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1.发明授权Liposomes encapsulating anticancer drugs and use thereof in the treatment of malignant tumors 失效封装抗癌药物的脂质体及其在治疗恶性肿瘤中的应用公开(公告)号：US07153490B2
公开(公告)日：2006-12-26
申请号：US10398627
申请日：2001-10-03
申请人： Antonio Parente Dueña , Ferran Pons Lambiez , Angels Fabra Fres , María Dolores Polo Trasancos , Josep Garces Garces , Francesca Reig Isart
发明人： Antonio Parente Dueña , Ferran Pons Lambiez , Angels Fabra Fres , María Dolores Polo Trasancos , Josep Garces Garces , Francesca Reig Isart
IPC分类号： A61K9/127
CPC分类号： A61K9/1271
摘要： Liposomes encapsulating anticancerous drugs and the use thereof in the treatment of malignant tumors. The liposomes are coated with a lipopeptide composed of three substructures: a lipid fragment, an active oligopeptide and an oligopeptide spacer between the other two fragments. Applicable in intravenous administration for treatment of malignant tumors.
摘要翻译： 包封抗癌药物的脂质体及其在治疗恶性肿瘤中的应用。 脂质体用由三个亚结构组成的脂肽包被：其它两个片段之间的脂质片段，活性寡肽和寡肽间隔物。 适用于静脉给药治疗恶性肿瘤。
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公开(公告)号：US06534091B1
公开(公告)日：2003-03-18
申请号：US10018542
申请日：2002-05-14
IPC分类号： A61K914
CPC分类号： C11D17/08 , A61K8/11 , A61K8/736 , A61K9/1652 , A61K9/5036 , A61K2800/412 , A61Q5/02 , A61Q17/04 , A61Q19/00 , A61Q19/10 , B01J13/02 , C11D17/0039 , Y10T428/2982 , Y10T428/2984 , Y10T428/2985 , Y10T428/2989 , Y10T428/31823 , Y10T428/31826 , Y10T428/3183 , Y10T428/31841 , Y10T428/31844
摘要： A microcapsule having a mean diameter of from about 0.1 to about 5 mm, a membrane and a matrix containing at least one active principle wherein the microcapsule is the product of the process comprising the steps of (a) forming an aqueous matrix by heating an aqueous solution comprised of a gel former, a chitosan and active principle; (b) adding the aqueous matrix to an aqueous solution of an anionic polymer selected from the group consisting of a salt of alginic acid and an anionic chitosan derivative.
摘要翻译： 具有约0.1至约5mm平均直径的微胶囊，含有至少一种活性成分的膜和基质，其中所述微胶囊是该方法的产物，该方法包括以下步骤：（a）通过加热水性基质 溶液由凝胶成型剂，壳聚糖和活性成分组成; （b）将水性基质加入到由藻酸和阴离子壳聚糖衍生物的盐组成的组中的阴离子聚合物的水溶液中。
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公开(公告)号：US06818296B1
公开(公告)日：2004-11-16
申请号：US10018731
申请日：2002-04-04
IPC分类号： B32B2700
CPC分类号： C11D17/0039 , A61K8/0208 , A61K8/11 , A61K9/1652 , A61K9/5036 , A61K2800/412 , A61Q5/00 , A61Q5/02 , A61Q17/04 , A61Q19/00 , A61Q19/10 , B01J13/02 , C08L5/00 , C11D3/227 , Y10T428/2984 , Y10T428/2985 , Y10T428/2989
摘要： A microcapsule having a mean diameter of from about 0.1 to about 5 mm, a membrane and a matrix containing at least one active principle wherein the microcapsule is the product of the process comprising the steps of (a) forming an aqueous matrix by heating an aqueous solution comprised of a gel former, a chitosan and active principle; (b) forming a dispersed matrix by adding the aqueous matrix in an oil phase; (c) contacting the dispersed matrix with an aqueous solution of an anionic polymer selected from the group consisting of a salt of alginic acid and an anionic chitosan derivative.
