公开(公告)号：US4205064A

公开(公告)日：1980-05-27

申请号：US28955

申请日：1979-04-11

申请人： Arthur F. Wagner ,  Nathaniel Grier ,  Tsung-Ting Shen

发明人： Arthur F. Wagner ,  Nathaniel Grier ,  Tsung-Ting Shen

IPC分类号： C07D265/08 ,  C08G73/02 ,  A61K31/14 ,  A61K31/74

CPC分类号： C07D265/08 ,  C08G73/0226 ,  C08G73/0233

摘要： Novel polymers having a linear backbone which is free from both branching and cross-linking, comprising quaternized nitrogen atoms linked to each other through trimethylene groups. By the term "linear backbone" is meant that the polymer has only acyclic groups, i. e. trimethylene, linking the nitrogen atoms in a single continuous chain; the polymer is free from "branching" when it has no repeating monomer units extending from the polymer backbone; and it is free from "cross-linking" when there is no joining of two linear backbones. These polymers are useful as antimicrobials, flocculating agents, antistatic agents, electroconductive agents for coating paper, chelating agents and bile acid binding agents, as well as in similar applications where their high charge to weight ratio and fully accessible nitrogen atoms can be employed. The polymers are obtained by the polymerization of dihydro-oxazine, reductive alkylation of the resulting polymer, followed by quaternization.

摘要翻译： 具有不含支链和交联的线性骨架的新型聚合物，其包含通过三亚甲基彼此连接的季铵化氮原子。 术语“直链骨架”是指聚合物仅具有非循环基团， e。 三亚甲基，连接单个连续链中的氮原子; 当聚合物没有从聚合物骨架延伸的重复单体单元时，没有“支化”; 当没有连接两个线性骨架时，它没有“交联”。 这些聚合物可用作抗微生物剂，絮凝剂，抗静电剂，用于涂布纸的导电剂，螯合剂和胆汁酸结合剂，以及可以使用其高电荷重量比和完全可及的氮原子的类似应用。 聚合物通过二氢恶嗪的聚合，所得聚合物的还原烷基化，然后季铵化得到。

公开(公告)号：US4098726A

公开(公告)日：1978-07-04

申请号：US783886

申请日：1977-04-01

申请人： Arthur F. Wagner ,  Nathaniel Grier ,  Tsung-Ying Shen

发明人： Arthur F. Wagner ,  Nathaniel Grier ,  Tsung-Ying Shen

IPC分类号： C08G73/00 ,  A61K31/14 ,  C07C67/00 ,  C07C209/00 ,  C07C209/12 ,  C07C211/63 ,  C08G73/02

CPC分类号： C08G73/0226 ,  C07C209/68 ,  C07C209/74

摘要： Novel polymers having a linear backbone which is free from both branching and cross-linking, comprising quaternized nitrogen atoms linked to each other through trimethylene groups. By the term "linear backbone" is meant that the polymer has only acyclic groups, i. e. trimethylene, linking the nitrogen atoms in a single continuous chain; the polymer is free from "branching" when it has no repeating monomer units extending from the polymer backbone; and it is free from "cross-linking" when there is no joining of two linear backbones. These polymers are useful as antimicrobials, flocculating agents, antistatic agents, electroconductive agents for coating paper, chelating agents and bile acid binding agents, as well as in similar applications where their high charge to weight ratio and fully accessible nitrogen atoms can be employed. The polymers are obtained by the polymerization of dihydro-oxazine, reductive alkylation of the resulting polymer, followed by quaternization.

摘要翻译： 具有不含支链和交联的线性骨架的新型聚合物，其包含通过三亚甲基彼此连接的季铵化氮原子。 术语“直链骨架”是指聚合物仅具有非循环基团， e。 三亚甲基，连接单个连续链中的氮原子; 当聚合物没有从聚合物骨架延伸的重复单体单元时，没有“支化”; 当没有连接两个线性骨架时，它没有“交联”。 这些聚合物可用作抗微生物剂，絮凝剂，抗静电剂，用于涂布纸的导电剂，螯合剂和胆汁酸结合剂，以及可以使用其高电荷重量比和完全可及的氮原子的类似应用。 聚合物通过二氢恶嗪的聚合，所得聚合物的还原烷基化，然后季铵化得到。

