摘要:
Non-peptide compounds comprising a central hydrazide motif and methods for the synthesis thereof are disclosed. The compounds act to antagonize the action of the glucagon peptide hormone.
摘要:
Non-peptide compounds that act as antagonists of the intestinal hormone glucagons-like peptide 1 (GLP-1) have a 9H-b-carboline central motif. The compounds exhibit advantageous physical, chemical and biological properties and inhibit GLP-1 peptide binding to the GLP-1 receptor and/or prevent activation of the receptor by bound GLP-1. The invention further relates to a method of inhibiting the binding of GLP-1 to the GLP-1 receptor and a method of inhibiting the activation of the GLP-1 receptor. Intermediate compounds useful for making non-peptide GLP-1 receptor antagonists are also described.
摘要:
Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
摘要:
Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
摘要:
Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
摘要:
Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
摘要:
Systems and methods are disclosed for creating personalized media content having multiple content layers in “one-click” fashion by selecting a background media template or by using an end-user media composition tool to create or modify a template. For example, the personalized media content can include at least two separate layers, the data of each being stored independently of one another. The two layers may include a background layer including at least one background character and an intermediate layer including an individualized three-dimensional (3D) head model, alignment information, and lighting information. The personalized media content can be displayed by overlaying the background layer using the alignment intermediate layer using the alignment information and the lighting information. In certain examples, template data associated with the background media is created and subsequently used on multiple occasions in generating personalized media content with various 3D head models.
摘要:
An apparatus used for reducing the incidence of aspiration in patients using a two-axis inclinometer is disclosed. The apparatus uses a two-axis inclinometer that is attached in the region of the patient's upper body to measure the absolute angular elevation of the patient's upper body, which is then transmitted to a display or other output device. In one embodiment, the instrument can be mounted to the head of a bed in a plurality of orientations and accurately measure the absolute angular elevation of the patient's upper body. In other embodiments the absolute angular elevation of the patient's upper body information is processed and transmitted to the nurses' station or to a data recorder. The disclosure also relates to a method for measuring the physical orientation of a patient, using such two-axis inclinometer apparatus.
摘要:
The invention relates to a form of a tilt switch that solves the problem of poor electrical contact, excessive/unpredictable hysteresis, high contact resistance, short life and/or electrical bounce. The tilt switch uses conventional ball-in-tube construction and adds a graphite powder film to all electrically conductive surfaces in the switch. This non-mercury tilt switch provides additional features such as enhanced electrical contact, reduced or eliminated hysteresis, lowered contact resistance, increased contact life and eliminates electrical bounce.
摘要:
Embodiments provide a spacecraft airlock system. Embodiments provide a method and apparatus for attaching space exposed payloads to a space station. The spacecraft airlock system provides a defined volume of space payload to the international space station. The airlock further includes a means of attaching to a space station, a closed structure attached to said means, said means of attaching is capable of robotic manipulation, and a cooling system for cooling payload components within said closed structure.