-
公开(公告)号：US20080223364A1
公开(公告)日：2008-09-18
申请号：US11724147
申请日：2007-03-14
IPC分类号： A61M16/00
CPC分类号： A61M15/00 , A61M11/003 , A61M11/02 , A61M15/0008 , A61M16/0627 , A61M2202/064 , A61M2205/3306 , A61M2205/70 , A61M2205/84 , A61M2250/00
摘要： Dry powder aerosol generators and related methods are provided. The dry powder aerosol generator includes a dispersion chamber having an internal cavity therein capable of receiving a dry powdered drug. The dispersion chamber includes a dosing port defined therein that is in fluid communication with the internal cavity. A dosing chamber for receiving a test subject is attachable to the dosing port, such that, when an airflow is created within the internal cavity, any dry powdered drug contained therein may fluidize and travel into the dosing chamber to provide opportunity for inhalation of the dry powdered drug by a test subject contained within the dosing chamber.
摘要翻译： 提供干粉烟雾发生器及相关方法。 干粉气溶胶发生器包括其中具有能够接收干粉状药物的内腔的分散室。 分散室包括限定在其中的与内腔流体连通的配量口。 用于接收测试对象的计量室可附接到计量端口，使得当在内部空腔内产生气流时，其中容纳的任何干粉状药物可以流化并进入计量室以提供吸入干燥的机会 通过包含在剂量室内的测试对象的粉末状药物。
-
公开(公告)号：US08205612B2
公开(公告)日：2012-06-26
申请号：US11724147
申请日：2007-03-14
CPC分类号： A61M15/00 , A61M11/003 , A61M11/02 , A61M15/0008 , A61M16/0627 , A61M2202/064 , A61M2205/3306 , A61M2205/70 , A61M2205/84 , A61M2250/00
摘要： Dry powder aerosol generators and related methods are provided. The dry powder aerosol generator includes a dispersion chamber having an internal cavity therein capable of receiving a dry powdered drug. The dispersion chamber includes a dosing port defined therein that is in fluid communication with the internal cavity. A dosing chamber for receiving a test subject is attachable to the dosing port, such that, when an airflow is created within the internal cavity, any dry powdered drug contained therein may fluidize and travel into the dosing chamber to provide opportunity for inhalation of the dry powdered drug by a test subject contained within the dosing chamber.
摘要翻译： 提供干粉烟雾发生器及相关方法。 干粉气溶胶发生器包括其中具有能够接收干粉状药物的内腔的分散室。 分散室包括限定在其中的与内腔流体连通的配量口。 用于接收测试对象的计量室可附接到计量端口，使得当在内部空腔内产生气流时，其中容纳的任何干粉状药物可以流化并进入计量室以提供吸入干燥的机会 通过包含在剂量室内的测试对象的粉末状药物。
-
3.发明授权Coated filament for evaporation/condensation aerosol generation of therapeutic agents and methods for using 有权用于蒸发/凝结烟雾剂的治疗剂的涂层丝和使用方法公开(公告)号：US08165460B2
公开(公告)日：2012-04-24
申请号：US11666367
申请日：2005-10-26
IPC分类号： A01G13/06
CPC分类号： A61M15/00 , A61M11/041 , A61M11/042
摘要： An apparatus for generating an aerosol of a therapeutic agent and methods of using the same are disclosed. The apparatus comprises a heating element having a surface and a composition coating at least a portion of the heating element surface. The composition comprises a carrier and a therapeutic agent, wherein when the heating element surface is heated to at least the vaporization point of the carrier, the carrier vaporizes and releases the therapeutic agent from the composition as an aerosol. The heating element can be a coiled filament. The therapeutic agent can be a small molecule, a polynucleotide, a polypeptide, or a recombinant virus. The apparatus can be incorporated into a delivery device, such as a metered dose inhaler or an exposure chamber.