公开(公告)号：US4161581A

公开(公告)日：1979-07-17

申请号：US837980

申请日：1977-09-29

申请人： Arthur F. Wagner ,  Nathaniel Grier ,  Tsung-Ying Shen

发明人： Arthur F. Wagner ,  Nathaniel Grier ,  Tsung-Ying Shen

IPC分类号： C07D265/08 ,  C08G73/02

CPC分类号： C08G73/0233 ,  C07D265/08 ,  C08G73/0226

摘要： Novel polymers having a linear backbone which is free from both branching and cross-linking, comprising either tertiary or quaternized nitrogen atoms linked to each other through ethylene groups. These polymers are useful as antimicrobials, flocculating agents, antistatic agents, electroconductive agents for coating paper, chelating agents and bile acid binding agents, as well as in similar applications where their high charge to weight ratio and fully accessible nitrogen atoms can be employed. The polymers are obtained by the polymerization of an oxazoline, hydrolysis or direct reduction, nitrogen substitution, and optional quaternization of the resulting polymer.

摘要翻译： 具有不含支链和交联的直链骨架的新型聚合物包括通过乙烯基彼此连接的叔或季铵化的氮原子。 这些聚合物可用作抗微生物剂，絮凝剂，抗静电剂，用于涂布纸的导电剂，螯合剂和胆汁酸结合剂，以及可以使用其高电荷重量比和完全可及的氮原子的类似应用。 通过恶唑啉的聚合，所得聚合物的水解或直接还原，氮取代和任选的季铵化获得聚合物。

公开(公告)号：US4217429A

公开(公告)日：1980-08-12

申请号：US028954

申请日：1979-04-11

申请人： Arthur F. Wagner ,  Nathaniel Grier ,  Tsung-Ying Shen

发明人： Arthur F. Wagner ,  Nathaniel Grier ,  Tsung-Ying Shen

IPC分类号： C07D265/08 ,  C08G73/02

CPC分类号： C07D265/08 ,  C08G73/0226 ,  C08G73/0233

摘要： Novel polymers having a linear backbone which is free from both branching and cross-linking, comprising quaternized nitrogen atoms linked to each other through trimethylene groups. By the term "linear backbone" is meant that the polymer has only acyclic groups, i.e. trimethylene, linking the nitrogen atoms in a single continuous chain; the polymer is free from "branching" when it has no repeating monomer units extending from the polymer backbone; and it is free from "cross-linking" when there is no joining of two linear backbones. These polymers are useful as antimicrobials, flocculating agents, antistatic agents, electroconductive agents for coating paper, chelating agents and bile acid binding agents, as well as in similar applications where their high charge to weight ratio and fully accessible nitrogen atoms can be employed. The polymers are obtained by the polymerization of dihydro-oxazine, reductive alkylation of the resulting polymer, followed by quaternization.

摘要翻译： 具有不含支链和交联的线性骨架的新型聚合物，其包含通过三亚甲基彼此连接的季铵化氮原子。 术语“直链骨架”是指聚合物只有非循环基团，即三亚甲基，连接单个连续链中的氮原子; 当聚合物没有从聚合物骨架延伸的重复单体单元时，没有“支化”; 当没有连接两个线性骨架时，它没有“交联”。 这些聚合物可用作抗微生物剂，絮凝剂，抗静电剂，用于涂布纸的导电剂，螯合剂和胆汁酸结合剂，以及可以使用其高电荷重量比和完全可及的氮原子的类似应用。 聚合物通过二氢恶嗪的聚合，所得聚合物的还原烷基化，然后季铵化得到。

公开(公告)号：US4206295A

公开(公告)日：1980-06-03

申请号：US28933

申请日：1979-04-11

申请人： Arthur F. Wagner ,  Nathaniel Grier ,  Tsung-Ying Shen

发明人： Arthur F. Wagner ,  Nathaniel Grier ,  Tsung-Ying Shen

IPC分类号： C07D265/08 ,  C08G73/02 ,  C08L79/00

CPC分类号： C08G73/0226 ,  C07D265/08 ,  C08G73/0233

摘要： Novel polymers having a linear backbone which is free from both branching and cross-linking, comprising quaternized nitrogen atoms linked to each other through trimethylene groups. By the term "linear backbone" is meant that the polymer has only acyclic groups, i.e. trimethylene, linking the nitrogen atoms in a single continuous chain; the polymer is free from "branching" when it has no repeating monomer units extending from the polymer backbone; and it is free from "cross-linking" when there is no joining of two linear backbones. These polymers are useful as antimicrobials, flocculating agents, antistatic agents, electroconductive agents for coating paper, chelating agents and bile acid binding agents, as well as in similar applications where their high charge to weight ratio and fully accessible nitrogen atoms can be employed. The polymers are obtained by the polymerization of dihydro-oxazine, reductive alkylation of the resulting polymer, followed by quaternization.

