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公开(公告)号：US20050209148A1
公开(公告)日：2005-09-22
申请号：US11064309
申请日：2005-02-22
申请人： Arnon Rosenthal , John Lin , Jennifer Stratton , Robert Klein , Jaume Pons
发明人： Arnon Rosenthal , John Lin , Jennifer Stratton , Robert Klein , Jaume Pons
CPC分类号： A61K38/185
摘要： The invention concerns methods for treating obesity, non-insulin dependent diabetes mellitus, metabolic syndrome, and other related diseases by administering an NT-4/5 polypeptide. The invention also concerns compositions and kits comprising an NT-4/5 polypeptide.
摘要翻译： 本发明涉及通过施用NT-4/5多肽来治疗肥胖症，非胰岛素依赖性糖尿病，代谢综合征和其它相关疾病的方法。 本发明还涉及包含NT-4/5多肽的组合物和试剂盒。
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公开(公告)号：US08586045B2
公开(公告)日：2013-11-19
申请号：US13179846
申请日：2011-07-11
申请人： Joerg Zeller , Kristian T. Poulsen , Yasmina Noubia Abdiche , Jaume Pons , Sierra Lee Jones Collier , Arnon Rosenthal
发明人： Joerg Zeller , Kristian T. Poulsen , Yasmina Noubia Abdiche , Jaume Pons , Sierra Lee Jones Collier , Arnon Rosenthal
IPC分类号： A61K39/395 , C12P21/08 , C07K16/00
CPC分类号： C07K16/18 , A61K31/4045 , A61K39/3955 , A61K2039/505 , C07K16/26 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/70 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster headache, and tension headache) and hot flushes, by administering an anti-CGRP antagonist antibody. Antagonist antibody G1 and antibodies derived from G1 directed to CGRP are also described.
摘要翻译： 本发明的特征在于通过施用抗CGRP拮抗剂抗体来预防或治疗CGRP相关疾病如血管舒缩症状，包括头痛（例如偏头痛，丛集性头痛和紧张性头痛）和热潮红的方法。 还描述了拮抗剂抗体G1和衍生自指向CGRP的G1的抗体。
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3.发明申请ANTIBODIES DIRECTED AGAINST AMYLOID-BETA PEPTIDE AND METHODS USING SAME 有权针对AMYLOID-BETA肽的抗体和使用其的方法公开(公告)号：US20120269805A1
公开(公告)日：2012-10-25
申请号：US13542485
申请日：2012-07-05
申请人： Arnon Rosenthal , Jaume Pons , Wei-Hsien Ho , Jan Markus Grimm
发明人： Arnon Rosenthal , Jaume Pons , Wei-Hsien Ho , Jan Markus Grimm
IPC分类号： A61K39/395 , A61P25/28
CPC分类号： C07K16/18 , A61K39/00 , A61K2039/505 , C07K16/00 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： Monoclonal antibody 9TL and antibodies derived from 9TL directed against amyloid-beta peptide and methods of using same for diagnosing and treatment of Alzheimer's disease and Aβ peptide associated diseases are described. Methods of using antibodies directed against amyloid-beta peptide having impaired effector function for treatment of Alzheimer's disease and Aβ peptide associated diseases are also described.
摘要翻译： 单克隆抗体9TL和衍生自针对淀粉样蛋白-β肽的9TL的抗体及其用于诊断和治疗阿尔茨海默病和A＆bgr的方法; 描述了肽相关疾病。 使用针对具有受损效应物功能的淀粉样蛋白-β肽的抗体治疗阿尔茨海默病和A＆Bgr的方法; 还描述了肽相关疾病。
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4.发明授权公开(公告)号：US08268593B2
公开(公告)日：2012-09-18
申请号：US12754579
申请日：2010-04-05
申请人： Arnon Rosenthal , Jaume Pons , Wei-Hsien Ho , Jan Markus Grimm
发明人： Arnon Rosenthal , Jaume Pons , Wei-Hsien Ho , Jan Markus Grimm
CPC分类号： C07K16/18 , A61K39/00 , A61K2039/505 , C07K16/00 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： Monoclonal antibody 9TL and antibodies derived from 9TL directed against amyloid-beta peptide and methods of using same for diagnosing and treatment of Alzheimer's disease and Aβ peptide associated diseases are described. Methods of using antibodies directed against amyloid-beta peptide having impaired effector function for treatment of Alzheimer's disease and Aβ peptide associated diseases are also described.