摘要翻译： 公开了一种用于产生治疗剂的气溶胶的装置及其使用方法。 该装置包括具有表面和组合物涂覆至少一部分加热元件表面的加热元件。 组合物包含载体和治疗剂，其中当将加热元件表面加热至至少载体的蒸发点时，载体以气雾剂的形式蒸发并释放治疗剂。 加热元件可以是螺旋丝。 治疗剂可以是小分子，多核苷酸，多肽或重组病毒。 该装置可以并入输送装置，例如计量剂量吸入器或曝光室。
-
公开(公告)号：US08156829B2
公开(公告)日：2012-04-17
申请号：US11666366
申请日：2005-10-26
CPC分类号： A61M15/009 , A61M11/001 , B05B17/0607
摘要： Methods of modulating a characteristic of a pharmaceutical compound spray by acoustic measurement and control of the pharmaceutical spray are disclosed. The methods include analyzing a selected characteristic of a pharmaceutical compound spray utilizing acoustic measurement to develop corresponding acoustic data. The methods further include controlling the selected characteristic by applying acoustic excitation to the pharmaceutical compound spray in accordance with the acoustic data developed.
摘要翻译： 公开了通过声学测量和药物喷雾的控制来调节药物化合物喷雾特性的方法。 所述方法包括使用声学测量来分析药物化合物喷雾的选定特征，以形成相应的声学数据。 所述方法还包括根据所开发的声学数据，通过向药物化合物喷雾施加声学激发来控制所选择的特征。
-
公开(公告)号：US20210393815A1
公开(公告)日：2021-12-23
申请号：US17466189
申请日：2021-09-03
申请人： Marek A. Osinski , Hugh D. C. Smyth , Leisha Marie Armijo , Hennaka Mudiyanselage Herath Nihal Bandara
发明人： Marek A. Osinski , Hugh D. C. Smyth , Leisha Marie Armijo , Hennaka Mudiyanselage Herath Nihal Bandara
摘要： Various embodiments disclosed relate to methods and compositions for antimicrobial treatment. In various embodiments, the present invention provides a method of antimicrobial treatment. The method includes at least one of exposing at least one microbe to a magnetic field, and contacting the at least one microbe with at least one nanoparticle including iron.
-
公开(公告)号：US11135325B2
公开(公告)日：2021-10-05
申请号：US15549974
申请日：2016-02-09
申请人： Marek A. Osinski , Hugh D. C. Smyth , Leisha Marie Armijo , Hennaka Mudiyanselage Herath Nihal Bandara
发明人： Marek A. Osinski , Hugh D. C. Smyth , Leisha Marie Armijo , Hennaka Mudiyanselage Herath Nihal Bandara
摘要： Various embodiments disclosed relate to methods and compositions for antimicrobial treatment. In various embodiments, the present invention provides a method of antimicrobial treatment. The method includes at least one of exposing at least one microbe to a magnetic field, and contacting the at least one microbe with at least one nanoparticle including iron.
-
公开(公告)号：US09492625B2
公开(公告)日：2016-11-15
申请号：US13505402
申请日：2010-11-12
CPC分类号： A61M15/0028 , A61M11/003 , A61M15/0031 , A61M15/0038 , A61M15/0086 , A61M2202/064 , A61M2205/0233 , A61M2206/16
摘要： A dry powder inhaler including a housing defining a chamber for receiving a dose of powdered medicament, an inhalation port in fluid communication with the chamber, at least one airflow inlet providing fluid communication between the chamber and an exterior of the housing, and a flutter element in the chamber and associated with a dose of powdered medicament. The flutter element has a tensioned distal end proximate the at least one airflow inlet and a free proximal end opposite to the distal end and downstream of the inlet. The flutter element is configured to vibrate in response to airflow through the chamber and aerosolize the dose of powdered medicament.