摘要翻译： 具有约0.1至约5mm平均直径的微胶囊，含有至少一种活性成分的膜和基质，其中所述微胶囊是该方法的产物，该方法包括以下步骤：（a）通过加热水性基质 溶液由凝胶成型剂，壳聚糖和活性成分组成; （b）通过将水性基质加入油相中形成分散的基质; （c）使分散的基质与选自藻酸和阴离子壳聚糖衍生物的盐的阴离子聚合物的水溶液接触。
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4.发明申请Method for delivering a peptide to a subject at a modulated rate via microcapsules of lactic-co-glycolic copolymer containing said peptide 有权通过含有所述肽的乳酸共 - 乙醇酸共聚物的微胶囊以调制速率将肽递送至受试者的方法公开(公告)号：US20080233198A1
公开(公告)日：2008-09-25
申请号：US12148893
申请日：2008-04-23
CPC分类号： A61K9/1647 , A61K9/1617 , A61K9/5015 , A61K9/5031
摘要： Micro-capsules for the slow release of drugs, consisting of a lactic-co-glycolic copolymer to which a plasticiser has been incorporated and which contain a drug of pharmaceutical interested within them.
摘要翻译： 用于缓慢释放药物的微胶囊，由掺入增塑剂的乳酸 - 共 - 乙醇酸共聚物组成，并含有其中感兴趣的药物药物。
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5.发明申请公开(公告)号：US20050123618A1
公开(公告)日：2005-06-09
申请号：US11042682
申请日：2005-01-25
IPC分类号： A61K9/52 , A61K9/16 , A61K9/50 , A61K38/04 , A61K38/22 , A61K47/14 , A61K47/34 , A61P5/02 , A61P5/22 , A61K38/09 , A61K9/14
CPC分类号： A61K9/1647 , A61K9/1617 , A61K9/5015 , A61K9/5031
摘要： Micro-capsules for the slow release of drugs, consisting of a lactic-co-glycolic copolymer to which a plasticiser has been incorporated and which contain a drug of pharmaceutical interested within them.
摘要翻译： 用于缓慢释放药物的微胶囊，由掺入增塑剂的乳酸 - 共 - 乙醇酸共聚物组成，并含有其中感兴趣的药物药物。
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6.发明申请Microcapsules for stabilization of cosmetic, pharmaceutical or food products 审中-公开用于化妆品，药物或食品稳定化的微胶囊公开(公告)号：US20060051408A1
公开(公告)日：2006-03-09
申请号：US11265467
申请日：2005-11-02
CPC分类号： A61Q19/00 , A23L27/72 , A23P10/30 , A23V2002/00 , A61K8/11 , A61K8/31 , A61K8/35 , A61K8/368 , A61K8/645 , A61K8/66 , A61K8/671 , A61K8/676 , A61K8/97 , A61K9/5026 , A61K9/5031 , A61K9/5042 , A61K9/5047 , A61K2800/412 , A61K2800/52 , A61Q5/02 , A61Q19/10 , A23V2200/224 , A23V2250/51088 , A23V2250/51084 , A23V2250/5118
摘要： Microcapsules for stabilisation of cosmetic, pharmaceutical or food products, of a size smaller than 500 μm, comprising a nucleus of an adsorbent material—natural or modified polysaccharide insoluble in water, or an adsorbent inorganic material—in which are contained the active ingredients and is coated by a polymeric material—natural, modified natural or synthetic polymer—apt for use in the cosmetics, pharmaceutics or food fields. Use of said microcapsules, characterised by their incorporation in cosmetic products such as gels, creams, lotions, emulsions, bath gels, shampoos and the like; incorporation in pharmaceutical and veterinary products applied topically, orally or parenterally; incorporation in food products for human or animal consumption and in diet products.
摘要翻译： 用于稳定化妆品，药物或食品的微胶囊，其尺寸小于500μm，包含吸附材料的核 - 天然或改性的不溶于水的多糖或其中含有活性成分的吸附剂无机材料，并且是 通过聚合材料（天然，改性天然或合成聚合物）涂覆，适用于化妆品，药物或食品领域。 使用所述微胶囊，其特征在于它们掺入化妆品中，例如凝胶，霜剂，洗液，乳液，浴凝胶，洗发剂等; 纳入药物和兽医产品，局部，口服或肠胃外应用; 纳入用于人类或动物消费的食品和饮食产品。
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公开(公告)号：US06979467B1
公开(公告)日：2005-12-27
申请号：US10018922
申请日：2000-06-23
IPC分类号： A23L1/00 , A61K8/11 , A61K8/64 , A61K8/66 , A61K8/72 , A61K8/73 , A61K8/92 , A61K8/96 , A61K9/16 , A61K9/50 , A61K9/62 , A61K9/64 , A61K9/66 , A61K47/30 , A61K47/36 , A61K47/42 , A61Q5/02 , A61Q17/04 , A61Q19/00 , A61Q19/10 , B01J13/02 , C08L5/00 , C11D3/18 , C11D3/22 , C11D3/37 , C11D17/00 , C11D17/08 , A61K9/14 , A61K9/127
CPC分类号： C11D17/0039 , A61K8/11 , A61K8/73 , A61K8/736 , A61K9/1652 , A61K9/5036 , A61K2800/412 , A61Q5/02 , A61Q17/04 , A61Q19/00 , A61Q19/10 , B01J13/02 , C08L5/00 , C11D3/18 , C11D3/227
摘要： A microcapsule having a mean diameter of from about 0.1 to about 5 mm, a membrane and a matrix containing at least one active principle wherein the microcapsule is the product of the process comprising the steps of (a) forming an aqueous matrix by heating an aqueous solution comprised of a gel former, an anionic polymer selected from the group consisting of a salt of alginic acid and an anionic chitosan derivative and active principle; (b) forming a dispersed matrix by adding the aqueous matrix in an oil phase; (c) contacting the dispersed matrix with an aqueous solution of chitosan.
