译： 一种指甲锉，包括锉刀和手柄，其中至少该锉刀由饼干瓷制成，锉刀片含有研磨剂。

    Process for Production of Hydrogen and/or Carbon Monoxide
    6.
    发明申请
    Process for Production of Hydrogen and/or Carbon Monoxide 审中-公开

    公开(公告)号：US20070264186A1

    公开(公告)日：2007-11-15

    申请号：US11660669

    申请日：2005-09-02

    申请人： Ib Dybkjaer ,  Anne Jensen ,  Carsten Laursen ,  Henrik Stahl

    发明人： Ib Dybkjaer ,  Anne Jensen ,  Carsten Laursen ,  Henrik Stahl

    IPC分类号： C01B3/38 ,  B01J8/06 ,  C01B31/18

    CPC分类号： C01B3/384 ,  B01J8/062 ,  B01J2208/00309 ,  B01J2219/00006 ,  C01B3/382 ,  C01B32/40 ,  C01B2203/0233 ,  C01B2203/0283 ,  C01B2203/0405 ,  C01B2203/043 ,  C01B2203/046 ,  C01B2203/0475 ,  C01B2203/061 ,  C01B2203/0816 ,  C01B2203/0827 ,  C01B2203/0894 ,  C01B2203/127 ,  C01B2203/1276 ,  C01B2203/141 ,  Y02P20/129

    摘要： A process for production of hydrogen and/or carbon monoxide rich gas from gaseous or liquid hydrocarbon feed-stock comprising the following steps: (a) desulphurisation of the hydrocarbon feed (1), mixing the feed (1) with steam (4) produced from waste heat in the process, feeding the mixture (6, 7) to a steam reforming section (8, 9) for conversion of the hydrocarbon feed by reaction with steam to form a process gas (12) comprising a mixture of hydrogen, carbon monoxide, carbon dioxide, residual methane and excess steam, (b) cooling the process gas (12) by steam production, (c) separating hydrogen and/or carbon monoxide (21) by conducting the process gas through a hydrogen and/or carbon monoxide purification section (20), (d) adding essentially all off-gas (22) from the purification section (20) as fuel to the reforming section (8, 9) to provide heat for the reforming reaction, (e) recovering hot flue gas (32) from the reforming section and cooling the hot flue gas at least partly by steam production, (f) recovering essentially all steam produced by cooling of process gas (12) and flue gas (32) as process steam (4), wherein the reforming section comprises at least two reforming reactors (8, 9) fed in parallel with the feed mixture of hydrocarbon feedstock (6, 7) and steam (4) and fired so that fuel (25, 26) is added in parallel to burners (29, 31) in the reforming reactors (8, 9), whereas combustion air (27) is added to a first reforming reactor (8) in an amount required to ensure a suitable adiabatic flame temperature and the partly cooled flue gas (30) from the first reforming reactor is used as combustion air in the at least one subsequent reforming reactor (9) arranged in series with respect to said combustion air in an amount required to ensure a suitable adiabatic flame temperature

    Peptide extended glycosylated polypeptides
    7.
    发明申请
    Peptide extended glycosylated polypeptides 审中-公开
    肽延伸糖基化多肽

    公开(公告)号：US20060160177A1

    公开(公告)日：2006-07-20

    申请号：US10967088

    申请日：2004-10-15

    申请人： Jens Okkels ,  Anne Jensen ,  Bart van den Hazel

    发明人： Jens Okkels ,  Anne Jensen ,  Bart van den Hazel

    IPC分类号： C07H21/04 ,  C12P21/06 ,  C12P19/34 ,  C07K9/00 ,  C07K14/47 ,  C12N5/06 ,  C12N1/18

    CPC分类号： A61K38/24 ,  C12P21/005

    摘要： Glycosylated polypeptides comprising the primary structure NH2-X-Pp-COOH, wherein X is a peptide addition comprising or contributing to a glycosylation site, and Pp is a polypeptide of interest or comprising the primary structure NH2-Px-X-Py-COOH, wherein Px is an N-terminal part of a polypeptide Pp of interest, Py is a C-terminal part of said polypeptide Pp, and X is a peptide addition comprising or contributing to a glycosylation site are provided. The glycosylated polypeptides possess improved properties as compared to the polypeptide of interest.

