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    Cyclic ether derivatives
    1.
    发明授权
    Cyclic ether derivatives 失效
    环醚衍生物

    公开(公告)号：US5219881A

    公开(公告)日：1993-06-15

    申请号：US804671

    申请日：1991-12-10

    申请人： Annie Hamon

    发明人： Annie Hamon

    IPC分类号： C07D317/22 ,  C07D327/04 ,  C07D405/04

    CPC分类号： C07D405/04 ,  C07D317/22 ,  C07D327/04

    摘要： The invention concerns a cyclic ether derivative of the formula I, ##STR1## wherein Ar.sup.1 is optionally substituted phenyl or naphthyl;A.sup.1 is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo-(3-6C)alkylene;Ar.sup.2 is optionally substituted phenylene, or a 6 membered heterocyclene moiety containing up to three nitrogen atoms;R.sup.1 and R.sup.2 together form a group of the formula --A.sup.2 --X--A.sup.3 -- wherein each of A.sup.2 and A.sup.3 is (1-6C)alkylene and X is oxy, thio, sulphinyl, sulphonyl or imino; andR.sup.3 is (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl or substituted (1-4C)alkyl;or a pharmaceutically-acceptable salt thereof.The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.

    摘要翻译： 本发明涉及式I的环醚衍生物，其中Ar 1是任选取代的苯基或萘基; A1为（1-6C）亚烷基，（3-6C）亚烯基，（3-6C）亚炔基或环 - （3-6C）亚烷基; Ar 2是任选取代的亚苯基，或含有至多三个氮原子的6元杂烯基部分; R1和R2一起形成式-A2-X-A3-的基团，其中A2和A3各自为（1-6C）亚烷基，X为氧基，硫基，亚磺酰基，磺酰基或亚氨基; （1-6C）烷基，（2-6C）烯基，（2-6C）炔基或取代的（1-4C）烷基; 或其药学上可接受的盐。 本发明的化合物是5-脂氧合酶的抑制剂。

    Heterocyclic cyclic ethers
    5.
    发明授权
    Heterocyclic cyclic ethers 失效
    杂环环醚

    公开(公告)号：US5302603A

    公开(公告)日：1994-04-12

    申请号：US993035

    申请日：1992-12-18

    申请人： Graham C. Crawley ,  Annie Hamon

    发明人： Graham C. Crawley ,  Annie Hamon

    IPC分类号： C07D405/12 ,  A61K31/44 ,  C07D401/10

    CPC分类号： C07D405/12

    摘要： The invention concerns a heterocyclic cyclic ether of the formula I ##STR1## wherein Q is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one or two nitrogen atoms;A is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo(3-6C)alkylene;X is oxy, thio, sulphinyl, sulphonyl or imino;Ar is phenylene which may optionally bear one or two substituents or Ar is an optionally substituted 6-membered heterocyclene moiety containing up to three nitrogen atoms;R.sup.1 and R.sup.2 together form a group of the formula --A.sup.2 --X.sup.2 --A.sup.3 -- which, together with the oxygen atom to which A.sup.2 is attached and with the carbon atom to which A.sup.3 is attached, defines a ring having 5 to 7 ring atoms, wherein A.sup.2 and A.sup.3 each is (1-3C)alkylene and X.sup.2 is oxy, thio, sulphinyl, sulphonyl or imino, and which ring may bear one, two or three substituents; andR.sup.3 is hydrogen, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl or substituted (1-4C)alkyl;or a pharmaceutically-acceptable salt thereof.The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.

    摘要翻译： 本发明涉及式I的杂环环醚其中Q是含有一个或两个氮原子的任选取代的6元单环或10元双环杂环部分; A是（1-6C）亚烷基，（3-6C）亚烯基，（3-6C）亚炔基或环（3-6C）亚烷基; X是氧基，硫基，亚磺酰基，磺酰基或亚氨基; Ar是可以任选地带有一个或两个取代基的亚苯基，或Ar是含有至多三个氮原子的任选取代的6元杂环烯部分; R1和R2一起形成式-A2-X2-A3-的基团，其与A2连接的氧原子和与A3连接的碳原子连同，定义为具有5至7个环原子的环， 其中A2和A3各自为（1-3C）亚烷基，X2为氧基，硫基，亚磺酰基，磺酰基或亚氨基，并且该环可以带有一个，两个或三个取代基; （1-6C）烷基，（2-6C）烯基，（2-6C）炔基或取代的（1-4C）烷基; 或其药学上可接受的盐。 本发明的化合物是5-脂氧合酶的抑制剂。

    Cyclic ether derivatives
    6.
    发明授权
    Cyclic ether derivatives 失效
    环醚衍生物