摘要翻译： 具有不含支链和交联的线性骨架的新型聚合物，其包含通过三亚甲基彼此连接的季铵化氮原子。 术语“直链骨架”是指聚合物只有非循环基团，即三亚甲基，连接单个连续链中的氮原子; 当聚合物没有从聚合物骨架延伸的重复单体单元时，没有“支化”; 当没有连接两个线性骨架时，它没有“交联”。 这些聚合物可用作抗微生物剂，絮凝剂，抗静电剂，用于涂布纸的导电剂，螯合剂和胆汁酸结合剂，以及可以使用其高电荷重量比和完全可及的氮原子的类似应用。 聚合物通过二氢恶嗪的聚合，所得聚合物的还原烷基化，然后季铵化得到。

公开(公告)号：US4335141A

公开(公告)日：1982-06-15

申请号：US106616

申请日：1979-12-26

申请人： Nathaniel Grier ,  Richard A. Dybas ,  Bruce E. Witzel

发明人： Nathaniel Grier ,  Richard A. Dybas ,  Bruce E. Witzel

IPC分类号： A61K31/275 ,  A61K20060101 ,  A61P29/00 ,  A61P31/04 ,  C07C20060101 ,  C07C67/00 ,  C07C253/00 ,  C07C255/24 ,  C07C255/30 ,  C07C255/45 ,  C07C121/45 ,  C07C121/43 ,  C07C121/48

CPC分类号： C07C255/00

摘要： 2-Substituted-aminopropene and propanenitriles of the formula: ##STR1## are effective antimicrobial agents (compounds of Formula II.), and potent anti-inflammatory agents of decreased acute toxicity (compounds of Formula I.).

摘要翻译： 具有下式的2-取代的氨基丙烯和丙腈具有有效的抗微生物剂（式II化合物），以及急性毒性降低的有效抗炎剂（式Ⅰ化合物）。

公开(公告)号：US4260760A

公开(公告)日：1981-04-07

申请号：US11294

申请日：1979-03-12

申请人： Richard A. Dybas ,  Nathaniel Grier ,  Bruce E. Witzel

发明人： Richard A. Dybas ,  Nathaniel Grier ,  Bruce E. Witzel

IPC分类号： A01N33/04 ,  A01N33/08 ,  A61K8/41 ,  A61Q11/00 ,  A61Q17/00 ,  A61Q19/00 ,  C07C45/42 ,  C07C45/48 ,  C07D241/04 ,  C07D295/00

CPC分类号： A61Q11/00 ,  A01N33/04 ,  A01N33/08 ,  A61K8/41 ,  A61Q17/005 ,  A61Q19/00 ,  C07C45/004 ,  C07C45/48 ,  C10M2201/02 ,  C10M2215/04 ,  C10M2215/042 ,  C10M2215/26 ,  C10M2217/046 ,  C10M2217/06 ,  C10N2240/401

摘要： Novel diphenyl and loweralkyl substituted diphenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful because of their low toxicity, and as such are advantageously included as the active agent in surgical scrubs, antibacterial soaps, as preservatives in cosmetic preparations, and the like. They also can be used for topical treatment of dermatological conditions having a bacterial origin or implication such as Acne vulgaris.