    摘要翻译： 包含一级结构NH 2 -X-Pp-COOH的糖基化多肽，其中X是包含或有助于糖基化位点的肽加成物，Pp是感兴趣的多肽或包含一级结构NH 其中P 是多肽Pp的N末端部分 感兴趣的是所述多肽Pp的C末端部分，并且X是包含或有助于糖基化位点的肽加成物。 与感兴趣的多肽相比，糖基化多肽具有改善的性质。

    Polynucleotides encoding interferon gamma peptide variants
    9.
    发明申请
    Polynucleotides encoding interferon gamma peptide variants 失效
    编码干扰素γ肽变体的多核苷酸

    公开(公告)号：US20050201982A1

    公开(公告)日：2005-09-15

    申请号：US11115906

    申请日：2005-04-27

    申请人： Bart Hazel ,  Anne Jensen ,  Frank Nygaard ,  Kim Anderson

    发明人： Bart Hazel ,  Anne Jensen ,  Frank Nygaard ,  Kim Anderson

    IPC分类号： A61K38/00 ,  C07K14/57 ,  A61K38/21 ,  C12P21/04

    CPC分类号： C07K14/57 ,  A61K38/00

    摘要： When interferon gamma (IFNG) is produced in mammalian cell lines a heterogenous population of IFNG polypeptides is obtained due to C-terminal processing of the IFNG polypeptide. Clearly, this constitutes a severe problem in that valuable polypeptide material is lost and, further, it is necessary to carry out time-consuming and cumbersome purification in order to obtain a homogenous population of active IFNG polypeptides having the desired length. It has now been found that an IFNG fragment containing 132 amino acid residues (truncated at the nucleotide level by introducing a stop-codon after the codon encoding amino acid residue no. 132) does not undergo C-terminal truncation or, at least, is not significantly C-terminally truncated. Furthermore, as the IFNG fragment containing 132 amino acid residues is active, this opens up the possibility of producing a homogenous active IFNG polypeptide in eukaryotic host cells, such as CHO cells. More particularly, the present invention relates to an IFNG polypeptide variant exhibiting IFNG activity and having the amino acid sequence shown in SEQ ID NO:12. In a highly preferred embodiment of the invention, the variant comprises at least one further modification, such as 1-10 further modifications, relative to the amino acid sequence shown in SEQ ID NO:12. A particular preferred further modification is E38N+S40T.

    摘要翻译： 当在哺乳动物细胞系中产生干扰素γ（IFNG）时，由于IFNG多肽的C末端加工，获得IFNG多肽的异源群体。 显然，这构成了一个严重的问题，即有价值的多肽材料丢失，而且还需要进行耗时且繁琐的纯化，以获得具有所需长度的活性IFNG多肽的均质群体。 现在已经发现，含有132个氨基酸残基的IFNG片段（在编码氨基酸残基132号的密码子后通过引入终止密码子在核苷酸水平被截短）不经历C-末端截短，或至少是 不显着C末端截断。 此外，由于含有132个氨基酸残基的IFNG片段是有活性的，因此可以在真核宿主细胞如CHO细胞中产生均一的活性IFNG多肽。 更具体地，本发明涉及表现出IFNG活性且具有SEQ ID NO：12所示氨基酸序列的IFNG多肽变体。 在本发明的一个非常优选的实施方案中，相对于SEQ ID NO：12所示的氨基酸序列，变体包含至少一个其它修饰，例如1-10个其它修饰。 特别优选的进一步修改是E38N + S40T。