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23 条记录 (耗时 0.045 秒)

    Pyranoindole inhibitors of COX--2
    8.
    发明授权
    Pyranoindole inhibitors of COX--2 失效
    COX-2的吡喃吲哚抑制剂

    公开(公告)号：US5776967A

    公开(公告)日：1998-07-07

    申请号：US888983

    申请日：1997-07-07

    申请人： Anthony F. Kreft ,  Craig E. Caufield ,  Amedeo A. Failli ,  Thomas J. Caggiano ,  Alexander A. Greenfield ,  Dennis M. Kubrak

    发明人： Anthony F. Kreft ,  Craig E. Caufield ,  Amedeo A. Failli ,  Thomas J. Caggiano ,  Alexander A. Greenfield ,  Dennis M. Kubrak

    IPC分类号： C07D209/86 ,  C07D491/04 ,  C07D491/052 ,  A61K31/40 ,  A61K31/35 ,  C07D209/80 ,  C07D311/78

    CPC分类号： C07D491/04 ,  C07D209/86

    摘要： This invention provides compounds of formula I having the structure ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are, each, independently, hydrogen, alkyl, alkenyl, alkynyl, alkoxy, aralkoxy, trifluroalkoxy, alkanoyloxy, hydroxy, halo, trifluoromethyl, cyano, amino, mono- or di-alkylamino, alkanamido, or alkanesulfonamido; R.sub.5 is hydrogen, alkyl, alkenyl, alkoxyalkyl or alkylcycloalkyl; R.sub.6 is hydrogen, alkyl or alkenyl; X is oxygen or carbon; A is oxygen or NZ; Z is hydroxyl, alkoxy, aryloxy, carboxyalkyloxy of 2-7 carbon atoms, arylamino, or alkylsulfonyamino of 1-6 carbon atoms; or a pharmaceutically acceptable salt thereof, which are useful in the treatment of arthritic disorders, colorectal cancer, and Alzheimer's disease.

    摘要翻译： 本发明提供具有结构式I的式I化合物，其中R 1，R 2，R 3和R 4各自独立地为氢，烷基，烯基，炔基，烷氧基，芳烷氧基，三氟烷氧基，烷酰氧基，羟基，卤素，三氟甲基， 氰基，氨基，单 - 或二 - 烷基氨基，烷酰氨基或烷磺酰氨基; R5是氢，烷基，烯基，烷氧基烷基或烷基环烷基; R6是氢，烷基或烯基; X是氧或碳; A是氧气或NZ; Z为2-7个碳原子的羟基，烷氧基，芳氧基，羧基烷氧基，芳基氨基或1-6个碳原子的烷基磺酰氨基; 或其药学上可接受的盐，其可用于治疗关节炎疾病，结肠直肠癌和阿尔茨海默氏病。

    Quinoline compounds as antiallergic and antiinflammatory agents
    9.
    发明授权
    Quinoline compounds as antiallergic and antiinflammatory agents 失效
    喹啉化合物作为抗过敏和抗炎药

    公开(公告)号：US4904786A

    公开(公告)日：1990-02-27

    申请号：US231130

    申请日：1988-08-11

    申请人： John H. Musser ,  Dennis M. Kubrak ,  Anthony F. Kreft, III ,  Reinhold H. W. Bender

    发明人： John H. Musser ,  Dennis M. Kubrak ,  Anthony F. Kreft, III ,  Reinhold H. W. Bender

    IPC分类号： C07D215/14 ,  C07D333/56

    CPC分类号： C07D215/14 ,  C07D333/56

    摘要： There are disclosed compounds of the formula ##STR1## wherein R.sup.1 is ##STR2## n is 0-5; R.sup.2 is hydrogen, loweralkyl, loweralkoxy, lower alkoxycarbonyl, trifluoromethyl, nitro, cyano or halo;R.sup.3 is hydrogen or loweralkyl;R.sup.4 hydrogen, lower alkyl, --COOR.sup.3 or ##STR3## R.sup.5 is lower alkyl, monofluoroloweralkyl, difluoroloweralkyl, polyfluoroloweralkyl, perfluoroloweralkyl or ##STR4## and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like, and as antiinflammatory agents.

    摘要翻译： 公开了下式的化合物：其中R 1是0-5;其中R 1是0-5; R2是氢，低级烷基，低级烷氧基，低级烷氧基羰基，三氟甲基，硝基，氰基或卤素; R3是氢或低级烷基; R4氢，低级烷基，-COOR3或R5是低级烷基，一氟氟烷基，二氟低级烷基，聚氟低烷基，全氟低级烷基或其药学上可接受的盐，以及它们在治疗白三烯介导的鼻支气管阻塞性空气通道中的用途 过敏性鼻炎，过敏性支气管哮喘等，作为抗炎药。

    2-(phenoxymethyl)-quinazolines as antiallergic and antiinflammatory agents
    10.
    发明授权
    2-(phenoxymethyl)-quinazolines as antiallergic and antiinflammatory agents 失效
    2-（苯氧基甲基） - 喹唑啉作为抗过敏和抗炎药

    公开(公告)号：US4772703A

    公开(公告)日：1988-09-20

    申请号：US50595

    申请日：1987-05-15

    申请人： John H. Musser ,  Dennis M. Kubrak ,  Anthony F. Kreft, III ,  Reinhold H. W. Bender

    发明人： John H. Musser ,  Dennis M. Kubrak ,  Anthony F. Kreft, III ,  Reinhold H. W. Bender

    IPC分类号： C07D215/14 ,  C07D333/56 ,  A61K31/505 ,  C07D239/74

    CPC分类号： C07D333/56 ,  C07D215/14

    摘要： There are disclosed compounds of the formula ##STR1## wherein ##STR2## R.sup.2 is hydrogen, loweralkyl, loweralkoxy, lower alkoxycarbonyl, trifluoromethyl, nitro, cyano or halo;R.sup.3 is hydrogen or loweralkyl;R.sup.4 is hydrogen, lower alkyl, --COOR.sup.3 or ##STR3## R.sup.5 is lower alkyl, monofluoroloweralkyl, difluoroloweralkyl, polyfluoroloweralkyl, perfluoroloweralkyl or ##STR4## and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like, and as antiinflammatory agents.

    摘要翻译： 公开了下式的化合物：其中，R 1是氢，低级烷基，低级烷氧基，低级烷氧基羰基，三氟甲基，硝基，氰基或卤素; R3是氢或低级烷基; R4是氢，低级烷基，-COOR3或R5是低级烷基，一氟氟烷基，二氟低级烷基，聚氟低烷基，全氟低级烷基或其药学上可接受的盐，以及它们在治疗白三烯介导的鼻支气管梗阻 空气通道条件，如过敏性鼻炎，过敏性支气管哮喘等，以及抗炎药。