摘要翻译： 具有约0.1至约5mm平均直径的微胶囊，含有至少一种活性成分的膜和基质，其中所述微胶囊是该方法的产物，该方法包括以下步骤：（a）通过加热水性基质 由凝胶形成剂，选自海藻酸盐和阴离子壳聚糖衍生物的阴离子聚合物组成的溶液和活性成分; （b）通过将水性基质加入油相中形成分散的基质; （c）使分散的基质与壳聚糖的水溶液接触。
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公开(公告)号：US20110130446A1
公开(公告)日：2011-06-02
申请号：US13057661
申请日：2009-08-06
IPC分类号： A61K31/337 , A61K47/14 , A61P35/04 , A61J1/06
CPC分类号： A61K9/0019 , A61K9/08 , A61K9/1075 , A61K31/337 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/26 , A61K47/44
摘要： New injectable taxane pharmaceutical composition. Stable composition with low percentage of ethanol and a lower ethanol/taxane ratio than that of the state-of-the-art taxane pharmaceutical compositions.
摘要翻译： 新型注射紫杉烷药物组合物。 具有低百分比的乙醇和比最先进的紫杉烷药物组合物低的乙醇/紫杉烷比的稳定组合物。
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公开(公告)号：US20070275078A1
公开(公告)日：2007-11-29
申请号：US10560990
申请日：2004-06-16
CPC分类号： A61K9/1617
摘要： The present invention relates to microcapsules for the administration of active ingredients, consisting of a core comprising one or more active ingredients, a surfactant and at least one wax or at least one fat, or a mixture of at least one wax and at least one fat, and of a coating comprising one or more non-fat substances selected from the group comprising polysaccharides, animal proteins, milk proteins and vegetable proteins.
摘要翻译： 本发明涉及用于施用活性成分的微胶囊，其由包含一种或多种活性成分的核心，表面活性剂和至少一种蜡或至少一种脂肪组成，或至少一种蜡和至少一种脂肪的混合物 以及包含选自多糖，动物蛋白，乳蛋白和植物蛋白的一种或多种非脂肪物质的涂层。
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10.发明授权公开(公告)号：US07022668B2
公开(公告)日：2006-04-04
申请号：US10480538
申请日：2002-06-07
申请人： Antonio Parente Duena , Josep Garces Garces , Jesus Guinea Sanchez , Josep Maria Garcia Anton , Ricardo Casaroli Marano , Manuel Reina Del Pozo , Senen Vilaro Coma
发明人： Antonio Parente Duena , Josep Garces Garces , Jesus Guinea Sanchez , Josep Maria Garcia Anton , Ricardo Casaroli Marano , Manuel Reina Del Pozo , Senen Vilaro Coma
CPC分类号： A61K8/64 , A61K9/0014 , A61K38/164 , A61Q3/00 , A61Q5/00 , A61Q19/00
摘要： Use of a glycoprotein produced by Pseudoalteromonas antartica and consisting of 14% carbohydrates and 86% protein in the preparation of pharmaceutical, veterinary and cosmetic compositions for topical or mucous application in the treatment and re-epithelialization of wounds and in the preparation of cosmetic compositions for treatment of skin, hair or nails.
摘要翻译： 在制备用于局部或粘液的药物，兽医和化妆品组合物中用于治疗和重新上皮化伤口以及在制备化妆品组合物中使用由假黄色短杆菌（Pseudoalteromonas antartica）产生并由14％碳水化合物和86％蛋白质产生的糖蛋白 治疗皮肤，头发或指甲。
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