摘要翻译： 新的二苯基和低级烷基取代的二苯基多胺是有用的抗微生物剂，以及藻类抑制剂。 它们由于其低毒性而特别有用，因此有利地包括作为外科手术洗涤剂中的活性剂，抗菌皂，化妆品制剂中的防腐剂等。 它们也可用于局部治疗具有细菌来源或暗示的皮肤病学症状，例如寻常痤疮。

公开(公告)号：US4119779A

公开(公告)日：1978-10-10

申请号：US795674

申请日：1977-05-11

申请人： Nathaniel Grier ,  Bruce E. Witzel

发明人： Nathaniel Grier ,  Bruce E. Witzel

IPC分类号： A01N43/64 ,  C07D405/06 ,  C07D405/14 ,  C10M169/00 ,  C07D263/04 ,  C07D263/06 ,  C07D405/10

CPC分类号： C07D405/06 ,  C10M169/00 ,  C10M2201/02 ,  C10M2201/063 ,  C10M2203/10 ,  C10M2207/026 ,  C10M2207/125 ,  C10M2207/129 ,  C10M2209/00 ,  C10M2209/02 ,  C10M2209/084 ,  C10M2209/10 ,  C10M2209/103 ,  C10M2209/104 ,  C10M2209/105 ,  C10M2209/12 ,  C10M2215/04 ,  C10M2215/042 ,  C10M2215/222 ,  C10M2215/26 ,  C10M2219/044 ,  C10M2219/083 ,  C10M2219/10 ,  C10M2219/102 ,  C10M2219/104 ,  C10M2219/106 ,  C10M2223/045 ,  C10M2223/10 ,  C10M2229/02 ,  C10M2229/05 ,  C10N2210/01 ,  C10N2210/02 ,  C10N2240/08 ,  C10N2240/40 ,  C10N2240/401

摘要： 1,3,5-s-Hexahydrotrisubstituted triazines exemplified by 1,3,5-tris(tetrahydrofurfuryl)-1,3,5-hexahydro-s-triazines are useful as antimicrobial agents particularly when employed as a component of metal-working compositions subject to fungal and bacterial attack.

摘要翻译： 1,3,5-三（四氢糠基）-1,3,5-六氢-s-三嗪作为抗微生物剂，特别是当用作金属加工组合物的组分时，可用作1,3,5-三（四氢糠基） 受真菌和细菌攻击。

公开(公告)号：US4035174A

公开(公告)日：1977-07-12

申请号：US670588

申请日：1976-03-26

申请人： Nathaniel Grier ,  Richard A. Dybas ,  Robert A. Strelitz

发明人： Nathaniel Grier ,  Richard A. Dybas ,  Robert A. Strelitz

IPC分类号： A01N33/04 ,  A01N33/08 ,  A01N9/20 ,  C02C5/02 ,  C07C87/02 ,  C07C87/16

CPC分类号： A01N33/08 ,  A01N33/04

摘要： Novel dibicyclo [3.1.1] and [2.2.1] heptyl and dibicyclo [3.1.1] and [2.2.1] heptenyl polyamines having a cyclohexylene group in the polyamine moiety are useful antimicrobial agents, as well as algae inhibitors. They are especially useful as hard surface disinfectants and as additives to oil well drilling muds, injection brines and industrial waters where microbial control is desired.

摘要翻译： 在多胺部分中具有亚环己基的新型二环[3.1.1]和[2.2.1]庚基和二环[3.1.1]和[2.2.1]庚烯基多胺是有用的抗微生物剂，以及藻类抑制剂。 它们特别适用于需要微生物控制的油井钻井泥浆，注射盐水和工业水中的硬表面消毒剂和添加剂。

公开(公告)号：US4340756A

公开(公告)日：1982-07-20

申请号：US231193

申请日：1981-02-04

申请人： Richard A. Dybas ,  Nathaniel Grier ,  Bruce E. Witzel

发明人： Richard A. Dybas ,  Nathaniel Grier ,  Bruce E. Witzel

IPC分类号： A01N33/04 ,  A01N33/08 ,  A61K8/41 ,  A61Q17/00 ,  C11D3/48 ,  C07C87/38

CPC分类号： A61K8/41 ,  A01N33/04 ,  A01N33/08 ,  A61Q17/005 ,  C11D3/48

摘要： Novel halophenyl and loweralkyl substituted halophenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful because of their low toxicity, and as such are advantageously included as the active agent in surgical scrubs, antibacterial soaps, as preservatives in cosmetic preparations, and the like.

摘要翻译： 新的卤代苯基和低级烷基取代的卤代苯基多胺是有用的抗微生物剂，以及藻类抑制剂。 它们由于其低毒性而特别有用，因此有利地包括作为外科手术洗涤剂中的活性剂，抗菌皂，化妆品制剂中的防腐剂等。