摘要翻译： 单克隆抗体9TL和衍生自针对淀粉样蛋白-β肽的9TL的抗体及其用于诊断和治疗阿尔茨海默病和A＆bgr的方法; 描述了肽相关疾病。 使用针对具有受损效应物功能的淀粉样蛋白-β肽的抗体治疗阿尔茨海默病和A＆Bgr的方法; 还描述了肽相关疾病。
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5.发明申请ANTAGONIST ANTIBODIES DIRECTED AGAINST CALCITONIN GENE-RELATED PEPTIDE AND METHODS USING SAME 有权针对CALCITONIN基因相关肽的ANTAGONIST抗体及其使用方法公开(公告)号：US20120009192A1
公开(公告)日：2012-01-12
申请号：US13179846
申请日：2011-07-11
申请人： Joerg Zeller , Kristian T. Poulsen , Yasmina N. Abdiche , Jaume Pons , Sierra Leigh Jones Collier , Arnon Rosenthal
发明人： Joerg Zeller , Kristian T. Poulsen , Yasmina N. Abdiche , Jaume Pons , Sierra Leigh Jones Collier , Arnon Rosenthal
CPC分类号： C07K16/18 , A61K31/4045 , A61K39/3955 , A61K2039/505 , C07K16/26 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/70 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster headache, and tension headache) and hot flushes, by administering an anti-CGRP antagonist antibody. Antagonist antibody G1 and antibodies derived from G1 directed to CGRP are also described.
摘要翻译： 本发明的特征在于通过施用抗CGRP拮抗剂抗体来预防或治疗CGRP相关疾病如血管舒缩症状，包括头痛（例如偏头痛，丛集性头痛和紧张性头痛）和热潮红的方法。 还描述了拮抗剂抗体G1和衍生自指向CGRP的G1的抗体。
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公开(公告)号：US08088384B2
公开(公告)日：2012-01-03
申请号：US12618896
申请日：2009-11-16
申请人： Jaume Pons , Arnon Rosenthal
发明人： Jaume Pons , Arnon Rosenthal
IPC分类号： A61K39/395 , A61P19/02 , C07K16/00 , C12P21/06
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.
摘要翻译： 本发明涉及抗NGF抗体（例如抗NGF拮抗剂抗体）和编码该抗体的多核苷酸。 本发明还涉及在治疗和/或预防疼痛（包括手术后疼痛，类风湿性关节炎疼痛和骨关节炎疼痛）中使用此类抗体和/或多核苷酸。
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公开(公告)号：US07927594B2
公开(公告)日：2011-04-19
申请号：US11194989
申请日：2005-08-01
申请人： Arnon Rosenthal , Jaume Pons , Wei-Hsien Ho , Jan Markus Grimm
发明人： Arnon Rosenthal , Jaume Pons , Wei-Hsien Ho , Jan Markus Grimm
IPC分类号： A61K39/395 , C12P21/08
CPC分类号： C07K16/18 , A61K39/00 , A61K2039/505 , C07K16/00 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： Monoclonal antibody 9TL and antibodies derived from 9TL directed against amyloid-beta peptide and methods of using same for diagnosing and treatment of Alzheimer's disease and Aβ peptide associated diseases are described. Methods of using antibodies directed against amyloid-beta peptide having impaired effector function for treatment of Alzheimer's disease and Aβ peptide associated diseases are also described.
摘要翻译： 单克隆抗体9TL和衍生自针对淀粉样蛋白-β肽的9TL的抗体及其用于诊断和治疗阿尔茨海默病和A＆bgr的方法; 描述了肽相关疾病。 使用针对具有受损效应物功能的淀粉样蛋白-β肽的抗体治疗阿尔茨海默病和A＆Bgr的方法; 还描述了肽相关疾病。
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公开(公告)号：US20060057702A1
公开(公告)日：2006-03-16
申请号：US11195207
申请日：2005-08-01
申请人： Arnon Rosenthal , Jaume Pons , Wei-Hsien Ho , Jan Grimm
发明人： Arnon Rosenthal , Jaume Pons , Wei-Hsien Ho , Jan Grimm
IPC分类号： C12N1/20
CPC分类号： C07K16/18 , A61K39/00 , A61K2039/505 , C07K16/00 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： Monoclonal antibody 9TL and antibodies derived from 9TL directed against amyloid-beta peptide and methods of using same for diagnosing and treatment of Alzheimer's disease and Aβ peptide associated diseases are described. Methods of using antibodies directed against amyloid-beta peptide having impaired effector function for treatment of Alzheimer's disease and Aβ peptide associated diseases are also described.
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公开(公告)号：US20060057701A1
公开(公告)日：2006-03-16
申请号：US11194989
申请日：2005-08-01
申请人： Arnon Rosenthal , Jaume Pons , Wei-Hsien Ho , Jan Grimm
发明人： Arnon Rosenthal , Jaume Pons , Wei-Hsien Ho , Jan Grimm
IPC分类号： C12N1/20
CPC分类号： C07K16/18 , A61K39/00 , A61K2039/505 , C07K16/00 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： Monoclonal antibody 9TL and antibodies derived from 9TL directed against amyloid-beta peptide and methods of using same for diagnosing and treatment of Alzheimer's disease and Aβ peptide associated diseases are described. Methods of using antibodies directed against amyloid-beta peptide having impaired effector function for treatment of Alzheimer's disease and Aβ peptide associated diseases are also described.
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公开(公告)号：US09212222B2
公开(公告)日：2015-12-15
申请号：US13302264
申请日：2011-11-22
申请人： Jaume Pons , Arnon Rosenthal
发明人： Jaume Pons , Arnon Rosenthal
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.
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