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1.发明授权System for purification and analysis of radiochemical products yielded by microfluidic synthesis devices 失效由微流体合成装置产生的放射化学产品的净化和分析系统公开(公告)号：US07741121B2
公开(公告)日：2010-06-22
申请号：US11895636
申请日：2007-08-23
IPC分类号： G01N23/00
CPC分类号： G01N30/88 , C07B59/00 , C07B63/00 , G01N30/82 , G01N2030/77 , G01N2030/8809 , Y10T137/86493 , Y10T436/11 , Y10T436/115831 , G01N30/6095
摘要： The present application is generally directed to microfluidic devices and methods for the achievement and assessment of chemical and radiochemical purity of (microfluidic) radio-synthesis products. More particularly, the current application relates to systems for purification and analysis of radiochemical products yielded by microfluidic synthesis devices.
摘要翻译： 本申请通常涉及用于实现和评估（微流体）放射合成产物的化学和放射化学纯度的微流体装置和方法。 更具体地，本申请涉及用于净化和分析由微流体合成装置产生的放射化学产物的系统。
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2.发明授权Microfluidic radiosynthesis system for positron emission tomography biomarkers 失效用于正电子发射断层扫描生物标志物的微流体放射合成系统公开(公告)号：US08071035B2
公开(公告)日：2011-12-06
申请号：US12102822
申请日：2008-04-14
申请人： Arkadij M Elizarov , Carroll Edward Ball , Jianzhong Zhang , Hartmuth C. Kolb , R. Michael Van Dam , Lawrence Talcott Diener , Sean Ford , Reza Miraghaie
发明人： Arkadij M Elizarov , Carroll Edward Ball , Jianzhong Zhang , Hartmuth C. Kolb , R. Michael Van Dam , Lawrence Talcott Diener , Sean Ford , Reza Miraghaie
CPC分类号： C07H5/02 , B01J19/0093 , B01J2219/00783 , B01J2219/0086 , B01J2219/00873 , B01J2219/00891 , B01J2219/00907 , B01J2219/00909
摘要： Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber.
摘要翻译： 公开了以快速，有效和紧凑的方式全面自动合成用于成像的放射性化合物的方法和装置，例如通过正电子发射断层摄影（PET）。 特别地，本发明的各种实施例提供了在具有不受限制的气流通过反应器的微流体装置上的整个放射合成循环的自动化的，独立的，免手操作的操作，从目标水开始并产生纯化的PET放射性示踪器 时间比传统化学系统短。 因此，本发明的一个方面涉及用于放射性标记的化合物的放射合成的微流体芯片，包括反应室，连接到反应室的一个或多个流动通道，连接到所述反应室的一个或多个通气口，以及一个或多个 更一体化的阀来实现进出所述反应室的流量控制。
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3.发明授权Microfluidic chip capable of synthesizing radioactively labeled molecules on a scale suitable for human imaging with positron emission tomography 有权能够以适合于使用正电子发射断层扫描的人成像的量表合成放射性标记分子的微流控芯片公开(公告)号：US08075851B2
公开(公告)日：2011-12-13
申请号：US11540344
申请日：2006-09-29
IPC分类号： B01L3/00
CPC分类号： B01F11/0042 , B01F11/0071 , B01F13/0059 , B01J19/0093 , B01J2219/00286 , B01J2219/00396 , B01J2219/00398 , B01J2219/00414 , B01J2219/00418 , B01J2219/00495 , B01J2219/00585 , B01J2219/00599 , B01J2219/00731 , B01J2219/00759 , B01J2219/00783 , B01J2219/00788 , B01J2219/00822 , B01J2219/00824 , B01J2219/00826 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00858 , B01J2219/0086 , B01J2219/00862 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00907 , B01J2219/00916 , B01J2219/00927 , B01J2219/00986
摘要： Described herein are automated, integrated microfluidic device comprising a chemical reaction chip comprising for performing chemical reaction, a microscale column integrated with the chip and configured for liquid flow from the column to at least one flow channel, and wherein the fluid flow into the column is controlled by on-chip valves; and comprising at least two on-chip valves for controlling fluid flow in the microfluidic device.
摘要翻译： 本文描述的是包括用于进行化学反应的化学反应芯片的自动化集成微流体装置，与芯片集成的微量柱，并且构造成用于从柱流到至少一个流动通道的液体流，并且其中流入塔的流体流是 由片上阀控制; 并且包括用于控制微流体装置中的流体流动的至少两个片上阀。
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