摘要翻译： 一种干粉吸入器，其包括限定用于接收一定剂量的粉末药物的室的壳体，与所述室流体连通的吸入口，至少一个气流入口，其提供所述腔室与所述壳体的外部之间的流体连通，以及颤动元件 并且与一定剂量的粉末状药物相关联。 颤振元件具有靠近至少一个气流入口的张紧的远端和与入口的远端和下游相对的自由近端。 颤振元件构造成响应于通过腔室的气流而振动并使粉末状药物的剂量雾化。
-
公开(公告)号：US08652366B2
公开(公告)日：2014-02-18
申请号：US13286625
申请日：2011-11-01
IPC分类号： B29B9/00
CPC分类号： B82Y5/00 , A61K9/146 , A61K47/36 , C08B37/003 , C08B37/0084 , C08J3/075 , C08J2305/04 , C08J2305/08 , C08L5/04 , C08L5/08 , Y02P20/544
摘要： Disclosed are aerosol-mediated methods for synthesizing particles for biomedical and drug delivery applications. The method is based on the production of particles from sprayed polymeric micro or nano-droplets obtained by, for example, an air-jet nebulization process that is followed by gelation and/or hardening in a crosslinking fluid, non-solvent, precipitating solvent, or supercritical fluid.
摘要翻译： 公开了用于合成用于生物医学和药物递送应用的颗粒的气溶胶介导的方法。 该方法基于通过例如空气喷射雾化方法获得的喷雾的聚合物微米或纳米液滴的颗粒的产生，随后在交联流体，非溶剂，沉淀溶剂中凝胶化和/或硬化， 或超临界流体。
-
9.发明授权Methods and systems for dosing and coating inhalation powders onto carrier particles 有权将吸入粉末给药和涂覆到载体颗粒上的方法和系统公开(公告)号：US08962063B2
公开(公告)日：2015-02-24
申请号：US13389558
申请日：2010-08-27
CPC分类号： A61K9/0075 , A61K9/14 , A61K31/58
摘要： A method of method of coating powdered medical agent onto a carrier particle for use in a dry powder inhaler may include applying ultrasonic energy to agglomerated powdered medical agent to deaggregate and aerosolize particles of the medical agent into particles having a desired average particle size, and coating at least one carrier particle with a desired amount of the deaggregated and aerosolized particles of the medical agent.
摘要翻译： 将粉末状药剂涂布在用于干粉吸入器的载体颗粒上的方法的方法可以包括将超声能量施加到附聚的粉末状药剂以将药剂的颗粒分解和雾化成具有所需平均粒径的颗粒，以及涂覆 至少一个具有所需量的药物剂的解聚集和雾化颗粒的载体颗粒。
-
公开(公告)号：US08715770B2
公开(公告)日：2014-05-06
申请号：US13582883
申请日：2011-03-09
CPC分类号： B05B7/144 , A61M15/0028 , A61M15/0065 , A61M15/009 , A61M2202/064 , A61M2205/0233 , A61M2205/0238 , B05B12/36 , B05B13/0207
摘要： A device for coating dry powder microparticles onto a surface may include a jet mill configured to mill dry powder particles into microparticles having a desired aerodynamic diameter and to deaggregate the microparticles, a feed hopper structured and arranged to feed dry powder particles to the jet mill, a surface configured to receive dry powder microparticles and an exit nozzle associated with the jet mill. The exit nozzle may be arranged to direct deaggregated micronized dry powder particles from the jet mill to the surface to be coated. The device may further include a holder structured and arranged to hold an item, wherein the item includes the surface. In some aspects of the device, the item may be a film.
摘要翻译： 用于将干燥粉末微粒涂覆到表面上的装置可以包括喷射式粉碎机，其被配置为将干燥粉末颗粒研磨成具有期望的空气动力学直径的微粒并且使微粒解聚，构造并布置成将干燥粉末颗粒送入喷射式粉碎机的进料斗， 被配置为接收干燥粉末微粒的表面和与喷射磨机相关联的出口喷嘴。 出口喷嘴可以布置成将来自喷射磨机的解聚集的微粉化干粉颗粒引导到待涂覆的表面。 该装置还可以包括构造和布置成保持物品的保持器，其中物品包括表面。 在设备的某些方面，该项目可以是电影。
-
-
-
-
-
-
-
-
-
搜索结果
10 条记录 (耗时 0.024 秒)