    公开(公告)号：US5098932A

    公开(公告)日：1992-03-24

    申请号：US454911

    申请日：1989-12-22

    申请人： Annie Hamon

    发明人： Annie Hamon

    IPC分类号： A61K31/335 ,  A61K31/34 ,  A61K31/357 ,  A61K31/39 ,  A61K31/44 ,  A61K31/443 ,  A61P43/00 ,  C07D317/22 ,  C07D317/26 ,  C07D317/28 ,  C07D317/34 ,  C07D317/72 ,  C07D319/06 ,  C07D319/12 ,  C07D321/00 ,  C07D327/04 ,  C07D405/04 ,  E04D20060101 ,  F24F20060101

    CPC分类号： C07D405/04 ,  C07D317/22 ,  C07D327/04

    摘要： The invention concerns a cyclic ether derivative of the formula I, ##STR1## wherein Ar.sup.1 is optionally substituted phenyl or naphthyl;A.sup.1 is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo(3-6C)alkylene;Ar.sup.2 is optionally substituted phenylene, or a 6 membered heterocyclene moiety containing up to three nitrogen atoms;R.sup.1 and R.sup.2 together form a group of the formula --A.sup.2 --X--A.sup.3 -- wherein each of A.sup.2 and A.sup.3 is (1-6C)alkylene and X is oxy, thio, sulphinyl, sulphonyl or imino; andR.sup.3 is (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl or substituted (1-4C)alkyl;or a pharmaceutically-acceptable salt thereof.The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.

    摘要翻译： 本发明涉及式I的环醚衍生物，其中Ar1是任选取代的苯基或萘基; A1为（1-6C）亚烷基，（3-6C）亚烯基，（3-6C）亚炔基或环（3-6C）亚烷基; Ar 2是任选取代的亚苯基，或含有至多三个氮原子的6元杂烯基部分; R1和R2一起形成式-A2-X-A3-的基团，其中A2和A3各自为（1-6C）亚烷基，X为氧基，硫基，亚磺酰基，磺酰基或亚氨基; （1-6C）烷基，（2-6C）烯基，（2-6C）炔基或取代的（1-4C）烷基; 或其药学上可接受的盐。 本发明的化合物是5-脂氧合酶的抑制剂。

    Heterocyclic cyclic ethers
    10.
    发明授权
    Heterocyclic cyclic ethers 失效
    杂环环醚

    公开(公告)号：US5196419A

    公开(公告)日：1993-03-23

    申请号：US785879

    申请日：1991-11-04

    申请人： Graham C. Crawley ,  Annie Hamon

    发明人： Graham C. Crawley ,  Annie Hamon

    IPC分类号： C07D405/12

    CPC分类号： C07D405/12

    摘要： The invention concerns a heterocyclic cyclic ether of the formula I ##STR1## wherein Q is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one or two nitrogen atoms;A is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo(3-6C)alkylene;X is oxy, thio, sulphinyl, sulphonyl or imino;Ar is phenylene which may optionally bear one or two substituents or Ar is an optionally substituted 6-membered heterocyclene moiety containing up to three nitrogen atoms;R.sup.1 and R.sup.2 together form a group of the formula --A.sup.2 --X.sup.2 --A.sup.3 -- which, together with the oxygen atom to which A.sup.2 is attached and with the carbon atom to which A.sup.3 is attached, defines a ring having 5 to 7 ring atoms, wherein A.sup.2 and A.sup.3 each is (1-3C)alkylene and X.sup.2 is oxy, thio, sulphinyl, sulphonyl or imino, and which ring may bear one, two or three substituents; andR.sup.3 is hydrogen, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl or substituted (1-4C)alkyl;or a pharmaceutically-acceptable salt thereof.The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.

    摘要翻译： 本发明涉及式I的杂环环醚其中Q是含有一个或两个氮原子的任选取代的6元单环或10元双环杂环部分; A是（1-6C）亚烷基，（3-6C）亚烯基，（3-6C）亚炔基或环（3-6C）亚烷基; X是氧基，硫基，亚磺酰基，磺酰基或亚氨基; Ar是可以任选地带有一个或两个取代基的亚苯基，或Ar是含有至多三个氮原子的任选取代的6元杂环烯部分; R1和R2一起形成式-A2-X2-A3-的基团，其与A2连接的氧原子和与A3连接的碳原子连同，定义为具有5至7个环原子的环， 其中A2和A3各自为（1-3C）亚烷基，X2为氧基，硫基，亚磺酰基，磺酰基或亚氨基，并且该环可以带有一个，两个或三个取代基; （1-6C）烷基，（2-6C）烯基，（2-6C）炔基或取代的（1-4C）烷基; 或其药学上可接受的盐。 本发明的化合物是5-脂氧合酶的抑制剂。